Incidental Mutation 'R5578:Taar1'
ID 437309
Institutional Source Beutler Lab
Gene Symbol Taar1
Ensembl Gene ENSMUSG00000056379
Gene Name trace amine-associated receptor 1
Synonyms Trar1, Tar1
MMRRC Submission 043133-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R5578 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 23796304-23797302 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23796718 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 139 (I139F)
Ref Sequence ENSEMBL: ENSMUSP00000049527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051532]
AlphaFold Q923Y8
Predicted Effect possibly damaging
Transcript: ENSMUST00000051532
AA Change: I139F

PolyPhen 2 Score 0.712 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000049527
Gene: ENSMUSG00000056379
AA Change: I139F

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 33 316 1.4e-11 PFAM
Pfam:7tm_1 39 301 2.4e-62 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a null mutation display decreased prepulse inhibition and increased sensitivity to amphetamines. Mice homozygous for another knock-out allele exhibit increased sensitivity to MDMA-induced hyperthermia, brain dopamine and serotonin levels, and induced hyperactivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap2 A G 16: 30,926,932 (GRCm39) S521P probably benign Het
Aqp11 A G 7: 97,386,665 (GRCm39) F177S probably damaging Het
Arhgap40 G T 2: 158,373,126 (GRCm39) G128V probably damaging Het
Aspm A T 1: 139,398,455 (GRCm39) K1011I probably damaging Het
Cachd1 A G 4: 100,722,203 (GRCm39) T89A probably benign Het
Cep89 ACTCCTCCTCCTCCTCCTCCTCCTC ACTCCTCCTCCTCCTCCTCCTC 7: 35,109,067 (GRCm39) probably benign Het
Cfhr2 A T 1: 139,758,806 (GRCm39) C81* probably null Het
Chd7 A G 4: 8,847,149 (GRCm39) T1631A probably benign Het
Clca4b T A 3: 144,638,196 (GRCm39) D22V probably benign Het
Csnk2a1-ps3 A G 1: 156,352,800 (GRCm39) M334V probably benign Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Cyp39a1 T A 17: 43,991,031 (GRCm39) N113K possibly damaging Het
Dnah11 A T 12: 117,982,537 (GRCm39) V2544D probably damaging Het
Dnai3 A T 3: 145,802,983 (GRCm39) Y69* probably null Het
Esr1 A C 10: 4,919,164 (GRCm39) Q418P probably damaging Het
Fam89a T A 8: 125,467,968 (GRCm39) K115* probably null Het
Fstl4 T A 11: 53,056,608 (GRCm39) V455D probably damaging Het
Gm20730 T A 6: 43,058,474 (GRCm39) M113L probably benign Het
H2ac21 T C 3: 96,127,554 (GRCm39) V108A probably damaging Het
Hk3 C T 13: 55,159,994 (GRCm39) V327M probably damaging Het
Itm2c T A 1: 85,830,774 (GRCm39) V57E possibly damaging Het
Lrba T C 3: 86,664,814 (GRCm39) Y565H probably benign Het
Mab21l1 C T 3: 55,691,435 (GRCm39) Q341* probably null Het
Mdm2 C T 10: 117,538,192 (GRCm39) E69K possibly damaging Het
Mdn1 A T 4: 32,728,167 (GRCm39) I2709F probably benign Het
Mpp7 T C 18: 7,355,101 (GRCm39) N442D probably benign Het
Ncoa3 A G 2: 165,896,248 (GRCm39) I384V probably benign Het
Pm20d1 A G 1: 131,743,760 (GRCm39) N475S probably benign Het
Rhpn2 A G 7: 35,070,135 (GRCm39) D131G probably damaging Het
S1pr5 T A 9: 21,155,847 (GRCm39) Y193F probably damaging Het
Sdk1 A T 5: 141,598,880 (GRCm39) K182* probably null Het
Slx4 T A 16: 3,804,726 (GRCm39) E696V probably damaging Het
Smyd4 C T 11: 75,295,602 (GRCm39) P753S probably benign Het
Stambp T G 6: 83,538,782 (GRCm39) D206A probably benign Het
Sult5a1 G T 8: 123,869,860 (GRCm39) Y262* probably null Het
Tchh A T 3: 93,351,618 (GRCm39) R353* probably null Het
Thnsl2 C T 6: 71,115,749 (GRCm39) V153I probably benign Het
Trmt5 C T 12: 73,331,837 (GRCm39) probably null Het
Trpa1 T A 1: 14,957,232 (GRCm39) Y728F probably damaging Het
Usp19 T C 9: 108,370,639 (GRCm39) V126A probably benign Het
Vcan A G 13: 89,839,622 (GRCm39) V1974A probably benign Het
Vmn2r120 T A 17: 57,829,514 (GRCm39) H461L probably benign Het
Zfp445 T C 9: 122,682,402 (GRCm39) Y513C probably benign Het
Zfp84 A C 7: 29,474,856 (GRCm39) M43L possibly damaging Het
Other mutations in Taar1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00782:Taar1 APN 10 23,796,344 (GRCm39) missense probably benign 0.00
R0022:Taar1 UTSW 10 23,796,625 (GRCm39) missense probably benign 0.45
R0126:Taar1 UTSW 10 23,796,445 (GRCm39) missense probably benign 0.00
R0442:Taar1 UTSW 10 23,796,380 (GRCm39) missense possibly damaging 0.80
R0720:Taar1 UTSW 10 23,796,971 (GRCm39) missense probably damaging 1.00
R0931:Taar1 UTSW 10 23,797,181 (GRCm39) missense probably damaging 1.00
R1270:Taar1 UTSW 10 23,796,431 (GRCm39) missense probably damaging 1.00
R1834:Taar1 UTSW 10 23,797,087 (GRCm39) missense probably benign 0.04
R2137:Taar1 UTSW 10 23,797,168 (GRCm39) missense probably benign
R3765:Taar1 UTSW 10 23,797,205 (GRCm39) missense probably damaging 1.00
R3873:Taar1 UTSW 10 23,796,482 (GRCm39) missense probably damaging 1.00
R5334:Taar1 UTSW 10 23,796,443 (GRCm39) missense probably damaging 1.00
R5418:Taar1 UTSW 10 23,797,214 (GRCm39) missense possibly damaging 0.91
R7048:Taar1 UTSW 10 23,796,722 (GRCm39) missense probably benign 0.40
R7096:Taar1 UTSW 10 23,796,809 (GRCm39) missense possibly damaging 0.48
R7163:Taar1 UTSW 10 23,796,918 (GRCm39) missense probably benign 0.38
R7707:Taar1 UTSW 10 23,797,135 (GRCm39) missense possibly damaging 0.69
R7854:Taar1 UTSW 10 23,796,680 (GRCm39) missense probably benign 0.00
R8036:Taar1 UTSW 10 23,797,033 (GRCm39) missense probably benign 0.01
R8442:Taar1 UTSW 10 23,796,522 (GRCm39) nonsense probably null
R8855:Taar1 UTSW 10 23,796,976 (GRCm39) missense possibly damaging 0.50
R9777:Taar1 UTSW 10 23,796,676 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGGCCATTGTCGACTTTCTG -3'
(R):5'- GGAAGTCATGAACGCCAGTACC -3'

Sequencing Primer
(F):5'- GCTGTCTGATAATGCCCTGCAG -3'
(R):5'- CCCCAGATACTTTACTAAAGAAGGG -3'
Posted On 2016-10-26