Mutagenetix > Incidental Mutation

Incidental Mutation 'R5562:Ncoa4-ps'

436674

Institutional Source

Beutler Lab

Gene Symbol

Ncoa4-ps

Ensembl Gene

ENSMUSG00000021908

Gene Name

nuclear receptor coactivator 4, pseudogene

Synonyms

Gm6768

MMRRC Submission

043119-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.374) question?

Stock #

R5562 (G1)

Quality Score

152

Status

Not validated

Chromosome

Chromosomal Location

119224713-119226590 bp(+) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

T to A at 119225957 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000022467

SMART Domains

Protein: ENSMUSP00000136708
Gene: ENSMUSG00000021908

Domain	Start	End	E-Value	Type
Pfam:ARA70	33	169	2.4e-28	PFAM
Pfam:ARA70	199	334	4.7e-51	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.1%
20x: 94.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh1a7	G	A	19: 20,679,628 (GRCm39)	Q383*	probably null	Het
Alkbh3	A	T	2: 93,826,724 (GRCm39)		probably null	Het
Amotl1	G	A	9: 14,486,593 (GRCm39)	P434S	possibly damaging	Het
Arfgef1	T	C	1: 10,214,971 (GRCm39)	E1641G	probably damaging	Het
Arih2	T	C	9: 108,484,546 (GRCm39)	T422A	probably damaging	Het
C7	A	T	15: 5,061,397 (GRCm39)	Y317*	probably null	Het
Car4	A	T	11: 84,854,924 (GRCm39)	M91L	probably benign	Het
Ccdc7a	T	C	8: 129,785,266 (GRCm39)	D98G	possibly damaging	Het
Cdc25b	A	G	2: 131,036,678 (GRCm39)	M493V	probably damaging	Het
Cdhr3	C	G	12: 33,101,054 (GRCm39)	R452T	probably benign	Het
Col6a2	G	A	10: 76,435,509 (GRCm39)	Q909*	probably null	Het
Cyp2j8	A	G	4: 96,358,890 (GRCm39)	I343T	probably damaging	Het
Dcstamp	G	A	15: 39,617,798 (GRCm39)	C69Y	possibly damaging	Het
Dnaaf8	C	A	16: 4,791,940 (GRCm39)		noncoding transcript	Het
Efhc1	C	T	1: 21,043,104 (GRCm39)	T341I	probably damaging	Het
Elovl2	A	G	13: 41,338,772 (GRCm39)	*276Q	probably null	Het
Fnip1	T	A	11: 54,380,168 (GRCm39)		probably null	Het
Foxc1	A	G	13: 31,991,573 (GRCm39)	H128R	probably damaging	Het
Gpr107	C	T	2: 31,042,375 (GRCm39)	A2V	probably damaging	Het
Gprc5c	G	T	11: 114,755,093 (GRCm39)	V257L	possibly damaging	Het
Kif15	A	T	9: 122,807,081 (GRCm39)	Q44H	probably damaging	Het
Masp1	T	C	16: 23,283,917 (GRCm39)		probably null	Het
Muc5b	T	C	7: 141,400,975 (GRCm39)	I530T	unknown	Het
Nherf2	A	G	17: 24,860,798 (GRCm39)	V137A	probably benign	Het
Nudt7	C	A	8: 114,874,723 (GRCm39)	A93D	probably damaging	Het
Or5w1b	T	C	2: 87,476,063 (GRCm39)	I135V	probably benign	Het
Pcdha8	A	G	18: 37,126,024 (GRCm39)	T169A	possibly damaging	Het
Prnp	A	G	2: 131,778,951 (GRCm39)	D201G	probably damaging	Het
Serinc1	G	A	10: 57,400,147 (GRCm39)	Q167*	probably null	Het
Slc13a5	A	G	11: 72,152,865 (GRCm39)	V35A	probably damaging	Het
Slc30a6	C	T	17: 74,719,700 (GRCm39)	T220I	possibly damaging	Het
Slc7a7	T	A	14: 54,646,269 (GRCm39)	M65L	probably benign	Het
Speg	T	A	1: 75,403,700 (GRCm39)	L2627Q	probably damaging	Het
Tank	A	G	2: 61,480,552 (GRCm39)	T363A	possibly damaging	Het
Taok3	T	A	5: 117,389,029 (GRCm39)	L478Q	probably damaging	Het
Trim55	A	T	3: 19,713,317 (GRCm39)	M123L	probably benign	Het
Trpm2	A	G	10: 77,795,773 (GRCm39)	V118A	possibly damaging	Het
Ttn	A	T	2: 76,600,803 (GRCm39)	Y17114N	probably damaging	Het
Unc5c	A	G	3: 141,474,291 (GRCm39)	T214A	probably damaging	Het
Ush2a	T	A	1: 188,308,414 (GRCm39)	V2021E	probably damaging	Het
Utp4	G	A	8: 107,649,557 (GRCm39)	D669N	probably benign	Het
Zfp560	G	T	9: 20,261,883 (GRCm39)	Y89*	probably null	Het
Zfp64	A	G	2: 168,767,642 (GRCm39)	S657P	probably benign	Het

Other mutations in Ncoa4-ps

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL01778:Ncoa4-ps	APN	12	119,226,231 (GRCm39)	exon	noncoding transcript
R0683:Ncoa4-ps	UTSW	12	119,224,813 (GRCm39)	exon	noncoding transcript
R1186:Ncoa4-ps	UTSW	12	119,225,206 (GRCm39)	exon	noncoding transcript
R1485:Ncoa4-ps	UTSW	12	119,224,785 (GRCm39)	exon	noncoding transcript
R1708:Ncoa4-ps	UTSW	12	119,225,968 (GRCm39)	exon	noncoding transcript
R1800:Ncoa4-ps	UTSW	12	119,225,506 (GRCm39)	exon	noncoding transcript
R2280:Ncoa4-ps	UTSW	12	119,226,573 (GRCm39)	exon	noncoding transcript
R4827:Ncoa4-ps	UTSW	12	119,225,529 (GRCm39)	exon	noncoding transcript
R4922:Ncoa4-ps	UTSW	12	119,226,252 (GRCm39)	exon	noncoding transcript
R5183:Ncoa4-ps	UTSW	12	119,225,023 (GRCm39)	exon	noncoding transcript
R5752:Ncoa4-ps	UTSW	12	119,226,349 (GRCm39)	exon	noncoding transcript
R6033:Ncoa4-ps	UTSW	12	119,225,475 (GRCm39)	exon	noncoding transcript
R6033:Ncoa4-ps	UTSW	12	119,225,475 (GRCm39)	exon	noncoding transcript
R6084:Ncoa4-ps	UTSW	12	119,225,386 (GRCm39)	exon	noncoding transcript
R6151:Ncoa4-ps	UTSW	12	119,224,841 (GRCm39)	exon	noncoding transcript
X0024:Ncoa4-ps	UTSW	12	119,225,419 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- CCTACAATGTGAGTGATTGGCTTG -3'
(R):5'- CATTTCTGGAAGGGCAGAGC -3'

Sequencing Primer
(F):5'- GACTCCTGTACCAACTGTCAGG -3'
(R):5'- CCACAGTGTCAGGGACTCTCTG -3'

Posted On

2016-10-24