Incidental Mutation 'R5568:Myo9a'
| ID |
437035 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo9a
|
| Ensembl Gene |
ENSMUSG00000039585 |
| Gene Name |
myosin IXa |
| Synonyms |
C130068I12Rik, 4732465J09Rik |
| MMRRC Submission |
043125-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5568 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
59658179-59836149 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 59781911 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Arginine
at position 1699
(H1699R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122852
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000128341]
[ENSMUST00000135298]
[ENSMUST00000136740]
|
| AlphaFold |
Q8C170 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000128341
AA Change: H1699R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000119401
Gene: ENSMUSG00000039585
AA Change: H1699R
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
14 |
112 |
5.57e-30 |
SMART |
|
low complexity region
|
129 |
137 |
N/A |
INTRINSIC |
|
MYSc
|
140 |
1018 |
N/A |
SMART |
|
IQ
|
1019 |
1041 |
1.79e1 |
SMART |
|
IQ
|
1042 |
1064 |
4.11e0 |
SMART |
|
IQ
|
1074 |
1096 |
1.9e-2 |
SMART |
|
IQ
|
1115 |
1137 |
1.01e-6 |
SMART |
|
IQ
|
1138 |
1160 |
8.71e-2 |
SMART |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
coiled coil region
|
1265 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1384 |
N/A |
INTRINSIC |
|
coiled coil region
|
1492 |
1539 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1685 |
1938 |
6e-89 |
BLAST |
|
low complexity region
|
1982 |
1993 |
N/A |
INTRINSIC |
|
C1
|
2002 |
2050 |
2.6e-9 |
SMART |
|
RhoGAP
|
2075 |
2250 |
3.36e-73 |
SMART |
|
coiled coil region
|
2320 |
2360 |
N/A |
INTRINSIC |
|
low complexity region
|
2419 |
2438 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135298
AA Change: H1699R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000117432
Gene: ENSMUSG00000039585
AA Change: H1699R
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
14 |
112 |
5.57e-30 |
SMART |
|
low complexity region
|
129 |
137 |
N/A |
INTRINSIC |
|
MYSc
|
140 |
1018 |
N/A |
SMART |
|
IQ
|
1019 |
1041 |
1.79e1 |
SMART |
|
IQ
|
1042 |
1064 |
4.11e0 |
SMART |
|
IQ
|
1074 |
1096 |
1.9e-2 |
SMART |
|
IQ
|
1115 |
1137 |
1.01e-6 |
SMART |
|
IQ
|
1138 |
1160 |
8.71e-2 |
SMART |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
coiled coil region
|
1265 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1384 |
N/A |
INTRINSIC |
|
coiled coil region
|
1492 |
1539 |
N/A |
INTRINSIC |
|
low complexity region
|
1744 |
1759 |
N/A |
INTRINSIC |
|
low complexity region
|
2053 |
2064 |
N/A |
INTRINSIC |
|
C1
|
2073 |
2121 |
2.6e-9 |
SMART |
|
RhoGAP
|
2146 |
2321 |
3.36e-73 |
SMART |
|
coiled coil region
|
2391 |
2431 |
N/A |
INTRINSIC |
|
low complexity region
|
2490 |
2509 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136740
AA Change: H1699R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000122852
Gene: ENSMUSG00000039585
AA Change: H1699R
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
14 |
112 |
5.57e-30 |
SMART |
|
low complexity region
|
129 |
137 |
N/A |
INTRINSIC |
|
MYSc
|
140 |
1018 |
N/A |
SMART |
|
IQ
|
1019 |
1041 |
1.79e1 |
SMART |
|
IQ
|
1042 |
1064 |
4.11e0 |
SMART |
|
IQ
|
1074 |
1096 |
1.9e-2 |
SMART |
|
IQ
|
1115 |
1137 |
1.01e-6 |
SMART |
|
IQ
|
1138 |
1160 |
8.71e-2 |
SMART |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
coiled coil region
|
1265 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1384 |
N/A |
INTRINSIC |
|
coiled coil region
|
1492 |
1539 |
N/A |
INTRINSIC |
|
low complexity region
|
1744 |
1759 |
N/A |
INTRINSIC |
|
low complexity region
|
2053 |
2064 |
N/A |
INTRINSIC |
|
C1
|
2073 |
2121 |
2.6e-9 |
SMART |
|
RhoGAP
|
2146 |
2321 |
3.36e-73 |
SMART |
|
coiled coil region
|
2409 |
2449 |
N/A |
INTRINSIC |
|
low complexity region
|
2508 |
2527 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147364
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215963
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.3%
- 20x: 95.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous KO leads to obstructive hydrocephaly caused by blockage of the third ventricle and the rostral aqueduct caused by developmental failures of their ependymal cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl4 |
T |
C |
4: 144,349,364 (GRCm39) |
V207A |
probably benign |
Het |
| Abcc10 |
C |
A |
17: 46,614,834 (GRCm39) |
|
probably null |
Het |
| Abcc9 |
A |
C |
6: 142,634,742 (GRCm39) |
V174G |
possibly damaging |
Het |
| Abl1 |
C |
T |
2: 31,669,086 (GRCm39) |
A155V |
probably damaging |
Het |
| Aco2 |
T |
A |
15: 81,787,787 (GRCm39) |
D212E |
probably damaging |
Het |
| Adam26b |
A |
T |
8: 43,973,529 (GRCm39) |
M491K |
probably benign |
Het |
| Anapc5 |
G |
A |
5: 122,929,988 (GRCm39) |
|
probably benign |
Het |
| Atf7 |
A |
G |
15: 102,471,757 (GRCm39) |
I46T |
probably damaging |
Het |
| Cacna1b |
A |
G |
2: 24,497,612 (GRCm39) |
S2100P |
probably damaging |
Het |
| Capn5 |
T |
A |
7: 97,775,137 (GRCm39) |
D501V |
probably damaging |
Het |
| Cc2d2a |
A |
G |
5: 43,866,433 (GRCm39) |
M748V |
probably damaging |
Het |
| Cd300c2 |
T |
C |
11: 114,891,662 (GRCm39) |
T71A |
probably damaging |
Het |
| Chmp2a |
T |
C |
7: 12,767,758 (GRCm39) |
M56V |
probably benign |
Het |
| Cilp |
A |
C |
9: 65,187,515 (GRCm39) |
R1203S |
probably benign |
Het |
| Clp1 |
T |
A |
2: 84,556,322 (GRCm39) |
K53* |
probably null |
Het |
| Crhbp |
T |
A |
13: 95,578,737 (GRCm39) |
D128V |
probably damaging |
Het |
| Crispld1 |
T |
A |
1: 17,820,495 (GRCm39) |
I292N |
probably benign |
Het |
| Cyp2c68 |
A |
T |
19: 39,677,526 (GRCm39) |
I488N |
probably benign |
Het |
| Cyp3a57 |
A |
T |
5: 145,307,456 (GRCm39) |
M149L |
probably benign |
Het |
| Ddx24 |
T |
A |
12: 103,390,547 (GRCm39) |
Q59L |
possibly damaging |
Het |
| Ddx27 |
A |
G |
2: 166,871,439 (GRCm39) |
H512R |
possibly damaging |
Het |
| Dlgap4 |
T |
A |
2: 156,604,821 (GRCm39) |
*993K |
probably null |
Het |
| Dmxl2 |
A |
T |
9: 54,330,643 (GRCm39) |
|
probably null |
Het |
| Dus4l |
A |
T |
12: 31,696,712 (GRCm39) |
F88L |
probably damaging |
Het |
| Ep400 |
A |
T |
5: 110,904,071 (GRCm39) |
V176E |
probably damaging |
Het |
| Fat3 |
T |
A |
9: 16,288,219 (GRCm39) |
K435* |
probably null |
Het |
| Fsip2 |
T |
C |
2: 82,816,908 (GRCm39) |
C4214R |
probably benign |
Het |
| Garin5a |
T |
G |
7: 44,150,428 (GRCm39) |
S207A |
probably damaging |
Het |
| Gfral |
T |
C |
9: 76,072,087 (GRCm39) |
*394W |
probably null |
Het |
| Glis1 |
T |
C |
4: 107,476,832 (GRCm39) |
S518P |
probably damaging |
Het |
| H2-T10 |
A |
G |
17: 36,430,079 (GRCm39) |
|
probably null |
Het |
| Hsbp1l1 |
T |
C |
18: 80,278,679 (GRCm39) |
T35A |
possibly damaging |
Het |
| Ighv5-12 |
A |
G |
12: 113,665,837 (GRCm39) |
F87S |
probably damaging |
Het |
| Ints13 |
A |
C |
6: 146,477,855 (GRCm39) |
D31E |
probably damaging |
Het |
| Kbtbd12 |
C |
T |
6: 88,595,609 (GRCm39) |
D74N |
probably damaging |
Het |
| Klrb1c |
A |
G |
6: 128,765,877 (GRCm39) |
|
probably benign |
Het |
| Kmt5b |
A |
T |
19: 3,836,538 (GRCm39) |
H25L |
probably benign |
Het |
| Krt28 |
A |
T |
11: 99,262,210 (GRCm39) |
M260K |
probably damaging |
Het |
| Krt79 |
A |
G |
15: 101,838,220 (GRCm39) |
S512P |
probably damaging |
Het |
| Lama1 |
A |
T |
17: 68,075,293 (GRCm39) |
|
probably null |
Het |
| Maneal |
T |
C |
4: 124,750,937 (GRCm39) |
E273G |
possibly damaging |
Het |
| Map4k3 |
T |
A |
17: 80,971,427 (GRCm39) |
Y80F |
possibly damaging |
Het |
| Mbd6 |
A |
G |
10: 127,119,297 (GRCm39) |
V946A |
possibly damaging |
Het |
| Mfsd14b |
A |
T |
13: 65,219,936 (GRCm39) |
|
probably null |
Het |
| Mrpl46 |
C |
G |
7: 78,430,242 (GRCm39) |
W176S |
probably damaging |
Het |
| Muc19 |
A |
G |
15: 91,768,468 (GRCm39) |
|
noncoding transcript |
Het |
| Mup3 |
T |
G |
4: 62,002,809 (GRCm39) |
E184A |
possibly damaging |
Het |
| Ndrg2 |
T |
A |
14: 52,144,420 (GRCm39) |
T269S |
probably damaging |
Het |
| Nfatc1 |
A |
T |
18: 80,693,037 (GRCm39) |
V688D |
probably benign |
Het |
| Ninj2 |
T |
C |
6: 120,175,670 (GRCm39) |
I101T |
probably benign |
Het |
| Nlrp10 |
T |
A |
7: 108,523,468 (GRCm39) |
M671L |
probably benign |
Het |
| Npsr1 |
T |
A |
9: 24,224,510 (GRCm39) |
L296I |
probably damaging |
Het |
| Or10d5 |
A |
G |
9: 39,861,983 (GRCm39) |
L28P |
probably benign |
Het |
| Or52r1b |
G |
T |
7: 102,691,517 (GRCm39) |
R272L |
possibly damaging |
Het |
| Pacsin1 |
T |
A |
17: 27,927,022 (GRCm39) |
D242E |
probably damaging |
Het |
| Pcdh1 |
T |
C |
18: 38,330,420 (GRCm39) |
Y861C |
probably damaging |
Het |
| Pcdha12 |
T |
C |
18: 37,153,443 (GRCm39) |
L54P |
probably damaging |
Het |
| Pcdhb18 |
T |
A |
18: 37,624,853 (GRCm39) |
S728T |
probably benign |
Het |
| Phyhd1 |
T |
A |
2: 30,167,022 (GRCm39) |
H108Q |
probably damaging |
Het |
| Plcb1 |
A |
T |
2: 135,212,513 (GRCm39) |
I1035F |
probably damaging |
Het |
| Plcl1 |
T |
C |
1: 55,735,309 (GRCm39) |
S217P |
possibly damaging |
Het |
| Plppr2 |
G |
A |
9: 21,852,425 (GRCm39) |
R103H |
probably damaging |
Het |
| Plxnb2 |
G |
A |
15: 89,041,638 (GRCm39) |
T1722I |
probably damaging |
Het |
| Pole3 |
T |
C |
4: 62,442,668 (GRCm39) |
N53S |
probably damaging |
Het |
| Ptk6 |
A |
T |
2: 180,841,488 (GRCm39) |
N140K |
possibly damaging |
Het |
| Rab12 |
C |
T |
17: 66,804,418 (GRCm39) |
R180H |
probably damaging |
Het |
| Rab36 |
G |
T |
10: 74,888,311 (GRCm39) |
V252L |
probably benign |
Het |
| Ranbp3 |
T |
C |
17: 57,008,543 (GRCm39) |
|
probably null |
Het |
| Rapgef2 |
A |
G |
3: 79,011,308 (GRCm39) |
L259P |
probably damaging |
Het |
| Rigi |
T |
A |
4: 40,222,140 (GRCm39) |
M380L |
probably benign |
Het |
| Scaf4 |
GGCTGCTGCTGCTGCTGCTGCTGCTG |
GGCTGCTGCTGCTGCTGCTGCTG |
16: 90,026,745 (GRCm39) |
|
probably benign |
Het |
| Scd2 |
T |
C |
19: 44,288,142 (GRCm39) |
F178S |
probably damaging |
Het |
| Shmt2 |
A |
G |
10: 127,356,250 (GRCm39) |
S87P |
probably damaging |
Het |
| Slf1 |
T |
A |
13: 77,194,823 (GRCm39) |
D834V |
probably damaging |
Het |
| Sorcs2 |
A |
C |
5: 36,203,874 (GRCm39) |
Y540* |
probably null |
Het |
| Srpk2 |
T |
A |
5: 23,730,697 (GRCm39) |
Q274L |
possibly damaging |
Het |
| Stradb |
T |
A |
1: 59,031,901 (GRCm39) |
M271K |
possibly damaging |
Het |
| Tfec |
T |
A |
6: 16,867,592 (GRCm39) |
Q16L |
possibly damaging |
Het |
| Tfg |
T |
C |
16: 56,521,450 (GRCm39) |
T63A |
probably benign |
Het |
| Ticrr |
G |
A |
7: 79,339,715 (GRCm39) |
|
probably null |
Het |
| Ticrr |
T |
A |
7: 79,345,044 (GRCm39) |
C1636* |
probably null |
Het |
| Tln2 |
A |
G |
9: 67,219,147 (GRCm39) |
I266T |
probably damaging |
Het |
| Tmcc1 |
G |
C |
6: 115,999,071 (GRCm39) |
R323G |
possibly damaging |
Het |
| Tnnt3 |
A |
G |
7: 142,065,777 (GRCm39) |
E138G |
probably damaging |
Het |
| Tpm2 |
C |
A |
4: 43,522,692 (GRCm39) |
E75* |
probably null |
Het |
| Ttn |
T |
G |
2: 76,580,922 (GRCm39) |
T23324P |
probably damaging |
Het |
| Ubr4 |
T |
G |
4: 139,119,349 (GRCm39) |
L176R |
probably damaging |
Het |
| Uhrf2 |
G |
T |
19: 30,016,488 (GRCm39) |
D46Y |
probably damaging |
Het |
| Ulbp1 |
A |
C |
10: 7,423,281 (GRCm39) |
S21A |
unknown |
Het |
| Usp17lb |
C |
T |
7: 104,490,415 (GRCm39) |
G170R |
probably damaging |
Het |
| Utp15 |
T |
C |
13: 98,394,433 (GRCm39) |
N153S |
probably benign |
Het |
| Vcan |
T |
A |
13: 89,836,790 (GRCm39) |
E2918V |
probably damaging |
Het |
| Vmn1r174 |
T |
A |
7: 23,453,919 (GRCm39) |
I195K |
probably damaging |
Het |
| Vmn1r76 |
C |
T |
7: 11,665,062 (GRCm39) |
V16I |
probably benign |
Het |
| Xdh |
T |
C |
17: 74,250,880 (GRCm39) |
D24G |
possibly damaging |
Het |
| Xylb |
T |
A |
9: 119,190,198 (GRCm39) |
H68Q |
probably benign |
Het |
|
| Other mutations in Myo9a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00427:Myo9a
|
APN |
9 |
59,750,342 (GRCm39) |
splice site |
probably benign |
|
|
IGL00510:Myo9a
|
APN |
9 |
59,739,464 (GRCm39) |
splice site |
probably benign |
|
|
IGL00710:Myo9a
|
APN |
9 |
59,782,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00963:Myo9a
|
APN |
9 |
59,807,655 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01087:Myo9a
|
APN |
9 |
59,697,361 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01145:Myo9a
|
APN |
9 |
59,762,658 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01403:Myo9a
|
APN |
9 |
59,778,846 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01528:Myo9a
|
APN |
9 |
59,686,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01608:Myo9a
|
APN |
9 |
59,778,119 (GRCm39) |
nonsense |
probably null |
|
|
IGL01701:Myo9a
|
APN |
9 |
59,791,877 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01918:Myo9a
|
APN |
9 |
59,686,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02026:Myo9a
|
APN |
9 |
59,813,245 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02139:Myo9a
|
APN |
9 |
59,687,275 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02176:Myo9a
|
APN |
9 |
59,777,836 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02272:Myo9a
|
APN |
9 |
59,791,883 (GRCm39) |
splice site |
probably benign |
|
|
IGL02283:Myo9a
|
APN |
9 |
59,778,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02499:Myo9a
|
APN |
9 |
59,722,669 (GRCm39) |
splice site |
probably benign |
|
|
IGL02652:Myo9a
|
APN |
9 |
59,771,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02666:Myo9a
|
APN |
9 |
59,832,187 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02878:Myo9a
|
APN |
9 |
59,815,583 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02982:Myo9a
|
APN |
9 |
59,815,491 (GRCm39) |
nonsense |
probably null |
|
|
IGL03072:Myo9a
|
APN |
9 |
59,716,725 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL03090:Myo9a
|
APN |
9 |
59,801,418 (GRCm39) |
splice site |
probably benign |
|
|
IGL03111:Myo9a
|
APN |
9 |
59,734,526 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL03389:Myo9a
|
APN |
9 |
59,776,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
essentials
|
UTSW |
9 |
59,802,149 (GRCm39) |
missense |
probably benign |
0.09 |
|
necessities
|
UTSW |
9 |
59,722,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4402001:Myo9a
|
UTSW |
9 |
59,777,719 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0013:Myo9a
|
UTSW |
9 |
59,767,489 (GRCm39) |
splice site |
probably benign |
|
|
R0013:Myo9a
|
UTSW |
9 |
59,767,489 (GRCm39) |
splice site |
probably benign |
|
|
R0018:Myo9a
|
UTSW |
9 |
59,779,007 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0018:Myo9a
|
UTSW |
9 |
59,779,007 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0329:Myo9a
|
UTSW |
9 |
59,830,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0423:Myo9a
|
UTSW |
9 |
59,802,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Myo9a
|
UTSW |
9 |
59,801,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Myo9a
|
UTSW |
9 |
59,829,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0652:Myo9a
|
UTSW |
9 |
59,779,209 (GRCm39) |
missense |
probably benign |
|
|
R0653:Myo9a
|
UTSW |
9 |
59,832,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0723:Myo9a
|
UTSW |
9 |
59,778,383 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0784:Myo9a
|
UTSW |
9 |
59,803,828 (GRCm39) |
splice site |
probably benign |
|
|
R0842:Myo9a
|
UTSW |
9 |
59,778,350 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1055:Myo9a
|
UTSW |
9 |
59,762,653 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1056:Myo9a
|
UTSW |
9 |
59,739,484 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1195:Myo9a
|
UTSW |
9 |
59,802,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Myo9a
|
UTSW |
9 |
59,802,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Myo9a
|
UTSW |
9 |
59,802,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1615:Myo9a
|
UTSW |
9 |
59,695,739 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1698:Myo9a
|
UTSW |
9 |
59,775,464 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1715:Myo9a
|
UTSW |
9 |
59,739,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1981:Myo9a
|
UTSW |
9 |
59,801,429 (GRCm39) |
missense |
probably benign |
|
|
R2228:Myo9a
|
UTSW |
9 |
59,801,463 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2272:Myo9a
|
UTSW |
9 |
59,722,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2327:Myo9a
|
UTSW |
9 |
59,687,048 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2990:Myo9a
|
UTSW |
9 |
59,832,172 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3161:Myo9a
|
UTSW |
9 |
59,739,598 (GRCm39) |
splice site |
probably benign |
|
|
R3721:Myo9a
|
UTSW |
9 |
59,775,463 (GRCm39) |
missense |
probably benign |
|
|
R3928:Myo9a
|
UTSW |
9 |
59,802,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Myo9a
|
UTSW |
9 |
59,802,149 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4212:Myo9a
|
UTSW |
9 |
59,813,349 (GRCm39) |
nonsense |
probably null |
|
|
R4610:Myo9a
|
UTSW |
9 |
59,779,165 (GRCm39) |
missense |
probably benign |
|
|
R4616:Myo9a
|
UTSW |
9 |
59,728,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4621:Myo9a
|
UTSW |
9 |
59,778,355 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4623:Myo9a
|
UTSW |
9 |
59,778,355 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4632:Myo9a
|
UTSW |
9 |
59,776,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4657:Myo9a
|
UTSW |
9 |
59,782,699 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4892:Myo9a
|
UTSW |
9 |
59,731,525 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4897:Myo9a
|
UTSW |
9 |
59,803,800 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4966:Myo9a
|
UTSW |
9 |
59,779,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4993:Myo9a
|
UTSW |
9 |
59,768,755 (GRCm39) |
nonsense |
probably null |
|
|
R5160:Myo9a
|
UTSW |
9 |
59,779,085 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5233:Myo9a
|
UTSW |
9 |
59,817,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5271:Myo9a
|
UTSW |
9 |
59,814,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5308:Myo9a
|
UTSW |
9 |
59,771,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5367:Myo9a
|
UTSW |
9 |
59,807,732 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5432:Myo9a
|
UTSW |
9 |
59,772,953 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5459:Myo9a
|
UTSW |
9 |
59,791,803 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5511:Myo9a
|
UTSW |
9 |
59,687,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5573:Myo9a
|
UTSW |
9 |
59,778,284 (GRCm39) |
missense |
probably benign |
|
|
R5589:Myo9a
|
UTSW |
9 |
59,802,527 (GRCm39) |
nonsense |
probably null |
|
|
R5607:Myo9a
|
UTSW |
9 |
59,771,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5633:Myo9a
|
UTSW |
9 |
59,775,467 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R5885:Myo9a
|
UTSW |
9 |
59,778,503 (GRCm39) |
missense |
probably benign |
|
|
R6024:Myo9a
|
UTSW |
9 |
59,762,671 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6086:Myo9a
|
UTSW |
9 |
59,697,340 (GRCm39) |
nonsense |
probably null |
|
|
R6146:Myo9a
|
UTSW |
9 |
59,778,512 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6194:Myo9a
|
UTSW |
9 |
59,777,033 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6213:Myo9a
|
UTSW |
9 |
59,734,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6368:Myo9a
|
UTSW |
9 |
59,832,231 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6550:Myo9a
|
UTSW |
9 |
59,775,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6612:Myo9a
|
UTSW |
9 |
59,734,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6665:Myo9a
|
UTSW |
9 |
59,779,155 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6951:Myo9a
|
UTSW |
9 |
59,802,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7026:Myo9a
|
UTSW |
9 |
59,722,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Myo9a
|
UTSW |
9 |
59,778,098 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7310:Myo9a
|
UTSW |
9 |
59,778,436 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7473:Myo9a
|
UTSW |
9 |
59,802,527 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7723:Myo9a
|
UTSW |
9 |
59,687,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7823:Myo9a
|
UTSW |
9 |
59,719,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7824:Myo9a
|
UTSW |
9 |
59,767,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Myo9a
|
UTSW |
9 |
59,695,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8031:Myo9a
|
UTSW |
9 |
59,687,374 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8055:Myo9a
|
UTSW |
9 |
59,814,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Myo9a
|
UTSW |
9 |
59,781,931 (GRCm39) |
missense |
probably benign |
|
|
R8250:Myo9a
|
UTSW |
9 |
59,767,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8260:Myo9a
|
UTSW |
9 |
59,817,961 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8355:Myo9a
|
UTSW |
9 |
59,817,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8432:Myo9a
|
UTSW |
9 |
59,687,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8470:Myo9a
|
UTSW |
9 |
59,739,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8528:Myo9a
|
UTSW |
9 |
59,767,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8681:Myo9a
|
UTSW |
9 |
59,775,394 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8690:Myo9a
|
UTSW |
9 |
59,782,657 (GRCm39) |
missense |
probably benign |
|
|
R8793:Myo9a
|
UTSW |
9 |
59,791,850 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8812:Myo9a
|
UTSW |
9 |
59,687,030 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9016:Myo9a
|
UTSW |
9 |
59,775,427 (GRCm39) |
nonsense |
probably null |
|
|
R9026:Myo9a
|
UTSW |
9 |
59,716,757 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9036:Myo9a
|
UTSW |
9 |
59,687,584 (GRCm39) |
nonsense |
probably null |
|
|
R9130:Myo9a
|
UTSW |
9 |
59,739,514 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9131:Myo9a
|
UTSW |
9 |
59,768,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9213:Myo9a
|
UTSW |
9 |
59,772,922 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9498:Myo9a
|
UTSW |
9 |
59,734,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9575:Myo9a
|
UTSW |
9 |
59,813,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9651:Myo9a
|
UTSW |
9 |
59,778,764 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9672:Myo9a
|
UTSW |
9 |
59,687,332 (GRCm39) |
missense |
probably benign |
0.16 |
|
RF018:Myo9a
|
UTSW |
9 |
59,776,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF019:Myo9a
|
UTSW |
9 |
59,829,055 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Myo9a
|
UTSW |
9 |
59,802,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAACTACCTACTTATATGCATGTG -3'
(R):5'- GGTACCATTCTTGACTAGTACACAC -3'
Sequencing Primer
(F):5'- CCCAAGGCTAGAACTACTTGGTG -3'
(R):5'- GCCTACAGCTTCCTTTTGAATGAATG -3'
|
| Posted On |
2016-10-24 |
Incidental Mutation