Incidental Mutation 'R5562:Aldh1a7'
ID 436687
Institutional Source Beutler Lab
Gene Symbol Aldh1a7
Ensembl Gene ENSMUSG00000024747
Gene Name aldehyde dehydrogenase family 1, subfamily A7
Synonyms Aldh-pb, Ahd2-like
MMRRC Submission 043119-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.231) question?
Stock # R5562 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 20670318-20704920 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 20679628 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 383 (Q383*)
Ref Sequence ENSEMBL: ENSMUSP00000025656 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025656]
AlphaFold O35945
Predicted Effect probably null
Transcript: ENSMUST00000025656
AA Change: Q383*
SMART Domains Protein: ENSMUSP00000025656
Gene: ENSMUSG00000024747
AA Change: Q383*

DomainStartEndE-ValueType
Pfam:Aldedh 29 492 2.5e-185 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alkbh3 A T 2: 93,826,724 (GRCm39) probably null Het
Amotl1 G A 9: 14,486,593 (GRCm39) P434S possibly damaging Het
Arfgef1 T C 1: 10,214,971 (GRCm39) E1641G probably damaging Het
Arih2 T C 9: 108,484,546 (GRCm39) T422A probably damaging Het
C7 A T 15: 5,061,397 (GRCm39) Y317* probably null Het
Car4 A T 11: 84,854,924 (GRCm39) M91L probably benign Het
Ccdc7a T C 8: 129,785,266 (GRCm39) D98G possibly damaging Het
Cdc25b A G 2: 131,036,678 (GRCm39) M493V probably damaging Het
Cdhr3 C G 12: 33,101,054 (GRCm39) R452T probably benign Het
Col6a2 G A 10: 76,435,509 (GRCm39) Q909* probably null Het
Cyp2j8 A G 4: 96,358,890 (GRCm39) I343T probably damaging Het
Dcstamp G A 15: 39,617,798 (GRCm39) C69Y possibly damaging Het
Dnaaf8 C A 16: 4,791,940 (GRCm39) noncoding transcript Het
Efhc1 C T 1: 21,043,104 (GRCm39) T341I probably damaging Het
Elovl2 A G 13: 41,338,772 (GRCm39) *276Q probably null Het
Fnip1 T A 11: 54,380,168 (GRCm39) probably null Het
Foxc1 A G 13: 31,991,573 (GRCm39) H128R probably damaging Het
Gpr107 C T 2: 31,042,375 (GRCm39) A2V probably damaging Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Kif15 A T 9: 122,807,081 (GRCm39) Q44H probably damaging Het
Masp1 T C 16: 23,283,917 (GRCm39) probably null Het
Muc5b T C 7: 141,400,975 (GRCm39) I530T unknown Het
Ncoa4-ps T A 12: 119,225,957 (GRCm39) noncoding transcript Het
Nherf2 A G 17: 24,860,798 (GRCm39) V137A probably benign Het
Nudt7 C A 8: 114,874,723 (GRCm39) A93D probably damaging Het
Or5w1b T C 2: 87,476,063 (GRCm39) I135V probably benign Het
Pcdha8 A G 18: 37,126,024 (GRCm39) T169A possibly damaging Het
Prnp A G 2: 131,778,951 (GRCm39) D201G probably damaging Het
Serinc1 G A 10: 57,400,147 (GRCm39) Q167* probably null Het
Slc13a5 A G 11: 72,152,865 (GRCm39) V35A probably damaging Het
Slc30a6 C T 17: 74,719,700 (GRCm39) T220I possibly damaging Het
Slc7a7 T A 14: 54,646,269 (GRCm39) M65L probably benign Het
Speg T A 1: 75,403,700 (GRCm39) L2627Q probably damaging Het
Tank A G 2: 61,480,552 (GRCm39) T363A possibly damaging Het
Taok3 T A 5: 117,389,029 (GRCm39) L478Q probably damaging Het
Trim55 A T 3: 19,713,317 (GRCm39) M123L probably benign Het
Trpm2 A G 10: 77,795,773 (GRCm39) V118A possibly damaging Het
Ttn A T 2: 76,600,803 (GRCm39) Y17114N probably damaging Het
Unc5c A G 3: 141,474,291 (GRCm39) T214A probably damaging Het
Ush2a T A 1: 188,308,414 (GRCm39) V2021E probably damaging Het
Utp4 G A 8: 107,649,557 (GRCm39) D669N probably benign Het
Zfp560 G T 9: 20,261,883 (GRCm39) Y89* probably null Het
Zfp64 A G 2: 168,767,642 (GRCm39) S657P probably benign Het
Other mutations in Aldh1a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00693:Aldh1a7 APN 19 20,677,410 (GRCm39) missense probably damaging 1.00
IGL01132:Aldh1a7 APN 19 20,704,404 (GRCm39) missense possibly damaging 0.76
IGL01630:Aldh1a7 APN 19 20,673,693 (GRCm39) splice site probably benign
IGL01901:Aldh1a7 APN 19 20,695,103 (GRCm39) missense probably damaging 0.99
IGL02324:Aldh1a7 APN 19 20,704,368 (GRCm39) missense probably damaging 1.00
IGL02822:Aldh1a7 APN 19 20,679,630 (GRCm39) missense possibly damaging 0.85
IGL03162:Aldh1a7 APN 19 20,685,645 (GRCm39) missense probably benign 0.21
PIT4514001:Aldh1a7 UTSW 19 20,679,604 (GRCm39) missense probably benign 0.07
R0125:Aldh1a7 UTSW 19 20,704,430 (GRCm39) splice site probably benign
R0268:Aldh1a7 UTSW 19 20,686,866 (GRCm39) critical splice acceptor site probably null
R0833:Aldh1a7 UTSW 19 20,679,607 (GRCm39) missense probably damaging 1.00
R1665:Aldh1a7 UTSW 19 20,704,825 (GRCm39) missense probably benign
R1709:Aldh1a7 UTSW 19 20,693,316 (GRCm39) missense probably damaging 1.00
R1772:Aldh1a7 UTSW 19 20,693,383 (GRCm39) missense probably damaging 1.00
R1917:Aldh1a7 UTSW 19 20,704,819 (GRCm39) missense probably benign
R2570:Aldh1a7 UTSW 19 20,677,320 (GRCm39) missense probably benign 0.35
R3778:Aldh1a7 UTSW 19 20,696,675 (GRCm39) missense possibly damaging 0.70
R3832:Aldh1a7 UTSW 19 20,685,602 (GRCm39) missense probably damaging 1.00
R3894:Aldh1a7 UTSW 19 20,673,762 (GRCm39) nonsense probably null
R4601:Aldh1a7 UTSW 19 20,693,343 (GRCm39) missense probably damaging 0.98
R4948:Aldh1a7 UTSW 19 20,704,374 (GRCm39) missense possibly damaging 0.77
R5606:Aldh1a7 UTSW 19 20,699,731 (GRCm39) missense probably damaging 1.00
R5641:Aldh1a7 UTSW 19 20,693,293 (GRCm39) missense probably benign 0.00
R5808:Aldh1a7 UTSW 19 20,685,561 (GRCm39) missense possibly damaging 0.79
R6646:Aldh1a7 UTSW 19 20,677,275 (GRCm39) missense possibly damaging 0.94
R6759:Aldh1a7 UTSW 19 20,677,320 (GRCm39) missense possibly damaging 0.89
R7034:Aldh1a7 UTSW 19 20,685,542 (GRCm39) missense possibly damaging 0.95
R7036:Aldh1a7 UTSW 19 20,685,542 (GRCm39) missense possibly damaging 0.95
R7150:Aldh1a7 UTSW 19 20,693,382 (GRCm39) missense probably damaging 1.00
R7255:Aldh1a7 UTSW 19 20,692,092 (GRCm39) missense probably damaging 1.00
R7875:Aldh1a7 UTSW 19 20,693,343 (GRCm39) missense possibly damaging 0.90
R7964:Aldh1a7 UTSW 19 20,693,406 (GRCm39) missense probably benign 0.05
R7964:Aldh1a7 UTSW 19 20,677,371 (GRCm39) missense probably damaging 0.99
R7984:Aldh1a7 UTSW 19 20,686,764 (GRCm39) missense probably damaging 0.98
R8547:Aldh1a7 UTSW 19 20,692,067 (GRCm39) missense possibly damaging 0.93
X0022:Aldh1a7 UTSW 19 20,696,679 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GATTCCTCAGTGCTCAGTCG -3'
(R):5'- TCACCTGCTTTGAATGACCAG -3'

Sequencing Primer
(F):5'- AGTGCTCAGTCGTGCTCAC -3'
(R):5'- GAATATCCTGGCATTTTTGACGC -3'
Posted On 2016-10-24