Incidental Mutation 'R5566:Plxnb2'
| ID |
436863 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxnb2
|
| Ensembl Gene |
ENSMUSG00000036606 |
| Gene Name |
plexin B2 |
| Synonyms |
1110007H23Rik, Debt |
| MMRRC Submission |
043123-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.938)
|
| Stock # |
R5566 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
89039752-89064960 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 89048223 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 696
(T696A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104955
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060808]
[ENSMUST00000109331]
|
| AlphaFold |
B2RXS4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000060808
AA Change: T696A
PolyPhen 2
Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000051731
Gene: ENSMUSG00000036606
AA Change: T696A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1275 |
1809 |
1.6e-225 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109331
AA Change: T696A
PolyPhen 2
Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000104955
Gene: ENSMUSG00000036606
AA Change: T696A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1274 |
1809 |
4.4e-251 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131062
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139372
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197760
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygotes for a targeted mutation of this gene die perinatally of exencephaly or survive and seem normal despite severe abnormalities in cerebellar layering and foliation; the external granule cell layer is disorganized due to continued proliferation and migration of differentiated granule cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
A |
11: 9,244,615 (GRCm39) |
Y2159* |
probably null |
Het |
| Abca3 |
A |
G |
17: 24,602,901 (GRCm39) |
T499A |
probably benign |
Het |
| Abcb5 |
T |
A |
12: 118,899,702 (GRCm39) |
T322S |
probably damaging |
Het |
| Adamts4 |
T |
A |
1: 171,078,419 (GRCm39) |
M1K |
probably null |
Het |
| Adamtsl4 |
C |
T |
3: 95,592,765 (GRCm39) |
|
probably null |
Het |
| Adh4 |
A |
T |
3: 138,129,950 (GRCm39) |
I259F |
probably damaging |
Het |
| Aff3 |
G |
A |
1: 38,220,505 (GRCm39) |
S1135F |
probably damaging |
Het |
| Arhgef16 |
T |
C |
4: 154,370,105 (GRCm39) |
D280G |
probably benign |
Het |
| Baiap3 |
T |
C |
17: 25,470,707 (GRCm39) |
E71G |
probably damaging |
Het |
| Calb2 |
A |
G |
8: 110,879,332 (GRCm39) |
I91T |
possibly damaging |
Het |
| Ccr5 |
A |
G |
9: 123,924,697 (GRCm39) |
N100S |
probably benign |
Het |
| Cep57 |
G |
T |
9: 13,732,871 (GRCm39) |
R25S |
probably damaging |
Het |
| Chadl |
A |
G |
15: 81,580,079 (GRCm39) |
L52P |
probably damaging |
Het |
| Clec12b |
T |
C |
6: 129,362,438 (GRCm39) |
T6A |
probably damaging |
Het |
| Cnga1 |
T |
A |
5: 72,775,593 (GRCm39) |
N43Y |
probably damaging |
Het |
| Col20a1 |
A |
T |
2: 180,628,316 (GRCm39) |
|
probably null |
Het |
| Csmd2 |
T |
C |
4: 128,356,682 (GRCm39) |
|
probably null |
Het |
| Ctps1 |
A |
T |
4: 120,411,300 (GRCm39) |
|
probably null |
Het |
| Cyp39a1 |
T |
A |
17: 43,996,099 (GRCm39) |
W224R |
possibly damaging |
Het |
| Defb29 |
A |
T |
2: 152,380,848 (GRCm39) |
Y54N |
probably benign |
Het |
| Dmbt1 |
A |
T |
7: 130,708,003 (GRCm39) |
D1241V |
probably damaging |
Het |
| Dnah1 |
A |
T |
14: 30,996,323 (GRCm39) |
I2671K |
probably benign |
Het |
| Dnah2 |
C |
A |
11: 69,407,395 (GRCm39) |
E158* |
probably null |
Het |
| Dynlt2b |
A |
G |
16: 32,238,718 (GRCm39) |
Y31C |
probably damaging |
Het |
| Edar |
A |
G |
10: 58,464,463 (GRCm39) |
S59P |
possibly damaging |
Het |
| Egr2 |
T |
A |
10: 67,376,596 (GRCm39) |
C339* |
probably null |
Het |
| Eif5b |
G |
A |
1: 38,084,765 (GRCm39) |
V871I |
possibly damaging |
Het |
| Eif5b |
G |
A |
1: 38,090,328 (GRCm39) |
G1169E |
probably damaging |
Het |
| Erap1 |
A |
G |
13: 74,810,531 (GRCm39) |
Y290C |
probably damaging |
Het |
| Fastkd5 |
T |
A |
2: 130,456,221 (GRCm39) |
T790S |
possibly damaging |
Het |
| Fkrp |
C |
T |
7: 16,544,849 (GRCm39) |
V338M |
probably damaging |
Het |
| Gabra6 |
T |
C |
11: 42,198,317 (GRCm39) |
T378A |
probably benign |
Het |
| Gm4924 |
C |
A |
10: 82,214,475 (GRCm39) |
Q17K |
possibly damaging |
Het |
| Gm9847 |
A |
G |
12: 14,545,000 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr108 |
A |
G |
17: 57,543,919 (GRCm39) |
F429S |
probably damaging |
Het |
| Gpr162 |
G |
A |
6: 124,837,901 (GRCm39) |
R250* |
probably null |
Het |
| Gtf2a1 |
A |
T |
12: 91,534,368 (GRCm39) |
D295E |
possibly damaging |
Het |
| Gtf2h3 |
C |
T |
5: 124,722,360 (GRCm39) |
T121I |
probably benign |
Het |
| Herc1 |
T |
A |
9: 66,372,819 (GRCm39) |
M3125K |
possibly damaging |
Het |
| Hoxb6 |
T |
A |
11: 96,191,580 (GRCm39) |
Y167* |
probably null |
Het |
| Hrob |
T |
A |
11: 102,146,659 (GRCm39) |
S312T |
probably damaging |
Het |
| Htt |
T |
C |
5: 35,006,419 (GRCm39) |
Y1443H |
probably damaging |
Het |
| Il21r |
A |
G |
7: 125,224,470 (GRCm39) |
D28G |
probably damaging |
Het |
| Impact |
T |
G |
18: 13,107,819 (GRCm39) |
V29G |
probably damaging |
Het |
| Itpr3 |
A |
G |
17: 27,334,926 (GRCm39) |
T2147A |
possibly damaging |
Het |
| Itsn2 |
T |
A |
12: 4,676,554 (GRCm39) |
L50Q |
probably damaging |
Het |
| Jade1 |
A |
G |
3: 41,559,338 (GRCm39) |
D473G |
possibly damaging |
Het |
| Kif26a |
T |
G |
12: 112,123,788 (GRCm39) |
L131R |
probably damaging |
Het |
| Kif2a |
A |
T |
13: 107,130,432 (GRCm39) |
M1K |
probably null |
Het |
| Lrsam1 |
C |
A |
2: 32,831,870 (GRCm39) |
Q368H |
probably damaging |
Het |
| Macf1 |
T |
C |
4: 123,328,957 (GRCm39) |
Q4592R |
probably damaging |
Het |
| Map3k5 |
T |
C |
10: 19,986,465 (GRCm39) |
V893A |
probably damaging |
Het |
| Med13l |
G |
T |
5: 118,866,730 (GRCm39) |
V595F |
possibly damaging |
Het |
| Mocs1 |
T |
A |
17: 49,761,211 (GRCm39) |
L435Q |
possibly damaging |
Het |
| Mtmr4 |
T |
C |
11: 87,495,356 (GRCm39) |
L471P |
probably damaging |
Het |
| Myo7a |
T |
C |
7: 97,714,023 (GRCm39) |
E1616G |
possibly damaging |
Het |
| Nacad |
T |
A |
11: 6,552,136 (GRCm39) |
S352C |
probably damaging |
Het |
| Nfat5 |
T |
A |
8: 108,095,767 (GRCm39) |
M817K |
possibly damaging |
Het |
| Ofcc1 |
C |
A |
13: 40,248,129 (GRCm39) |
L668F |
probably damaging |
Het |
| Or12j2 |
C |
A |
7: 139,915,980 (GRCm39) |
D68E |
probably damaging |
Het |
| Or7e178 |
T |
C |
9: 20,225,265 (GRCm39) |
Q309R |
probably benign |
Het |
| Or8j3c |
G |
A |
2: 86,253,721 (GRCm39) |
Q100* |
probably null |
Het |
| Prkab2 |
T |
A |
3: 97,569,609 (GRCm39) |
F58L |
probably benign |
Het |
| Prpf4 |
G |
T |
4: 62,334,206 (GRCm39) |
L220F |
probably benign |
Het |
| Rad18 |
A |
T |
6: 112,658,307 (GRCm39) |
D199E |
probably benign |
Het |
| Raet1e |
T |
C |
10: 22,050,304 (GRCm39) |
L29P |
probably damaging |
Het |
| Ralgapb |
A |
C |
2: 158,336,630 (GRCm39) |
T1089P |
possibly damaging |
Het |
| Rest |
A |
G |
5: 77,430,173 (GRCm39) |
E864G |
probably benign |
Het |
| Rgsl1 |
T |
A |
1: 153,669,520 (GRCm39) |
I289F |
probably damaging |
Het |
| Rint1 |
T |
C |
5: 24,015,951 (GRCm39) |
Y406H |
probably damaging |
Het |
| Rmc1 |
T |
C |
18: 12,313,749 (GRCm39) |
I26T |
possibly damaging |
Het |
| Rpl31 |
C |
T |
1: 39,409,108 (GRCm39) |
R41C |
probably benign |
Het |
| Scn8a |
T |
C |
15: 100,872,415 (GRCm39) |
S485P |
probably damaging |
Het |
| Slamf1 |
T |
A |
1: 171,615,538 (GRCm39) |
V249E |
possibly damaging |
Het |
| Slc39a12 |
C |
T |
2: 14,412,414 (GRCm39) |
T362I |
possibly damaging |
Het |
| Sos1 |
C |
T |
17: 80,761,319 (GRCm39) |
V126I |
possibly damaging |
Het |
| Srcap |
T |
C |
7: 127,124,475 (GRCm39) |
F215S |
probably damaging |
Het |
| Supt4a |
T |
A |
11: 87,634,113 (GRCm39) |
S110T |
probably benign |
Het |
| Tbc1d30 |
T |
A |
10: 121,138,015 (GRCm39) |
T232S |
probably damaging |
Het |
| Tenm3 |
A |
G |
8: 48,732,041 (GRCm39) |
C1288R |
probably damaging |
Het |
| Tespa1 |
T |
A |
10: 130,191,356 (GRCm39) |
L100* |
probably null |
Het |
| Tgm1 |
C |
A |
14: 55,949,893 (GRCm39) |
R105L |
probably damaging |
Het |
| Tgoln1 |
G |
A |
6: 72,593,018 (GRCm39) |
T154I |
possibly damaging |
Het |
| Trp53i13 |
G |
A |
11: 77,399,552 (GRCm39) |
T259I |
probably damaging |
Het |
| Tubgcp4 |
T |
A |
2: 121,015,251 (GRCm39) |
F320I |
possibly damaging |
Het |
| Tut7 |
A |
T |
13: 59,936,443 (GRCm39) |
C817* |
probably null |
Het |
| Vmn1r21 |
A |
C |
6: 57,821,079 (GRCm39) |
Y122D |
probably benign |
Het |
| Vmn1r75 |
T |
A |
7: 11,614,407 (GRCm39) |
D46E |
probably damaging |
Het |
| Vmn2r120 |
A |
T |
17: 57,852,290 (GRCm39) |
L9M |
possibly damaging |
Het |
| Vmn2r59 |
A |
G |
7: 41,696,247 (GRCm39) |
I165T |
possibly damaging |
Het |
| Vmn2r76 |
A |
T |
7: 85,875,286 (GRCm39) |
Y564N |
probably damaging |
Het |
| Wee1 |
G |
T |
7: 109,725,257 (GRCm39) |
E300* |
probably null |
Het |
| Xdh |
T |
C |
17: 74,200,617 (GRCm39) |
D1168G |
probably damaging |
Het |
| Zfp54 |
A |
G |
17: 21,653,706 (GRCm39) |
T67A |
probably damaging |
Het |
| Zfp941 |
G |
T |
7: 140,392,679 (GRCm39) |
H227N |
probably benign |
Het |
| Zpr1 |
T |
A |
9: 46,192,373 (GRCm39) |
V399D |
possibly damaging |
Het |
| Zzz3 |
A |
G |
3: 152,161,461 (GRCm39) |
E285G |
probably damaging |
Het |
|
| Other mutations in Plxnb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00546:Plxnb2
|
APN |
15 |
89,046,569 (GRCm39) |
splice site |
probably benign |
|
|
IGL01574:Plxnb2
|
APN |
15 |
89,046,886 (GRCm39) |
splice site |
probably null |
|
|
IGL01695:Plxnb2
|
APN |
15 |
89,041,417 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL01763:Plxnb2
|
APN |
15 |
89,046,184 (GRCm39) |
splice site |
probably null |
|
|
IGL01921:Plxnb2
|
APN |
15 |
89,048,474 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02129:Plxnb2
|
APN |
15 |
89,044,613 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02153:Plxnb2
|
APN |
15 |
89,050,016 (GRCm39) |
nonsense |
probably null |
|
|
IGL02637:Plxnb2
|
APN |
15 |
89,048,260 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02892:Plxnb2
|
APN |
15 |
89,045,425 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03108:Plxnb2
|
APN |
15 |
89,042,234 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL03115:Plxnb2
|
APN |
15 |
89,046,641 (GRCm39) |
splice site |
probably benign |
|
|
P0040:Plxnb2
|
UTSW |
15 |
89,047,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0022:Plxnb2
|
UTSW |
15 |
89,047,479 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0095:Plxnb2
|
UTSW |
15 |
89,049,534 (GRCm39) |
missense |
probably benign |
|
|
R0103:Plxnb2
|
UTSW |
15 |
89,045,972 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0544:Plxnb2
|
UTSW |
15 |
89,042,816 (GRCm39) |
splice site |
probably benign |
|
|
R0671:Plxnb2
|
UTSW |
15 |
89,042,184 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1279:Plxnb2
|
UTSW |
15 |
89,046,524 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1530:Plxnb2
|
UTSW |
15 |
89,051,395 (GRCm39) |
missense |
probably benign |
|
|
R1542:Plxnb2
|
UTSW |
15 |
89,050,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1610:Plxnb2
|
UTSW |
15 |
89,042,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Plxnb2
|
UTSW |
15 |
89,046,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Plxnb2
|
UTSW |
15 |
89,046,187 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1996:Plxnb2
|
UTSW |
15 |
89,042,971 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1997:Plxnb2
|
UTSW |
15 |
89,042,971 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2031:Plxnb2
|
UTSW |
15 |
89,047,013 (GRCm39) |
nonsense |
probably null |
|
|
R2049:Plxnb2
|
UTSW |
15 |
89,043,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2072:Plxnb2
|
UTSW |
15 |
89,042,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2076:Plxnb2
|
UTSW |
15 |
89,042,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Plxnb2
|
UTSW |
15 |
89,040,765 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2418:Plxnb2
|
UTSW |
15 |
89,045,272 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R2419:Plxnb2
|
UTSW |
15 |
89,045,272 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R3752:Plxnb2
|
UTSW |
15 |
89,041,458 (GRCm39) |
splice site |
probably benign |
|
|
R3825:Plxnb2
|
UTSW |
15 |
89,050,602 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4154:Plxnb2
|
UTSW |
15 |
89,043,845 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4197:Plxnb2
|
UTSW |
15 |
89,041,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4385:Plxnb2
|
UTSW |
15 |
89,044,826 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4434:Plxnb2
|
UTSW |
15 |
89,047,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4678:Plxnb2
|
UTSW |
15 |
89,045,131 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4717:Plxnb2
|
UTSW |
15 |
89,041,622 (GRCm39) |
nonsense |
probably null |
|
|
R4773:Plxnb2
|
UTSW |
15 |
89,051,150 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4905:Plxnb2
|
UTSW |
15 |
89,041,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5368:Plxnb2
|
UTSW |
15 |
89,043,796 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5418:Plxnb2
|
UTSW |
15 |
89,050,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5484:Plxnb2
|
UTSW |
15 |
89,048,412 (GRCm39) |
splice site |
probably null |
|
|
R5520:Plxnb2
|
UTSW |
15 |
89,051,746 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5568:Plxnb2
|
UTSW |
15 |
89,041,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5619:Plxnb2
|
UTSW |
15 |
89,047,012 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5685:Plxnb2
|
UTSW |
15 |
89,051,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5688:Plxnb2
|
UTSW |
15 |
89,042,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5809:Plxnb2
|
UTSW |
15 |
89,051,774 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5813:Plxnb2
|
UTSW |
15 |
89,044,962 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5866:Plxnb2
|
UTSW |
15 |
89,051,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6016:Plxnb2
|
UTSW |
15 |
89,045,225 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6117:Plxnb2
|
UTSW |
15 |
89,042,203 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6187:Plxnb2
|
UTSW |
15 |
89,051,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6260:Plxnb2
|
UTSW |
15 |
89,049,494 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6263:Plxnb2
|
UTSW |
15 |
89,046,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6269:Plxnb2
|
UTSW |
15 |
89,044,916 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6351:Plxnb2
|
UTSW |
15 |
89,041,973 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6522:Plxnb2
|
UTSW |
15 |
89,048,629 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6856:Plxnb2
|
UTSW |
15 |
89,048,523 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6930:Plxnb2
|
UTSW |
15 |
89,044,592 (GRCm39) |
missense |
probably benign |
|
|
R7354:Plxnb2
|
UTSW |
15 |
89,049,928 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7513:Plxnb2
|
UTSW |
15 |
89,042,525 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7522:Plxnb2
|
UTSW |
15 |
89,045,977 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7730:Plxnb2
|
UTSW |
15 |
89,046,533 (GRCm39) |
missense |
probably benign |
|
|
R7766:Plxnb2
|
UTSW |
15 |
89,045,474 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7781:Plxnb2
|
UTSW |
15 |
89,041,225 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8126:Plxnb2
|
UTSW |
15 |
89,047,506 (GRCm39) |
missense |
probably benign |
|
|
R8131:Plxnb2
|
UTSW |
15 |
89,042,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8372:Plxnb2
|
UTSW |
15 |
89,042,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8736:Plxnb2
|
UTSW |
15 |
89,046,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8772:Plxnb2
|
UTSW |
15 |
89,046,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9022:Plxnb2
|
UTSW |
15 |
89,048,471 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9044:Plxnb2
|
UTSW |
15 |
89,044,566 (GRCm39) |
splice site |
probably benign |
|
|
R9253:Plxnb2
|
UTSW |
15 |
89,052,015 (GRCm39) |
missense |
probably benign |
|
|
R9398:Plxnb2
|
UTSW |
15 |
89,045,122 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9562:Plxnb2
|
UTSW |
15 |
89,050,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9568:Plxnb2
|
UTSW |
15 |
89,045,160 (GRCm39) |
nonsense |
probably null |
|
|
R9613:Plxnb2
|
UTSW |
15 |
89,048,496 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0027:Plxnb2
|
UTSW |
15 |
89,044,916 (GRCm39) |
missense |
probably benign |
0.18 |
|
Z1177:Plxnb2
|
UTSW |
15 |
89,043,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCTGTATCTCCAGAAGCTCCCG -3'
(R):5'- CCAGGCAGAACTGTGGTTAG -3'
Sequencing Primer
(F):5'- GACTGTCCATAGCAGCTGACTATG -3'
(R):5'- CAGAACTGTGGTTAGGACGATG -3'
|
| Posted On |
2016-10-24 |
Incidental Mutation