Incidental Mutation 'R5537:Mrgprx1'
ID434875
Institutional Source Beutler Lab
Gene Symbol Mrgprx1
Ensembl Gene ENSMUSG00000070552
Gene NameMAS-related GPR, member X1
SynonymsMrgprc11, MrgC11
MMRRC Submission 043095-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R5537 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location48020971-48027597 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 48021150 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Leucine at position 283 (H283L)
Ref Sequence ENSEMBL: ENSMUSP00000091954 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094390]
Predicted Effect probably benign
Transcript: ENSMUST00000094390
AA Change: H283L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000091954
Gene: ENSMUSG00000070552
AA Change: H283L

DomainStartEndE-ValueType
Pfam:7tm_1 43 202 1.9e-7 PFAM
low complexity region 227 245 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.3%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A T 5: 8,955,485 I1123F probably damaging Het
Acsl3 C T 1: 78,706,356 R702C probably damaging Het
Ank1 A G 8: 23,114,876 E1031G probably damaging Het
Ankle2 T C 5: 110,249,495 S536P probably damaging Het
Arfgef2 G T 2: 166,856,593 probably null Het
Bahd1 G T 2: 118,915,980 D27Y probably damaging Het
Brinp2 C T 1: 158,255,013 V246I probably damaging Het
Ccdc187 C A 2: 26,276,225 A731S probably benign Het
Cdc37l1 T A 19: 28,995,118 N70K probably damaging Het
Cdk5r1 A G 11: 80,477,999 Y164C probably damaging Het
Clrn3 A T 7: 135,514,062 H186Q probably benign Het
Col12a1 G A 9: 79,699,590 T517I probably damaging Het
Crhr1 T A 11: 104,163,856 N98K possibly damaging Het
Dst C T 1: 34,189,878 S2362L probably benign Het
Eapp G A 12: 54,692,059 T98I probably benign Het
Gm8394 A G 10: 85,314,049 noncoding transcript Het
Iqsec3 T C 6: 121,412,644 probably benign Het
Kctd12 A G 14: 102,982,277 V55A probably benign Het
Kmt2d G A 15: 98,852,109 probably benign Het
Lgr5 T C 10: 115,456,689 D432G probably benign Het
Nlrp4e T C 7: 23,320,489 F134L probably benign Het
Olfr1030 T A 2: 85,984,226 Y129N possibly damaging Het
Olfr1307 A T 2: 111,945,048 M136K probably damaging Het
Olfr394 T C 11: 73,887,697 K225R probably benign Het
Olfr902 T A 9: 38,449,242 Y123* probably null Het
Pfkp C A 13: 6,619,242 W235L probably damaging Het
Prom1 C T 5: 44,000,776 probably null Het
Rab14 A T 2: 35,192,637 F12L possibly damaging Het
Rnf40 T A 7: 127,596,089 I429N probably benign Het
S100pbp G A 4: 129,182,188 P115S probably benign Het
Scarf1 G A 11: 75,525,531 A600T probably damaging Het
Slc6a5 T C 7: 49,959,311 F755L probably benign Het
Slc7a2 A T 8: 40,913,986 I510F probably benign Het
Spag16 T C 1: 69,827,016 S5P probably benign Het
Tex15 A G 8: 33,571,613 Y631C probably damaging Het
Tmem182 A T 1: 40,854,909 I195F probably benign Het
Tox A G 4: 6,697,510 L431P probably damaging Het
Tprn G A 2: 25,263,357 A224T probably benign Het
Tsg101 T C 7: 46,891,128 K294E probably benign Het
Tubb2a C A 13: 34,075,451 V119L probably benign Het
Vps37d C T 5: 135,074,402 E129K possibly damaging Het
Zfp974 TAATCTGTCTCCAAATCTG TAATCTG 7: 27,912,246 probably benign Het
Zpld1 A G 16: 55,233,640 V263A possibly damaging Het
Other mutations in Mrgprx1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Mrgprx1 APN 7 48021486 missense probably benign 0.00
IGL01326:Mrgprx1 APN 7 48021769 missense probably benign 0.26
IGL02117:Mrgprx1 APN 7 48021623 nonsense probably null
IGL02219:Mrgprx1 APN 7 48021729 missense probably benign 0.20
IGL02431:Mrgprx1 APN 7 48021127 missense probably benign 0.00
IGL02441:Mrgprx1 APN 7 48021588 missense probably benign 0.39
IGL02682:Mrgprx1 APN 7 48021992 missense probably damaging 1.00
R0219:Mrgprx1 UTSW 7 48021546 missense probably damaging 1.00
R4366:Mrgprx1 UTSW 7 48021193 missense probably damaging 0.98
R4521:Mrgprx1 UTSW 7 48021699 missense probably benign
R4801:Mrgprx1 UTSW 7 48021211 missense possibly damaging 0.89
R4802:Mrgprx1 UTSW 7 48021211 missense possibly damaging 0.89
R5452:Mrgprx1 UTSW 7 48021808 missense probably benign 0.07
R6444:Mrgprx1 UTSW 7 48021814 missense possibly damaging 0.87
R6834:Mrgprx1 UTSW 7 48021637 missense probably damaging 0.99
R7406:Mrgprx1 UTSW 7 48021985 missense possibly damaging 0.62
RF020:Mrgprx1 UTSW 7 48021511 small insertion probably benign
RF024:Mrgprx1 UTSW 7 48021511 small insertion probably benign
RF026:Mrgprx1 UTSW 7 48021509 small insertion probably benign
RF043:Mrgprx1 UTSW 7 48021509 small insertion probably benign
Z1088:Mrgprx1 UTSW 7 48021129 missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TTGCAATCATAGAGGTGTTTCTGAG -3'
(R):5'- ATTCTCTGTGGTCCCAGGAG -3'

Sequencing Primer
(F):5'- TCATAGAGGTGTTTCTGAGAGAAG -3'
(R):5'- AGGCTGTATGTTACCATCGC -3'
Posted On2016-10-24