Incidental Mutation 'R5537:Or1e34'
ID 434887
Institutional Source Beutler Lab
Gene Symbol Or1e34
Ensembl Gene ENSMUSG00000056921
Gene Name olfactory receptor family 1 subfamily E member 34
Synonyms GA_x6K02T2P1NL-4043306-4042374, Olfr394, MOR135-8
MMRRC Submission 043095-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.256) question?
Stock # R5537 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 73778264-73779196 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73778523 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 225 (K225R)
Ref Sequence ENSEMBL: ENSMUSP00000149527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071478] [ENSMUST00000214284] [ENSMUST00000216608]
AlphaFold Q8VGR5
Predicted Effect probably benign
Transcript: ENSMUST00000071478
AA Change: K225R

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000071415
Gene: ENSMUSG00000056921
AA Change: K225R

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.4e-55 PFAM
Pfam:7TM_GPCR_Srsx 33 303 4e-7 PFAM
Pfam:7tm_1 39 288 1.9e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214284
AA Change: K225R

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000216608
AA Change: K225R

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A T 5: 9,005,485 (GRCm39) I1123F probably damaging Het
Acsl3 C T 1: 78,684,073 (GRCm39) R702C probably damaging Het
Ank1 A G 8: 23,604,892 (GRCm39) E1031G probably damaging Het
Ankle2 T C 5: 110,397,361 (GRCm39) S536P probably damaging Het
Arfgef2 G T 2: 166,698,513 (GRCm39) probably null Het
Bahd1 G T 2: 118,746,461 (GRCm39) D27Y probably damaging Het
Brinp2 C T 1: 158,082,583 (GRCm39) V246I probably damaging Het
Ccdc187 C A 2: 26,166,237 (GRCm39) A731S probably benign Het
Cdc37l1 T A 19: 28,972,518 (GRCm39) N70K probably damaging Het
Cdk5r1 A G 11: 80,368,825 (GRCm39) Y164C probably damaging Het
Clrn3 A T 7: 135,115,791 (GRCm39) H186Q probably benign Het
Col12a1 G A 9: 79,606,872 (GRCm39) T517I probably damaging Het
Crhr1 T A 11: 104,054,682 (GRCm39) N98K possibly damaging Het
Dst C T 1: 34,228,959 (GRCm39) S2362L probably benign Het
Eapp G A 12: 54,738,844 (GRCm39) T98I probably benign Het
Iqsec3 T C 6: 121,389,603 (GRCm39) probably benign Het
Kctd12 A G 14: 103,219,713 (GRCm39) V55A probably benign Het
Kmt2d G A 15: 98,749,990 (GRCm39) probably benign Het
Lgr5 T C 10: 115,292,594 (GRCm39) D432G probably benign Het
Mrgprx1 T A 7: 47,670,898 (GRCm39) H283L probably benign Het
Nlrp4e T C 7: 23,019,914 (GRCm39) F134L probably benign Het
Or4f14b A T 2: 111,775,393 (GRCm39) M136K probably damaging Het
Or5m5 T A 2: 85,814,570 (GRCm39) Y129N possibly damaging Het
Or8b43 T A 9: 38,360,538 (GRCm39) Y123* probably null Het
Pfkp C A 13: 6,669,278 (GRCm39) W235L probably damaging Het
Prom1 C T 5: 44,158,118 (GRCm39) probably null Het
Psma5-ps A G 10: 85,149,913 (GRCm39) noncoding transcript Het
Rab14 A T 2: 35,082,649 (GRCm39) F12L possibly damaging Het
Rnf40 T A 7: 127,195,261 (GRCm39) I429N probably benign Het
S100pbp G A 4: 129,075,981 (GRCm39) P115S probably benign Het
Scarf1 G A 11: 75,416,357 (GRCm39) A600T probably damaging Het
Slc6a5 T C 7: 49,609,059 (GRCm39) F755L probably benign Het
Slc7a2 A T 8: 41,367,023 (GRCm39) I510F probably benign Het
Spag16 T C 1: 69,866,175 (GRCm39) S5P probably benign Het
Tex15 A G 8: 34,061,641 (GRCm39) Y631C probably damaging Het
Tmem182 A T 1: 40,894,069 (GRCm39) I195F probably benign Het
Tox A G 4: 6,697,510 (GRCm39) L431P probably damaging Het
Tprn G A 2: 25,153,369 (GRCm39) A224T probably benign Het
Tsg101 T C 7: 46,540,876 (GRCm39) K294E probably benign Het
Tubb2a C A 13: 34,259,434 (GRCm39) V119L probably benign Het
Vps37d C T 5: 135,103,256 (GRCm39) E129K possibly damaging Het
Zfp974 TAATCTGTCTCCAAATCTG TAATCTG 7: 27,611,671 (GRCm39) probably benign Het
Zpld1 A G 16: 55,054,003 (GRCm39) V263A possibly damaging Het
Other mutations in Or1e34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Or1e34 APN 11 73,779,075 (GRCm39) missense probably damaging 1.00
IGL01655:Or1e34 APN 11 73,778,753 (GRCm39) missense probably benign 0.01
IGL02173:Or1e34 APN 11 73,778,949 (GRCm39) missense possibly damaging 0.72
IGL02308:Or1e34 APN 11 73,779,121 (GRCm39) missense probably benign 0.09
IGL02656:Or1e34 APN 11 73,778,865 (GRCm39) missense probably damaging 0.98
R0079:Or1e34 UTSW 11 73,778,563 (GRCm39) missense probably benign 0.22
R0119:Or1e34 UTSW 11 73,778,656 (GRCm39) missense probably benign 0.11
R0136:Or1e34 UTSW 11 73,778,656 (GRCm39) missense probably benign 0.11
R0136:Or1e34 UTSW 11 73,778,611 (GRCm39) missense probably benign 0.00
R0255:Or1e34 UTSW 11 73,778,655 (GRCm39) missense probably benign
R0545:Or1e34 UTSW 11 73,778,843 (GRCm39) nonsense probably null
R0599:Or1e34 UTSW 11 73,778,730 (GRCm39) missense probably benign 0.19
R0655:Or1e34 UTSW 11 73,778,631 (GRCm39) missense possibly damaging 0.88
R0657:Or1e34 UTSW 11 73,778,656 (GRCm39) missense probably benign 0.11
R0657:Or1e34 UTSW 11 73,778,611 (GRCm39) missense probably benign 0.00
R0720:Or1e34 UTSW 11 73,778,688 (GRCm39) missense probably benign 0.12
R1112:Or1e34 UTSW 11 73,779,060 (GRCm39) missense probably damaging 0.99
R2353:Or1e34 UTSW 11 73,778,660 (GRCm39) missense probably benign 0.02
R2924:Or1e34 UTSW 11 73,778,337 (GRCm39) missense probably damaging 0.99
R4583:Or1e34 UTSW 11 73,778,629 (GRCm39) missense probably damaging 1.00
R5231:Or1e34 UTSW 11 73,778,781 (GRCm39) missense probably damaging 1.00
R5806:Or1e34 UTSW 11 73,778,373 (GRCm39) missense probably damaging 0.99
R7131:Or1e34 UTSW 11 73,778,780 (GRCm39) nonsense probably null
R7325:Or1e34 UTSW 11 73,779,101 (GRCm39) missense probably benign 0.19
R7361:Or1e34 UTSW 11 73,778,827 (GRCm39) missense probably damaging 1.00
R9446:Or1e34 UTSW 11 73,778,530 (GRCm39) missense probably benign 0.18
R9711:Or1e34 UTSW 11 73,778,696 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGGGAGTCACCACTGTGTAC -3'
(R):5'- TGGATACTGACAACATCACATGCC -3'

Sequencing Primer
(F):5'- CTGTGTACATCATAGCCATGGCAG -3'
(R):5'- ACTGTCTTTTTGTGAGAACAATGTGC -3'
Posted On 2016-10-24