Incidental Mutation 'R5573:Or8b53'
ID 435781
Institutional Source Beutler Lab
Gene Symbol Or8b53
Ensembl Gene ENSMUSG00000061039
Gene Name olfactory receptor family 8 subfamily B member 53
Synonyms MOR165-6, GA_x6K02T2PVTD-32458442-32459374, Olfr920
MMRRC Submission 043128-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R5573 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38664092-38668159 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38667000 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 5 (N5K)
Ref Sequence ENSEMBL: ENSMUSP00000074300 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074740]
AlphaFold E9Q413
Predicted Effect probably damaging
Transcript: ENSMUST00000074740
AA Change: N5K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074300
Gene: ENSMUSG00000061039
AA Change: N5K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.2e-47 PFAM
Pfam:7tm_1 41 290 3.6e-22 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.3%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef28 A T 13: 98,065,999 (GRCm39) V1618D probably benign Het
Asic5 T A 3: 81,911,791 (GRCm39) F129Y probably benign Het
Cachd1 A C 4: 100,831,276 (GRCm39) K689N probably damaging Het
Cbfa2t2 A G 2: 154,278,782 (GRCm39) probably benign Het
Cdh26 T C 2: 178,108,482 (GRCm39) V360A probably damaging Het
Col9a3 C T 2: 180,261,525 (GRCm39) A605V probably benign Het
Csn3 A G 5: 88,077,910 (GRCm39) T139A probably benign Het
Ddx27 G T 2: 166,859,806 (GRCm39) K79N possibly damaging Het
Dhx29 G A 13: 113,069,749 (GRCm39) D211N probably benign Het
Dlg2 A G 7: 91,646,532 (GRCm39) probably null Het
Dse C A 10: 34,028,678 (GRCm39) R804L probably benign Het
Fgb T C 3: 82,956,984 (GRCm39) probably null Het
Gm11011 A T 2: 169,429,392 (GRCm39) I31K unknown Het
Hira A G 16: 18,735,349 (GRCm39) T272A probably damaging Het
Lcmt1 T A 7: 123,000,686 (GRCm39) H117Q probably benign Het
Mettl23 A G 11: 116,734,437 (GRCm39) probably benign Het
Mtmr2 T C 9: 13,704,463 (GRCm39) Y197H probably benign Het
Myo9a T G 9: 59,778,284 (GRCm39) S1347A probably benign Het
Myrfl A G 10: 116,658,661 (GRCm39) V432A probably damaging Het
Npdc1 G A 2: 25,298,957 (GRCm39) D284N probably damaging Het
Obscn G T 11: 58,925,531 (GRCm39) H6347Q possibly damaging Het
Or52r1b A T 7: 102,691,547 (GRCm39) Y282F probably damaging Het
Peg10 A G 6: 4,755,913 (GRCm39) probably benign Het
Pfkfb3 A G 2: 11,506,483 (GRCm39) V10A probably benign Het
Phf12 A G 11: 77,915,871 (GRCm39) D175G probably damaging Het
Plekhg6 T G 6: 125,352,755 (GRCm39) I131L possibly damaging Het
Ptbp3 A G 4: 59,485,626 (GRCm39) V95A probably damaging Het
Rbbp8 A G 18: 11,855,664 (GRCm39) T604A probably benign Het
Rbbp8nl G A 2: 179,921,586 (GRCm39) P266L possibly damaging Het
Ryr1 T C 7: 28,715,148 (GRCm39) S4659G unknown Het
Serpinb9d A G 13: 33,380,423 (GRCm39) probably null Het
Slc22a28 A C 19: 8,048,462 (GRCm39) I395S possibly damaging Het
Slco6c1 T A 1: 97,055,656 (GRCm39) I82L probably benign Het
Sptan1 C T 2: 29,876,504 (GRCm39) R295* probably null Het
Tdrd9 C T 12: 111,964,336 (GRCm39) probably null Het
Ube2v2 A G 16: 15,374,343 (GRCm39) L77P possibly damaging Het
Ugt3a1 T C 15: 9,361,769 (GRCm39) S182P probably damaging Het
Vwa5b1 T C 4: 138,336,201 (GRCm39) E131G probably damaging Het
Wdr18 C T 10: 79,800,872 (GRCm39) A145V probably benign Het
Xpnpep1 A G 19: 52,993,253 (GRCm39) I358T probably damaging Het
Zfp946 T A 17: 22,673,676 (GRCm39) C143* probably null Het
Other mutations in Or8b53
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01686:Or8b53 APN 9 38,667,550 (GRCm39) missense probably damaging 1.00
IGL01728:Or8b53 APN 9 38,667,391 (GRCm39) missense possibly damaging 0.63
IGL01867:Or8b53 APN 9 38,667,194 (GRCm39) missense probably damaging 1.00
IGL02271:Or8b53 APN 9 38,667,784 (GRCm39) missense probably benign
IGL03078:Or8b53 APN 9 38,667,541 (GRCm39) nonsense probably null
R0166:Or8b53 UTSW 9 38,667,484 (GRCm39) missense probably benign
R0446:Or8b53 UTSW 9 38,667,114 (GRCm39) missense probably damaging 1.00
R0453:Or8b53 UTSW 9 38,667,425 (GRCm39) missense probably damaging 0.99
R0556:Or8b53 UTSW 9 38,667,041 (GRCm39) missense possibly damaging 0.88
R1585:Or8b53 UTSW 9 38,667,716 (GRCm39) missense probably damaging 1.00
R2847:Or8b53 UTSW 9 38,667,332 (GRCm39) missense possibly damaging 0.89
R4676:Or8b53 UTSW 9 38,666,955 (GRCm39) start gained probably benign
R4825:Or8b53 UTSW 9 38,667,703 (GRCm39) missense probably damaging 1.00
R5026:Or8b53 UTSW 9 38,667,041 (GRCm39) missense probably benign 0.01
R5144:Or8b53 UTSW 9 38,667,689 (GRCm39) missense possibly damaging 0.90
R5872:Or8b53 UTSW 9 38,667,412 (GRCm39) missense probably benign 0.06
R6131:Or8b53 UTSW 9 38,667,362 (GRCm39) missense probably damaging 1.00
R6729:Or8b53 UTSW 9 38,667,124 (GRCm39) missense probably benign 0.00
R7731:Or8b53 UTSW 9 38,667,542 (GRCm39) missense possibly damaging 0.90
R7800:Or8b53 UTSW 9 38,667,914 (GRCm39) missense probably damaging 0.97
R8960:Or8b53 UTSW 9 38,667,385 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- GTTTCTACTTGTGTCACAGAGATG -3'
(R):5'- TGAGTCATACAACCCACATAGGAG -3'

Sequencing Primer
(F):5'- ACTTGTGTCACAGAGATGATAAAAC -3'
(R):5'- TTACAGAAGAGTAACAAAAGTCCAC -3'
Posted On 2016-10-24