Incidental Mutation 'R5573:Cdh26'
ID 435765
Institutional Source Beutler Lab
Gene Symbol Cdh26
Ensembl Gene ENSMUSG00000039155
Gene Name cadherin-like 26
Synonyms LOC381409
MMRRC Submission 043128-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5573 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 178072324-178129159 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 178108482 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 360 (V360A)
Ref Sequence ENSEMBL: ENSMUSP00000104540 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042092] [ENSMUST00000108912]
AlphaFold P59862
Predicted Effect probably damaging
Transcript: ENSMUST00000042092
AA Change: V360A

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000048829
Gene: ENSMUSG00000039155
AA Change: V360A

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
CA 36 138 5.06e-2 SMART
CA 162 248 1.23e-19 SMART
CA 271 370 1.01e-6 SMART
CA 393 476 2.86e-20 SMART
transmembrane domain 592 614 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000108912
AA Change: V360A

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000104540
Gene: ENSMUSG00000039155
AA Change: V360A

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
CA 36 138 5.06e-2 SMART
CA 162 248 1.23e-19 SMART
CA 271 370 1.01e-6 SMART
CA 393 476 2.86e-20 SMART
transmembrane domain 592 614 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176869
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.3%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cadherin protein family. Cadherins are a family of calcium-dependent adhesion molecules that mediate cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization, migration and differentiation. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This protein is expressed in gastrointestinal epithelial cells and may be upregulated during allergic inflammation. This protein interacts with alpha integrins and may also be involved in leukocyte migration and adhesion. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef28 A T 13: 98,065,999 (GRCm39) V1618D probably benign Het
Asic5 T A 3: 81,911,791 (GRCm39) F129Y probably benign Het
Cachd1 A C 4: 100,831,276 (GRCm39) K689N probably damaging Het
Cbfa2t2 A G 2: 154,278,782 (GRCm39) probably benign Het
Col9a3 C T 2: 180,261,525 (GRCm39) A605V probably benign Het
Csn3 A G 5: 88,077,910 (GRCm39) T139A probably benign Het
Ddx27 G T 2: 166,859,806 (GRCm39) K79N possibly damaging Het
Dhx29 G A 13: 113,069,749 (GRCm39) D211N probably benign Het
Dlg2 A G 7: 91,646,532 (GRCm39) probably null Het
Dse C A 10: 34,028,678 (GRCm39) R804L probably benign Het
Fgb T C 3: 82,956,984 (GRCm39) probably null Het
Gm11011 A T 2: 169,429,392 (GRCm39) I31K unknown Het
Hira A G 16: 18,735,349 (GRCm39) T272A probably damaging Het
Lcmt1 T A 7: 123,000,686 (GRCm39) H117Q probably benign Het
Mettl23 A G 11: 116,734,437 (GRCm39) probably benign Het
Mtmr2 T C 9: 13,704,463 (GRCm39) Y197H probably benign Het
Myo9a T G 9: 59,778,284 (GRCm39) S1347A probably benign Het
Myrfl A G 10: 116,658,661 (GRCm39) V432A probably damaging Het
Npdc1 G A 2: 25,298,957 (GRCm39) D284N probably damaging Het
Obscn G T 11: 58,925,531 (GRCm39) H6347Q possibly damaging Het
Or52r1b A T 7: 102,691,547 (GRCm39) Y282F probably damaging Het
Or8b53 T A 9: 38,667,000 (GRCm39) N5K probably damaging Het
Peg10 A G 6: 4,755,913 (GRCm39) probably benign Het
Pfkfb3 A G 2: 11,506,483 (GRCm39) V10A probably benign Het
Phf12 A G 11: 77,915,871 (GRCm39) D175G probably damaging Het
Plekhg6 T G 6: 125,352,755 (GRCm39) I131L possibly damaging Het
Ptbp3 A G 4: 59,485,626 (GRCm39) V95A probably damaging Het
Rbbp8 A G 18: 11,855,664 (GRCm39) T604A probably benign Het
Rbbp8nl G A 2: 179,921,586 (GRCm39) P266L possibly damaging Het
Ryr1 T C 7: 28,715,148 (GRCm39) S4659G unknown Het
Serpinb9d A G 13: 33,380,423 (GRCm39) probably null Het
Slc22a28 A C 19: 8,048,462 (GRCm39) I395S possibly damaging Het
Slco6c1 T A 1: 97,055,656 (GRCm39) I82L probably benign Het
Sptan1 C T 2: 29,876,504 (GRCm39) R295* probably null Het
Tdrd9 C T 12: 111,964,336 (GRCm39) probably null Het
Ube2v2 A G 16: 15,374,343 (GRCm39) L77P possibly damaging Het
Ugt3a1 T C 15: 9,361,769 (GRCm39) S182P probably damaging Het
Vwa5b1 T C 4: 138,336,201 (GRCm39) E131G probably damaging Het
Wdr18 C T 10: 79,800,872 (GRCm39) A145V probably benign Het
Xpnpep1 A G 19: 52,993,253 (GRCm39) I358T probably damaging Het
Zfp946 T A 17: 22,673,676 (GRCm39) C143* probably null Het
Other mutations in Cdh26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00846:Cdh26 APN 2 178,123,417 (GRCm39) missense possibly damaging 0.86
IGL01341:Cdh26 APN 2 178,099,240 (GRCm39) missense probably damaging 0.99
IGL02636:Cdh26 APN 2 178,091,755 (GRCm39) missense probably damaging 1.00
IGL03144:Cdh26 APN 2 178,109,967 (GRCm39) missense probably damaging 0.99
R0244:Cdh26 UTSW 2 178,123,425 (GRCm39) missense possibly damaging 0.88
R0245:Cdh26 UTSW 2 178,123,425 (GRCm39) missense possibly damaging 0.88
R0466:Cdh26 UTSW 2 178,123,425 (GRCm39) missense possibly damaging 0.88
R0467:Cdh26 UTSW 2 178,123,425 (GRCm39) missense possibly damaging 0.88
R0514:Cdh26 UTSW 2 178,108,621 (GRCm39) critical splice donor site probably null
R0610:Cdh26 UTSW 2 178,091,691 (GRCm39) missense probably damaging 1.00
R0733:Cdh26 UTSW 2 178,128,724 (GRCm39) missense probably damaging 1.00
R1592:Cdh26 UTSW 2 178,091,684 (GRCm39) missense probably damaging 1.00
R2483:Cdh26 UTSW 2 178,108,382 (GRCm39) missense probably damaging 1.00
R3756:Cdh26 UTSW 2 178,111,794 (GRCm39) splice site probably benign
R4617:Cdh26 UTSW 2 178,102,435 (GRCm39) intron probably benign
R4914:Cdh26 UTSW 2 178,091,614 (GRCm39) missense probably benign 0.02
R4915:Cdh26 UTSW 2 178,091,614 (GRCm39) missense probably benign 0.02
R4917:Cdh26 UTSW 2 178,091,614 (GRCm39) missense probably benign 0.02
R4918:Cdh26 UTSW 2 178,091,614 (GRCm39) missense probably benign 0.02
R5086:Cdh26 UTSW 2 178,083,210 (GRCm39) nonsense probably null
R5809:Cdh26 UTSW 2 178,101,919 (GRCm39) nonsense probably null
R5941:Cdh26 UTSW 2 178,123,443 (GRCm39) nonsense probably null
R6284:Cdh26 UTSW 2 178,091,677 (GRCm39) missense probably damaging 1.00
R6341:Cdh26 UTSW 2 178,113,366 (GRCm39) splice site probably null
R6496:Cdh26 UTSW 2 178,091,654 (GRCm39) missense probably damaging 1.00
R7132:Cdh26 UTSW 2 178,128,555 (GRCm39) missense possibly damaging 0.56
R7664:Cdh26 UTSW 2 178,111,835 (GRCm39) missense probably benign 0.02
R7694:Cdh26 UTSW 2 178,101,896 (GRCm39) missense probably damaging 0.96
R7814:Cdh26 UTSW 2 178,111,828 (GRCm39) missense probably damaging 0.98
R8089:Cdh26 UTSW 2 178,099,370 (GRCm39) critical splice donor site probably null
R8103:Cdh26 UTSW 2 178,110,006 (GRCm39) missense probably damaging 1.00
R8412:Cdh26 UTSW 2 178,104,517 (GRCm39) missense probably damaging 0.98
R8413:Cdh26 UTSW 2 178,110,022 (GRCm39) missense probably damaging 0.99
R9025:Cdh26 UTSW 2 178,104,409 (GRCm39) missense probably benign 0.01
R9621:Cdh26 UTSW 2 178,111,983 (GRCm39) missense probably damaging 1.00
R9628:Cdh26 UTSW 2 178,083,213 (GRCm39) missense
RF002:Cdh26 UTSW 2 178,108,424 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCCTGATGACTCTGCGGAG -3'
(R):5'- GCATTCAGGTGTCCAACAGTC -3'

Sequencing Primer
(F):5'- GAGCTTCCTGCAGCCAG -3'
(R):5'- AGGTGTCCAACAGTCCCCTC -3'
Posted On 2016-10-24