Incidental Mutation 'R5549:Or13a26'
ID 435039
Institutional Source Beutler Lab
Gene Symbol Or13a26
Ensembl Gene ENSMUSG00000057997
Gene Name olfactory receptor family 13 subfamily A member 26
Synonyms GA_x6K02T2PBJ9-42850324-42851256, MOR253-3, Olfr541
MMRRC Submission 043106-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R5549 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 140284166-140285104 bp(+) (GRCm39)
Type of Mutation splice site (161 bp from exon)
DNA Base Change (assembly) A to G at 140284712 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080681] [ENSMUST00000209857] [ENSMUST00000210357]
AlphaFold Q8VGM0
Predicted Effect probably benign
Transcript: ENSMUST00000080681
AA Change: I183V

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000079508
Gene: ENSMUSG00000057997
AA Change: I183V

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 2.2e-49 PFAM
Pfam:7TM_GPCR_Srsx 37 180 5e-8 PFAM
Pfam:7tm_1 43 292 1.2e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000209857
Predicted Effect probably benign
Transcript: ENSMUST00000210357
AA Change: I183V

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T C 14: 32,384,993 (GRCm39) E324G possibly damaging Het
Acad8 C T 9: 26,896,847 (GRCm39) R204Q probably damaging Het
Adgrg7 T G 16: 56,570,790 (GRCm39) T413P probably damaging Het
Ankrd11 A G 8: 123,617,117 (GRCm39) I2224T probably benign Het
Arhgap23 A G 11: 97,357,394 (GRCm39) D964G probably damaging Het
Atf6b A G 17: 34,870,657 (GRCm39) D367G probably damaging Het
Axdnd1 A G 1: 156,226,104 (GRCm39) L131P probably damaging Het
Bmp8b T C 4: 123,018,278 (GRCm39) V383A probably damaging Het
C5ar2 A G 7: 15,970,868 (GRCm39) V353A probably damaging Het
Ccr5 C A 9: 123,925,408 (GRCm39) A337E probably benign Het
Cftr G A 6: 18,227,953 (GRCm39) V382I probably benign Het
Csmd3 G C 15: 48,048,753 (GRCm39) S446C probably damaging Het
Cyp2d12 A G 15: 82,440,498 (GRCm39) T96A probably benign Het
Diaph3 T G 14: 87,216,106 (GRCm39) I465L probably benign Het
Fabp3 A G 4: 130,209,018 (GRCm39) *134W probably null Het
Fgf22 G T 10: 79,592,696 (GRCm39) M130I probably damaging Het
Flnc G A 6: 29,453,690 (GRCm39) V1792M probably damaging Het
Grik3 G A 4: 125,579,838 (GRCm39) A528T possibly damaging Het
Hecw2 G A 1: 53,964,850 (GRCm39) R659W possibly damaging Het
Hmbs C T 9: 44,250,774 (GRCm39) probably null Het
Ift122 T G 6: 115,868,983 (GRCm39) L490R probably damaging Het
Igkv4-63 T C 6: 69,355,116 (GRCm39) H55R probably damaging Het
Itga4 A T 2: 79,086,611 (GRCm39) N96I probably damaging Het
Kcna7 A T 7: 45,056,063 (GRCm39) H93L probably damaging Het
Klhdc7b A G 15: 89,271,562 (GRCm39) I815V probably benign Het
Lcmt1 G A 7: 123,027,330 (GRCm39) E298K probably damaging Het
Ly6g6f A G 17: 35,302,333 (GRCm39) V68A possibly damaging Het
Map3k8 C T 18: 4,340,762 (GRCm39) C184Y probably damaging Het
Mcemp1 A G 8: 3,718,340 (GRCm39) T183A possibly damaging Het
Mobp T G 9: 119,996,876 (GRCm39) S2R probably damaging Het
Mprip A G 11: 59,651,644 (GRCm39) S1783G probably benign Het
Mterf3 C A 13: 67,076,321 (GRCm39) A129S probably benign Het
Nfkb2 G T 19: 46,296,006 (GRCm39) E170D probably benign Het
Nr2c1 A G 10: 94,003,558 (GRCm39) T239A probably benign Het
Odr4 A G 1: 150,247,909 (GRCm39) S325P possibly damaging Het
Oplah G A 15: 76,182,466 (GRCm39) A963V probably damaging Het
Parp14 C T 16: 35,661,505 (GRCm39) S1481N probably benign Het
Prxl2a T C 14: 40,726,013 (GRCm39) K44E possibly damaging Het
Rictor C T 15: 6,816,391 (GRCm39) T1221M probably damaging Het
Rpe G A 1: 66,755,163 (GRCm39) D182N probably damaging Het
Slc24a3 C A 2: 145,448,784 (GRCm39) P443T probably damaging Het
Slc25a47 T C 12: 108,822,143 (GRCm39) *311Q probably null Het
Sox2 C G 3: 34,705,142 (GRCm39) A193G probably benign Het
Svep1 T C 4: 58,057,954 (GRCm39) S3284G probably benign Het
Zfp369 A T 13: 65,445,194 (GRCm39) H779L probably damaging Het
Zfp513 A T 5: 31,357,947 (GRCm39) L144Q possibly damaging Het
Zfp526 T C 7: 24,925,109 (GRCm39) F456S possibly damaging Het
Zfp791 C T 8: 85,836,835 (GRCm39) G343D probably damaging Het
Zfp941 A C 7: 140,388,021 (GRCm39) I664S possibly damaging Het
Zkscan3 A G 13: 21,578,233 (GRCm39) V189A probably damaging Het
Other mutations in Or13a26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01011:Or13a26 APN 7 140,284,350 (GRCm39) missense probably damaging 1.00
IGL01872:Or13a26 APN 7 140,284,176 (GRCm39) missense possibly damaging 0.59
IGL02814:Or13a26 APN 7 140,285,046 (GRCm39) missense probably damaging 1.00
R0690:Or13a26 UTSW 7 140,284,700 (GRCm39) missense possibly damaging 0.88
R1019:Or13a26 UTSW 7 140,284,407 (GRCm39) missense probably damaging 1.00
R1665:Or13a26 UTSW 7 140,284,707 (GRCm39) missense probably damaging 1.00
R1696:Or13a26 UTSW 7 140,284,409 (GRCm39) nonsense probably null
R4065:Or13a26 UTSW 7 140,284,182 (GRCm39) missense probably benign
R4517:Or13a26 UTSW 7 140,285,004 (GRCm39) missense probably damaging 1.00
R6327:Or13a26 UTSW 7 140,284,616 (GRCm39) missense probably damaging 1.00
R7288:Or13a26 UTSW 7 140,284,942 (GRCm39) nonsense probably null
R7307:Or13a26 UTSW 7 140,285,060 (GRCm39) missense probably benign 0.39
R7454:Or13a26 UTSW 7 140,284,547 (GRCm39) missense probably damaging 1.00
R8725:Or13a26 UTSW 7 140,284,607 (GRCm39) missense probably benign
R9404:Or13a26 UTSW 7 140,284,722 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCAGCATCTTCTGAGCTGC -3'
(R):5'- TAGAAAAGGCCTTCCTCTTGC -3'

Sequencing Primer
(F):5'- CATGGCCTATGACCGCTATGTG -3'
(R):5'- GCCCTCAGCAGAACGCATG -3'
Posted On 2016-10-24