Incidental Mutation 'R5556:Flt3'
ID 435381
Institutional Source Beutler Lab
Gene Symbol Flt3
Ensembl Gene ENSMUSG00000042817
Gene Name FMS-like tyrosine kinase 3
Synonyms CD135, Flk-2, Flt-3, Flk2, wmfl
MMRRC Submission 043113-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5556 (G1)
Quality Score 185
Status Not validated
Chromosome 5
Chromosomal Location 147267551-147337299 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 147269807 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000049324] [ENSMUST00000049324]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000049324
SMART Domains Protein: ENSMUSP00000039041
Gene: ENSMUSG00000042817

DomainStartEndE-ValueType
low complexity region 10 18 N/A INTRINSIC
IG 79 162 1.87e0 SMART
IG 258 346 2.57e0 SMART
internal_repeat_1 380 529 8.53e-14 PROSPERO
TyrKc 611 946 1.7e-140 SMART
Predicted Effect probably null
Transcript: ENSMUST00000049324
SMART Domains Protein: ENSMUSP00000039041
Gene: ENSMUSG00000042817

DomainStartEndE-ValueType
low complexity region 10 18 N/A INTRINSIC
IG 79 162 1.87e0 SMART
IG 258 346 2.57e0 SMART
internal_repeat_1 380 529 8.53e-14 PROSPERO
TyrKc 611 946 1.7e-140 SMART
Predicted Effect probably null
Transcript: ENSMUST00000176456
SMART Domains Protein: ENSMUSP00000135582
Gene: ENSMUSG00000042817

DomainStartEndE-ValueType
low complexity region 10 18 N/A INTRINSIC
IG 79 162 1.87e0 SMART
IG 258 346 2.57e0 SMART
Pfam:Ig_2 433 530 3.7e-2 PFAM
TyrKc 611 946 1.7e-140 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
PHENOTYPE: Mice functionally null for this gene display abnormal lymphopoiesis. Homozygous ENU mutant mice are sensitive to infection by mouse cytomegalovirus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427D14Rik T A 11: 72,066,026 (GRCm39) probably null Het
Abca13 A T 11: 9,208,546 (GRCm39) I240F possibly damaging Het
Accs A G 2: 93,666,428 (GRCm39) Y420H probably damaging Het
Aco2 T C 15: 81,773,520 (GRCm39) Y20H probably damaging Het
Adck2 T C 6: 39,560,869 (GRCm39) V419A probably benign Het
Bahd1 T A 2: 118,746,751 (GRCm39) N123K probably damaging Het
Cast A G 13: 74,844,008 (GRCm39) probably null Het
Cd164l2 T A 4: 132,951,016 (GRCm39) V157E probably damaging Het
Cdk11b C T 4: 155,718,604 (GRCm39) Q185* probably null Het
Ces2g T C 8: 105,694,074 (GRCm39) F470S probably benign Het
Cherp C G 8: 73,221,824 (GRCm39) Q313H probably damaging Het
Chrna4 A G 2: 180,675,773 (GRCm39) V110A possibly damaging Het
Cndp2 A G 18: 84,690,249 (GRCm39) V231A probably benign Het
Cst7 A T 2: 150,412,488 (GRCm39) H17L probably benign Het
Decr1 C T 4: 15,919,244 (GRCm39) D300N probably damaging Het
Dennd4b G A 3: 90,175,675 (GRCm39) R148Q probably damaging Het
Dgkb T G 12: 38,177,363 (GRCm39) V230G probably damaging Het
Dis3l2 T C 1: 86,901,126 (GRCm39) V439A possibly damaging Het
Disp3 C T 4: 148,342,614 (GRCm39) G612D probably benign Het
Dock7 T C 4: 98,832,972 (GRCm39) T1962A probably damaging Het
Entrep2 A G 7: 64,505,957 (GRCm39) F96S probably damaging Het
Fibp T A 19: 5,514,227 (GRCm39) V304E possibly damaging Het
Kifc3 G A 8: 95,835,087 (GRCm39) Q233* probably null Het
Klhl42 C A 6: 147,009,610 (GRCm39) S483Y probably benign Het
Map3k19 G A 1: 127,762,284 (GRCm39) R276* probably null Het
Mecom A G 3: 30,292,249 (GRCm39) S87P probably damaging Het
Med13 A G 11: 86,218,664 (GRCm39) V416A probably benign Het
Mepe G A 5: 104,486,078 (GRCm39) G406D probably damaging Het
Met T G 6: 17,534,175 (GRCm39) L673V probably benign Het
Mlh3 A T 12: 85,315,267 (GRCm39) Y306* probably null Het
Nrxn2 C A 19: 6,540,121 (GRCm39) A814E probably damaging Het
Nsmaf C T 4: 6,398,621 (GRCm39) V828I probably benign Het
Or2j3 T A 17: 38,615,964 (GRCm39) K129N possibly damaging Het
Or9r7 A T 10: 129,962,728 (GRCm39) L66H probably damaging Het
Panx1 A G 9: 14,918,929 (GRCm39) I310T possibly damaging Het
Pcare T C 17: 72,059,420 (GRCm39) K86E possibly damaging Het
Pcdhb6 T A 18: 37,467,442 (GRCm39) L121Q probably damaging Het
Plekha7 G A 7: 115,763,384 (GRCm39) T406I probably benign Het
Prtg T C 9: 72,758,986 (GRCm39) S447P probably damaging Het
Ptprr A G 10: 116,087,054 (GRCm39) Y267C probably damaging Het
Rbpjl A G 2: 164,249,982 (GRCm39) T134A probably benign Het
Relch C A 1: 105,620,892 (GRCm39) Q456K probably benign Het
Rpe C A 1: 66,745,625 (GRCm39) T55N probably damaging Het
Scn1a T C 2: 66,155,141 (GRCm39) D606G probably benign Het
Setd5 T A 6: 113,124,463 (GRCm39) N1105K probably benign Het
Sh3d21 T C 4: 126,056,029 (GRCm39) N126D possibly damaging Het
Shank1 A G 7: 43,993,739 (GRCm39) probably benign Het
Srgap3 T A 6: 112,716,039 (GRCm39) D627V probably damaging Het
Tacc2 T A 7: 130,276,336 (GRCm39) S1796T probably damaging Het
Tmco3 G A 8: 13,344,870 (GRCm39) V217I probably damaging Het
Trgc4 A T 13: 19,536,477 (GRCm39) R178S unknown Het
Tspan10 A T 11: 120,335,541 (GRCm39) Y217F possibly damaging Het
Usp3 G A 9: 66,451,303 (GRCm39) T153M possibly damaging Het
Xdh G T 17: 74,204,759 (GRCm39) T1067K probably benign Het
Zfp334 T C 2: 165,222,504 (GRCm39) D513G probably benign Het
Other mutations in Flt3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Flt3 APN 5 147,291,686 (GRCm39) missense probably damaging 1.00
IGL01083:Flt3 APN 5 147,291,680 (GRCm39) missense probably damaging 1.00
IGL01749:Flt3 APN 5 147,294,838 (GRCm39) missense probably benign 0.02
IGL01765:Flt3 APN 5 147,294,788 (GRCm39) missense probably benign
IGL02109:Flt3 APN 5 147,287,491 (GRCm39) missense probably benign 0.00
IGL02490:Flt3 APN 5 147,268,106 (GRCm39) missense probably damaging 1.00
IGL02631:Flt3 APN 5 147,281,362 (GRCm39) missense probably damaging 1.00
IGL03117:Flt3 APN 5 147,293,020 (GRCm39) missense probably benign
flick UTSW 5 147,278,048 (GRCm39) missense probably damaging 1.00
warmflash UTSW 5 147,303,728 (GRCm39) critical splice donor site probably null
R0070:Flt3 UTSW 5 147,309,536 (GRCm39) splice site probably benign
R0070:Flt3 UTSW 5 147,309,536 (GRCm39) splice site probably benign
R0320:Flt3 UTSW 5 147,306,389 (GRCm39) splice site probably benign
R0347:Flt3 UTSW 5 147,294,802 (GRCm39) missense probably damaging 1.00
R0512:Flt3 UTSW 5 147,278,080 (GRCm39) nonsense probably null
R0968:Flt3 UTSW 5 147,278,037 (GRCm39) missense possibly damaging 0.46
R1180:Flt3 UTSW 5 147,278,048 (GRCm39) missense probably damaging 1.00
R1266:Flt3 UTSW 5 147,293,670 (GRCm39) missense probably benign 0.00
R1562:Flt3 UTSW 5 147,281,323 (GRCm39) missense probably damaging 1.00
R1803:Flt3 UTSW 5 147,303,865 (GRCm39) nonsense probably null
R2000:Flt3 UTSW 5 147,278,048 (GRCm39) missense probably damaging 1.00
R2021:Flt3 UTSW 5 147,306,300 (GRCm39) missense probably damaging 0.98
R2079:Flt3 UTSW 5 147,291,893 (GRCm39) missense probably damaging 0.97
R2261:Flt3 UTSW 5 147,284,873 (GRCm39) missense probably benign 0.00
R2263:Flt3 UTSW 5 147,284,873 (GRCm39) missense probably benign 0.00
R3087:Flt3 UTSW 5 147,284,856 (GRCm39) missense probably benign 0.15
R3727:Flt3 UTSW 5 147,291,733 (GRCm39) missense probably damaging 0.96
R3939:Flt3 UTSW 5 147,293,053 (GRCm39) missense possibly damaging 0.87
R4469:Flt3 UTSW 5 147,312,454 (GRCm39) splice site silent
R4527:Flt3 UTSW 5 147,293,163 (GRCm39) missense probably benign 0.37
R4592:Flt3 UTSW 5 147,291,509 (GRCm39) missense possibly damaging 0.67
R4655:Flt3 UTSW 5 147,286,403 (GRCm39) missense possibly damaging 0.51
R4686:Flt3 UTSW 5 147,313,858 (GRCm39) missense probably damaging 1.00
R4867:Flt3 UTSW 5 147,271,250 (GRCm39) missense probably damaging 1.00
R4897:Flt3 UTSW 5 147,306,110 (GRCm39) missense probably damaging 1.00
R4941:Flt3 UTSW 5 147,293,185 (GRCm39) critical splice acceptor site probably null
R5254:Flt3 UTSW 5 147,312,500 (GRCm39) missense possibly damaging 0.60
R5325:Flt3 UTSW 5 147,312,459 (GRCm39) missense probably benign 0.00
R5395:Flt3 UTSW 5 147,291,633 (GRCm39) missense probably damaging 1.00
R5445:Flt3 UTSW 5 147,291,905 (GRCm39) nonsense probably null
R5469:Flt3 UTSW 5 147,291,893 (GRCm39) missense possibly damaging 0.63
R5660:Flt3 UTSW 5 147,306,291 (GRCm39) missense possibly damaging 0.79
R5879:Flt3 UTSW 5 147,271,719 (GRCm39) missense probably damaging 1.00
R5885:Flt3 UTSW 5 147,286,439 (GRCm39) missense probably damaging 1.00
R6554:Flt3 UTSW 5 147,312,545 (GRCm39) missense probably damaging 0.99
R6813:Flt3 UTSW 5 147,291,653 (GRCm39) missense probably damaging 0.97
R7451:Flt3 UTSW 5 147,286,477 (GRCm39) missense probably damaging 1.00
R7469:Flt3 UTSW 5 147,268,084 (GRCm39) missense probably benign 0.18
R7537:Flt3 UTSW 5 147,271,247 (GRCm39) missense probably damaging 1.00
R7605:Flt3 UTSW 5 147,286,386 (GRCm39) missense probably benign 0.01
R7651:Flt3 UTSW 5 147,291,732 (GRCm39) missense probably damaging 1.00
R7842:Flt3 UTSW 5 147,271,263 (GRCm39) missense probably damaging 1.00
R8051:Flt3 UTSW 5 147,295,765 (GRCm39) intron probably benign
R8236:Flt3 UTSW 5 147,293,670 (GRCm39) missense probably benign 0.00
R8305:Flt3 UTSW 5 147,284,864 (GRCm39) missense probably damaging 0.96
R8337:Flt3 UTSW 5 147,269,698 (GRCm39) critical splice donor site probably null
R8680:Flt3 UTSW 5 147,320,265 (GRCm39) missense probably benign 0.13
R8682:Flt3 UTSW 5 147,320,265 (GRCm39) missense probably benign 0.13
R8697:Flt3 UTSW 5 147,294,811 (GRCm39) missense possibly damaging 0.94
R8824:Flt3 UTSW 5 147,271,673 (GRCm39) missense probably damaging 1.00
R8959:Flt3 UTSW 5 147,303,774 (GRCm39) missense possibly damaging 0.93
R9235:Flt3 UTSW 5 147,320,202 (GRCm39) missense possibly damaging 0.89
R9324:Flt3 UTSW 5 147,313,790 (GRCm39) missense probably benign 0.27
R9544:Flt3 UTSW 5 147,291,442 (GRCm39) missense possibly damaging 0.76
R9570:Flt3 UTSW 5 147,309,424 (GRCm39) missense possibly damaging 0.91
R9622:Flt3 UTSW 5 147,303,841 (GRCm39) missense possibly damaging 0.92
R9668:Flt3 UTSW 5 147,293,694 (GRCm39) missense probably benign 0.13
X0018:Flt3 UTSW 5 147,303,876 (GRCm39) missense possibly damaging 0.54
Z1088:Flt3 UTSW 5 147,286,374 (GRCm39) critical splice donor site probably null
Z1177:Flt3 UTSW 5 147,320,211 (GRCm39) missense probably benign 0.27
Z31818:Flt3 UTSW 5 147,303,728 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AGATGATCGGCCTAAACCAG -3'
(R):5'- CCTGAGGATTTGACTTCACCTC -3'

Sequencing Primer
(F):5'- CCAGATATGAGGCCATTAGTGCC -3'
(R):5'- GAGGATTTGACTTCACCTCACTCTC -3'
Posted On 2016-10-24