Incidental Mutation 'R5576:Or7g34'
ID 437214
Institutional Source Beutler Lab
Gene Symbol Or7g34
Ensembl Gene ENSMUSG00000095667
Gene Name olfactory receptor family 7 subfamily G member 34
Synonyms MOR147-3, GA_x6K02T2PVTD-13313295-13312357, Olfr854
MMRRC Submission 043131-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.379) question?
Stock # R5576 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 19477731-19478678 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19478369 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 101 (M101L)
Ref Sequence ENSEMBL: ENSMUSP00000148270 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072419] [ENSMUST00000212872]
AlphaFold Q8VFF1
Predicted Effect probably benign
Transcript: ENSMUST00000072419
AA Change: M104L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000072248
Gene: ENSMUSG00000095667
AA Change: M104L

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2.3e-51 PFAM
Pfam:7TM_GPCR_Srsx 38 308 9.6e-7 PFAM
Pfam:7tm_1 44 293 1.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212872
AA Change: M101L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.4%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik G A 5: 109,885,570 (GRCm39) T96I probably benign Het
Add2 G T 6: 86,084,457 (GRCm39) probably null Het
Agbl1 C T 7: 75,984,985 (GRCm39) T134M probably benign Het
Agfg1 T A 1: 82,848,445 (GRCm39) S32T probably benign Het
Ankrd17 A C 5: 90,391,083 (GRCm39) S2087A probably benign Het
Apob A T 12: 8,048,662 (GRCm39) E1012V probably damaging Het
Baiap2 T A 11: 119,887,737 (GRCm39) V297E probably benign Het
BC034090 T G 1: 155,117,214 (GRCm39) K301N probably benign Het
Bhlha9 T C 11: 76,563,595 (GRCm39) I74T probably damaging Het
Btnl9 T C 11: 49,069,712 (GRCm39) H189R probably benign Het
Ccdc122 G A 14: 77,329,317 (GRCm39) M123I probably benign Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Dnah9 T C 11: 65,724,922 (GRCm39) probably null Het
Dnaja2 A T 8: 86,266,033 (GRCm39) L351I possibly damaging Het
Efcab6 C A 15: 83,834,201 (GRCm39) S469I probably benign Het
Esp15 C A 17: 39,953,564 (GRCm39) T17K probably damaging Het
Fads1 A G 19: 10,163,238 (GRCm39) T172A probably benign Het
Fbp2 A T 13: 62,985,005 (GRCm39) D305E probably benign Het
Golga4 A G 9: 118,382,602 (GRCm39) T541A probably benign Het
Herc3 T C 6: 58,865,710 (GRCm39) Y768H probably benign Het
Kmt2a A G 9: 44,753,931 (GRCm39) V514A possibly damaging Het
Melk A G 4: 44,312,255 (GRCm39) E141G probably null Het
Nln A G 13: 104,195,338 (GRCm39) Y245H probably damaging Het
Nrap C T 19: 56,310,414 (GRCm39) R1563H probably damaging Het
Or8b44 A C 9: 38,410,204 (GRCm39) K80Q probably damaging Het
Pde4b T A 4: 102,287,359 (GRCm39) I34N probably damaging Het
Pex11g A G 8: 3,515,875 (GRCm39) S53P probably damaging Het
Pole A T 5: 110,459,931 (GRCm39) K1112* probably null Het
Ppfia4 T G 1: 134,250,788 (GRCm39) D184A possibly damaging Het
Rpp30 T A 19: 36,079,251 (GRCm39) D216E probably benign Het
Sbno2 C T 10: 79,903,171 (GRCm39) A398T probably damaging Het
Sbp T A 17: 24,164,552 (GRCm39) S94T probably benign Het
Skp1 T G 11: 52,133,415 (GRCm39) D33E possibly damaging Het
Slc17a8 A G 10: 89,433,364 (GRCm39) W220R probably damaging Het
Slfn9 A T 11: 82,872,258 (GRCm39) M826K probably benign Het
Snx2 A G 18: 53,343,822 (GRCm39) K322E probably benign Het
Spata32 T A 11: 103,100,653 (GRCm39) N38I possibly damaging Het
Sycp1 T C 3: 102,726,218 (GRCm39) R969G probably damaging Het
Trgc2 T C 13: 19,489,301 (GRCm39) I144V probably benign Het
Trpc1 A G 9: 95,603,377 (GRCm39) L385S probably damaging Het
Vmn2r105 C T 17: 20,444,836 (GRCm39) probably null Het
Xrcc6 T A 15: 81,906,693 (GRCm39) D79E probably damaging Het
Zan A T 5: 137,426,744 (GRCm39) C2467* probably null Het
Zfp26 A G 9: 20,348,803 (GRCm39) V587A possibly damaging Het
Zfp553 C T 7: 126,835,875 (GRCm39) R477C possibly damaging Het
Other mutations in Or7g34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00930:Or7g34 APN 9 19,478,471 (GRCm39) missense probably damaging 1.00
IGL02072:Or7g34 APN 9 19,478,245 (GRCm39) missense probably benign 0.00
IGL02156:Or7g34 APN 9 19,478,494 (GRCm39) missense probably damaging 1.00
IGL02187:Or7g34 APN 9 19,478,393 (GRCm39) missense probably benign 0.16
IGL02252:Or7g34 APN 9 19,478,267 (GRCm39) missense probably damaging 0.99
R0519:Or7g34 UTSW 9 19,478,245 (GRCm39) missense probably benign 0.21
R0755:Or7g34 UTSW 9 19,478,415 (GRCm39) missense possibly damaging 0.94
R0899:Or7g34 UTSW 9 19,477,843 (GRCm39) missense probably damaging 1.00
R1832:Or7g34 UTSW 9 19,478,492 (GRCm39) missense possibly damaging 0.88
R2115:Or7g34 UTSW 9 19,478,618 (GRCm39) missense probably benign 0.12
R4326:Or7g34 UTSW 9 19,478,318 (GRCm39) missense possibly damaging 0.95
R4328:Or7g34 UTSW 9 19,478,318 (GRCm39) missense possibly damaging 0.95
R4329:Or7g34 UTSW 9 19,478,318 (GRCm39) missense possibly damaging 0.95
R4379:Or7g34 UTSW 9 19,478,038 (GRCm39) missense probably benign 0.15
R4381:Or7g34 UTSW 9 19,478,038 (GRCm39) missense probably benign 0.15
R6102:Or7g34 UTSW 9 19,478,318 (GRCm39) missense possibly damaging 0.87
R7449:Or7g34 UTSW 9 19,478,162 (GRCm39) missense probably benign 0.06
R7515:Or7g34 UTSW 9 19,477,949 (GRCm39) missense probably damaging 1.00
R8143:Or7g34 UTSW 9 19,478,587 (GRCm39) missense probably benign 0.04
R8813:Or7g34 UTSW 9 19,477,895 (GRCm39) missense probably damaging 1.00
R9515:Or7g34 UTSW 9 19,478,396 (GRCm39) missense possibly damaging 0.74
Z1176:Or7g34 UTSW 9 19,477,822 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGGCTGTGCATTAAAGAATCCAC -3'
(R):5'- AGCCTGTCTTGGTCAGCTTG -3'

Sequencing Primer
(F):5'- GTGCATTAAAGAATCCACAATGC -3'
(R):5'- TTACCATTTTCGGGAACATGC -3'
Posted On 2016-10-26