Incidental Mutation 'R5556:Ces2g'
ID 435396
Institutional Source Beutler Lab
Gene Symbol Ces2g
Ensembl Gene ENSMUSG00000031877
Gene Name carboxylesterase 2G
Synonyms 2210023G05Rik
MMRRC Submission 043113-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.047) question?
Stock # R5556 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 105688350-105696169 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 105694074 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 470 (F470S)
Ref Sequence ENSEMBL: ENSMUSP00000049315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043183]
AlphaFold E9PV38
Predicted Effect probably benign
Transcript: ENSMUST00000043183
AA Change: F470S

PolyPhen 2 Score 0.135 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000049315
Gene: ENSMUSG00000031877
AA Change: F470S

DomainStartEndE-ValueType
Pfam:COesterase 11 539 1.4e-176 PFAM
Pfam:Abhydrolase_3 144 245 4.9e-11 PFAM
Pfam:Peptidase_S9 159 331 8.1e-7 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212330
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427D14Rik T A 11: 72,066,026 (GRCm39) probably null Het
Abca13 A T 11: 9,208,546 (GRCm39) I240F possibly damaging Het
Accs A G 2: 93,666,428 (GRCm39) Y420H probably damaging Het
Aco2 T C 15: 81,773,520 (GRCm39) Y20H probably damaging Het
Adck2 T C 6: 39,560,869 (GRCm39) V419A probably benign Het
Bahd1 T A 2: 118,746,751 (GRCm39) N123K probably damaging Het
Cast A G 13: 74,844,008 (GRCm39) probably null Het
Cd164l2 T A 4: 132,951,016 (GRCm39) V157E probably damaging Het
Cdk11b C T 4: 155,718,604 (GRCm39) Q185* probably null Het
Cherp C G 8: 73,221,824 (GRCm39) Q313H probably damaging Het
Chrna4 A G 2: 180,675,773 (GRCm39) V110A possibly damaging Het
Cndp2 A G 18: 84,690,249 (GRCm39) V231A probably benign Het
Cst7 A T 2: 150,412,488 (GRCm39) H17L probably benign Het
Decr1 C T 4: 15,919,244 (GRCm39) D300N probably damaging Het
Dennd4b G A 3: 90,175,675 (GRCm39) R148Q probably damaging Het
Dgkb T G 12: 38,177,363 (GRCm39) V230G probably damaging Het
Dis3l2 T C 1: 86,901,126 (GRCm39) V439A possibly damaging Het
Disp3 C T 4: 148,342,614 (GRCm39) G612D probably benign Het
Dock7 T C 4: 98,832,972 (GRCm39) T1962A probably damaging Het
Entrep2 A G 7: 64,505,957 (GRCm39) F96S probably damaging Het
Fibp T A 19: 5,514,227 (GRCm39) V304E possibly damaging Het
Flt3 T A 5: 147,269,807 (GRCm39) probably null Het
Kifc3 G A 8: 95,835,087 (GRCm39) Q233* probably null Het
Klhl42 C A 6: 147,009,610 (GRCm39) S483Y probably benign Het
Map3k19 G A 1: 127,762,284 (GRCm39) R276* probably null Het
Mecom A G 3: 30,292,249 (GRCm39) S87P probably damaging Het
Med13 A G 11: 86,218,664 (GRCm39) V416A probably benign Het
Mepe G A 5: 104,486,078 (GRCm39) G406D probably damaging Het
Met T G 6: 17,534,175 (GRCm39) L673V probably benign Het
Mlh3 A T 12: 85,315,267 (GRCm39) Y306* probably null Het
Nrxn2 C A 19: 6,540,121 (GRCm39) A814E probably damaging Het
Nsmaf C T 4: 6,398,621 (GRCm39) V828I probably benign Het
Or2j3 T A 17: 38,615,964 (GRCm39) K129N possibly damaging Het
Or9r7 A T 10: 129,962,728 (GRCm39) L66H probably damaging Het
Panx1 A G 9: 14,918,929 (GRCm39) I310T possibly damaging Het
Pcare T C 17: 72,059,420 (GRCm39) K86E possibly damaging Het
Pcdhb6 T A 18: 37,467,442 (GRCm39) L121Q probably damaging Het
Plekha7 G A 7: 115,763,384 (GRCm39) T406I probably benign Het
Prtg T C 9: 72,758,986 (GRCm39) S447P probably damaging Het
Ptprr A G 10: 116,087,054 (GRCm39) Y267C probably damaging Het
Rbpjl A G 2: 164,249,982 (GRCm39) T134A probably benign Het
Relch C A 1: 105,620,892 (GRCm39) Q456K probably benign Het
Rpe C A 1: 66,745,625 (GRCm39) T55N probably damaging Het
Scn1a T C 2: 66,155,141 (GRCm39) D606G probably benign Het
Setd5 T A 6: 113,124,463 (GRCm39) N1105K probably benign Het
Sh3d21 T C 4: 126,056,029 (GRCm39) N126D possibly damaging Het
Shank1 A G 7: 43,993,739 (GRCm39) probably benign Het
Srgap3 T A 6: 112,716,039 (GRCm39) D627V probably damaging Het
Tacc2 T A 7: 130,276,336 (GRCm39) S1796T probably damaging Het
Tmco3 G A 8: 13,344,870 (GRCm39) V217I probably damaging Het
Trgc4 A T 13: 19,536,477 (GRCm39) R178S unknown Het
Tspan10 A T 11: 120,335,541 (GRCm39) Y217F possibly damaging Het
Usp3 G A 9: 66,451,303 (GRCm39) T153M possibly damaging Het
Xdh G T 17: 74,204,759 (GRCm39) T1067K probably benign Het
Zfp334 T C 2: 165,222,504 (GRCm39) D513G probably benign Het
Other mutations in Ces2g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Ces2g APN 8 105,694,471 (GRCm39) splice site probably benign
IGL00901:Ces2g APN 8 105,691,761 (GRCm39) missense probably benign 0.01
IGL02101:Ces2g APN 8 105,691,769 (GRCm39) splice site probably null
IGL02146:Ces2g APN 8 105,693,576 (GRCm39) missense possibly damaging 0.94
IGL02624:Ces2g APN 8 105,691,380 (GRCm39) missense probably damaging 1.00
IGL03091:Ces2g APN 8 105,691,386 (GRCm39) missense probably damaging 1.00
PIT4810001:Ces2g UTSW 8 105,691,521 (GRCm39) missense possibly damaging 0.52
R0025:Ces2g UTSW 8 105,692,628 (GRCm39) splice site probably benign
R0025:Ces2g UTSW 8 105,692,628 (GRCm39) splice site probably benign
R0122:Ces2g UTSW 8 105,694,932 (GRCm39) missense probably damaging 0.96
R0494:Ces2g UTSW 8 105,693,199 (GRCm39) missense probably benign
R1127:Ces2g UTSW 8 105,694,094 (GRCm39) splice site probably null
R1337:Ces2g UTSW 8 105,690,597 (GRCm39) missense possibly damaging 0.63
R1619:Ces2g UTSW 8 105,693,984 (GRCm39) missense probably damaging 1.00
R1813:Ces2g UTSW 8 105,693,569 (GRCm39) missense probably benign 0.32
R2240:Ces2g UTSW 8 105,689,134 (GRCm39) missense probably benign 0.11
R2255:Ces2g UTSW 8 105,694,046 (GRCm39) missense probably damaging 1.00
R2307:Ces2g UTSW 8 105,695,044 (GRCm39) missense probably benign 0.01
R2566:Ces2g UTSW 8 105,692,621 (GRCm39) critical splice donor site probably null
R4026:Ces2g UTSW 8 105,691,377 (GRCm39) missense probably damaging 0.99
R4469:Ces2g UTSW 8 105,692,602 (GRCm39) missense probably benign 0.14
R4631:Ces2g UTSW 8 105,694,094 (GRCm39) splice site probably null
R4859:Ces2g UTSW 8 105,694,094 (GRCm39) splice site probably null
R4900:Ces2g UTSW 8 105,693,989 (GRCm39) nonsense probably null
R4925:Ces2g UTSW 8 105,691,526 (GRCm39) missense probably benign 0.27
R5524:Ces2g UTSW 8 105,693,527 (GRCm39) missense probably benign 0.00
R6795:Ces2g UTSW 8 105,694,449 (GRCm39) missense probably damaging 0.96
R6988:Ces2g UTSW 8 105,690,540 (GRCm39) missense probably benign
R7653:Ces2g UTSW 8 105,689,285 (GRCm39) missense probably damaging 1.00
R7724:Ces2g UTSW 8 105,693,484 (GRCm39) missense probably benign 0.02
R7740:Ces2g UTSW 8 105,692,962 (GRCm39) missense probably damaging 0.98
R7856:Ces2g UTSW 8 105,693,014 (GRCm39) missense not run
R8123:Ces2g UTSW 8 105,693,555 (GRCm39) missense probably benign 0.06
R8690:Ces2g UTSW 8 105,693,605 (GRCm39) missense probably benign 0.01
R8724:Ces2g UTSW 8 105,692,955 (GRCm39) missense probably benign 0.01
R8732:Ces2g UTSW 8 105,689,195 (GRCm39) missense possibly damaging 0.78
R8825:Ces2g UTSW 8 105,693,954 (GRCm39) missense probably benign 0.13
R9441:Ces2g UTSW 8 105,690,623 (GRCm39) missense possibly damaging 0.52
R9688:Ces2g UTSW 8 105,691,304 (GRCm39) missense probably benign 0.42
Z1177:Ces2g UTSW 8 105,690,593 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCTTGCGATTCCAAGTAACAATG -3'
(R):5'- ACCCATGCAAGCCTCTAATTG -3'

Sequencing Primer
(F):5'- GCGATTCCAAGTAACAATGTATCAAG -3'
(R):5'- AATTGAATTCCTGCCTCGATGTG -3'
Posted On 2016-10-24