Mutagenetix > Incidental Mutation

Incidental Mutation 'R5540:Fpr-rs7'

435926

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs7

Ensembl Gene

ENSMUSG00000071276

Gene Name

formyl peptide receptor, related sequence 7

Synonyms

MMRRC Submission

043098-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

R5540 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

20113210-20114226 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 20114094 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 45 (G45R)

Ref Sequence

ENSEMBL: ENSMUSP00000093297 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095637]

AlphaFold

Q71MR7

Predicted Effect

probably damaging
Transcript: ENSMUST00000095637
AA Change: G45R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000093297
Gene: ENSMUSG00000071276
AA Change: G45R

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	1.2e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176711

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 96.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700008O03Rik	A	G	7: 44,362,947	S15P	probably damaging	Het
Actl7a	A	T	4: 56,744,388	H305L	probably benign	Het
Adam26b	C	A	8: 43,521,617	C116F	probably damaging	Het
Adgrl2	A	G	3: 148,837,562		probably null	Het
Akr1b10	A	G	6: 34,394,112	T238A	probably damaging	Het
Akr1c18	A	G	13: 4,137,179	V186A	probably benign	Het
Alpk3	G	A	7: 81,095,436	V1311M	probably damaging	Het
Aox1	A	G	1: 58,104,410	N1229S	probably benign	Het
Apobec3	T	A	15: 79,897,919	N43K	probably benign	Het
Arid1a	A	C	4: 133,680,454	D2247E	unknown	Het
Asph	A	G	4: 9,635,906	L77S	probably damaging	Het
Cd300ld	T	A	11: 114,987,405	T94S	probably damaging	Het
Celf2	T	C	2: 6,553,932	T382A	probably benign	Het
Cfap54	C	T	10: 92,972,608	A1402T	possibly damaging	Het
Chrnb1	A	T	11: 69,795,650	V48E	probably benign	Het
Col6a5	T	A	9: 105,862,776	E2548V	probably benign	Het
Crebrf	A	G	17: 26,742,097	D56G	possibly damaging	Het
Dctn5	A	G	7: 122,135,052	T40A	probably benign	Het
Dmxl2	A	T	9: 54,393,857	N2323K	probably benign	Het
Dync1h1	A	G	12: 110,660,950	Q4021R	probably benign	Het
Dyrk1a	T	G	16: 94,685,343		probably null	Het
Ephb3	T	A	16: 21,220,860	F454Y	probably damaging	Het
Fam71b	A	G	11: 46,404,888	N29S	probably damaging	Het
Fbxo38	A	G	18: 62,514,793		probably null	Het
Flg	T	C	3: 93,277,616	F15S	probably damaging	Het
Fndc3b	G	A	3: 27,501,502	P301L	probably damaging	Het
Gfi1	T	A	5: 107,720,125	T360S	probably damaging	Het
Grik4	T	C	9: 42,520,947	H918R	probably damaging	Het
Hpx	A	G	7: 105,591,912	S385P	possibly damaging	Het
Kdm5b	A	G	1: 134,631,241	D1501G	probably damaging	Het
Kif20b	A	T	19: 34,938,460	M546L	probably benign	Het
Map3k9	G	T	12: 81,772,813	N222K	probably damaging	Het
Me1	A	G	9: 86,679,873	L53P	possibly damaging	Het
Mis18bp1	T	C	12: 65,148,746	E748G	possibly damaging	Het
Morc3	T	A	16: 93,847,380	N186K	probably benign	Het
Mtor	A	G	4: 148,454,708	T221A	probably benign	Het
Muc6	A	G	7: 141,649,585		probably null	Het
Myh8	C	A	11: 67,286,440	T444N	probably benign	Het
Myo7b	A	G	18: 32,007,090	Y216H	probably damaging	Het
Myom1	G	A	17: 71,109,787	V1382M	probably damaging	Het
Nbeal2	A	T	9: 110,631,733	Y1718N	probably damaging	Het
Npc1l1	A	G	11: 6,214,546	S1168P	probably damaging	Het
Olfr1431	T	A	19: 12,210,460	I298N	probably damaging	Het
Olfr463	T	A	11: 87,893,685	K80*	probably null	Het
Olfr48	A	G	2: 89,844,667	F102S	probably damaging	Het
Olfr561	C	T	7: 102,774,929	A135V	probably benign	Het
Olfr765	G	T	10: 129,046,495	D189E	probably damaging	Het
Pcdha4	C	A	18: 36,954,837	A691E	probably benign	Het
Pde6a	T	G	18: 61,231,366	F165V	probably damaging	Het
Pqlc2	A	T	4: 139,300,344	L229Q	probably damaging	Het
Ptpn14	A	T	1: 189,846,364	M340L	probably benign	Het
Rnasel	G	T	1: 153,755,144	E469*	probably null	Het
Rsph3a	T	G	17: 7,945,958	L50R	probably benign	Het
Rusc2	A	G	4: 43,423,975	Y1043C	probably damaging	Het
Serpinb6b	A	T	13: 32,977,558	K86*	probably null	Het
Serpine1	T	C	5: 137,063,209	T392A	probably benign	Het
Shcbp1	A	T	8: 4,744,529	D421E	probably damaging	Het
Slc24a1	A	G	9: 64,948,581	V348A	unknown	Het
Slc26a7	A	G	4: 14,506,621	F605L	probably benign	Het
Spag17	A	C	3: 100,056,272	E1102A	possibly damaging	Het
Stab2	A	G	10: 86,848,125	V2390A	probably benign	Het
Stk11	A	G	10: 80,126,049	I35V	probably benign	Het
Stk24	T	C	14: 121,294,281	D321G	possibly damaging	Het
Tbx4	A	T	11: 85,911,168	N209I	possibly damaging	Het
Tmem225	T	C	9: 40,149,385	L80P	probably damaging	Het
Tnfrsf4	C	T	4: 156,013,923	T17I	probably benign	Het
Traf3ip1	G	A	1: 91,501,315	R268Q	probably benign	Het
Trhde	T	A	10: 114,800,592	I237F	probably benign	Het
Ugt2a1	A	T	5: 87,486,056	W231R	probably damaging	Het
Vash1	ACTGCTGCTGCTGCTGCTGC	ACTGCTGCTGCTGCTGC	12: 86,680,057		probably benign	Het
Vps16	T	A	2: 130,442,385	D685E	probably benign	Het
Washc4	A	G	10: 83,573,793	D602G	probably damaging	Het
Wdr59	A	G	8: 111,485,184	L377P	possibly damaging	Het
Wdr81	T	C	11: 75,449,070	E1364G	probably damaging	Het

Other mutations in Fpr-rs7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Fpr-rs7	APN	17	20113218	nonsense	probably null
IGL01386:Fpr-rs7	APN	17	20114192	missense	probably damaging	0.98
IGL02293:Fpr-rs7	APN	17	20113970	missense	probably benign	0.01
IGL03303:Fpr-rs7	APN	17	20113739	missense	possibly damaging	0.55
R0731:Fpr-rs7	UTSW	17	20113854	missense	probably benign	0.00
R0826:Fpr-rs7	UTSW	17	20113626	missense	probably benign	0.01
R1439:Fpr-rs7	UTSW	17	20113607	missense	probably benign	0.10
R1590:Fpr-rs7	UTSW	17	20113416	missense	probably benign	0.05
R1778:Fpr-rs7	UTSW	17	20114015	missense	probably damaging	1.00
R4715:Fpr-rs7	UTSW	17	20113428	missense	probably benign	0.00
R4744:Fpr-rs7	UTSW	17	20114003	missense	probably benign	0.17
R4921:Fpr-rs7	UTSW	17	20113820	missense	possibly damaging	0.70
R5677:Fpr-rs7	UTSW	17	20114103	missense	probably benign
R5959:Fpr-rs7	UTSW	17	20113749	missense	probably benign	0.01
R6042:Fpr-rs7	UTSW	17	20113215	missense	probably benign	0.00
R7921:Fpr-rs7	UTSW	17	20113405	missense	probably benign	0.03
R7984:Fpr-rs7	UTSW	17	20113409	missense	probably benign	0.01
R8137:Fpr-rs7	UTSW	17	20113793	missense	possibly damaging	0.49
R8172:Fpr-rs7	UTSW	17	20114181	missense	probably benign	0.04
R8762:Fpr-rs7	UTSW	17	20113527	missense	probably benign	0.07
R9134:Fpr-rs7	UTSW	17	20114063	missense	probably damaging	1.00
Z1176:Fpr-rs7	UTSW	17	20113393	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- TACAGCGATCCATGGCAATG -3'
(R):5'- GCTAGATCTGAGAAACAGTCATTG -3'

Sequencing Primer
(F):5'- CGATCCATGGCAATGAAAGTAATC -3'
(R):5'- ACAGTCATTGTTGAAATGTTGCAGG -3'

Posted On

2016-10-24