Incidental Mutation 'R5564:Clasp2'
ID 436750
Institutional Source Beutler Lab
Gene Symbol Clasp2
Ensembl Gene ENSMUSG00000033392
Gene Name CLIP associating protein 2
Synonyms CLASP2alpha, 1500004F14Rik, CLASP2gamma, CLASP2, CLASP2beta, 8030404L10Rik
MMRRC Submission 043121-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5564 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 113570541-113748750 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 113641836 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149670 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111838] [ENSMUST00000163895] [ENSMUST00000163895] [ENSMUST00000166734] [ENSMUST00000166734] [ENSMUST00000213663] [ENSMUST00000215022] [ENSMUST00000214522] [ENSMUST00000216817]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000111838
SMART Domains Protein: ENSMUSP00000107469
Gene: ENSMUSG00000033392

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 877 2.03e-1 SMART
low complexity region 995 1009 N/A INTRINSIC
TOG 1043 1274 1.49e-24 SMART
Predicted Effect probably null
Transcript: ENSMUST00000163895
SMART Domains Protein: ENSMUSP00000128460
Gene: ENSMUSG00000033392

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 583 593 N/A INTRINSIC
low complexity region 635 655 N/A INTRINSIC
TOG 661 898 2.03e-1 SMART
low complexity region 1016 1030 N/A INTRINSIC
TOG 1064 1295 1.49e-24 SMART
Predicted Effect probably null
Transcript: ENSMUST00000163895
SMART Domains Protein: ENSMUSP00000128460
Gene: ENSMUSG00000033392

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 583 593 N/A INTRINSIC
low complexity region 635 655 N/A INTRINSIC
TOG 661 898 2.03e-1 SMART
low complexity region 1016 1030 N/A INTRINSIC
TOG 1064 1295 1.49e-24 SMART
Predicted Effect probably null
Transcript: ENSMUST00000166734
SMART Domains Protein: ENSMUSP00000130201
Gene: ENSMUSG00000033392

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 878 7.51e-1 SMART
low complexity region 996 1010 N/A INTRINSIC
TOG 1044 1275 1.49e-24 SMART
Predicted Effect probably null
Transcript: ENSMUST00000166734
SMART Domains Protein: ENSMUSP00000130201
Gene: ENSMUSG00000033392

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 878 7.51e-1 SMART
low complexity region 996 1010 N/A INTRINSIC
TOG 1044 1275 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213663
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213902
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213966
Predicted Effect probably benign
Transcript: ENSMUST00000215022
Predicted Effect probably null
Transcript: ENSMUST00000214522
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214860
Predicted Effect probably benign
Transcript: ENSMUST00000216817
Meta Mutation Damage Score 0.9477 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.5%
Validation Efficiency 98% (57/58)
MGI Phenotype PHENOTYPE: Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm2 T C 3: 59,659,513 (GRCm39) V322A probably benign Het
Abca8b G T 11: 109,825,407 (GRCm39) L1598M probably benign Het
Adam4 T C 12: 81,466,348 (GRCm39) T758A probably benign Het
B3galnt2 T C 13: 14,169,814 (GRCm39) I424T probably damaging Het
Cacna1g T C 11: 94,321,312 (GRCm39) Y1316C probably damaging Het
Cacna2d1 T C 5: 16,517,517 (GRCm39) S388P probably damaging Het
Ccdc157 A G 11: 4,098,765 (GRCm39) L247S probably damaging Het
Cdh8 A G 8: 99,757,498 (GRCm39) I700T possibly damaging Het
Cdhr3 G T 12: 33,098,985 (GRCm39) Y535* probably null Het
Col16a1 T A 4: 129,947,151 (GRCm39) D165E probably damaging Het
Col9a1 A T 1: 24,234,436 (GRCm39) probably benign Het
Cpa3 A T 3: 20,296,307 (GRCm39) I10N possibly damaging Het
Cstf3 T A 2: 104,439,347 (GRCm39) probably benign Het
Dnah3 C A 7: 119,570,689 (GRCm39) probably null Het
E2f6 T C 12: 16,874,706 (GRCm39) C263R probably benign Het
Eps8l2 C A 7: 140,936,534 (GRCm39) Q288K possibly damaging Het
Fam193a T A 5: 34,578,199 (GRCm39) V231D probably damaging Het
Gjd3 C T 11: 102,691,029 (GRCm39) G325S probably benign Het
Gpatch8 T A 11: 102,429,111 (GRCm39) E39D unknown Het
Gpr107 C T 2: 31,042,375 (GRCm39) A2V probably damaging Het
Kansl3 G T 1: 36,385,045 (GRCm39) H629N possibly damaging Het
Kcna10 C A 3: 107,101,545 (GRCm39) H59N probably benign Het
Kitl A T 10: 99,915,886 (GRCm39) E138D possibly damaging Het
Kpna2 T C 11: 106,881,571 (GRCm39) K353R probably damaging Het
M1ap T A 6: 82,958,798 (GRCm39) I143N probably damaging Het
Macf1 A G 4: 123,420,538 (GRCm39) S239P possibly damaging Het
Med13l T A 5: 118,880,105 (GRCm39) S1066T probably damaging Het
Mettl23 G T 11: 116,739,865 (GRCm39) E47* probably null Het
Or52i2 T C 7: 102,319,433 (GRCm39) F102S probably damaging Het
Or5af1 C T 11: 58,722,039 (GRCm39) Q20* probably null Het
Proca1 T A 11: 78,092,699 (GRCm39) D48E possibly damaging Het
Rab34 T G 11: 78,082,458 (GRCm39) V227G probably damaging Het
Rab7 A T 6: 87,990,632 (GRCm39) L14Q probably damaging Het
Rasgef1c C T 11: 49,847,934 (GRCm39) S23F probably benign Het
Rit1 A G 3: 88,633,457 (GRCm39) probably benign Het
Scin T C 12: 40,174,568 (GRCm39) T172A probably benign Het
Scmh1 C A 4: 120,325,575 (GRCm39) N97K probably damaging Het
Skint6 T C 4: 112,846,162 (GRCm39) E655G possibly damaging Het
Slc22a15 A G 3: 101,771,905 (GRCm39) V243A probably benign Het
Smg1 A G 7: 117,789,042 (GRCm39) probably benign Het
Smim7 C T 8: 73,324,867 (GRCm39) G3R probably damaging Het
Snurf C T 7: 59,645,282 (GRCm39) R44H possibly damaging Het
Snx13 G A 12: 35,174,471 (GRCm39) A667T possibly damaging Het
Sowaha T G 11: 53,369,590 (GRCm39) H382P probably damaging Het
Tbc1d2 C T 4: 46,629,912 (GRCm39) G252R probably benign Het
Tmem259 G T 10: 79,814,442 (GRCm39) probably null Het
Topbp1 A G 9: 103,211,277 (GRCm39) T945A probably damaging Het
Tor1aip2 T C 1: 155,939,307 (GRCm39) probably benign Het
Ube3b T C 5: 114,527,136 (GRCm39) V118A probably damaging Het
Usp38 T C 8: 81,711,717 (GRCm39) K773E probably damaging Het
Wnk1 G A 6: 119,925,852 (GRCm39) probably benign Het
Zfp871 A G 17: 32,994,842 (GRCm39) V111A possibly damaging Het
Other mutations in Clasp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00772:Clasp2 APN 9 113,735,060 (GRCm39) splice site probably benign
IGL00885:Clasp2 APN 9 113,740,484 (GRCm39) missense probably damaging 1.00
IGL01314:Clasp2 APN 9 113,735,195 (GRCm39) missense possibly damaging 0.89
IGL01344:Clasp2 APN 9 113,642,360 (GRCm39) splice site probably null
IGL01567:Clasp2 APN 9 113,709,164 (GRCm39) missense probably damaging 1.00
IGL02238:Clasp2 APN 9 113,709,088 (GRCm39) missense probably damaging 1.00
IGL02299:Clasp2 APN 9 113,709,057 (GRCm39) missense probably damaging 1.00
IGL02323:Clasp2 APN 9 113,697,794 (GRCm39) splice site probably benign
IGL02635:Clasp2 APN 9 113,737,910 (GRCm39) missense probably damaging 0.98
IGL02645:Clasp2 APN 9 113,719,129 (GRCm39) missense probably damaging 1.00
IGL02976:Clasp2 APN 9 113,735,204 (GRCm39) missense probably damaging 1.00
IGL03190:Clasp2 APN 9 113,673,208 (GRCm39) nonsense probably null
IGL03219:Clasp2 APN 9 113,677,545 (GRCm39) splice site probably benign
PIT4810001:Clasp2 UTSW 9 113,735,135 (GRCm39) missense probably damaging 1.00
R0067:Clasp2 UTSW 9 113,689,209 (GRCm39) splice site probably benign
R0067:Clasp2 UTSW 9 113,689,209 (GRCm39) splice site probably benign
R0421:Clasp2 UTSW 9 113,683,370 (GRCm39) missense probably benign 0.02
R0432:Clasp2 UTSW 9 113,738,487 (GRCm39) missense probably benign 0.00
R0458:Clasp2 UTSW 9 113,735,292 (GRCm39) splice site probably null
R0865:Clasp2 UTSW 9 113,740,568 (GRCm39) missense possibly damaging 0.57
R0972:Clasp2 UTSW 9 113,676,773 (GRCm39) missense possibly damaging 0.58
R1037:Clasp2 UTSW 9 113,725,702 (GRCm39) splice site probably benign
R1925:Clasp2 UTSW 9 113,735,265 (GRCm39) missense possibly damaging 0.88
R2015:Clasp2 UTSW 9 113,740,568 (GRCm39) missense possibly damaging 0.57
R2066:Clasp2 UTSW 9 113,735,225 (GRCm39) missense possibly damaging 0.86
R2330:Clasp2 UTSW 9 113,705,372 (GRCm39) missense probably damaging 1.00
R2568:Clasp2 UTSW 9 113,707,832 (GRCm39) missense probably benign
R3011:Clasp2 UTSW 9 113,730,581 (GRCm39) missense probably damaging 1.00
R3879:Clasp2 UTSW 9 113,719,029 (GRCm39) missense probably damaging 0.98
R3915:Clasp2 UTSW 9 113,737,805 (GRCm39) missense probably damaging 0.99
R3928:Clasp2 UTSW 9 113,735,173 (GRCm39) missense probably benign 0.28
R4323:Clasp2 UTSW 9 113,719,027 (GRCm39) missense possibly damaging 0.91
R4571:Clasp2 UTSW 9 113,676,789 (GRCm39) missense probably damaging 1.00
R4975:Clasp2 UTSW 9 113,732,984 (GRCm39) missense probably damaging 1.00
R5445:Clasp2 UTSW 9 113,733,014 (GRCm39) missense probably damaging 1.00
R5697:Clasp2 UTSW 9 113,689,190 (GRCm39) missense probably benign 0.01
R5780:Clasp2 UTSW 9 113,679,220 (GRCm39) missense probably damaging 0.99
R5787:Clasp2 UTSW 9 113,691,310 (GRCm39) missense probably damaging 1.00
R6011:Clasp2 UTSW 9 113,705,315 (GRCm39) missense probably benign 0.07
R6026:Clasp2 UTSW 9 113,740,646 (GRCm39) missense probably benign 0.13
R6090:Clasp2 UTSW 9 113,681,803 (GRCm39) missense probably benign 0.06
R6262:Clasp2 UTSW 9 113,705,420 (GRCm39) critical splice donor site probably null
R6427:Clasp2 UTSW 9 113,721,512 (GRCm39) missense probably damaging 1.00
R6464:Clasp2 UTSW 9 113,602,785 (GRCm39) missense probably damaging 1.00
R6586:Clasp2 UTSW 9 113,642,332 (GRCm39) missense probably damaging 1.00
R6628:Clasp2 UTSW 9 113,725,788 (GRCm39) missense probably damaging 1.00
R6745:Clasp2 UTSW 9 113,704,338 (GRCm39) nonsense probably null
R7032:Clasp2 UTSW 9 113,683,391 (GRCm39) missense probably benign 0.04
R7165:Clasp2 UTSW 9 113,615,467 (GRCm39) splice site probably null
R7221:Clasp2 UTSW 9 113,681,825 (GRCm39) missense probably damaging 0.99
R7336:Clasp2 UTSW 9 113,705,421 (GRCm39) splice site probably null
R7583:Clasp2 UTSW 9 113,737,755 (GRCm39) missense probably benign 0.02
R7774:Clasp2 UTSW 9 113,677,804 (GRCm39) splice site probably null
R7895:Clasp2 UTSW 9 113,733,016 (GRCm39) missense probably benign 0.03
R8084:Clasp2 UTSW 9 113,676,823 (GRCm39) missense probably benign 0.16
R8109:Clasp2 UTSW 9 113,740,588 (GRCm39) missense probably damaging 1.00
R8171:Clasp2 UTSW 9 113,732,974 (GRCm39) missense possibly damaging 0.88
R8230:Clasp2 UTSW 9 113,721,482 (GRCm39) missense possibly damaging 0.73
R8810:Clasp2 UTSW 9 113,728,649 (GRCm39) missense probably damaging 1.00
R8879:Clasp2 UTSW 9 113,602,773 (GRCm39) missense probably benign 0.39
R8888:Clasp2 UTSW 9 113,732,936 (GRCm39) missense possibly damaging 0.54
R8889:Clasp2 UTSW 9 113,709,251 (GRCm39) missense probably damaging 1.00
R8892:Clasp2 UTSW 9 113,709,251 (GRCm39) missense probably damaging 1.00
R8922:Clasp2 UTSW 9 113,725,728 (GRCm39) nonsense probably null
R9042:Clasp2 UTSW 9 113,735,065 (GRCm39) missense probably benign
R9195:Clasp2 UTSW 9 113,671,045 (GRCm39) missense probably benign 0.06
R9355:Clasp2 UTSW 9 113,664,309 (GRCm39) missense probably damaging 1.00
R9481:Clasp2 UTSW 9 113,670,669 (GRCm39) missense probably damaging 1.00
R9502:Clasp2 UTSW 9 113,737,866 (GRCm39) missense probably benign 0.01
R9523:Clasp2 UTSW 9 113,705,372 (GRCm39) missense probably damaging 0.98
R9525:Clasp2 UTSW 9 113,740,677 (GRCm39) missense probably damaging 1.00
R9653:Clasp2 UTSW 9 113,670,993 (GRCm39) missense probably benign 0.01
R9699:Clasp2 UTSW 9 113,738,614 (GRCm39) critical splice donor site probably null
R9738:Clasp2 UTSW 9 113,590,665 (GRCm39) nonsense probably null
R9775:Clasp2 UTSW 9 113,725,740 (GRCm39) missense probably benign
X0022:Clasp2 UTSW 9 113,681,740 (GRCm39) missense probably damaging 1.00
Z1177:Clasp2 UTSW 9 113,599,289 (GRCm39) missense probably damaging 1.00
Z1177:Clasp2 UTSW 9 113,737,863 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCACCTTGCAGCTGATTGG -3'
(R):5'- GGCATATTGTCACATTTCCCAC -3'

Sequencing Primer
(F):5'- TGTTGCAGCACCTAGGGCAG -3'
(R):5'- TTGTCACATTTCCCACATACAGAG -3'
Posted On 2016-10-24