Mutagenetix > Incidental Mutation

Incidental Mutation 'R5532:Iigp1c'

436250

Institutional Source

Beutler Lab

Gene Symbol

Iigp1c

Ensembl Gene

ENSMUSG00000073555

Gene Name

interferon inducible GTPase 1C

Synonyms

Gm4951

MMRRC Submission

043090-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5532 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

60345152-60380892 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 60379142 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 226 (I226V)

Ref Sequence

ENSEMBL: ENSMUSP00000031549 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031549]

AlphaFold

Q3UED7

Predicted Effect

probably benign
Transcript: ENSMUST00000031549
AA Change: I226V

PolyPhen 2 Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000031549
Gene: ENSMUSG00000073555
AA Change: I226V

Domain	Start	End	E-Value	Type
Pfam:IIGP	34	402	4.8e-157	PFAM
Pfam:MMR_HSR1	70	198	2.8e-8	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.1%
20x: 94.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	T	A	6: 128,530,293 (GRCm39)		probably null	Het
Adsl	C	G	15: 80,848,110 (GRCm39)	P118A	probably damaging	Het
Ano6	C	T	15: 95,860,122 (GRCm39)	P748L	probably damaging	Het
Arhgap10	A	T	8: 78,146,701 (GRCm39)	N234K	probably benign	Het
Arhgap18	T	A	10: 26,722,104 (GRCm39)	I25K	possibly damaging	Het
AW551984	T	C	9: 39,508,481 (GRCm39)	Y345C	probably damaging	Het
Ccdc146	A	G	5: 21,510,329 (GRCm39)	V561A	probably benign	Het
Cenpv	G	A	11: 62,418,398 (GRCm39)	T185M	probably damaging	Het
Fat2	T	A	11: 55,153,163 (GRCm39)	D3683V	probably damaging	Het
Galns	T	C	8: 123,311,765 (GRCm39)	D415G	possibly damaging	Het
Gatad2a	G	A	8: 70,369,070 (GRCm39)	T259M	probably damaging	Het
Gja8	T	C	3: 96,827,648 (GRCm39)	S5G	probably benign	Het
Ifi209	T	C	1: 173,466,542 (GRCm39)	S125P	probably damaging	Het
Il12rb2	G	A	6: 67,269,246 (GRCm39)	R856W	probably damaging	Het
Kcnq3	A	T	15: 65,869,622 (GRCm39)	Y605*	probably null	Het
Klk1b16	T	C	7: 43,790,950 (GRCm39)	S251P	probably benign	Het
Map2	A	G	1: 66,453,779 (GRCm39)	N890D	probably damaging	Het
Map4	T	A	9: 109,863,746 (GRCm39)	S324T	probably benign	Het
Mmp28	T	C	11: 83,333,684 (GRCm39)	D419G	probably damaging	Het
Mtnr1b	A	G	9: 15,774,210 (GRCm39)	L283P	probably benign	Het
Ndufb7	T	A	8: 84,298,063 (GRCm39)	Y95N	probably damaging	Het
Nfrkb	C	T	9: 31,309,075 (GRCm39)	R280W	probably damaging	Het
Npc1l1	A	G	11: 6,174,245 (GRCm39)	Y687H	probably damaging	Het
Or6f1	A	C	7: 85,970,879 (GRCm39)	F94V	possibly damaging	Het
Or8b40	C	T	9: 38,027,923 (GRCm39)	T277I	probably benign	Het
Or8g51	T	C	9: 38,608,943 (GRCm39)	T240A	probably damaging	Het
Or8h9	T	A	2: 86,788,924 (GRCm39)	R293*	probably null	Het
Pabpc4l	T	C	3: 46,401,044 (GRCm39)	D200G	probably benign	Het
Plekhg6	T	C	6: 125,349,514 (GRCm39)	E361G	possibly damaging	Het
Pramel31	A	T	4: 144,090,061 (GRCm39)	D367V	probably damaging	Het
Rictor	A	G	15: 6,819,046 (GRCm39)	Y1423C	probably damaging	Het
Rsf1	G	A	7: 97,329,902 (GRCm39)	D1143N	probably damaging	Het
Spsb4	C	T	9: 96,877,627 (GRCm39)		probably null	Het
Strada	G	T	11: 106,061,843 (GRCm39)	A136E	probably damaging	Het
Syce2	A	T	8: 85,610,131 (GRCm39)	Q73L	probably damaging	Het
Teddm2	A	T	1: 153,726,130 (GRCm39)	V195D	probably benign	Het
Tex36	A	T	7: 133,203,712 (GRCm39)	N12K	probably benign	Het
Ubtf	A	G	11: 102,199,785 (GRCm39)	S484P	probably benign	Het
Ufd1	T	G	16: 18,636,680 (GRCm39)	L66R	probably damaging	Het
Vmn2r74	C	T	7: 85,601,197 (GRCm39)	A814T	probably benign	Het
Vmn2r98	T	C	17: 19,287,645 (GRCm39)	S493P	possibly damaging	Het
Xrcc1	T	A	7: 24,267,353 (GRCm39)		probably null	Het
Zfp277	A	C	12: 40,385,308 (GRCm39)	C305G	probably damaging	Het
Zfp998	A	T	13: 66,579,740 (GRCm39)	C248S	probably damaging	Het

Other mutations in Iigp1c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00717:Iigp1c	APN	18	60,379,365 (GRCm39)	missense	probably damaging	1.00
IGL00807:Iigp1c	APN	18	60,378,483 (GRCm39)	missense	probably damaging	1.00
IGL00956:Iigp1c	APN	18	60,379,262 (GRCm39)	missense	probably damaging	1.00
IGL01017:Iigp1c	APN	18	60,378,508 (GRCm39)	missense	possibly damaging	0.87
IGL01929:Iigp1c	APN	18	60,379,554 (GRCm39)	missense	probably benign	0.02
IGL02267:Iigp1c	APN	18	60,379,470 (GRCm39)	missense	probably damaging	0.97
IGL02276:Iigp1c	APN	18	60,379,151 (GRCm39)	missense	probably damaging	0.99
IGL02499:Iigp1c	APN	18	60,378,710 (GRCm39)	missense	probably damaging	1.00
IGL02538:Iigp1c	APN	18	60,378,944 (GRCm39)	nonsense	probably null
IGL03139:Iigp1c	APN	18	60,379,221 (GRCm39)	missense	probably benign	0.01
IGL03209:Iigp1c	APN	18	60,379,143 (GRCm39)	missense	probably damaging	1.00
IGL03270:Iigp1c	APN	18	60,378,548 (GRCm39)	missense	probably benign	0.01
IGL03325:Iigp1c	APN	18	60,378,883 (GRCm39)	nonsense	probably null
Carboniferous	UTSW	18	60,378,840 (GRCm39)	missense	probably damaging	1.00
Oily	UTSW	18	60,378,724 (GRCm39)	missense	probably damaging	1.00
R0554:Iigp1c	UTSW	18	60,378,489 (GRCm39)	missense	probably benign	0.15
R2046:Iigp1c	UTSW	18	60,378,571 (GRCm39)	missense	probably benign	0.00
R2296:Iigp1c	UTSW	18	60,378,542 (GRCm39)	missense	probably benign	0.00
R4583:Iigp1c	UTSW	18	60,379,152 (GRCm39)	missense	possibly damaging	0.93
R5500:Iigp1c	UTSW	18	60,379,092 (GRCm39)	missense	probably damaging	0.99
R5938:Iigp1c	UTSW	18	60,378,724 (GRCm39)	missense	probably damaging	1.00
R6446:Iigp1c	UTSW	18	60,378,840 (GRCm39)	missense	probably damaging	1.00
R7191:Iigp1c	UTSW	18	60,379,329 (GRCm39)	missense	probably benign	0.01
R7238:Iigp1c	UTSW	18	60,379,355 (GRCm39)	missense	possibly damaging	0.64
R7443:Iigp1c	UTSW	18	60,379,122 (GRCm39)	missense	probably benign	0.11
R9261:Iigp1c	UTSW	18	60,353,820 (GRCm39)	intron	probably benign
R9650:Iigp1c	UTSW	18	60,379,470 (GRCm39)	missense	probably damaging	0.97
Z1177:Iigp1c	UTSW	18	60,379,368 (GRCm39)	missense	probably benign	0.23

Predicted Primers

PCR Primer
(F):5'- ATTATTATTTCGGCCACACGC -3'
(R):5'- AGCCTTCCAGCCAAGTCTTC -3'

Sequencing Primer
(F):5'- ATTTCGGCCACACGCTTCAAG -3'
(R):5'- AGTCTTCCACCTCAGAAAATTTCG -3'

Posted On

2016-10-24