Incidental Mutation 'R5554:Ifi209'
ID 435257
Institutional Source Beutler Lab
Gene Symbol Ifi209
Ensembl Gene ENSMUSG00000043263
Gene Name interferon activated gene 209
Synonyms Ifix, Pyhin-1, Pyhin1
MMRRC Submission 043111-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R5554 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 173458483-173475494 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 173468763 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 198 (S198T)
Ref Sequence ENSEMBL: ENSMUSP00000061900 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056071] [ENSMUST00000193727]
AlphaFold Q8BV49
Predicted Effect probably benign
Transcript: ENSMUST00000056071
AA Change: S198T

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000061900
Gene: ENSMUSG00000043263
AA Change: S198T

DomainStartEndE-ValueType
PYRIN 6 83 3.54e-17 SMART
low complexity region 152 169 N/A INTRINSIC
Pfam:HIN 231 396 4.2e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193727
AA Change: S198T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000142161
Gene: ENSMUSG00000043263
AA Change: S198T

DomainStartEndE-ValueType
PYRIN 6 83 1.7e-21 SMART
low complexity region 152 169 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200598
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.1%
Validation Efficiency 97% (73/75)
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aarsd1 C A 11: 101,304,807 (GRCm39) R227L probably benign Het
Adamtsl1 A G 4: 86,195,182 (GRCm39) Q533R possibly damaging Het
Adgb C T 10: 10,216,217 (GRCm39) R1524H probably damaging Het
Ank2 A T 3: 126,792,622 (GRCm39) N739K possibly damaging Het
Ankrd39 C T 1: 36,581,062 (GRCm39) G96R probably damaging Het
Anxa10 G A 8: 62,514,080 (GRCm39) P249L possibly damaging Het
Banp G A 8: 122,718,334 (GRCm39) E183K probably damaging Het
BC051665 C G 13: 60,932,435 (GRCm39) L83F probably damaging Het
Btn1a1 A T 13: 23,643,295 (GRCm39) F385I possibly damaging Het
Chchd4 A T 6: 91,441,999 (GRCm39) *140R probably null Het
Dcpp2 T C 17: 24,119,545 (GRCm39) Y120H probably damaging Het
Dlx2 G A 2: 71,375,805 (GRCm39) R173C possibly damaging Het
Dmbt1 C A 7: 130,701,030 (GRCm39) Y1069* probably null Het
Dop1a T A 9: 86,403,710 (GRCm39) F1637I probably damaging Het
Dusp18 T C 11: 3,847,202 (GRCm39) I64T probably damaging Het
Evi5l A G 8: 4,256,491 (GRCm39) probably benign Het
Fiz1 T C 7: 5,015,849 (GRCm39) H47R probably damaging Het
Fndc3b G T 3: 27,697,162 (GRCm39) P17T possibly damaging Het
Foxa1 T A 12: 57,589,077 (GRCm39) Q381L probably benign Het
Gda A G 19: 21,405,837 (GRCm39) probably null Het
Gm10044 T C 14: 7,771,181 (GRCm38) noncoding transcript Het
Gm12258 T A 11: 58,749,294 (GRCm39) S156R possibly damaging Het
Gm973 A G 1: 59,566,131 (GRCm39) R117G probably benign Het
Grwd1 C T 7: 45,480,064 (GRCm39) V48I probably damaging Het
Inka2 T A 3: 105,623,930 (GRCm39) S82R possibly damaging Het
Itga1 A T 13: 115,129,010 (GRCm39) C549* probably null Het
Kmt2c C A 5: 25,499,608 (GRCm39) G511C probably damaging Het
Knstrn T C 2: 118,664,444 (GRCm39) probably benign Het
Lrp2 T C 2: 69,382,768 (GRCm39) Y39C possibly damaging Het
Maco1 T C 4: 134,555,445 (GRCm39) I343V probably benign Het
Micos10 T C 4: 138,833,218 (GRCm39) probably benign Het
N4bp2 T C 5: 65,965,457 (GRCm39) Y1169H probably benign Het
Nbr1 C T 11: 101,455,633 (GRCm39) T129I probably benign Het
Or52e8 A C 7: 104,625,189 (GRCm39) M1R probably null Het
Or5k15 A T 16: 58,710,169 (GRCm39) M138K possibly damaging Het
Or7g25 T C 9: 19,160,039 (GRCm39) I219V probably benign Het
Oxct1 T A 15: 4,120,677 (GRCm39) F254I probably benign Het
Patj T A 4: 98,342,633 (GRCm39) S576T possibly damaging Het
Pdxdc1 A T 16: 13,690,363 (GRCm39) C202S probably benign Het
Pet100 A T 8: 3,672,381 (GRCm39) I19F probably damaging Het
Pik3r5 T C 11: 68,385,059 (GRCm39) Y655H probably damaging Het
Pkhd1 A G 1: 20,151,476 (GRCm39) S3807P probably damaging Het
Ptma A G 1: 86,454,649 (GRCm39) T8A probably damaging Het
Ptpn3 G T 4: 57,240,843 (GRCm39) N257K probably damaging Het
R3hdm1 C A 1: 128,164,409 (GRCm39) Q1108K probably benign Het
Rimbp2 T C 5: 128,857,406 (GRCm39) D815G probably damaging Het
Scn10a A G 9: 119,523,196 (GRCm39) F66L probably benign Het
Selenot T C 3: 58,484,296 (GRCm39) probably null Het
Serpinb8 A G 1: 107,526,705 (GRCm39) T82A probably benign Het
Serpini2 G A 3: 75,175,295 (GRCm39) probably benign Het
Slc1a6 G T 10: 78,631,816 (GRCm39) G214V probably benign Het
Slc5a6 C A 5: 31,195,444 (GRCm39) A425S probably damaging Het
Smo C A 6: 29,736,123 (GRCm39) N38K possibly damaging Het
Smtn A T 11: 3,470,811 (GRCm39) C909* probably null Het
Sntg2 C T 12: 30,308,040 (GRCm39) R215H probably benign Het
Stk4 T A 2: 163,941,645 (GRCm39) V287E probably benign Het
Tdrd7 A G 4: 46,005,358 (GRCm39) D388G possibly damaging Het
Ttn A T 2: 76,642,652 (GRCm39) F13294L probably damaging Het
Ube2j1 T G 4: 33,040,745 (GRCm39) F84V probably damaging Het
Ugt3a1 A G 15: 9,370,287 (GRCm39) Q477R probably damaging Het
Utf1 T C 7: 139,523,859 (GRCm39) S25P probably benign Het
Vmn1r184 A T 7: 25,966,413 (GRCm39) H53L probably damaging Het
Vmn2r13 A T 5: 109,339,860 (GRCm39) N38K possibly damaging Het
Vps13a C T 19: 16,699,775 (GRCm39) D756N probably damaging Het
Vwa1 G T 4: 155,857,695 (GRCm39) D34E probably damaging Het
Zfhx2 A C 14: 55,301,774 (GRCm39) L2070R probably damaging Het
Zfp984 A G 4: 147,840,362 (GRCm39) V163A probably benign Het
Zp3r A T 1: 130,511,208 (GRCm39) M325K probably benign Het
Other mutations in Ifi209
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Ifi209 APN 1 173,466,529 (GRCm39) missense possibly damaging 0.88
IGL02598:Ifi209 APN 1 173,472,281 (GRCm39) missense probably damaging 0.99
IGL02712:Ifi209 APN 1 173,470,267 (GRCm39) missense possibly damaging 0.68
IGL03131:Ifi209 APN 1 173,468,800 (GRCm39) missense possibly damaging 0.86
IGL03368:Ifi209 APN 1 173,470,057 (GRCm39) missense possibly damaging 0.91
R0880:Ifi209 UTSW 1 173,472,379 (GRCm39) missense probably damaging 1.00
R1317:Ifi209 UTSW 1 173,465,029 (GRCm39) missense possibly damaging 0.96
R1640:Ifi209 UTSW 1 173,464,931 (GRCm39) missense probably damaging 0.98
R1769:Ifi209 UTSW 1 173,468,728 (GRCm39) missense probably benign 0.11
R2349:Ifi209 UTSW 1 173,470,122 (GRCm39) missense probably damaging 1.00
R5096:Ifi209 UTSW 1 173,472,300 (GRCm39) missense probably benign 0.17
R5369:Ifi209 UTSW 1 173,464,873 (GRCm39) start codon destroyed probably null 1.00
R5484:Ifi209 UTSW 1 173,468,640 (GRCm39) missense probably benign 0.18
R5532:Ifi209 UTSW 1 173,466,542 (GRCm39) missense probably damaging 0.99
R5551:Ifi209 UTSW 1 173,468,763 (GRCm39) missense probably benign 0.01
R5749:Ifi209 UTSW 1 173,464,893 (GRCm39) missense probably damaging 1.00
R5960:Ifi209 UTSW 1 173,466,382 (GRCm39) splice site probably null
R6401:Ifi209 UTSW 1 173,472,269 (GRCm39) missense probably damaging 0.99
R7042:Ifi209 UTSW 1 173,470,236 (GRCm39) missense probably benign 0.34
R7304:Ifi209 UTSW 1 173,470,156 (GRCm39) missense possibly damaging 0.88
R7521:Ifi209 UTSW 1 173,470,261 (GRCm39) missense probably damaging 0.97
R7742:Ifi209 UTSW 1 173,470,198 (GRCm39) missense probably damaging 1.00
R7763:Ifi209 UTSW 1 173,470,445 (GRCm39) missense probably damaging 1.00
R7975:Ifi209 UTSW 1 173,468,722 (GRCm39) missense probably benign 0.24
R8498:Ifi209 UTSW 1 173,470,069 (GRCm39) missense probably benign 0.05
R8873:Ifi209 UTSW 1 173,470,156 (GRCm39) missense probably damaging 1.00
R9178:Ifi209 UTSW 1 173,464,969 (GRCm39) missense probably damaging 1.00
R9673:Ifi209 UTSW 1 173,470,332 (GRCm39) missense probably damaging 1.00
R9752:Ifi209 UTSW 1 173,472,235 (GRCm39) missense probably damaging 0.99
Z1088:Ifi209 UTSW 1 173,468,712 (GRCm39) missense probably benign 0.00
Z1088:Ifi209 UTSW 1 173,464,973 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TTACCAACTGCTTCCCGAAG -3'
(R):5'- ATTGCTACACTCTCTGGTGC -3'

Sequencing Primer
(F):5'- GGAACCAAGCCATTCAAATTTCTC -3'
(R):5'- ATCCATAAGACTGGCTTGGC -3'
Posted On 2016-10-24