Mutagenetix > Incidental Mutation

Incidental Mutation 'R5570:Vmn1r115'

435608

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r115

Ensembl Gene

ENSMUSG00000091435

Gene Name

vomeronasal 1 receptor 115

Synonyms

Gm8549

MMRRC Submission

043127-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R5570 (G1)

Quality Score

219

Status

Not validated

Chromosome

Chromosomal Location

20844098-20844985 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 20844630 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glycine at position 119 (V119G)

Ref Sequence

ENSEMBL: ENSMUSP00000128692 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169374]

AlphaFold

K7N6Y3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000169374
AA Change: V119G

PolyPhen 2 Score 0.871 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000128692
Gene: ENSMUSG00000091435
AA Change: V119G

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	294	1.4e-15	PFAM
Pfam:7tm_1	31	292	3.5e-7	PFAM
Pfam:V1R	41	289	8e-15	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.5%
20x: 95.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acrv1	C	A	9: 36,694,281	S41R	probably damaging	Het
Aqr	G	A	2: 114,148,970	T328M	probably damaging	Het
Arhgap26	C	A	18: 39,099,618	D99E	probably damaging	Het
Boc	G	A	16: 44,492,824	T559I	probably damaging	Het
Cadps	A	T	14: 12,473,497	I876N	possibly damaging	Het
Cep72	T	C	13: 74,040,141	Q211R	probably benign	Het
Clmp	T	C	9: 40,772,530		probably null	Het
Coq6	T	A	12: 84,368,639	D145E	probably benign	Het
Crym	T	C	7: 120,201,893	E11G	probably benign	Het
Defb36	T	A	2: 152,612,583	V54E	probably damaging	Het
Dlg5	C	A	14: 24,192,913	E55*	probably null	Het
Dock2	G	T	11: 34,727,406	R128S	probably damaging	Het
E330034G19Rik	A	G	14: 24,296,824	K60E	possibly damaging	Het
Eps8l2	G	A	7: 141,355,007	R76Q	possibly damaging	Het
Espn	T	C	4: 152,123,780	E460G	probably damaging	Het
Fbxl18	A	G	5: 142,895,267		probably benign	Het
Fgd5	T	C	6: 91,988,687	S476P	probably damaging	Het
Gsto1	T	C	19: 47,857,899	W62R	probably damaging	Het
Gtf2h3	C	T	5: 124,584,297	T121I	probably benign	Het
Gxylt1	A	G	15: 93,254,299		probably null	Het
Hs6st1	C	T	1: 36,103,638	P218L	probably benign	Het
Kif5c	A	G	2: 49,730,199	D226G	possibly damaging	Het
Krt1	A	G	15: 101,846,905	F473S	probably benign	Het
Lpxn	T	A	19: 12,832,659	M265K	possibly damaging	Het
Map3k9	A	G	12: 81,732,024	L505P	possibly damaging	Het
Mcm3ap	C	T	10: 76,481,096	R645W	possibly damaging	Het
Msr1	T	C	8: 39,611,719	I305V	probably benign	Het
Muc4	A	G	16: 32,777,692	E3237G	possibly damaging	Het
Necap1	T	C	6: 122,881,512	F105L	probably damaging	Het
Nploc4	C	T	11: 120,384,614	V499M	probably benign	Het
Nup93	T	C	8: 94,314,670	V812A	probably damaging	Het
Olfr1012	G	A	2: 85,759,650	S242F	probably damaging	Het
Olfr1328	T	A	4: 118,934,066	I259F	possibly damaging	Het
Olfr49	A	G	14: 54,282,368	F176L	probably damaging	Het
Parn	G	A	16: 13,665,930	P50L	probably damaging	Het
Pcdhb7	T	C	18: 37,344,171	C787R	probably benign	Het
Pdk2	A	T	11: 95,030,000	I175N	probably damaging	Het
Pelo	T	C	13: 115,089,616	I102V	probably benign	Het
Phf12	A	G	11: 78,018,111	D339G	possibly damaging	Het
Phlpp1	A	T	1: 106,173,432	I477F	probably benign	Het
Pigt	T	A	2: 164,501,562	Y319*	probably null	Het
Pmpca	A	G	2: 26,390,541	E133G	probably damaging	Het
Ptgs2	A	G	1: 150,104,108	I321M		Het
Pus7l	G	A	15: 94,527,865	P552S	probably benign	Het
Qsox2	A	G	2: 26,225,218	M1T	probably null	Het
Rara	C	G	11: 98,972,652	R382G	probably damaging	Het
Rbbp6	A	G	7: 123,001,834		probably benign	Het
Rev3l	T	C	10: 39,852,075		probably null	Het
Robo3	T	A	9: 37,425,275	Y399F	possibly damaging	Het
Rpl31	C	T	1: 39,370,027	R41C	probably benign	Het
Skint3	A	G	4: 112,235,798	M20V	probably benign	Het
Slc17a6	A	G	7: 51,658,756	D276G	probably benign	Het
Sult3a2	A	T	10: 33,778,272	V128D	probably damaging	Het
Syt3	T	A	7: 44,390,619	V92E	possibly damaging	Het
Them7	A	G	2: 105,378,808	T158A	probably benign	Het
Utp14b	G	A	1: 78,665,401	D339N	probably damaging	Het
Vars	T	C	17: 35,016,238	F1259L	probably benign	Het
Zc3h12a	C	T	4: 125,120,373	R293H	probably damaging	Het
Zfp638	A	T	6: 83,979,188	E1592D	probably damaging	Het

Other mutations in Vmn1r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02340:Vmn1r115	APN	7	20844528	missense	possibly damaging	0.70
R0243:Vmn1r115	UTSW	7	20844402	missense	probably benign	0.02
R1901:Vmn1r115	UTSW	7	20844273	missense	probably benign
R2020:Vmn1r115	UTSW	7	20844169	missense	probably null	0.38
R4411:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R4412:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R4413:Vmn1r115	UTSW	7	20844282	missense	probably benign	0.01
R5226:Vmn1r115	UTSW	7	20844244	missense	probably damaging	1.00
R5986:Vmn1r115	UTSW	7	20844522	missense	probably benign	0.44
R6180:Vmn1r115	UTSW	7	20844715	missense	probably damaging	0.98
R8169:Vmn1r115	UTSW	7	20844219	missense	probably damaging	1.00
R8310:Vmn1r115	UTSW	7	20844894	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGCCTACAATGAATCCAGAAGTG -3'
(R):5'- CCAGACAGGTGATTTTAAGCCAC -3'

Sequencing Primer
(F):5'- GTGGAACAGAACAAGTTGCTTTTAG -3'
(R):5'- TATGGCCAATGCCTTGAC -3'

Posted On

2016-10-24