Incidental Mutation 'R5560:Vmn2r72'
ID |
436526 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r72
|
Ensembl Gene |
ENSMUSG00000051877 |
Gene Name |
vomeronasal 2, receptor 72 |
Synonyms |
EG244114, Vmn2r72-ps |
MMRRC Submission |
043117-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.087)
|
Stock # |
R5560 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
85386992-85404189 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 85401150 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Leucine
at position 90
(I90L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000133014
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000063425]
|
AlphaFold |
D3Z4N8 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000063425
AA Change: I90L
PolyPhen 2
Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000133014 Gene: ENSMUSG00000051877 AA Change: I90L
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
469 |
2.3e-28 |
PFAM |
Pfam:NCD3G
|
512 |
564 |
1.2e-18 |
PFAM |
Pfam:7tm_3
|
594 |
832 |
4e-53 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 97.7%
- 20x: 92.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 81 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acyp2 |
C |
T |
11: 30,456,354 (GRCm39) |
E98K |
possibly damaging |
Het |
Adipor1 |
T |
C |
1: 134,353,778 (GRCm39) |
W188R |
possibly damaging |
Het |
Agrn |
T |
C |
4: 156,262,954 (GRCm39) |
D441G |
probably damaging |
Het |
Ankrd55 |
T |
C |
13: 112,520,024 (GRCm39) |
S570P |
probably benign |
Het |
Ano9 |
C |
G |
7: 140,690,395 (GRCm39) |
G80R |
probably damaging |
Het |
Arhgef2 |
T |
A |
3: 88,541,744 (GRCm39) |
V250E |
probably damaging |
Het |
Atp2b2 |
T |
C |
6: 113,751,319 (GRCm39) |
D583G |
possibly damaging |
Het |
Bcar3 |
T |
A |
3: 122,220,224 (GRCm39) |
D40E |
possibly damaging |
Het |
Capn12 |
A |
G |
7: 28,582,285 (GRCm39) |
D133G |
probably benign |
Het |
Ccna1 |
A |
T |
3: 54,955,990 (GRCm39) |
Y269N |
probably damaging |
Het |
Cct6b |
A |
T |
11: 82,632,239 (GRCm39) |
Y250N |
probably damaging |
Het |
Cep112 |
A |
C |
11: 108,328,061 (GRCm39) |
K98Q |
probably damaging |
Het |
Chst13 |
T |
C |
6: 90,295,251 (GRCm39) |
D54G |
probably damaging |
Het |
Clstn2 |
G |
T |
9: 97,351,872 (GRCm39) |
H518N |
possibly damaging |
Het |
Cntnap1 |
T |
A |
11: 101,073,261 (GRCm39) |
L581M |
probably damaging |
Het |
Cog3 |
T |
A |
14: 75,966,833 (GRCm39) |
M446L |
probably damaging |
Het |
Dennd2c |
T |
A |
3: 103,068,871 (GRCm39) |
I756K |
probably damaging |
Het |
Dennd3 |
T |
G |
15: 73,404,744 (GRCm39) |
L273R |
probably damaging |
Het |
Dhx34 |
C |
A |
7: 15,952,466 (GRCm39) |
R53L |
probably benign |
Het |
Dnah9 |
G |
A |
11: 65,772,566 (GRCm39) |
T3722I |
probably benign |
Het |
Dnajb12 |
GC |
G |
10: 59,728,574 (GRCm39) |
|
probably null |
Het |
Dusp6 |
A |
G |
10: 99,102,103 (GRCm39) |
Y217C |
probably damaging |
Het |
Dync2i1 |
T |
C |
12: 116,181,733 (GRCm39) |
S769G |
probably damaging |
Het |
Dyrk1b |
G |
A |
7: 27,883,678 (GRCm39) |
R178Q |
possibly damaging |
Het |
Eif4g1 |
T |
A |
16: 20,505,645 (GRCm39) |
C1009S |
probably benign |
Het |
Frmpd1 |
A |
T |
4: 45,243,697 (GRCm39) |
T57S |
probably damaging |
Het |
Gask1a |
T |
C |
9: 121,807,289 (GRCm39) |
F478L |
possibly damaging |
Het |
Gjc2 |
A |
G |
11: 59,068,185 (GRCm39) |
V99A |
possibly damaging |
Het |
Gm9955 |
A |
T |
18: 24,842,149 (GRCm39) |
|
probably benign |
Het |
Gpr158 |
A |
G |
2: 21,831,101 (GRCm39) |
I734V |
possibly damaging |
Het |
H1f2 |
A |
G |
13: 23,923,390 (GRCm39) |
S187G |
probably benign |
Het |
Herc1 |
A |
T |
9: 66,358,401 (GRCm39) |
H2494L |
probably benign |
Het |
Hjurp |
GT |
GTT |
1: 88,194,246 (GRCm39) |
|
probably null |
Het |
Hmgcs1 |
A |
G |
13: 120,161,351 (GRCm39) |
|
probably null |
Het |
Invs |
A |
T |
4: 48,416,084 (GRCm39) |
T655S |
probably benign |
Het |
Ipo9 |
G |
A |
1: 135,329,983 (GRCm39) |
L486F |
probably damaging |
Het |
Katnip |
T |
C |
7: 125,453,733 (GRCm39) |
V1150A |
probably benign |
Het |
Kcnj6 |
A |
T |
16: 94,633,824 (GRCm39) |
L96M |
probably benign |
Het |
Lfng |
A |
G |
5: 140,600,022 (GRCm39) |
D354G |
possibly damaging |
Het |
Lgsn |
T |
C |
1: 31,235,953 (GRCm39) |
L139P |
probably damaging |
Het |
Madd |
C |
A |
2: 90,993,890 (GRCm39) |
V923L |
probably damaging |
Het |
Mical1 |
A |
T |
10: 41,354,961 (GRCm39) |
I157F |
probably damaging |
Het |
Mis18bp1 |
T |
C |
12: 65,199,590 (GRCm39) |
N154S |
possibly damaging |
Het |
Mrps14 |
A |
G |
1: 160,023,105 (GRCm39) |
K6R |
probably benign |
Het |
Mug1 |
T |
A |
6: 121,838,032 (GRCm39) |
C421S |
probably damaging |
Het |
Myo18b |
A |
G |
5: 113,016,161 (GRCm39) |
I696T |
probably damaging |
Het |
Naf1 |
T |
C |
8: 67,336,197 (GRCm39) |
Y375H |
probably damaging |
Het |
Nsf |
T |
A |
11: 103,754,081 (GRCm39) |
E485V |
possibly damaging |
Het |
Nup188 |
A |
G |
2: 30,199,897 (GRCm39) |
D307G |
probably damaging |
Het |
Ocel1 |
C |
A |
8: 71,825,122 (GRCm39) |
P108T |
probably damaging |
Het |
Oip5 |
A |
G |
2: 119,443,540 (GRCm39) |
S177P |
probably damaging |
Het |
Omg |
A |
G |
11: 79,392,584 (GRCm39) |
W425R |
possibly damaging |
Het |
Or1ad8 |
A |
C |
11: 50,898,350 (GRCm39) |
I184L |
possibly damaging |
Het |
Or1l4 |
A |
G |
2: 37,091,942 (GRCm39) |
I230V |
probably benign |
Het |
Or5an10 |
G |
A |
19: 12,276,008 (GRCm39) |
Q163* |
probably null |
Het |
Or8g26 |
A |
C |
9: 39,095,480 (GRCm39) |
E2A |
probably benign |
Het |
Pikfyve |
A |
G |
1: 65,292,566 (GRCm39) |
Y1339C |
probably damaging |
Het |
Polr3e |
A |
G |
7: 120,522,172 (GRCm39) |
D6G |
possibly damaging |
Het |
Pou4f3 |
C |
A |
18: 42,528,480 (GRCm39) |
P141Q |
probably benign |
Het |
Rcsd1 |
T |
A |
1: 165,483,070 (GRCm39) |
N337I |
possibly damaging |
Het |
Rhoj |
C |
T |
12: 75,438,486 (GRCm39) |
P91S |
probably damaging |
Het |
Rnf10 |
A |
G |
5: 115,388,057 (GRCm39) |
F367S |
probably damaging |
Het |
Rnft1 |
A |
T |
11: 86,384,022 (GRCm39) |
R307S |
probably benign |
Het |
Ryr3 |
A |
T |
2: 112,585,222 (GRCm39) |
F2788Y |
probably damaging |
Het |
Scgb1c1 |
A |
G |
7: 140,426,137 (GRCm39) |
K78E |
possibly damaging |
Het |
Scn5a |
G |
T |
9: 119,389,352 (GRCm39) |
A123E |
probably damaging |
Het |
Setd2 |
T |
A |
9: 110,378,907 (GRCm39) |
Y623* |
probably null |
Het |
Slc49a3 |
A |
T |
5: 108,596,729 (GRCm39) |
M1K |
probably null |
Het |
Spmap2l |
A |
G |
5: 77,164,333 (GRCm39) |
D112G |
possibly damaging |
Het |
Tbl2 |
C |
T |
5: 135,186,445 (GRCm39) |
Q216* |
probably null |
Het |
Tnc |
A |
G |
4: 63,926,946 (GRCm39) |
I860T |
probably damaging |
Het |
Trafd1 |
T |
C |
5: 121,511,366 (GRCm39) |
K484R |
possibly damaging |
Het |
Trank1 |
T |
C |
9: 111,219,635 (GRCm39) |
V2124A |
probably damaging |
Het |
Trpm4 |
A |
T |
7: 44,959,756 (GRCm39) |
W713R |
probably damaging |
Het |
Uap1l1 |
T |
C |
2: 25,252,688 (GRCm39) |
T451A |
probably benign |
Het |
Uba6 |
A |
T |
5: 86,279,119 (GRCm39) |
C668S |
probably damaging |
Het |
Ubxn11 |
T |
C |
4: 133,853,935 (GRCm39) |
F441S |
probably damaging |
Het |
Vmn1r22 |
C |
T |
6: 57,877,723 (GRCm39) |
V85M |
probably damaging |
Het |
Zfp330 |
T |
C |
8: 83,491,585 (GRCm39) |
E196G |
probably benign |
Het |
Zfp746 |
A |
G |
6: 48,059,108 (GRCm39) |
V167A |
possibly damaging |
Het |
Zfp994 |
T |
C |
17: 22,420,694 (GRCm39) |
E85G |
possibly damaging |
Het |
|
Other mutations in Vmn2r72 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00931:Vmn2r72
|
APN |
7 |
85,398,854 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01019:Vmn2r72
|
APN |
7 |
85,387,542 (GRCm39) |
missense |
probably benign |
0.26 |
IGL01445:Vmn2r72
|
APN |
7 |
85,398,854 (GRCm39) |
missense |
probably benign |
0.06 |
IGL02076:Vmn2r72
|
APN |
7 |
85,387,575 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02082:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02086:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02089:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02125:Vmn2r72
|
APN |
7 |
85,399,919 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02146:Vmn2r72
|
APN |
7 |
85,387,170 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02272:Vmn2r72
|
APN |
7 |
85,399,901 (GRCm39) |
missense |
probably benign |
|
IGL02514:Vmn2r72
|
APN |
7 |
85,387,907 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL02662:Vmn2r72
|
APN |
7 |
85,387,391 (GRCm39) |
missense |
probably benign |
0.26 |
IGL02697:Vmn2r72
|
APN |
7 |
85,387,879 (GRCm39) |
missense |
probably benign |
0.36 |
IGL02733:Vmn2r72
|
APN |
7 |
85,401,021 (GRCm39) |
missense |
probably benign |
0.05 |
IGL03070:Vmn2r72
|
APN |
7 |
85,401,249 (GRCm39) |
splice site |
probably benign |
|
IGL03150:Vmn2r72
|
APN |
7 |
85,400,384 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03159:Vmn2r72
|
APN |
7 |
85,404,162 (GRCm39) |
missense |
probably benign |
0.05 |
IGL03333:Vmn2r72
|
APN |
7 |
85,400,075 (GRCm39) |
missense |
probably benign |
0.10 |
R0081:Vmn2r72
|
UTSW |
7 |
85,401,044 (GRCm39) |
missense |
probably benign |
0.01 |
R0090:Vmn2r72
|
UTSW |
7 |
85,404,084 (GRCm39) |
missense |
probably benign |
|
R0655:Vmn2r72
|
UTSW |
7 |
85,387,319 (GRCm39) |
nonsense |
probably null |
|
R0778:Vmn2r72
|
UTSW |
7 |
85,398,947 (GRCm39) |
missense |
probably benign |
0.00 |
R1169:Vmn2r72
|
UTSW |
7 |
85,400,517 (GRCm39) |
missense |
probably benign |
0.01 |
R1172:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
R1173:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
R1175:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
R1248:Vmn2r72
|
UTSW |
7 |
85,398,396 (GRCm39) |
missense |
probably benign |
0.02 |
R1302:Vmn2r72
|
UTSW |
7 |
85,387,465 (GRCm39) |
missense |
probably damaging |
1.00 |
R1506:Vmn2r72
|
UTSW |
7 |
85,398,419 (GRCm39) |
missense |
probably benign |
|
R1632:Vmn2r72
|
UTSW |
7 |
85,401,000 (GRCm39) |
missense |
probably benign |
0.13 |
R1775:Vmn2r72
|
UTSW |
7 |
85,387,378 (GRCm39) |
missense |
probably benign |
0.01 |
R1962:Vmn2r72
|
UTSW |
7 |
85,398,369 (GRCm39) |
missense |
probably benign |
0.00 |
R2201:Vmn2r72
|
UTSW |
7 |
85,387,444 (GRCm39) |
missense |
probably benign |
0.12 |
R2290:Vmn2r72
|
UTSW |
7 |
85,387,549 (GRCm39) |
missense |
probably damaging |
1.00 |
R2327:Vmn2r72
|
UTSW |
7 |
85,387,464 (GRCm39) |
missense |
probably damaging |
1.00 |
R2424:Vmn2r72
|
UTSW |
7 |
85,400,161 (GRCm39) |
missense |
probably damaging |
1.00 |
R2655:Vmn2r72
|
UTSW |
7 |
85,400,477 (GRCm39) |
missense |
possibly damaging |
0.95 |
R2860:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
R2861:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
R2862:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
R3009:Vmn2r72
|
UTSW |
7 |
85,398,850 (GRCm39) |
missense |
probably benign |
0.00 |
R3797:Vmn2r72
|
UTSW |
7 |
85,387,285 (GRCm39) |
missense |
probably benign |
0.44 |
R3798:Vmn2r72
|
UTSW |
7 |
85,387,285 (GRCm39) |
missense |
probably benign |
0.44 |
R3902:Vmn2r72
|
UTSW |
7 |
85,398,943 (GRCm39) |
missense |
possibly damaging |
0.52 |
R3959:Vmn2r72
|
UTSW |
7 |
85,400,339 (GRCm39) |
missense |
probably benign |
0.36 |
R3974:Vmn2r72
|
UTSW |
7 |
85,399,017 (GRCm39) |
missense |
probably damaging |
1.00 |
R4399:Vmn2r72
|
UTSW |
7 |
85,387,708 (GRCm39) |
missense |
probably damaging |
1.00 |
R4421:Vmn2r72
|
UTSW |
7 |
85,387,708 (GRCm39) |
missense |
probably damaging |
1.00 |
R4426:Vmn2r72
|
UTSW |
7 |
85,387,036 (GRCm39) |
nonsense |
probably null |
|
R4522:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
R4523:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
R4533:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
R4691:Vmn2r72
|
UTSW |
7 |
85,387,119 (GRCm39) |
nonsense |
probably null |
|
R4781:Vmn2r72
|
UTSW |
7 |
85,387,069 (GRCm39) |
missense |
probably benign |
0.14 |
R4863:Vmn2r72
|
UTSW |
7 |
85,399,806 (GRCm39) |
missense |
possibly damaging |
0.91 |
R4952:Vmn2r72
|
UTSW |
7 |
85,400,317 (GRCm39) |
missense |
probably benign |
|
R4991:Vmn2r72
|
UTSW |
7 |
85,400,338 (GRCm39) |
missense |
probably damaging |
0.99 |
R4995:Vmn2r72
|
UTSW |
7 |
85,387,693 (GRCm39) |
missense |
probably damaging |
1.00 |
R5095:Vmn2r72
|
UTSW |
7 |
85,387,061 (GRCm39) |
missense |
probably damaging |
0.98 |
R5174:Vmn2r72
|
UTSW |
7 |
85,387,048 (GRCm39) |
missense |
probably benign |
0.00 |
R5276:Vmn2r72
|
UTSW |
7 |
85,387,462 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5395:Vmn2r72
|
UTSW |
7 |
85,400,105 (GRCm39) |
missense |
possibly damaging |
0.71 |
R5933:Vmn2r72
|
UTSW |
7 |
85,387,058 (GRCm39) |
missense |
probably benign |
0.05 |
R6033:Vmn2r72
|
UTSW |
7 |
85,387,137 (GRCm39) |
missense |
probably damaging |
1.00 |
R6033:Vmn2r72
|
UTSW |
7 |
85,387,137 (GRCm39) |
missense |
probably damaging |
1.00 |
R6354:Vmn2r72
|
UTSW |
7 |
85,399,747 (GRCm39) |
critical splice donor site |
probably null |
|
R6362:Vmn2r72
|
UTSW |
7 |
85,400,382 (GRCm39) |
missense |
probably damaging |
1.00 |
R6594:Vmn2r72
|
UTSW |
7 |
85,398,892 (GRCm39) |
missense |
probably benign |
0.32 |
R6794:Vmn2r72
|
UTSW |
7 |
85,387,204 (GRCm39) |
missense |
probably damaging |
1.00 |
R7113:Vmn2r72
|
UTSW |
7 |
85,399,011 (GRCm39) |
splice site |
probably null |
|
R7189:Vmn2r72
|
UTSW |
7 |
85,404,125 (GRCm39) |
missense |
probably benign |
0.36 |
R7266:Vmn2r72
|
UTSW |
7 |
85,387,482 (GRCm39) |
nonsense |
probably null |
|
R7323:Vmn2r72
|
UTSW |
7 |
85,399,771 (GRCm39) |
missense |
probably benign |
|
R7426:Vmn2r72
|
UTSW |
7 |
85,400,348 (GRCm39) |
missense |
probably benign |
|
R7606:Vmn2r72
|
UTSW |
7 |
85,400,362 (GRCm39) |
missense |
possibly damaging |
0.91 |
R7651:Vmn2r72
|
UTSW |
7 |
85,401,146 (GRCm39) |
missense |
probably damaging |
1.00 |
R7688:Vmn2r72
|
UTSW |
7 |
85,404,098 (GRCm39) |
missense |
probably benign |
0.32 |
R7753:Vmn2r72
|
UTSW |
7 |
85,399,834 (GRCm39) |
missense |
probably damaging |
1.00 |
R7843:Vmn2r72
|
UTSW |
7 |
85,398,838 (GRCm39) |
missense |
probably benign |
0.01 |
R8157:Vmn2r72
|
UTSW |
7 |
85,400,441 (GRCm39) |
missense |
probably benign |
0.09 |
R8254:Vmn2r72
|
UTSW |
7 |
85,400,227 (GRCm39) |
missense |
probably damaging |
1.00 |
R8389:Vmn2r72
|
UTSW |
7 |
85,401,168 (GRCm39) |
missense |
probably damaging |
0.99 |
R8444:Vmn2r72
|
UTSW |
7 |
85,387,383 (GRCm39) |
missense |
probably benign |
|
R8989:Vmn2r72
|
UTSW |
7 |
85,404,134 (GRCm39) |
missense |
probably benign |
0.10 |
R9015:Vmn2r72
|
UTSW |
7 |
85,398,388 (GRCm39) |
missense |
probably benign |
0.01 |
R9080:Vmn2r72
|
UTSW |
7 |
85,387,464 (GRCm39) |
missense |
probably damaging |
1.00 |
R9269:Vmn2r72
|
UTSW |
7 |
85,400,411 (GRCm39) |
missense |
probably benign |
0.03 |
R9317:Vmn2r72
|
UTSW |
7 |
85,404,022 (GRCm39) |
missense |
probably benign |
0.04 |
R9509:Vmn2r72
|
UTSW |
7 |
85,404,075 (GRCm39) |
missense |
probably benign |
|
Z1176:Vmn2r72
|
UTSW |
7 |
85,398,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
PCR Primer
(F):5'- TATACATGAACATGAGTGGTCCTAG -3'
(R):5'- TCCCTTTTCTGTCAGTTAAAACCAG -3'
Sequencing Primer
(F):5'- AGTTACTGCCCATATAGGAGCTG -3'
(R):5'- GGCTCTTGCTTGTACAGTT -3'
|
Posted On |
2016-10-24 |