Incidental Mutation 'R5542:Vmn1r175'
ID 436030
Institutional Source Beutler Lab
Gene Symbol Vmn1r175
Ensembl Gene ENSMUSG00000095632
Gene Name vomeronasal 1 receptor 175
Synonyms Gm6299
MMRRC Submission 043100-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5542 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 23507711-23508625 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23508531 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 32 (I32N)
Ref Sequence ENSEMBL: ENSMUSP00000154170 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166141] [ENSMUST00000228383]
AlphaFold K7N6T9
Predicted Effect possibly damaging
Transcript: ENSMUST00000166141
AA Change: I32N

PolyPhen 2 Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000126357
Gene: ENSMUSG00000095632
AA Change: I32N

DomainStartEndE-ValueType
Pfam:TAS2R 8 296 8.8e-15 PFAM
Pfam:7tm_1 13 285 2.5e-6 PFAM
Pfam:V1R 41 295 4.4e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000228383
AA Change: I32N

PolyPhen 2 Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2 C T 3: 59,932,484 (GRCm39) T333I probably damaging Het
Acacb C T 5: 114,333,798 (GRCm39) R574C probably damaging Het
Actr10 T C 12: 71,001,430 (GRCm39) probably benign Het
Ankdd1a T A 9: 65,411,472 (GRCm39) probably null Het
Anks4b C T 7: 119,781,646 (GRCm39) Q226* probably null Het
AW146154 C A 7: 41,130,801 (GRCm39) G105V probably benign Het
Cdh4 T A 2: 179,502,019 (GRCm39) N326K probably damaging Het
Cnbd1 T C 4: 18,860,517 (GRCm39) T410A possibly damaging Het
Cndp2 A T 18: 84,690,201 (GRCm39) M247K probably damaging Het
Crx G A 7: 15,602,262 (GRCm39) R139C probably damaging Het
Ctrc A G 4: 141,571,037 (GRCm39) Y68H probably damaging Het
Ddx4 T C 13: 112,757,779 (GRCm39) D326G probably damaging Het
Edem1 C T 6: 108,831,290 (GRCm39) R584C possibly damaging Het
Emcn A G 3: 137,085,638 (GRCm39) T79A probably benign Het
Ext1 C A 15: 52,939,213 (GRCm39) W612L probably damaging Het
Fbrsl1 C T 5: 110,526,307 (GRCm39) G437R probably damaging Het
Fbxo7 A C 10: 85,869,149 (GRCm39) Q201P probably benign Het
Fbxo9 T C 9: 78,008,938 (GRCm39) M12V possibly damaging Het
Fcgbpl1 A T 7: 27,854,914 (GRCm39) I1847F probably damaging Het
Flii A G 11: 60,609,688 (GRCm39) S640P probably benign Het
Fsip2 A T 2: 82,812,207 (GRCm39) N2842I possibly damaging Het
Fst G T 13: 114,592,241 (GRCm39) Q159K probably damaging Het
Fuom A T 7: 139,680,025 (GRCm39) *109R probably null Het
Hhipl2 A G 1: 183,214,055 (GRCm39) D377G probably damaging Het
Hspa14 A G 2: 3,503,560 (GRCm39) V116A possibly damaging Het
Ighm A G 12: 113,382,601 (GRCm39) probably benign Het
Ighv1-85 T A 12: 115,963,847 (GRCm39) Y51F probably benign Het
Ighv2-3 A T 12: 113,574,833 (GRCm39) D107E probably benign Het
Ighv2-6-8 T A 12: 113,760,187 (GRCm39) M1L probably benign Het
Ipo5 T C 14: 121,163,683 (GRCm39) V247A probably benign Het
Itga9 T C 9: 118,672,729 (GRCm39) F154L possibly damaging Het
Itprid1 C A 6: 55,955,380 (GRCm39) P996Q probably damaging Het
Knl1 T A 2: 118,898,829 (GRCm39) C177S possibly damaging Het
Lrrc17 G A 5: 21,780,156 (GRCm39) G377S probably damaging Het
Marveld3 A T 8: 110,675,249 (GRCm39) I189K probably benign Het
Msantd2 G A 9: 37,428,555 (GRCm39) G185R probably damaging Het
Mtcl1 G A 17: 66,691,354 (GRCm39) probably benign Het
Muc21 T C 17: 35,933,395 (GRCm39) probably benign Het
Mycbpap A T 11: 94,398,572 (GRCm39) probably null Het
Nbeal1 A G 1: 60,316,353 (GRCm39) D1852G probably benign Het
Ndc80 A T 17: 71,807,276 (GRCm39) V560D probably benign Het
Nscme3l A T 19: 5,553,463 (GRCm39) V106D probably damaging Het
Or1e25 T A 11: 73,494,030 (GRCm39) V208E possibly damaging Het
Or2t48 A C 11: 58,420,710 (GRCm39) V34G probably benign Het
Or56a3 A T 7: 104,735,565 (GRCm39) D214V probably damaging Het
Or6a2 A T 7: 106,600,286 (GRCm39) S260R probably damaging Het
Or9i1b T C 19: 13,896,411 (GRCm39) V9A probably benign Het
Pcdhga4 A T 18: 37,819,651 (GRCm39) Y400F probably damaging Het
Pkd2 A G 5: 104,634,515 (GRCm39) silent Het
Plxna4 T A 6: 32,183,165 (GRCm39) I913F probably damaging Het
Psmc1 T C 12: 100,086,399 (GRCm39) probably null Het
Robo2 G A 16: 73,695,853 (GRCm39) T1430I probably benign Het
Safb2 G A 17: 56,882,647 (GRCm39) R329C probably damaging Het
Septin14 T C 5: 129,774,926 (GRCm39) H83R probably damaging Het
Slc16a10 A G 10: 39,952,784 (GRCm39) F237L probably benign Het
Slc37a1 A T 17: 31,559,236 (GRCm39) T439S probably damaging Het
Slc6a6 T C 6: 91,712,170 (GRCm39) F233S probably damaging Het
Smyd3 A T 1: 179,238,024 (GRCm39) D114E probably benign Het
Sned1 T C 1: 93,199,324 (GRCm39) I468T probably benign Het
Speer4a1 T A 5: 26,241,736 (GRCm39) N130I probably damaging Het
Tdrd7 T C 4: 46,029,757 (GRCm39) V1030A probably benign Het
Trip12 A T 1: 84,727,065 (GRCm39) D1135E probably damaging Het
Tsga10 T A 1: 37,800,598 (GRCm39) D542V probably damaging Het
Ubqlnl G A 7: 103,798,904 (GRCm39) Q198* probably null Het
Unc93a2 A T 17: 7,637,187 (GRCm39) C334S probably benign Het
Usp46 A T 5: 74,189,902 (GRCm39) M43K probably benign Het
Vmn1r29 C T 6: 58,285,108 (GRCm39) T276I probably benign Het
Vmn1r81 A T 7: 11,994,034 (GRCm39) D191E probably damaging Het
Zbtb5 C A 4: 44,995,052 (GRCm39) V111F probably damaging Het
Zfp12 C T 5: 143,230,240 (GRCm39) P189L possibly damaging Het
Zfp729b A G 13: 67,739,140 (GRCm39) F1042L probably benign Het
Other mutations in Vmn1r175
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02944:Vmn1r175 APN 7 23,508,591 (GRCm39) missense probably damaging 0.97
PIT4531001:Vmn1r175 UTSW 7 23,508,603 (GRCm39) missense possibly damaging 0.62
R1163:Vmn1r175 UTSW 7 23,507,937 (GRCm39) missense probably benign 0.30
R1901:Vmn1r175 UTSW 7 23,508,218 (GRCm39) missense probably benign 0.00
R1926:Vmn1r175 UTSW 7 23,508,466 (GRCm39) missense possibly damaging 0.81
R1957:Vmn1r175 UTSW 7 23,507,808 (GRCm39) missense probably benign 0.21
R2163:Vmn1r175 UTSW 7 23,508,352 (GRCm39) missense probably benign 0.29
R2381:Vmn1r175 UTSW 7 23,508,093 (GRCm39) missense probably benign 0.31
R3109:Vmn1r175 UTSW 7 23,508,393 (GRCm39) missense probably benign 0.00
R3419:Vmn1r175 UTSW 7 23,508,075 (GRCm39) missense probably damaging 0.96
R3941:Vmn1r175 UTSW 7 23,508,393 (GRCm39) missense probably benign 0.00
R4982:Vmn1r175 UTSW 7 23,508,494 (GRCm39) missense possibly damaging 0.61
R5191:Vmn1r175 UTSW 7 23,508,447 (GRCm39) missense possibly damaging 0.91
R5326:Vmn1r175 UTSW 7 23,508,531 (GRCm39) missense possibly damaging 0.88
R5333:Vmn1r175 UTSW 7 23,508,004 (GRCm39) missense possibly damaging 0.69
R5476:Vmn1r175 UTSW 7 23,508,556 (GRCm39) missense possibly damaging 0.82
R5761:Vmn1r175 UTSW 7 23,507,905 (GRCm39) missense probably benign 0.01
R5918:Vmn1r175 UTSW 7 23,508,372 (GRCm39) missense probably damaging 1.00
R6163:Vmn1r175 UTSW 7 23,508,591 (GRCm39) missense possibly damaging 0.71
R6563:Vmn1r175 UTSW 7 23,508,030 (GRCm39) missense possibly damaging 0.61
R7476:Vmn1r175 UTSW 7 23,507,847 (GRCm39) missense probably benign 0.01
R7616:Vmn1r175 UTSW 7 23,508,031 (GRCm39) missense possibly damaging 0.79
R8100:Vmn1r175 UTSW 7 23,508,012 (GRCm39) missense probably damaging 1.00
R8157:Vmn1r175 UTSW 7 23,508,523 (GRCm39) missense probably benign 0.00
R8699:Vmn1r175 UTSW 7 23,508,234 (GRCm39) missense probably benign 0.01
R8744:Vmn1r175 UTSW 7 23,508,403 (GRCm39) missense probably benign 0.00
R9595:Vmn1r175 UTSW 7 23,508,508 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGCCAAATGAAGTACCCAAGTTTAC -3'
(R):5'- AAGTAGAGCTGCCCTTCGTG -3'

Sequencing Primer
(F):5'- CCAAGTTTACATTTTAGGTCAGTTGG -3'
(R):5'- CCTTCGTGGGGGAAAATGTC -3'
Posted On 2016-10-24