Mutagenetix > Incidental Mutation

Incidental Mutation 'R5544:Morn4'

436171

Institutional Source

Beutler Lab

Gene Symbol

Morn4

Ensembl Gene

ENSMUSG00000049670

Gene Name

MORN repeat containing 4

Synonyms

MMRRC Submission

043102-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.205) question?

Stock #

R5544 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

42063378-42074796 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 42064686 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 101 (T101A)

Ref Sequence

ENSEMBL: ENSMUSP00000062887 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051772]

AlphaFold

Q6PGF2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000051772
AA Change: T101A

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000062887
Gene: ENSMUSG00000049670
AA Change: T101A

Domain	Start	End	E-Value	Type
MORN	14	35	1.64e-5	SMART
MORN	37	58	4.15e-2	SMART
MORN	60	81	1.86e-4	SMART
MORN	83	104	1.84e0	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.4%
20x: 95.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts8	G	A	9: 30,863,999 (GRCm39)	A372T	probably damaging	Het
Ap4m1	A	G	5: 138,176,632 (GRCm39)	T411A	probably benign	Het
Arid3b	T	A	9: 57,705,380 (GRCm39)	K274*	probably null	Het
Bcan	A	G	3: 87,900,360 (GRCm39)		probably null	Het
Birc6	A	C	17: 74,977,369 (GRCm39)	N4388T	probably damaging	Het
C9	T	A	15: 6,526,508 (GRCm39)	V514D	probably damaging	Het
Cdk2	A	C	10: 128,535,008 (GRCm39)	D336E	probably benign	Het
Corin	A	T	5: 72,462,357 (GRCm39)	Y825*	probably null	Het
Cyp17a1	A	G	19: 46,661,093 (GRCm39)	Y64H	probably damaging	Het
Dock4	T	G	12: 40,884,701 (GRCm39)	I1735S	possibly damaging	Het
Dock7	T	C	4: 98,855,494 (GRCm39)	H1486R	probably damaging	Het
Fam171b	C	A	2: 83,685,871 (GRCm39)	A185D	possibly damaging	Het
Fbxl13	A	G	5: 21,729,489 (GRCm39)	I441T	probably damaging	Het
Gm7347	T	A	5: 26,260,016 (GRCm39)	D178V	possibly damaging	Het
Greb1	C	A	12: 16,723,797 (GRCm39)	C1884F	probably damaging	Het
Kdr	G	A	5: 76,121,403 (GRCm39)	R536*	probably null	Het
Lamc2	T	C	1: 152,999,799 (GRCm39)	T1187A	possibly damaging	Het
Mal	T	A	2: 127,476,937 (GRCm39)	H142L	probably damaging	Het
Map4k2	A	C	19: 6,395,944 (GRCm39)		probably null	Het
Neto2	A	G	8: 86,374,506 (GRCm39)	V241A	possibly damaging	Het
Nprl2	T	C	9: 107,421,808 (GRCm39)	V232A	probably benign	Het
Pcdhb13	T	C	18: 37,576,573 (GRCm39)	V317A	possibly damaging	Het
Pcdhb17	T	A	18: 37,620,474 (GRCm39)	C755S	possibly damaging	Het
Pgc	A	G	17: 48,043,429 (GRCm39)	D259G	probably benign	Het
Ptprh	C	A	7: 4,583,909 (GRCm39)	E228*	probably null	Het
R3hdml	A	G	2: 163,340,342 (GRCm39)	T170A	probably damaging	Het
Retreg2	T	G	1: 75,121,333 (GRCm39)	*174G	probably null	Het
Rps6ka1	A	G	4: 133,599,326 (GRCm39)	S34P	probably benign	Het
Rptn	A	G	3: 93,305,780 (GRCm39)	T1038A	possibly damaging	Het
Sel1l3	A	T	5: 53,357,644 (GRCm39)	V116D	probably damaging	Het
Sidt2	A	T	9: 45,855,753 (GRCm39)	Y509N	probably damaging	Het
Slc16a11	T	A	11: 70,105,826 (GRCm39)		probably null	Het
Thsd7a	G	T	6: 12,379,470 (GRCm39)	Q985K	possibly damaging	Het
Ttn	T	C	2: 76,556,882 (GRCm39)	N30041S	probably benign	Het
Vmn1r231	A	G	17: 21,110,840 (GRCm39)	I25T	probably damaging	Het
Wdr81	T	C	11: 75,332,623 (GRCm39)	D1926G	probably damaging	Het

Other mutations in Morn4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00971:Morn4	APN	19	42,064,559 (GRCm39)	missense	possibly damaging	0.53
IGL02572:Morn4	APN	19	42,064,886 (GRCm39)	splice site	probably benign
IGL02933:Morn4	APN	19	42,064,661 (GRCm39)	missense	probably benign	0.01
FR4449:Morn4	UTSW	19	42,064,548 (GRCm39)	small insertion	probably benign
FR4548:Morn4	UTSW	19	42,064,548 (GRCm39)	small insertion	probably benign
R1997:Morn4	UTSW	19	42,064,977 (GRCm39)	missense	possibly damaging	0.71
R2239:Morn4	UTSW	19	42,066,471 (GRCm39)	missense	possibly damaging	0.93
R4409:Morn4	UTSW	19	42,066,986 (GRCm39)	missense	possibly damaging	0.53
R5695:Morn4	UTSW	19	42,064,556 (GRCm39)	missense	possibly damaging	0.96
R6986:Morn4	UTSW	19	42,066,453 (GRCm39)	missense	possibly damaging	0.71
R7024:Morn4	UTSW	19	42,066,483 (GRCm39)	missense	possibly damaging	0.92
R8721:Morn4	UTSW	19	42,066,439 (GRCm39)	missense	possibly damaging	0.85
RF025:Morn4	UTSW	19	42,064,550 (GRCm39)	nonsense	probably null
RF030:Morn4	UTSW	19	42,064,550 (GRCm39)	nonsense	probably null
RF036:Morn4	UTSW	19	42,064,553 (GRCm39)	nonsense	probably null
RF040:Morn4	UTSW	19	42,064,550 (GRCm39)	nonsense	probably null
RF042:Morn4	UTSW	19	42,064,550 (GRCm39)	nonsense	probably null
RF044:Morn4	UTSW	19	42,064,553 (GRCm39)	nonsense	probably null
RF057:Morn4	UTSW	19	42,064,545 (GRCm39)	nonsense	probably null
X0063:Morn4	UTSW	19	42,066,407 (GRCm39)	missense	possibly damaging	0.71

Predicted Primers

PCR Primer
(F):5'- TACGGATCCTTTCCAGCTGC -3'
(R):5'- ATGACAACATGACCTTTGAGGG -3'

Sequencing Primer
(F):5'- TTTCCAGCTGCGCCCAAAG -3'
(R):5'- GGTAAGTTTCAGCTCAGTAGAATG -3'

Posted On

2016-10-24