Incidental Mutation 'R5540:Rusc2'
| ID |
435868 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rusc2
|
| Ensembl Gene |
ENSMUSG00000035969 |
| Gene Name |
RUN and SH3 domain containing 2 |
| Synonyms |
|
| MMRRC Submission |
043098-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.158)
|
| Stock # |
R5540 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
43381979-43427088 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 43423975 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 1043
(Y1043C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000118528
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035645]
[ENSMUST00000052829]
[ENSMUST00000098106]
[ENSMUST00000107928]
[ENSMUST00000107929]
[ENSMUST00000131668]
[ENSMUST00000149221]
[ENSMUST00000149676]
[ENSMUST00000171134]
[ENSMUST00000173682]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000035645
AA Change: Y1043C
PolyPhen 2
Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000038379
Gene: ENSMUSG00000035969
AA Change: Y1043C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
SH3
|
1457 |
1512 |
7.4e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000052829
|
| SMART Domains |
Protein: ENSMUSP00000058980
Gene: ENSMUSG00000042788
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2475
|
15 |
47 |
2.9e-12 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000098106
AA Change: Y1043C
PolyPhen 2
Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000095710
Gene: ENSMUSG00000035969
AA Change: Y1043C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
SH3
|
1457 |
1512 |
7.4e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107928
|
| SMART Domains |
Protein: ENSMUSP00000103561
Gene: ENSMUSG00000042788
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2475
|
15 |
76 |
1.3e-20 |
PFAM |
|
Pfam:DUF2475
|
212 |
251 |
6.9e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107929
|
| SMART Domains |
Protein: ENSMUSP00000103562
Gene: ENSMUSG00000042788
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2475
|
15 |
76 |
1.5e-20 |
PFAM |
|
Pfam:DUF2475
|
232 |
271 |
7.7e-10 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123447
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125393
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131668
AA Change: Y1043C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000118528
Gene: ENSMUSG00000035969
AA Change: Y1043C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146710
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149221
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149556
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154754
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150066
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155080
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149676
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171134
|
| SMART Domains |
Protein: ENSMUSP00000127145
Gene: ENSMUSG00000042788
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2475
|
15 |
76 |
7.2e-21 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173682
|
| SMART Domains |
Protein: ENSMUSP00000133715
Gene: ENSMUSG00000035969
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
703 |
N/A |
INTRINSIC |
|
low complexity region
|
733 |
740 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.6%
- 20x: 96.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700008O03Rik |
A |
G |
7: 44,362,947 (GRCm38) |
S15P |
probably damaging |
Het |
| Actl7a |
A |
T |
4: 56,744,388 (GRCm38) |
H305L |
probably benign |
Het |
| Adam26b |
C |
A |
8: 43,521,617 (GRCm38) |
C116F |
probably damaging |
Het |
| Adgrl2 |
A |
G |
3: 148,837,562 (GRCm38) |
|
probably null |
Het |
| Akr1b10 |
A |
G |
6: 34,394,112 (GRCm38) |
T238A |
probably damaging |
Het |
| Akr1c18 |
A |
G |
13: 4,137,179 (GRCm38) |
V186A |
probably benign |
Het |
| Alpk3 |
G |
A |
7: 81,095,436 (GRCm38) |
V1311M |
probably damaging |
Het |
| Aox1 |
A |
G |
1: 58,104,410 (GRCm38) |
N1229S |
probably benign |
Het |
| Apobec3 |
T |
A |
15: 79,897,919 (GRCm38) |
N43K |
probably benign |
Het |
| Arid1a |
A |
C |
4: 133,680,454 (GRCm38) |
D2247E |
unknown |
Het |
| Asph |
A |
G |
4: 9,635,906 (GRCm38) |
L77S |
probably damaging |
Het |
| Cd300ld |
T |
A |
11: 114,987,405 (GRCm38) |
T94S |
probably damaging |
Het |
| Celf2 |
T |
C |
2: 6,553,932 (GRCm38) |
T382A |
probably benign |
Het |
| Cfap54 |
C |
T |
10: 92,972,608 (GRCm38) |
A1402T |
possibly damaging |
Het |
| Chrnb1 |
A |
T |
11: 69,795,650 (GRCm38) |
V48E |
probably benign |
Het |
| Col6a5 |
T |
A |
9: 105,862,776 (GRCm38) |
E2548V |
probably benign |
Het |
| Crebrf |
A |
G |
17: 26,742,097 (GRCm38) |
D56G |
possibly damaging |
Het |
| Dctn5 |
A |
G |
7: 122,135,052 (GRCm38) |
T40A |
probably benign |
Het |
| Dmxl2 |
A |
T |
9: 54,393,857 (GRCm38) |
N2323K |
probably benign |
Het |
| Dync1h1 |
A |
G |
12: 110,660,950 (GRCm38) |
Q4021R |
probably benign |
Het |
| Dyrk1a |
T |
G |
16: 94,685,343 (GRCm38) |
|
probably null |
Het |
| Ephb3 |
T |
A |
16: 21,220,860 (GRCm38) |
F454Y |
probably damaging |
Het |
| Fam71b |
A |
G |
11: 46,404,888 (GRCm38) |
N29S |
probably damaging |
Het |
| Fbxo38 |
A |
G |
18: 62,514,793 (GRCm38) |
|
probably null |
Het |
| Flg |
T |
C |
3: 93,277,616 (GRCm38) |
F15S |
probably damaging |
Het |
| Fndc3b |
G |
A |
3: 27,501,502 (GRCm38) |
P301L |
probably damaging |
Het |
| Fpr-rs7 |
C |
T |
17: 20,114,094 (GRCm38) |
G45R |
probably damaging |
Het |
| Gfi1 |
T |
A |
5: 107,720,125 (GRCm38) |
T360S |
probably damaging |
Het |
| Grik4 |
T |
C |
9: 42,520,947 (GRCm38) |
H918R |
probably damaging |
Het |
| Hpx |
A |
G |
7: 105,591,912 (GRCm38) |
S385P |
possibly damaging |
Het |
| Kdm5b |
A |
G |
1: 134,631,241 (GRCm38) |
D1501G |
probably damaging |
Het |
| Kif20b |
A |
T |
19: 34,938,460 (GRCm38) |
M546L |
probably benign |
Het |
| Map3k9 |
G |
T |
12: 81,772,813 (GRCm38) |
N222K |
probably damaging |
Het |
| Me1 |
A |
G |
9: 86,679,873 (GRCm38) |
L53P |
possibly damaging |
Het |
| Mis18bp1 |
T |
C |
12: 65,148,746 (GRCm38) |
E748G |
possibly damaging |
Het |
| Morc3 |
T |
A |
16: 93,847,380 (GRCm38) |
N186K |
probably benign |
Het |
| Mtor |
A |
G |
4: 148,454,708 (GRCm38) |
T221A |
probably benign |
Het |
| Muc6 |
A |
G |
7: 141,649,585 (GRCm38) |
|
probably null |
Het |
| Myh8 |
C |
A |
11: 67,286,440 (GRCm38) |
T444N |
probably benign |
Het |
| Myo7b |
A |
G |
18: 32,007,090 (GRCm38) |
Y216H |
probably damaging |
Het |
| Myom1 |
G |
A |
17: 71,109,787 (GRCm38) |
V1382M |
probably damaging |
Het |
| Nbeal2 |
A |
T |
9: 110,631,733 (GRCm38) |
Y1718N |
probably damaging |
Het |
| Npc1l1 |
A |
G |
11: 6,214,546 (GRCm38) |
S1168P |
probably damaging |
Het |
| Olfr1431 |
T |
A |
19: 12,210,460 (GRCm38) |
I298N |
probably damaging |
Het |
| Olfr463 |
T |
A |
11: 87,893,685 (GRCm38) |
K80* |
probably null |
Het |
| Olfr48 |
A |
G |
2: 89,844,667 (GRCm38) |
F102S |
probably damaging |
Het |
| Olfr561 |
C |
T |
7: 102,774,929 (GRCm38) |
A135V |
probably benign |
Het |
| Olfr765 |
G |
T |
10: 129,046,495 (GRCm38) |
D189E |
probably damaging |
Het |
| Pcdha4 |
C |
A |
18: 36,954,837 (GRCm38) |
A691E |
probably benign |
Het |
| Pde6a |
T |
G |
18: 61,231,366 (GRCm38) |
F165V |
probably damaging |
Het |
| Pqlc2 |
A |
T |
4: 139,300,344 (GRCm38) |
L229Q |
probably damaging |
Het |
| Ptpn14 |
A |
T |
1: 189,846,364 (GRCm38) |
M340L |
probably benign |
Het |
| Rnasel |
G |
T |
1: 153,755,144 (GRCm38) |
E469* |
probably null |
Het |
| Rsph3a |
T |
G |
17: 7,945,958 (GRCm38) |
L50R |
probably benign |
Het |
| Serpinb6b |
A |
T |
13: 32,977,558 (GRCm38) |
K86* |
probably null |
Het |
| Serpine1 |
T |
C |
5: 137,063,209 (GRCm38) |
T392A |
probably benign |
Het |
| Shcbp1 |
A |
T |
8: 4,744,529 (GRCm38) |
D421E |
probably damaging |
Het |
| Slc24a1 |
A |
G |
9: 64,948,581 (GRCm38) |
V348A |
unknown |
Het |
| Slc26a7 |
A |
G |
4: 14,506,621 (GRCm38) |
F605L |
probably benign |
Het |
| Spag17 |
A |
C |
3: 100,056,272 (GRCm38) |
E1102A |
possibly damaging |
Het |
| Stab2 |
A |
G |
10: 86,848,125 (GRCm38) |
V2390A |
probably benign |
Het |
| Stk11 |
A |
G |
10: 80,126,049 (GRCm38) |
I35V |
probably benign |
Het |
| Stk24 |
T |
C |
14: 121,294,281 (GRCm38) |
D321G |
possibly damaging |
Het |
| Tbx4 |
A |
T |
11: 85,911,168 (GRCm38) |
N209I |
possibly damaging |
Het |
| Tmem225 |
T |
C |
9: 40,149,385 (GRCm38) |
L80P |
probably damaging |
Het |
| Tnfrsf4 |
C |
T |
4: 156,013,923 (GRCm38) |
T17I |
probably benign |
Het |
| Traf3ip1 |
G |
A |
1: 91,501,315 (GRCm38) |
R268Q |
probably benign |
Het |
| Trhde |
T |
A |
10: 114,800,592 (GRCm38) |
I237F |
probably benign |
Het |
| Ugt2a1 |
A |
T |
5: 87,486,056 (GRCm38) |
W231R |
probably damaging |
Het |
| Vash1 |
ACTGCTGCTGCTGCTGCTGC |
ACTGCTGCTGCTGCTGC |
12: 86,680,057 (GRCm38) |
|
probably benign |
Het |
| Vps16 |
T |
A |
2: 130,442,385 (GRCm38) |
D685E |
probably benign |
Het |
| Washc4 |
A |
G |
10: 83,573,793 (GRCm38) |
D602G |
probably damaging |
Het |
| Wdr59 |
A |
G |
8: 111,485,184 (GRCm38) |
L377P |
possibly damaging |
Het |
| Wdr81 |
T |
C |
11: 75,449,070 (GRCm38) |
E1364G |
probably damaging |
Het |
|
| Other mutations in Rusc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01358:Rusc2
|
APN |
4 |
43,426,116 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL01474:Rusc2
|
APN |
4 |
43,416,434 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01541:Rusc2
|
APN |
4 |
43,415,840 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01628:Rusc2
|
APN |
4 |
43,425,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01969:Rusc2
|
APN |
4 |
43,415,738 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL02030:Rusc2
|
APN |
4 |
43,416,095 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL02079:Rusc2
|
APN |
4 |
43,425,668 (GRCm38) |
missense |
probably benign |
|
|
IGL02115:Rusc2
|
APN |
4 |
43,426,136 (GRCm38) |
splice site |
probably benign |
|
|
IGL02122:Rusc2
|
APN |
4 |
43,421,685 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
IGL02350:Rusc2
|
APN |
4 |
43,425,351 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL02357:Rusc2
|
APN |
4 |
43,425,351 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL02437:Rusc2
|
APN |
4 |
43,415,545 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02930:Rusc2
|
APN |
4 |
43,416,376 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03154:Rusc2
|
APN |
4 |
43,425,806 (GRCm38) |
missense |
probably benign |
0.00 |
|
P0026:Rusc2
|
UTSW |
4 |
43,415,840 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R0036:Rusc2
|
UTSW |
4 |
43,424,009 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0068:Rusc2
|
UTSW |
4 |
43,424,100 (GRCm38) |
splice site |
probably benign |
|
|
R0068:Rusc2
|
UTSW |
4 |
43,424,100 (GRCm38) |
splice site |
probably benign |
|
|
R0114:Rusc2
|
UTSW |
4 |
43,422,055 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0255:Rusc2
|
UTSW |
4 |
43,423,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0471:Rusc2
|
UTSW |
4 |
43,425,486 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1381:Rusc2
|
UTSW |
4 |
43,416,137 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1413:Rusc2
|
UTSW |
4 |
43,416,568 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1416:Rusc2
|
UTSW |
4 |
43,421,617 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R1731:Rusc2
|
UTSW |
4 |
43,426,046 (GRCm38) |
missense |
probably benign |
|
|
R1864:Rusc2
|
UTSW |
4 |
43,421,719 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R1897:Rusc2
|
UTSW |
4 |
43,421,749 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2010:Rusc2
|
UTSW |
4 |
43,415,212 (GRCm38) |
missense |
probably benign |
0.06 |
|
R2212:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2275:Rusc2
|
UTSW |
4 |
43,416,260 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2885:Rusc2
|
UTSW |
4 |
43,415,456 (GRCm38) |
missense |
probably benign |
0.28 |
|
R2886:Rusc2
|
UTSW |
4 |
43,415,456 (GRCm38) |
missense |
probably benign |
0.28 |
|
R3412:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3413:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3414:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3852:Rusc2
|
UTSW |
4 |
43,416,424 (GRCm38) |
missense |
probably benign |
0.45 |
|
R4135:Rusc2
|
UTSW |
4 |
43,425,563 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R4272:Rusc2
|
UTSW |
4 |
43,415,533 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4574:Rusc2
|
UTSW |
4 |
43,416,080 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4888:Rusc2
|
UTSW |
4 |
43,423,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5010:Rusc2
|
UTSW |
4 |
43,415,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5071:Rusc2
|
UTSW |
4 |
43,415,240 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5131:Rusc2
|
UTSW |
4 |
43,414,948 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5177:Rusc2
|
UTSW |
4 |
43,421,805 (GRCm38) |
splice site |
probably null |
|
|
R5561:Rusc2
|
UTSW |
4 |
43,415,932 (GRCm38) |
nonsense |
probably null |
|
|
R5628:Rusc2
|
UTSW |
4 |
43,425,348 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5645:Rusc2
|
UTSW |
4 |
43,425,758 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6129:Rusc2
|
UTSW |
4 |
43,424,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6362:Rusc2
|
UTSW |
4 |
43,416,416 (GRCm38) |
missense |
probably benign |
0.30 |
|
R6633:Rusc2
|
UTSW |
4 |
43,414,852 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6980:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm38) |
missense |
probably benign |
0.35 |
|
R7491:Rusc2
|
UTSW |
4 |
43,426,528 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7641:Rusc2
|
UTSW |
4 |
43,425,335 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R7698:Rusc2
|
UTSW |
4 |
43,414,900 (GRCm38) |
nonsense |
probably null |
|
|
R7710:Rusc2
|
UTSW |
4 |
43,416,119 (GRCm38) |
missense |
probably benign |
0.07 |
|
R8052:Rusc2
|
UTSW |
4 |
43,421,851 (GRCm38) |
missense |
probably benign |
|
|
R8061:Rusc2
|
UTSW |
4 |
43,422,492 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8127:Rusc2
|
UTSW |
4 |
43,423,747 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R8319:Rusc2
|
UTSW |
4 |
43,425,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8355:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm38) |
missense |
probably benign |
0.35 |
|
R8397:Rusc2
|
UTSW |
4 |
43,424,206 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8455:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm38) |
missense |
probably benign |
0.35 |
|
R8553:Rusc2
|
UTSW |
4 |
43,416,508 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8725:Rusc2
|
UTSW |
4 |
43,401,351 (GRCm38) |
intron |
probably benign |
|
|
R8725:Rusc2
|
UTSW |
4 |
43,415,396 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8727:Rusc2
|
UTSW |
4 |
43,401,351 (GRCm38) |
intron |
probably benign |
|
|
R8834:Rusc2
|
UTSW |
4 |
43,416,431 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9295:Rusc2
|
UTSW |
4 |
43,416,382 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9483:Rusc2
|
UTSW |
4 |
43,415,897 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9666:Rusc2
|
UTSW |
4 |
43,416,262 (GRCm38) |
missense |
probably benign |
0.21 |
|
R9705:Rusc2
|
UTSW |
4 |
43,424,936 (GRCm38) |
missense |
probably benign |
0.00 |
|
X0025:Rusc2
|
UTSW |
4 |
43,422,226 (GRCm38) |
missense |
probably benign |
0.00 |
|
X0066:Rusc2
|
UTSW |
4 |
43,422,204 (GRCm38) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AAGAGCTGAGCTATGCCCTG -3'
(R):5'- GCAGGTTTGGAGATCACATTTC -3'
Sequencing Primer
(F):5'- TGAGCTATGCCCTGCAGACTC -3'
(R):5'- GGAGATCACATTTCTAACTTCTGG -3'
|
| Posted On |
2016-10-24 |
Incidental Mutation