Incidental Mutation 'R5543:Mmp15'
ID 436105
Institutional Source Beutler Lab
Gene Symbol Mmp15
Ensembl Gene ENSMUSG00000031790
Gene Name matrix metallopeptidase 15
Synonyms Membrane type 2-MMP, MT2-MMP
MMRRC Submission 043101-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5543 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 95352268-95375080 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 95368101 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 201 (F201S)
Ref Sequence ENSEMBL: ENSMUSP00000034243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034243]
AlphaFold O54732
Predicted Effect possibly damaging
Transcript: ENSMUST00000034243
AA Change: F201S

PolyPhen 2 Score 0.853 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000034243
Gene: ENSMUSG00000031790
AA Change: F201S

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Pfam:PG_binding_1 42 102 3.2e-13 PFAM
ZnMc 131 301 5.31e-59 SMART
low complexity region 306 353 N/A INTRINSIC
HX 370 413 5.92e-8 SMART
HX 415 459 2.31e-10 SMART
HX 462 508 2.98e-13 SMART
HX 510 555 2.01e-10 SMART
Pfam:DUF3377 586 657 1.2e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212235
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. A deficiency of the encoded protein in mice is compatible with normal development and postnatal growth. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130023H24Rik C A 7: 128,237,181 (GRCm38) S80I probably benign Het
Aak1 T C 6: 86,982,645 (GRCm38) probably null Het
Abcc6 A G 7: 45,989,536 (GRCm38) probably null Het
Acvr1 A G 2: 58,463,145 (GRCm38) S268P probably damaging Het
Apod T C 16: 31,303,533 (GRCm38) probably null Het
Atp5o T C 16: 91,926,530 (GRCm38) I58V probably benign Het
AU040320 C T 4: 126,841,224 (GRCm38) T777M probably damaging Het
BC067074 C A 13: 113,320,873 (GRCm38) T1151K probably damaging Het
Ccne2 A T 4: 11,194,026 (GRCm38) N89I probably benign Het
Dnah7a A G 1: 53,504,069 (GRCm38) V2314A probably damaging Het
Dopey2 T C 16: 93,798,920 (GRCm38) S1881P probably damaging Het
E4f1 A G 17: 24,447,362 (GRCm38) V24A possibly damaging Het
Esrrg A T 1: 188,150,254 (GRCm38) D236V probably damaging Het
Fam240b T A 13: 64,485,922 (GRCm38) I27F possibly damaging Het
Fat1 T A 8: 45,023,479 (GRCm38) I1854N probably damaging Het
Fchsd2 T C 7: 101,271,699 (GRCm38) Y480H probably damaging Het
Fras1 A G 5: 96,528,535 (GRCm38) N47S probably benign Het
Gabrr3 T C 16: 59,433,507 (GRCm38) S196P probably damaging Het
Gbp8 T A 5: 105,017,830 (GRCm38) D319V possibly damaging Het
Hrh3 G T 2: 180,103,970 (GRCm38) A61E probably damaging Het
Idua T C 5: 108,670,229 (GRCm38) I89T probably benign Het
Ifitm3 T A 7: 141,009,817 (GRCm38) I108F unknown Het
Izumo4 T C 10: 80,702,834 (GRCm38) F40S probably damaging Het
Kifc2 A G 15: 76,667,042 (GRCm38) R679G probably damaging Het
Klk14 G A 7: 43,692,077 (GRCm38) C51Y probably damaging Het
Ldha A T 7: 46,850,890 (GRCm38) I171F possibly damaging Het
Lrfn4 T C 19: 4,612,163 (GRCm38) S609G probably benign Het
Myof C T 19: 37,981,330 (GRCm38) V295I probably benign Het
Olfr1024 G T 2: 85,904,328 (GRCm38) A242D probably damaging Het
Olfr30 T A 11: 58,455,167 (GRCm38) M261L probably damaging Het
Olfr354 C T 2: 36,907,357 (GRCm38) T137I possibly damaging Het
Parp14 T C 16: 35,834,767 (GRCm38) D1778G probably benign Het
Pcnt A T 10: 76,412,052 (GRCm38) D969E probably benign Het
Pibf1 A T 14: 99,112,992 (GRCm38) N192I probably benign Het
Pitpnm3 A G 11: 72,056,197 (GRCm38) F792S probably damaging Het
Pkd2 T A 5: 104,489,333 (GRCm38) I604N probably damaging Het
Pla2g15 T C 8: 106,161,143 (GRCm38) Y188H probably damaging Het
Plxnc1 G T 10: 94,864,774 (GRCm38) D643E probably benign Het
Prrc2c G A 1: 162,673,511 (GRCm38) P1241L probably damaging Het
Ptprd T C 4: 76,059,753 (GRCm38) E173G probably damaging Het
Shank3 T C 15: 89,532,354 (GRCm38) V232A probably damaging Het
Shbg A G 11: 69,616,738 (GRCm38) I171T probably damaging Het
Slc22a14 A T 9: 119,173,608 (GRCm38) F404L probably benign Het
Slc37a3 C A 6: 39,355,026 (GRCm38) G158C probably damaging Het
Slfn9 C A 11: 82,982,381 (GRCm38) L565F probably damaging Het
Tex43 G A 18: 56,594,688 (GRCm38) probably benign Het
Trank1 T A 9: 111,366,112 (GRCm38) M1068K probably damaging Het
Trbv15 A T 6: 41,141,253 (GRCm38) I15L probably benign Het
Ttn A T 2: 76,811,243 (GRCm38) L5176Q possibly damaging Het
Ttn C T 2: 76,739,574 (GRCm38) V26992M probably damaging Het
Ugt2b34 T A 5: 86,906,701 (GRCm38) I74F probably damaging Het
Vamp3 A G 4: 151,051,020 (GRCm38) L47P probably damaging Het
Zfp143 T A 7: 110,083,315 (GRCm38) C363* probably null Het
Zfp438 T C 18: 5,213,761 (GRCm38) E399G probably damaging Het
Other mutations in Mmp15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01467:Mmp15 APN 8 95,366,331 (GRCm38) missense probably benign 0.31
IGL03001:Mmp15 APN 8 95,368,217 (GRCm38) missense probably damaging 0.97
R0147:Mmp15 UTSW 8 95,372,317 (GRCm38) missense probably benign 0.18
R0148:Mmp15 UTSW 8 95,372,317 (GRCm38) missense probably benign 0.18
R0437:Mmp15 UTSW 8 95,370,772 (GRCm38) missense probably benign 0.04
R0465:Mmp15 UTSW 8 95,367,998 (GRCm38) missense probably damaging 1.00
R0548:Mmp15 UTSW 8 95,372,351 (GRCm38) missense probably damaging 1.00
R0574:Mmp15 UTSW 8 95,365,401 (GRCm38) missense possibly damaging 0.73
R0685:Mmp15 UTSW 8 95,372,134 (GRCm38) missense possibly damaging 0.81
R0763:Mmp15 UTSW 8 95,368,228 (GRCm38) missense probably benign 0.01
R1341:Mmp15 UTSW 8 95,372,303 (GRCm38) missense probably benign 0.03
R1428:Mmp15 UTSW 8 95,369,562 (GRCm38) missense probably benign 0.34
R1840:Mmp15 UTSW 8 95,365,420 (GRCm38) missense probably damaging 1.00
R2061:Mmp15 UTSW 8 95,370,779 (GRCm38) missense possibly damaging 0.91
R2219:Mmp15 UTSW 8 95,370,173 (GRCm38) missense probably benign 0.38
R4760:Mmp15 UTSW 8 95,368,196 (GRCm38) missense possibly damaging 0.61
R4762:Mmp15 UTSW 8 95,372,330 (GRCm38) missense probably benign 0.00
R5233:Mmp15 UTSW 8 95,371,068 (GRCm38) missense probably benign 0.08
R5394:Mmp15 UTSW 8 95,366,404 (GRCm38) missense probably damaging 0.96
R5502:Mmp15 UTSW 8 95,368,184 (GRCm38) missense possibly damaging 0.96
R6027:Mmp15 UTSW 8 95,372,176 (GRCm38) missense probably benign 0.00
R6341:Mmp15 UTSW 8 95,365,463 (GRCm38) critical splice donor site probably null
R6720:Mmp15 UTSW 8 95,365,314 (GRCm38) missense probably benign 0.22
R7788:Mmp15 UTSW 8 95,368,148 (GRCm38) missense probably damaging 1.00
R8033:Mmp15 UTSW 8 95,367,962 (GRCm38) missense probably benign 0.01
R8679:Mmp15 UTSW 8 95,366,354 (GRCm38) missense possibly damaging 0.83
R8791:Mmp15 UTSW 8 95,369,660 (GRCm38) nonsense probably null
R9028:Mmp15 UTSW 8 95,369,688 (GRCm38) missense probably benign 0.01
R9227:Mmp15 UTSW 8 95,366,331 (GRCm38) missense probably benign 0.06
R9230:Mmp15 UTSW 8 95,366,331 (GRCm38) missense probably benign 0.06
R9350:Mmp15 UTSW 8 95,366,374 (GRCm38) missense probably damaging 0.97
R9632:Mmp15 UTSW 8 95,372,103 (GRCm38) critical splice acceptor site probably null
R9695:Mmp15 UTSW 8 95,370,786 (GRCm38) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- CAGAACTACACTGAGAAGCTGG -3'
(R):5'- GGCTTCAGAGTCATGAATAGGG -3'

Sequencing Primer
(F):5'- AAGCTGGGCTGGTACAACTC -3'
(R):5'- GAGTCATGAATAGGGGACATTCTCTC -3'
Posted On 2016-10-24