Incidental Mutation 'R5556:4933427D14Rik'
ID 435403
Institutional Source Beutler Lab
Gene Symbol 4933427D14Rik
Ensembl Gene ENSMUSG00000020807
Gene Name RIKEN cDNA 4933427D14 gene
Synonyms Gm43951
MMRRC Submission 043113-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5556 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 72044755-72098308 bp(-) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) T to A at 72066026 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000104146 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108506] [ENSMUST00000131546] [ENSMUST00000142530]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000108506
SMART Domains Protein: ENSMUSP00000104146
Gene: ENSMUSG00000020807

DomainStartEndE-ValueType
Pfam:DUF4673 1 954 N/A PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131546
SMART Domains Protein: ENSMUSP00000122273
Gene: ENSMUSG00000020807

DomainStartEndE-ValueType
low complexity region 84 93 N/A INTRINSIC
coiled coil region 210 231 N/A INTRINSIC
coiled coil region 256 279 N/A INTRINSIC
low complexity region 291 305 N/A INTRINSIC
low complexity region 360 377 N/A INTRINSIC
low complexity region 545 559 N/A INTRINSIC
coiled coil region 625 653 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000142530
SMART Domains Protein: ENSMUSP00000115276
Gene: ENSMUSG00000020807

DomainStartEndE-ValueType
low complexity region 84 93 N/A INTRINSIC
coiled coil region 210 231 N/A INTRINSIC
coiled coil region 256 279 N/A INTRINSIC
low complexity region 291 305 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156696
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,208,546 (GRCm39) I240F possibly damaging Het
Accs A G 2: 93,666,428 (GRCm39) Y420H probably damaging Het
Aco2 T C 15: 81,773,520 (GRCm39) Y20H probably damaging Het
Adck2 T C 6: 39,560,869 (GRCm39) V419A probably benign Het
Bahd1 T A 2: 118,746,751 (GRCm39) N123K probably damaging Het
Cast A G 13: 74,844,008 (GRCm39) probably null Het
Cd164l2 T A 4: 132,951,016 (GRCm39) V157E probably damaging Het
Cdk11b C T 4: 155,718,604 (GRCm39) Q185* probably null Het
Ces2g T C 8: 105,694,074 (GRCm39) F470S probably benign Het
Cherp C G 8: 73,221,824 (GRCm39) Q313H probably damaging Het
Chrna4 A G 2: 180,675,773 (GRCm39) V110A possibly damaging Het
Cndp2 A G 18: 84,690,249 (GRCm39) V231A probably benign Het
Cst7 A T 2: 150,412,488 (GRCm39) H17L probably benign Het
Decr1 C T 4: 15,919,244 (GRCm39) D300N probably damaging Het
Dennd4b G A 3: 90,175,675 (GRCm39) R148Q probably damaging Het
Dgkb T G 12: 38,177,363 (GRCm39) V230G probably damaging Het
Dis3l2 T C 1: 86,901,126 (GRCm39) V439A possibly damaging Het
Disp3 C T 4: 148,342,614 (GRCm39) G612D probably benign Het
Dock7 T C 4: 98,832,972 (GRCm39) T1962A probably damaging Het
Entrep2 A G 7: 64,505,957 (GRCm39) F96S probably damaging Het
Fibp T A 19: 5,514,227 (GRCm39) V304E possibly damaging Het
Flt3 T A 5: 147,269,807 (GRCm39) probably null Het
Kifc3 G A 8: 95,835,087 (GRCm39) Q233* probably null Het
Klhl42 C A 6: 147,009,610 (GRCm39) S483Y probably benign Het
Map3k19 G A 1: 127,762,284 (GRCm39) R276* probably null Het
Mecom A G 3: 30,292,249 (GRCm39) S87P probably damaging Het
Med13 A G 11: 86,218,664 (GRCm39) V416A probably benign Het
Mepe G A 5: 104,486,078 (GRCm39) G406D probably damaging Het
Met T G 6: 17,534,175 (GRCm39) L673V probably benign Het
Mlh3 A T 12: 85,315,267 (GRCm39) Y306* probably null Het
Nrxn2 C A 19: 6,540,121 (GRCm39) A814E probably damaging Het
Nsmaf C T 4: 6,398,621 (GRCm39) V828I probably benign Het
Or2j3 T A 17: 38,615,964 (GRCm39) K129N possibly damaging Het
Or9r7 A T 10: 129,962,728 (GRCm39) L66H probably damaging Het
Panx1 A G 9: 14,918,929 (GRCm39) I310T possibly damaging Het
Pcare T C 17: 72,059,420 (GRCm39) K86E possibly damaging Het
Pcdhb6 T A 18: 37,467,442 (GRCm39) L121Q probably damaging Het
Plekha7 G A 7: 115,763,384 (GRCm39) T406I probably benign Het
Prtg T C 9: 72,758,986 (GRCm39) S447P probably damaging Het
Ptprr A G 10: 116,087,054 (GRCm39) Y267C probably damaging Het
Rbpjl A G 2: 164,249,982 (GRCm39) T134A probably benign Het
Relch C A 1: 105,620,892 (GRCm39) Q456K probably benign Het
Rpe C A 1: 66,745,625 (GRCm39) T55N probably damaging Het
Scn1a T C 2: 66,155,141 (GRCm39) D606G probably benign Het
Setd5 T A 6: 113,124,463 (GRCm39) N1105K probably benign Het
Sh3d21 T C 4: 126,056,029 (GRCm39) N126D possibly damaging Het
Shank1 A G 7: 43,993,739 (GRCm39) probably benign Het
Srgap3 T A 6: 112,716,039 (GRCm39) D627V probably damaging Het
Tacc2 T A 7: 130,276,336 (GRCm39) S1796T probably damaging Het
Tmco3 G A 8: 13,344,870 (GRCm39) V217I probably damaging Het
Trgc4 A T 13: 19,536,477 (GRCm39) R178S unknown Het
Tspan10 A T 11: 120,335,541 (GRCm39) Y217F possibly damaging Het
Usp3 G A 9: 66,451,303 (GRCm39) T153M possibly damaging Het
Xdh G T 17: 74,204,759 (GRCm39) T1067K probably benign Het
Zfp334 T C 2: 165,222,504 (GRCm39) D513G probably benign Het
Other mutations in 4933427D14Rik
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00707:4933427D14Rik APN 11 72,069,330 (GRCm39) missense probably damaging 1.00
IGL01643:4933427D14Rik APN 11 72,082,414 (GRCm39) missense probably damaging 1.00
IGL02004:4933427D14Rik APN 11 72,082,423 (GRCm39) missense possibly damaging 0.62
IGL02308:4933427D14Rik APN 11 72,093,308 (GRCm39) missense probably damaging 1.00
IGL02378:4933427D14Rik APN 11 72,080,424 (GRCm39) missense probably benign 0.02
IGL02715:4933427D14Rik APN 11 72,089,714 (GRCm39) missense probably damaging 1.00
IGL03330:4933427D14Rik APN 11 72,050,254 (GRCm39) missense probably damaging 1.00
IGL03384:4933427D14Rik APN 11 72,086,673 (GRCm39) missense possibly damaging 0.87
BB002:4933427D14Rik UTSW 11 72,071,327 (GRCm39) missense probably benign 0.31
BB012:4933427D14Rik UTSW 11 72,071,327 (GRCm39) missense probably benign 0.31
IGL03047:4933427D14Rik UTSW 11 72,057,552 (GRCm39) missense possibly damaging 0.74
R0114:4933427D14Rik UTSW 11 72,086,625 (GRCm39) missense probably damaging 1.00
R0526:4933427D14Rik UTSW 11 72,060,609 (GRCm39) missense probably damaging 1.00
R0653:4933427D14Rik UTSW 11 72,066,371 (GRCm39) nonsense probably null
R0669:4933427D14Rik UTSW 11 72,089,671 (GRCm39) missense possibly damaging 0.73
R0729:4933427D14Rik UTSW 11 72,050,281 (GRCm39) missense probably benign 0.07
R1797:4933427D14Rik UTSW 11 72,089,285 (GRCm39) missense possibly damaging 0.77
R3973:4933427D14Rik UTSW 11 72,089,567 (GRCm39) missense probably damaging 1.00
R4744:4933427D14Rik UTSW 11 72,066,365 (GRCm39) missense probably damaging 0.98
R4897:4933427D14Rik UTSW 11 72,082,342 (GRCm39) missense probably damaging 1.00
R5023:4933427D14Rik UTSW 11 72,057,581 (GRCm39) missense probably benign 0.07
R5057:4933427D14Rik UTSW 11 72,057,581 (GRCm39) missense probably benign 0.07
R5100:4933427D14Rik UTSW 11 72,057,477 (GRCm39) missense probably damaging 1.00
R5497:4933427D14Rik UTSW 11 72,056,360 (GRCm39) missense probably benign 0.22
R5631:4933427D14Rik UTSW 11 72,067,590 (GRCm39) missense possibly damaging 0.71
R5683:4933427D14Rik UTSW 11 72,093,266 (GRCm39) missense probably benign
R5742:4933427D14Rik UTSW 11 72,056,379 (GRCm39) missense possibly damaging 0.63
R6247:4933427D14Rik UTSW 11 72,049,768 (GRCm39) missense probably benign 0.02
R6267:4933427D14Rik UTSW 11 72,086,580 (GRCm39) missense probably damaging 1.00
R6296:4933427D14Rik UTSW 11 72,086,580 (GRCm39) missense probably damaging 1.00
R6860:4933427D14Rik UTSW 11 72,080,412 (GRCm39) missense probably damaging 1.00
R7023:4933427D14Rik UTSW 11 72,069,229 (GRCm39) critical splice donor site probably null
R7328:4933427D14Rik UTSW 11 72,060,606 (GRCm39) critical splice donor site probably null
R7514:4933427D14Rik UTSW 11 72,086,628 (GRCm39) missense probably damaging 1.00
R7544:4933427D14Rik UTSW 11 72,089,765 (GRCm39) missense probably damaging 1.00
R7925:4933427D14Rik UTSW 11 72,071,327 (GRCm39) missense probably benign 0.31
R8204:4933427D14Rik UTSW 11 72,057,606 (GRCm39) missense probably benign 0.01
R8280:4933427D14Rik UTSW 11 72,086,667 (GRCm39) missense possibly damaging 0.70
R8316:4933427D14Rik UTSW 11 72,059,612 (GRCm39) missense possibly damaging 0.70
R8366:4933427D14Rik UTSW 11 72,067,521 (GRCm39) nonsense probably null
R8384:4933427D14Rik UTSW 11 72,057,591 (GRCm39) missense probably benign 0.08
R8722:4933427D14Rik UTSW 11 72,080,422 (GRCm39) missense probably benign 0.00
R8944:4933427D14Rik UTSW 11 72,049,851 (GRCm39) splice site probably benign
R9749:4933427D14Rik UTSW 11 72,080,521 (GRCm39) missense possibly damaging 0.95
X0063:4933427D14Rik UTSW 11 72,067,595 (GRCm39) missense probably benign
X0065:4933427D14Rik UTSW 11 72,080,401 (GRCm39) missense possibly damaging 0.65
Z1176:4933427D14Rik UTSW 11 72,049,826 (GRCm39) missense probably benign 0.12
Z1186:4933427D14Rik UTSW 11 72,089,360 (GRCm39) missense probably benign 0.00
Z1186:4933427D14Rik UTSW 11 72,089,750 (GRCm39) missense probably damaging 1.00
Z1186:4933427D14Rik UTSW 11 72,067,535 (GRCm39) missense possibly damaging 0.73
Z1186:4933427D14Rik UTSW 11 72,080,442 (GRCm39) missense probably damaging 1.00
Z1186:4933427D14Rik UTSW 11 72,086,538 (GRCm39) frame shift probably null
Z1186:4933427D14Rik UTSW 11 72,086,569 (GRCm39) missense possibly damaging 0.73
Z1186:4933427D14Rik UTSW 11 72,086,580 (GRCm39) missense probably damaging 1.00
Z1186:4933427D14Rik UTSW 11 72,086,590 (GRCm39) frame shift probably null
Z1186:4933427D14Rik UTSW 11 72,086,595 (GRCm39) missense probably damaging 1.00
Z1186:4933427D14Rik UTSW 11 72,089,308 (GRCm39) missense probably benign 0.13
Z1187:4933427D14Rik UTSW 11 72,089,308 (GRCm39) missense probably benign 0.13
Z1187:4933427D14Rik UTSW 11 72,086,590 (GRCm39) frame shift probably null
Z1187:4933427D14Rik UTSW 11 72,086,580 (GRCm39) missense probably damaging 1.00
Z1187:4933427D14Rik UTSW 11 72,086,569 (GRCm39) missense possibly damaging 0.73
Z1187:4933427D14Rik UTSW 11 72,086,538 (GRCm39) frame shift probably null
Z1187:4933427D14Rik UTSW 11 72,086,536 (GRCm39) frame shift probably null
Z1187:4933427D14Rik UTSW 11 72,080,442 (GRCm39) missense probably damaging 1.00
Z1187:4933427D14Rik UTSW 11 72,067,535 (GRCm39) missense possibly damaging 0.73
Z1187:4933427D14Rik UTSW 11 72,089,750 (GRCm39) missense probably damaging 1.00
Z1187:4933427D14Rik UTSW 11 72,089,360 (GRCm39) missense probably benign 0.00
Z1188:4933427D14Rik UTSW 11 72,089,360 (GRCm39) missense probably benign 0.00
Z1188:4933427D14Rik UTSW 11 72,089,308 (GRCm39) missense probably benign 0.13
Z1188:4933427D14Rik UTSW 11 72,086,590 (GRCm39) frame shift probably null
Z1188:4933427D14Rik UTSW 11 72,086,580 (GRCm39) missense probably damaging 1.00
Z1188:4933427D14Rik UTSW 11 72,086,569 (GRCm39) missense possibly damaging 0.73
Z1188:4933427D14Rik UTSW 11 72,086,538 (GRCm39) frame shift probably null
Z1188:4933427D14Rik UTSW 11 72,080,442 (GRCm39) missense probably damaging 1.00
Z1188:4933427D14Rik UTSW 11 72,067,535 (GRCm39) missense possibly damaging 0.73
Z1188:4933427D14Rik UTSW 11 72,089,750 (GRCm39) missense probably damaging 1.00
Z1189:4933427D14Rik UTSW 11 72,089,360 (GRCm39) missense probably benign 0.00
Z1189:4933427D14Rik UTSW 11 72,089,750 (GRCm39) missense probably damaging 1.00
Z1189:4933427D14Rik UTSW 11 72,067,535 (GRCm39) missense possibly damaging 0.73
Z1189:4933427D14Rik UTSW 11 72,080,442 (GRCm39) missense probably damaging 1.00
Z1189:4933427D14Rik UTSW 11 72,086,538 (GRCm39) frame shift probably null
Z1189:4933427D14Rik UTSW 11 72,086,569 (GRCm39) missense possibly damaging 0.73
Z1189:4933427D14Rik UTSW 11 72,086,580 (GRCm39) missense probably damaging 1.00
Z1189:4933427D14Rik UTSW 11 72,086,590 (GRCm39) frame shift probably null
Z1189:4933427D14Rik UTSW 11 72,086,595 (GRCm39) missense probably damaging 1.00
Z1189:4933427D14Rik UTSW 11 72,089,308 (GRCm39) missense probably benign 0.13
Z1190:4933427D14Rik UTSW 11 72,089,308 (GRCm39) missense probably benign 0.13
Z1190:4933427D14Rik UTSW 11 72,086,595 (GRCm39) missense probably damaging 1.00
Z1190:4933427D14Rik UTSW 11 72,086,590 (GRCm39) frame shift probably null
Z1190:4933427D14Rik UTSW 11 72,086,580 (GRCm39) missense probably damaging 1.00
Z1190:4933427D14Rik UTSW 11 72,086,569 (GRCm39) missense possibly damaging 0.73
Z1190:4933427D14Rik UTSW 11 72,086,538 (GRCm39) frame shift probably null
Z1190:4933427D14Rik UTSW 11 72,080,442 (GRCm39) missense probably damaging 1.00
Z1190:4933427D14Rik UTSW 11 72,067,535 (GRCm39) missense possibly damaging 0.73
Z1190:4933427D14Rik UTSW 11 72,089,750 (GRCm39) missense probably damaging 1.00
Z1190:4933427D14Rik UTSW 11 72,089,360 (GRCm39) missense probably benign 0.00
Z1191:4933427D14Rik UTSW 11 72,089,308 (GRCm39) missense probably benign 0.13
Z1191:4933427D14Rik UTSW 11 72,086,595 (GRCm39) missense probably damaging 1.00
Z1191:4933427D14Rik UTSW 11 72,086,590 (GRCm39) frame shift probably null
Z1191:4933427D14Rik UTSW 11 72,086,580 (GRCm39) missense probably damaging 1.00
Z1191:4933427D14Rik UTSW 11 72,086,569 (GRCm39) missense possibly damaging 0.73
Z1191:4933427D14Rik UTSW 11 72,086,538 (GRCm39) frame shift probably null
Z1191:4933427D14Rik UTSW 11 72,080,442 (GRCm39) missense probably damaging 1.00
Z1191:4933427D14Rik UTSW 11 72,067,535 (GRCm39) missense possibly damaging 0.73
Z1191:4933427D14Rik UTSW 11 72,089,750 (GRCm39) missense probably damaging 1.00
Z1191:4933427D14Rik UTSW 11 72,089,360 (GRCm39) missense probably benign 0.00
Z1192:4933427D14Rik UTSW 11 72,089,308 (GRCm39) missense probably benign 0.13
Z1192:4933427D14Rik UTSW 11 72,086,595 (GRCm39) missense probably damaging 1.00
Z1192:4933427D14Rik UTSW 11 72,086,590 (GRCm39) frame shift probably null
Z1192:4933427D14Rik UTSW 11 72,086,580 (GRCm39) missense probably damaging 1.00
Z1192:4933427D14Rik UTSW 11 72,086,569 (GRCm39) missense possibly damaging 0.73
Z1192:4933427D14Rik UTSW 11 72,086,538 (GRCm39) frame shift probably null
Z1192:4933427D14Rik UTSW 11 72,080,442 (GRCm39) missense probably damaging 1.00
Z1192:4933427D14Rik UTSW 11 72,067,535 (GRCm39) missense possibly damaging 0.73
Z1192:4933427D14Rik UTSW 11 72,089,750 (GRCm39) missense probably damaging 1.00
Z1192:4933427D14Rik UTSW 11 72,089,360 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CGCAGTGCCTTGGGATATAAG -3'
(R):5'- CCTAGGAAGTCTTCAGGAGAGC -3'

Sequencing Primer
(F):5'- CCTTGGGATATAAGGCAGCAAAC -3'
(R):5'- TCTTCAGGAGAGCAGAGATAGAAGC -3'
Posted On 2016-10-24