Mutagenetix > Incidental Mutation

Incidental Mutation 'R5590:Mycbp2'

437480

Institutional Source

Beutler Lab

Gene Symbol

Mycbp2

Ensembl Gene

ENSMUSG00000033004

Gene Name

MYC binding protein 2

Synonyms

C130061D10Rik, Phr1, Pam

MMRRC Submission

043143-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R5590 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

103113411-103346814 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 103123355 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Arginine at position 4497 (M4497R)

Ref Sequence

ENSEMBL: ENSMUSP00000124710 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159855] [ENSMUST00000160758]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000159855
AA Change: M4497R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000124710
Gene: ENSMUSG00000033004
AA Change: M4497R

Domain	Start	End	E-Value	Type
low complexity region	5	27	N/A	INTRINSIC
low complexity region	47	55	N/A	INTRINSIC
low complexity region	100	127	N/A	INTRINSIC
low complexity region	178	191	N/A	INTRINSIC
Pfam:RCC1_2	683	712	1.4e-10	PFAM
low complexity region	737	750	N/A	INTRINSIC
low complexity region	793	815	N/A	INTRINSIC
Pfam:RCC1_2	942	971	5.5e-10	PFAM
Pfam:RCC1	958	1006	4.8e-15	PFAM
Pfam:PHR	1235	1385	8.2e-44	PFAM
Pfam:PHR	1723	1880	1.4e-43	PFAM
low complexity region	1935	1948	N/A	INTRINSIC
low complexity region	2182	2195	N/A	INTRINSIC
Pfam:Filamin	2261	2431	7.5e-9	PFAM
Pfam:SH3_3	2472	2539	4.1e-9	PFAM
internal_repeat_3	2612	2679	1.69e-7	PROSPERO
low complexity region	2701	2710	N/A	INTRINSIC
low complexity region	2884	2917	N/A	INTRINSIC
low complexity region	2970	2984	N/A	INTRINSIC
coiled coil region	3263	3290	N/A	INTRINSIC
low complexity region	3352	3365	N/A	INTRINSIC
low complexity region	3418	3433	N/A	INTRINSIC
low complexity region	3678	3695	N/A	INTRINSIC
APC10	3810	3968	1.11e-18	SMART
low complexity region	4103	4115	N/A	INTRINSIC
low complexity region	4190	4212	N/A	INTRINSIC
Blast:BBOX	4327	4370	7e-7	BLAST
RING	4496	4546	5.35e-5	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000160758
AA Change: M4387R

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000124601
Gene: ENSMUSG00000033004
AA Change: M4387R

Domain	Start	End	E-Value	Type
low complexity region	14	22	N/A	INTRINSIC
low complexity region	67	94	N/A	INTRINSIC
low complexity region	145	158	N/A	INTRINSIC
Pfam:RCC1_2	650	679	1e-10	PFAM
low complexity region	704	717	N/A	INTRINSIC
low complexity region	760	782	N/A	INTRINSIC
Pfam:RCC1_2	909	938	1.5e-9	PFAM
Pfam:RCC1	925	973	1.3e-15	PFAM
Pfam:PHR	1202	1353	1.6e-50	PFAM
Pfam:PHR	1690	1848	3.1e-58	PFAM
low complexity region	1902	1915	N/A	INTRINSIC
low complexity region	2149	2162	N/A	INTRINSIC
Pfam:Filamin	2228	2398	7.6e-9	PFAM
Pfam:SH3_3	2439	2507	2.3e-10	PFAM
internal_repeat_3	2554	2621	2e-7	PROSPERO
low complexity region	2643	2652	N/A	INTRINSIC
low complexity region	2774	2807	N/A	INTRINSIC
low complexity region	2860	2874	N/A	INTRINSIC
coiled coil region	3153	3180	N/A	INTRINSIC
low complexity region	3242	3255	N/A	INTRINSIC
low complexity region	3308	3323	N/A	INTRINSIC
low complexity region	3568	3585	N/A	INTRINSIC
APC10	3700	3858	1.11e-18	SMART
low complexity region	3993	4005	N/A	INTRINSIC
low complexity region	4080	4102	N/A	INTRINSIC
Blast:BBOX	4217	4260	7e-7	BLAST
RING	4386	4436	5.35e-5	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000161008
AA Change: M1213R

SMART Domains

Protein: ENSMUSP00000124443
Gene: ENSMUSG00000033004
AA Change: M1213R

Domain	Start	End	E-Value	Type
low complexity region	66	79	N/A	INTRINSIC
low complexity region	132	147	N/A	INTRINSIC
low complexity region	392	409	N/A	INTRINSIC
APC10	524	682	1.11e-18	SMART
low complexity region	820	832	N/A	INTRINSIC
low complexity region	907	929	N/A	INTRINSIC
Blast:BBOX	1042	1085	2e-6	BLAST
RING	1213	1263	5.35e-5	SMART

Meta Mutation Damage Score

0.7609

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 96.2%

Validation Efficiency

100% (108/108)

MGI Phenotype

PHENOTYPE: Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance. [provided by MGI curators]

Allele List at MGI

All alleles(10) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5) Chemically induced(3)

Other mutations in this stock

Total: 105 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110008L16Rik	T	C	12: 55,304,472 (GRCm38)	S189P	possibly damaging	Het
3100002H09Rik	T	G	4: 124,610,487 (GRCm38)	M91L	unknown	Het
A2m	C	T	6: 121,676,932 (GRCm38)	T1408M	probably damaging	Het
Abca16	C	T	7: 120,544,772 (GRCm38)	T1671M	probably damaging	Het
Adamts8	A	T	9: 30,951,336 (GRCm38)	N279I	probably damaging	Het
Adgre1	T	A	17: 57,445,034 (GRCm38)	I594N	probably damaging	Het
Aldh4a1	T	A	4: 139,642,104 (GRCm38)	V322E	probably damaging	Het
Atp12a	A	T	14: 56,373,380 (GRCm38)	Y327F	probably benign	Het
C4b	T	C	17: 34,740,335 (GRCm38)	T422A	probably damaging	Het
Cacna1c	A	T	6: 118,687,182 (GRCm38)	S668T	probably damaging	Het
Cchcr1	A	T	17: 35,526,680 (GRCm38)	E426D	probably damaging	Het
Ccr3	G	A	9: 124,028,793 (GRCm38)	G55D	probably damaging	Het
Cdipt	T	A	7: 126,979,532 (GRCm38)		probably null	Het
Cep19	A	G	16: 32,103,898 (GRCm38)		probably benign	Het
Cts6	T	A	13: 61,201,812 (GRCm38)	M56L	probably benign	Het
Cyp3a11	C	A	5: 145,865,977 (GRCm38)	M235I	probably benign	Het
Dnajc21	A	T	15: 10,462,277 (GRCm38)	D87E	possibly damaging	Het
Ell	A	C	8: 70,539,707 (GRCm38)	M1L	possibly damaging	Het
Esyt3	T	C	9: 99,358,413 (GRCm38)		probably benign	Het
Ets1	T	C	9: 32,728,798 (GRCm38)		probably benign	Het
Fam222b	T	A	11: 78,155,032 (GRCm38)	M473K	probably benign	Het
Fanca	T	C	8: 123,303,963 (GRCm38)		probably benign	Het
Fbrsl1	G	T	5: 110,381,618 (GRCm38)	A67D	probably damaging	Het
Fchsd1	G	A	18: 37,961,327 (GRCm38)	P622L	probably damaging	Het
Gal3st2c	T	G	1: 94,008,301 (GRCm38)		probably null	Het
Gins2	T	G	8: 120,581,747 (GRCm38)	H166P	possibly damaging	Het
Gm10118	A	T	10: 63,927,066 (GRCm38)		probably benign	Het
Gm9979	A	T	13: 40,705,813 (GRCm38)		noncoding transcript	Het
Hspbap1	A	G	16: 35,801,663 (GRCm38)	Y126C	probably damaging	Het
Hspd1	A	T	1: 55,084,769 (GRCm38)	I64N	probably damaging	Het
Igkv3-4	A	T	6: 70,672,283 (GRCm38)	S89C	probably damaging	Het
Il10ra	T	A	9: 45,265,626 (GRCm38)	K134*	probably null	Het
Il12rb1	G	A	8: 70,813,767 (GRCm38)	C252Y	possibly damaging	Het
Il24	A	T	1: 130,882,516 (GRCm38)	V201E	possibly damaging	Het
Inpp1	A	G	1: 52,794,661 (GRCm38)	I92T	probably damaging	Het
Kcnh5	T	C	12: 74,976,689 (GRCm38)	D535G	probably benign	Het
Kcnq4	T	A	4: 120,715,885 (GRCm38)	I240F	probably damaging	Het
Kctd17	G	A	15: 78,437,302 (GRCm38)		probably benign	Het
Leo1	T	A	9: 75,457,141 (GRCm38)	I521N	possibly damaging	Het
Mdga1	A	G	17: 29,839,867 (GRCm38)	L722P	probably damaging	Het
Met	G	T	6: 17,548,782 (GRCm38)	V942L	probably benign	Het
Mfn1	A	T	3: 32,563,847 (GRCm38)	T110S	probably benign	Het
Mrps15	T	C	4: 126,048,695 (GRCm38)	I79T	probably benign	Het
Mylk	T	A	16: 34,879,352 (GRCm38)	S362T	probably benign	Het
Mypn	A	G	10: 63,120,048 (GRCm38)	F1209L	probably benign	Het
Nab2	T	C	10: 127,664,657 (GRCm38)	S189G	probably damaging	Het
Naxe	A	C	3: 88,056,533 (GRCm38)		probably null	Het
Ncf1	A	G	5: 134,223,501 (GRCm38)	V232A	probably damaging	Het
Nell1	A	G	7: 50,279,611 (GRCm38)	Y422C	probably damaging	Het
Nmnat2	G	T	1: 153,094,061 (GRCm38)	G176V	probably damaging	Het
Npr1	A	G	3: 90,454,842 (GRCm38)	S999P	probably damaging	Het
Nuak1	T	C	10: 84,375,255 (GRCm38)	D323G	probably benign	Het
Olfr1424	A	G	19: 12,059,278 (GRCm38)	V158A	probably benign	Het
Olfr191	A	G	16: 59,085,997 (GRCm38)	F162S	probably benign	Het
Olfr918	T	A	9: 38,672,965 (GRCm38)	T160S	probably damaging	Het
Osbpl8	T	C	10: 111,272,168 (GRCm38)	S342P	probably damaging	Het
Pag1	A	T	3: 9,699,422 (GRCm38)	Y224N	probably damaging	Het
Pald1	T	A	10: 61,343,710 (GRCm38)	H460L	probably damaging	Het
Per2	G	A	1: 91,427,856 (GRCm38)	Q727*	probably null	Het
Pex19	T	C	1: 172,133,212 (GRCm38)	V134A	probably benign	Het
Phlpp1	A	T	1: 106,392,927 (GRCm38)	I1551F	possibly damaging	Het
Ppef2	A	T	5: 92,239,139 (GRCm38)	V313D	probably damaging	Het
Pzp	A	C	6: 128,523,796 (GRCm38)	F153C	probably damaging	Het
Rasl11a	A	G	5: 146,845,242 (GRCm38)	H9R	probably benign	Het
Rfx3	A	T	19: 27,802,380 (GRCm38)		probably null	Het
Rmnd5b	A	T	11: 51,627,962 (GRCm38)	I68N	probably damaging	Het
Senp5	T	A	16: 31,989,513 (GRCm38)	S281C	probably damaging	Het
Sh3rf1	G	A	8: 61,361,732 (GRCm38)	E442K	probably benign	Het
Slc12a3	G	A	8: 94,345,788 (GRCm38)	V645M	probably damaging	Het
Slc22a16	T	C	10: 40,581,341 (GRCm38)	F193L	possibly damaging	Het
Slc35f1	A	T	10: 53,108,178 (GRCm38)	T345S	possibly damaging	Het
Slc9a1	G	A	4: 133,421,563 (GRCm38)	R704H	probably damaging	Het
Spta1	A	T	1: 174,175,770 (GRCm38)	Y89F	possibly damaging	Het
Sspo	A	G	6: 48,474,491 (GRCm38)	E2741G	probably damaging	Het
Strn4	G	A	7: 16,833,874 (GRCm38)		probably null	Het
Tanc2	A	G	11: 105,923,306 (GRCm38)	T1859A	probably damaging	Het
Tbc1d14	A	T	5: 36,525,045 (GRCm38)	Y3N	probably damaging	Het
Tdrd9	C	A	12: 112,051,980 (GRCm38)	R1278S	probably benign	Het
Tenm4	C	A	7: 96,797,401 (GRCm38)	A826E	possibly damaging	Het
Tenm4	G	T	7: 96,797,400 (GRCm38)	A826S	possibly damaging	Het
Tet2	C	T	3: 133,476,480 (GRCm38)		probably null	Het
Tfec	A	G	6: 16,834,200 (GRCm38)	L236P	probably benign	Het
Tjap1	A	G	17: 46,258,871 (GRCm38)	S388P	probably damaging	Het
Tle1	T	C	4: 72,124,971 (GRCm38)	T554A	possibly damaging	Het
Tmem17	G	A	11: 22,517,450 (GRCm38)	V83I	probably benign	Het
Tnrc6b	C	T	15: 80,876,502 (GRCm38)	H137Y	probably damaging	Het
Tomm5	T	C	4: 45,106,679 (GRCm38)		probably benign	Het
Top3b	T	A	16: 16,891,577 (GRCm38)		probably benign	Het
Tph1	T	C	7: 46,653,792 (GRCm38)	H254R	probably damaging	Het
Tpte	T	C	8: 22,351,452 (GRCm38)	Y487H	probably damaging	Het
Trappc13	T	A	13: 104,148,241 (GRCm38)	D241V	probably damaging	Het
Trrap	A	G	5: 144,782,265 (GRCm38)	I193V	probably benign	Het
Tspear	A	T	10: 77,870,365 (GRCm38)	H323L	probably benign	Het
Ttc39a	A	T	4: 109,432,987 (GRCm38)		probably null	Het
Ttn	A	T	2: 76,811,243 (GRCm38)	L5176Q	possibly damaging	Het
Tubg1	A	G	11: 101,124,032 (GRCm38)	D200G	probably damaging	Het
Ugdh	C	A	5: 65,422,874 (GRCm38)		probably benign	Het
Uso1	A	G	5: 92,180,608 (GRCm38)	N355D	probably benign	Het
Vamp4	T	C	1: 162,592,679 (GRCm38)		probably null	Het
Vmn2r5	T	C	3: 64,504,076 (GRCm38)	D357G	probably damaging	Het
Vps52	A	G	17: 33,961,221 (GRCm38)	T300A	probably benign	Het
Wt1	A	T	2: 105,127,284 (GRCm38)	H163L	probably damaging	Het
Xirp2	T	C	2: 67,514,035 (GRCm38)	S2207P	probably benign	Het
Xpo6	A	T	7: 126,107,078 (GRCm38)	I30N	probably damaging	Het
Zfp386	T	A	12: 116,059,727 (GRCm38)	I320K	probably benign	Het

Other mutations in Mycbp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Mycbp2	APN	14	103,223,050 (GRCm38)	missense	probably damaging	1.00
IGL00518:Mycbp2	APN	14	103,155,808 (GRCm38)	missense	probably damaging	1.00
IGL00650:Mycbp2	APN	14	103,143,228 (GRCm38)	missense	probably damaging	0.97
IGL00653:Mycbp2	APN	14	103,143,228 (GRCm38)	missense	probably damaging	0.97
IGL00742:Mycbp2	APN	14	103,201,352 (GRCm38)	missense	probably damaging	1.00
IGL00755:Mycbp2	APN	14	103,194,621 (GRCm38)	missense	possibly damaging	0.72
IGL00793:Mycbp2	APN	14	103,126,753 (GRCm38)	missense	possibly damaging	0.77
IGL00916:Mycbp2	APN	14	103,291,283 (GRCm38)	splice site	probably benign
IGL00960:Mycbp2	APN	14	103,229,384 (GRCm38)	missense	possibly damaging	0.95
IGL00977:Mycbp2	APN	14	103,172,642 (GRCm38)	missense	probably damaging	0.98
IGL01349:Mycbp2	APN	14	103,122,547 (GRCm38)	missense	probably damaging	0.98
IGL01369:Mycbp2	APN	14	103,155,510 (GRCm38)	missense	possibly damaging	0.61
IGL01410:Mycbp2	APN	14	103,229,492 (GRCm38)	splice site	probably null
IGL01586:Mycbp2	APN	14	103,140,869 (GRCm38)	critical splice donor site	probably null
IGL01593:Mycbp2	APN	14	103,291,287 (GRCm38)	critical splice donor site	probably null
IGL01693:Mycbp2	APN	14	103,127,979 (GRCm38)	missense	probably damaging	0.99
IGL01730:Mycbp2	APN	14	103,135,204 (GRCm38)	nonsense	probably null
IGL01820:Mycbp2	APN	14	103,188,501 (GRCm38)	missense	probably damaging	1.00
IGL01974:Mycbp2	APN	14	103,143,211 (GRCm38)	missense	possibly damaging	0.88
IGL02071:Mycbp2	APN	14	103,154,907 (GRCm38)	nonsense	probably null
IGL02178:Mycbp2	APN	14	103,224,366 (GRCm38)	missense	probably benign	0.01
IGL02324:Mycbp2	APN	14	103,242,207 (GRCm38)	missense	probably damaging	1.00
IGL02442:Mycbp2	APN	14	103,314,375 (GRCm38)	missense	probably benign
IGL02607:Mycbp2	APN	14	103,285,273 (GRCm38)	missense	probably damaging	1.00
IGL02679:Mycbp2	APN	14	103,205,185 (GRCm38)	missense	probably benign
IGL02702:Mycbp2	APN	14	103,220,124 (GRCm38)	missense	probably benign	0.01
IGL02709:Mycbp2	APN	14	103,155,261 (GRCm38)	missense	probably damaging	0.97
IGL02736:Mycbp2	APN	14	103,114,242 (GRCm38)	splice site	probably benign
IGL02866:Mycbp2	APN	14	103,129,992 (GRCm38)	missense	probably damaging	0.98
IGL02939:Mycbp2	APN	14	103,177,279 (GRCm38)	missense	probably benign
IGL03082:Mycbp2	APN	14	103,204,369 (GRCm38)	missense	probably benign	0.23
IGL03142:Mycbp2	APN	14	103,298,776 (GRCm38)	missense	probably damaging	0.99
IGL03155:Mycbp2	APN	14	103,155,453 (GRCm38)	missense	probably benign	0.06
IGL03236:Mycbp2	APN	14	103,298,698 (GRCm38)	missense	probably damaging	0.99
IGL03256:Mycbp2	APN	14	103,188,589 (GRCm38)	missense	possibly damaging	0.92
IGL03303:Mycbp2	APN	14	103,247,758 (GRCm38)	missense	probably damaging	1.00
compost	UTSW	14	103,156,453 (GRCm38)	missense	probably damaging	1.00
decompose	UTSW	14	103,219,979 (GRCm38)	missense	probably benign	0.12
moulder	UTSW	14	103,188,592 (GRCm38)	missense	probably damaging	1.00
N/A - 293:Mycbp2	UTSW	14	103,224,462 (GRCm38)	splice site	probably benign
R0040:Mycbp2	UTSW	14	103,224,272 (GRCm38)	missense	probably benign	0.11
R0040:Mycbp2	UTSW	14	103,224,272 (GRCm38)	missense	probably benign	0.11
R0057:Mycbp2	UTSW	14	103,152,142 (GRCm38)	missense	probably damaging	0.97
R0063:Mycbp2	UTSW	14	103,156,634 (GRCm38)	unclassified	probably benign
R0097:Mycbp2	UTSW	14	103,155,762 (GRCm38)	missense	probably damaging	1.00
R0097:Mycbp2	UTSW	14	103,155,762 (GRCm38)	missense	probably damaging	1.00
R0268:Mycbp2	UTSW	14	103,314,325 (GRCm38)	nonsense	probably null
R0388:Mycbp2	UTSW	14	103,156,667 (GRCm38)	missense	probably benign	0.01
R0410:Mycbp2	UTSW	14	103,135,133 (GRCm38)	missense	probably damaging	1.00
R0530:Mycbp2	UTSW	14	103,182,459 (GRCm38)	missense	probably damaging	1.00
R0591:Mycbp2	UTSW	14	103,196,391 (GRCm38)	unclassified	probably benign
R0671:Mycbp2	UTSW	14	103,194,588 (GRCm38)	missense	possibly damaging	0.95
R0755:Mycbp2	UTSW	14	103,174,794 (GRCm38)	missense	probably damaging	1.00
R0817:Mycbp2	UTSW	14	103,229,418 (GRCm38)	missense	probably damaging	0.99
R0818:Mycbp2	UTSW	14	103,229,418 (GRCm38)	missense	probably damaging	0.99
R0819:Mycbp2	UTSW	14	103,229,418 (GRCm38)	missense	probably damaging	0.99
R0881:Mycbp2	UTSW	14	103,220,013 (GRCm38)	missense	probably benign
R0903:Mycbp2	UTSW	14	103,275,857 (GRCm38)	missense	probably damaging	0.99
R0940:Mycbp2	UTSW	14	103,262,693 (GRCm38)	unclassified	probably benign
R0961:Mycbp2	UTSW	14	103,184,835 (GRCm38)	missense	probably damaging	1.00
R1004:Mycbp2	UTSW	14	103,140,917 (GRCm38)	missense	probably benign	0.00
R1138:Mycbp2	UTSW	14	103,174,826 (GRCm38)	missense	possibly damaging	0.84
R1170:Mycbp2	UTSW	14	103,200,152 (GRCm38)	nonsense	probably null
R1211:Mycbp2	UTSW	14	103,120,563 (GRCm38)	missense	probably benign	0.31
R1268:Mycbp2	UTSW	14	103,208,782 (GRCm38)	missense	probably damaging	1.00
R1298:Mycbp2	UTSW	14	103,155,898 (GRCm38)	missense	probably damaging	1.00
R1341:Mycbp2	UTSW	14	103,298,867 (GRCm38)	splice site	probably benign
R1469:Mycbp2	UTSW	14	103,188,520 (GRCm38)	missense	probably damaging	0.99
R1469:Mycbp2	UTSW	14	103,188,520 (GRCm38)	missense	probably damaging	0.99
R1513:Mycbp2	UTSW	14	103,204,389 (GRCm38)	missense	probably damaging	1.00
R1528:Mycbp2	UTSW	14	103,232,597 (GRCm38)	missense	possibly damaging	0.91
R1564:Mycbp2	UTSW	14	103,169,851 (GRCm38)	splice site	probably null
R1565:Mycbp2	UTSW	14	103,252,509 (GRCm38)	missense	possibly damaging	0.82
R1656:Mycbp2	UTSW	14	103,247,758 (GRCm38)	missense	probably damaging	1.00
R1694:Mycbp2	UTSW	14	103,227,511 (GRCm38)	missense	probably damaging	1.00
R1709:Mycbp2	UTSW	14	103,224,416 (GRCm38)	missense	probably damaging	1.00
R1728:Mycbp2	UTSW	14	103,155,178 (GRCm38)	missense	probably damaging	0.98
R1751:Mycbp2	UTSW	14	103,248,405 (GRCm38)	missense	probably damaging	0.98
R1767:Mycbp2	UTSW	14	103,248,405 (GRCm38)	missense	probably damaging	0.98
R1772:Mycbp2	UTSW	14	103,182,419 (GRCm38)	missense	probably damaging	1.00
R1784:Mycbp2	UTSW	14	103,155,178 (GRCm38)	missense	probably damaging	0.98
R1823:Mycbp2	UTSW	14	103,252,509 (GRCm38)	missense	possibly damaging	0.82
R1824:Mycbp2	UTSW	14	103,252,509 (GRCm38)	missense	possibly damaging	0.82
R1844:Mycbp2	UTSW	14	103,155,714 (GRCm38)	missense	possibly damaging	0.94
R1916:Mycbp2	UTSW	14	103,184,883 (GRCm38)	missense	probably damaging	1.00
R1944:Mycbp2	UTSW	14	103,229,404 (GRCm38)	missense	probably damaging	1.00
R1983:Mycbp2	UTSW	14	103,145,971 (GRCm38)	missense	probably damaging	0.97
R2002:Mycbp2	UTSW	14	103,248,403 (GRCm38)	missense	probably damaging	0.98
R2031:Mycbp2	UTSW	14	103,188,592 (GRCm38)	missense	probably damaging	1.00
R2035:Mycbp2	UTSW	14	103,260,239 (GRCm38)	missense	probably damaging	1.00
R2048:Mycbp2	UTSW	14	103,232,524 (GRCm38)	critical splice donor site	probably null
R2061:Mycbp2	UTSW	14	103,287,260 (GRCm38)	missense	probably damaging	0.99
R2113:Mycbp2	UTSW	14	103,220,076 (GRCm38)	missense	probably damaging	0.99
R2128:Mycbp2	UTSW	14	103,201,230 (GRCm38)	missense	probably benign	0.01
R2134:Mycbp2	UTSW	14	103,208,893 (GRCm38)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,208,893 (GRCm38)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,145,942 (GRCm38)	missense	probably benign
R2146:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2147:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2148:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2150:Mycbp2	UTSW	14	103,155,922 (GRCm38)	missense	probably damaging	0.97
R2163:Mycbp2	UTSW	14	103,169,855 (GRCm38)	critical splice donor site	probably null
R2248:Mycbp2	UTSW	14	103,169,859 (GRCm38)	missense	possibly damaging	0.50
R2265:Mycbp2	UTSW	14	103,262,749 (GRCm38)	missense	probably benign	0.39
R2272:Mycbp2	UTSW	14	103,144,338 (GRCm38)	missense	probably null	0.66
R2379:Mycbp2	UTSW	14	103,174,950 (GRCm38)	missense	probably benign
R2495:Mycbp2	UTSW	14	103,200,118 (GRCm38)	missense	probably damaging	0.99
R2508:Mycbp2	UTSW	14	103,131,245 (GRCm38)	missense	probably damaging	0.99
R2510:Mycbp2	UTSW	14	103,155,255 (GRCm38)	missense	probably damaging	0.96
R2851:Mycbp2	UTSW	14	103,144,333 (GRCm38)	missense	probably damaging	0.99
R2852:Mycbp2	UTSW	14	103,144,333 (GRCm38)	missense	probably damaging	0.99
R2965:Mycbp2	UTSW	14	103,297,358 (GRCm38)	missense	probably benign	0.00
R3156:Mycbp2	UTSW	14	103,208,743 (GRCm38)	splice site	probably benign
R3404:Mycbp2	UTSW	14	103,200,114 (GRCm38)	missense	probably damaging	0.99
R3410:Mycbp2	UTSW	14	103,135,117 (GRCm38)	missense	probably damaging	1.00
R3429:Mycbp2	UTSW	14	103,229,430 (GRCm38)	missense	probably damaging	1.00
R3706:Mycbp2	UTSW	14	103,156,414 (GRCm38)	missense	probably benign	0.31
R3772:Mycbp2	UTSW	14	103,133,788 (GRCm38)	missense	possibly damaging	0.82
R3778:Mycbp2	UTSW	14	103,197,285 (GRCm38)	missense	probably damaging	0.99
R3883:Mycbp2	UTSW	14	103,295,250 (GRCm38)	missense	probably damaging	0.97
R3884:Mycbp2	UTSW	14	103,295,250 (GRCm38)	missense	probably damaging	0.97
R3887:Mycbp2	UTSW	14	103,174,797 (GRCm38)	missense	probably damaging	0.98
R3923:Mycbp2	UTSW	14	103,126,713 (GRCm38)	missense	probably damaging	1.00
R3926:Mycbp2	UTSW	14	103,204,500 (GRCm38)	missense	probably damaging	1.00
R3959:Mycbp2	UTSW	14	103,295,252 (GRCm38)	missense	probably benign	0.00
R3966:Mycbp2	UTSW	14	103,138,725 (GRCm38)	splice site	probably benign
R4021:Mycbp2	UTSW	14	103,152,157 (GRCm38)	missense	probably damaging	0.97
R4363:Mycbp2	UTSW	14	103,248,457 (GRCm38)	missense	probably damaging	1.00
R4405:Mycbp2	UTSW	14	103,123,445 (GRCm38)	missense	probably damaging	1.00
R4407:Mycbp2	UTSW	14	103,287,228 (GRCm38)	missense	probably damaging	1.00
R4410:Mycbp2	UTSW	14	103,135,266 (GRCm38)	missense	probably damaging	1.00
R4434:Mycbp2	UTSW	14	103,133,789 (GRCm38)	missense	probably damaging	0.99
R4448:Mycbp2	UTSW	14	103,188,502 (GRCm38)	missense	possibly damaging	0.89
R4452:Mycbp2	UTSW	14	103,155,658 (GRCm38)	missense	probably damaging	0.99
R4573:Mycbp2	UTSW	14	103,346,297 (GRCm38)	missense	probably benign	0.05
R4589:Mycbp2	UTSW	14	103,177,313 (GRCm38)	missense	probably benign	0.04
R4621:Mycbp2	UTSW	14	103,219,979 (GRCm38)	missense	probably benign	0.12
R4622:Mycbp2	UTSW	14	103,219,979 (GRCm38)	missense	probably benign	0.12
R4729:Mycbp2	UTSW	14	103,188,591 (GRCm38)	missense	probably damaging	1.00
R4770:Mycbp2	UTSW	14	103,219,944 (GRCm38)	missense	probably benign	0.41
R4790:Mycbp2	UTSW	14	103,229,437 (GRCm38)	missense	probably damaging	1.00
R4884:Mycbp2	UTSW	14	103,211,295 (GRCm38)	missense	probably damaging	1.00
R4885:Mycbp2	UTSW	14	103,145,946 (GRCm38)	missense	possibly damaging	0.86
R4956:Mycbp2	UTSW	14	103,287,239 (GRCm38)	missense	probably damaging	0.99
R4980:Mycbp2	UTSW	14	103,260,385 (GRCm38)	splice site	probably null
R4994:Mycbp2	UTSW	14	103,169,994 (GRCm38)	missense	probably benign
R5029:Mycbp2	UTSW	14	103,156,510 (GRCm38)	missense	probably benign	0.21
R5038:Mycbp2	UTSW	14	103,296,939 (GRCm38)	missense	probably damaging	1.00
R5044:Mycbp2	UTSW	14	103,139,235 (GRCm38)	critical splice donor site	probably null
R5231:Mycbp2	UTSW	14	103,346,214 (GRCm38)	critical splice donor site	probably null
R5305:Mycbp2	UTSW	14	103,346,321 (GRCm38)	missense	probably benign	0.00
R5322:Mycbp2	UTSW	14	103,185,683 (GRCm38)	critical splice acceptor site	probably null
R5376:Mycbp2	UTSW	14	103,242,432 (GRCm38)	nonsense	probably null
R5414:Mycbp2	UTSW	14	103,306,261 (GRCm38)	missense	probably damaging	1.00
R5453:Mycbp2	UTSW	14	103,201,401 (GRCm38)	missense	probably damaging	0.99
R5462:Mycbp2	UTSW	14	103,200,126 (GRCm38)	missense	probably damaging	1.00
R5499:Mycbp2	UTSW	14	103,242,179 (GRCm38)	missense	probably damaging	1.00
R5502:Mycbp2	UTSW	14	103,173,814 (GRCm38)	missense	probably damaging	1.00
R5524:Mycbp2	UTSW	14	103,295,237 (GRCm38)	missense	probably damaging	1.00
R5533:Mycbp2	UTSW	14	103,282,645 (GRCm38)	nonsense	probably null
R5569:Mycbp2	UTSW	14	103,135,243 (GRCm38)	missense	probably damaging	1.00
R5574:Mycbp2	UTSW	14	103,142,767 (GRCm38)	missense	possibly damaging	0.94
R5579:Mycbp2	UTSW	14	103,291,333 (GRCm38)	missense	probably damaging	0.98
R5592:Mycbp2	UTSW	14	103,194,677 (GRCm38)	missense	probably benign	0.02
R5643:Mycbp2	UTSW	14	103,287,334 (GRCm38)	missense	probably damaging	1.00
R5644:Mycbp2	UTSW	14	103,287,334 (GRCm38)	missense	probably damaging	1.00
R5645:Mycbp2	UTSW	14	103,188,615 (GRCm38)	critical splice acceptor site	probably null
R5645:Mycbp2	UTSW	14	103,188,608 (GRCm38)	missense	probably damaging	1.00
R5646:Mycbp2	UTSW	14	103,169,910 (GRCm38)	missense	probably benign	0.09
R5648:Mycbp2	UTSW	14	103,291,342 (GRCm38)	missense	probably damaging	1.00
R5651:Mycbp2	UTSW	14	103,282,665 (GRCm38)	missense	probably null	0.99
R5668:Mycbp2	UTSW	14	103,120,519 (GRCm38)	missense	possibly damaging	0.62
R5745:Mycbp2	UTSW	14	103,156,453 (GRCm38)	missense	possibly damaging	0.94
R5751:Mycbp2	UTSW	14	103,148,550 (GRCm38)	missense	probably damaging	0.99
R5756:Mycbp2	UTSW	14	103,133,974 (GRCm38)	missense	probably damaging	0.99
R5837:Mycbp2	UTSW	14	103,124,403 (GRCm38)	missense	probably damaging	1.00
R5984:Mycbp2	UTSW	14	103,126,684 (GRCm38)	missense	probably damaging	0.98
R6005:Mycbp2	UTSW	14	103,156,723 (GRCm38)	missense	probably benign
R6063:Mycbp2	UTSW	14	103,135,146 (GRCm38)	missense	probably damaging	1.00
R6091:Mycbp2	UTSW	14	103,223,046 (GRCm38)	missense	probably damaging	1.00
R6120:Mycbp2	UTSW	14	103,275,887 (GRCm38)	missense	probably benign	0.01
R6129:Mycbp2	UTSW	14	103,285,400 (GRCm38)	missense	probably benign	0.21
R6147:Mycbp2	UTSW	14	103,155,509 (GRCm38)	nonsense	probably null
R6161:Mycbp2	UTSW	14	103,298,747 (GRCm38)	missense	probably damaging	1.00
R6187:Mycbp2	UTSW	14	103,147,017 (GRCm38)	missense	probably damaging	1.00
R6208:Mycbp2	UTSW	14	103,295,228 (GRCm38)	missense	probably benign	0.11
R6228:Mycbp2	UTSW	14	103,260,229 (GRCm38)	missense	probably benign	0.24
R6301:Mycbp2	UTSW	14	103,155,426 (GRCm38)	missense	probably damaging	1.00
R6311:Mycbp2	UTSW	14	103,262,740 (GRCm38)	missense	possibly damaging	0.93
R6329:Mycbp2	UTSW	14	103,155,852 (GRCm38)	missense	probably benign	0.00
R6439:Mycbp2	UTSW	14	103,155,475 (GRCm38)	missense	probably benign	0.00
R6462:Mycbp2	UTSW	14	103,136,557 (GRCm38)	critical splice donor site	probably null
R6528:Mycbp2	UTSW	14	103,142,881 (GRCm38)	missense	probably damaging	0.99
R6736:Mycbp2	UTSW	14	103,191,567 (GRCm38)	missense	probably null	1.00
R6821:Mycbp2	UTSW	14	103,139,409 (GRCm38)	missense	probably damaging	1.00
R6851:Mycbp2	UTSW	14	103,260,194 (GRCm38)	critical splice donor site	probably null
R6948:Mycbp2	UTSW	14	103,285,267 (GRCm38)	missense	possibly damaging	0.94
R6977:Mycbp2	UTSW	14	103,154,906 (GRCm38)	missense	probably damaging	0.99
R6985:Mycbp2	UTSW	14	103,206,681 (GRCm38)	missense	possibly damaging	0.79
R7035:Mycbp2	UTSW	14	103,174,981 (GRCm38)	missense	probably benign
R7054:Mycbp2	UTSW	14	103,156,098 (GRCm38)	missense	possibly damaging	0.90
R7108:Mycbp2	UTSW	14	103,122,603 (GRCm38)	missense	probably damaging	1.00
R7117:Mycbp2	UTSW	14	103,154,077 (GRCm38)	missense	probably benign	0.21
R7137:Mycbp2	UTSW	14	103,282,679 (GRCm38)	missense	possibly damaging	0.94
R7169:Mycbp2	UTSW	14	103,260,200 (GRCm38)	missense	possibly damaging	0.78
R7218:Mycbp2	UTSW	14	103,133,846 (GRCm38)	missense	probably benign
R7234:Mycbp2	UTSW	14	103,215,337 (GRCm38)	missense	probably damaging	0.98
R7238:Mycbp2	UTSW	14	103,156,297 (GRCm38)	missense	probably damaging	1.00
R7244:Mycbp2	UTSW	14	103,208,909 (GRCm38)	missense	probably damaging	0.98
R7265:Mycbp2	UTSW	14	103,197,243 (GRCm38)	critical splice donor site	probably null
R7286:Mycbp2	UTSW	14	103,120,591 (GRCm38)	missense	probably damaging	1.00
R7332:Mycbp2	UTSW	14	103,197,357 (GRCm38)	missense	probably damaging	0.97
R7332:Mycbp2	UTSW	14	103,156,453 (GRCm38)	missense	probably damaging	1.00
R7384:Mycbp2	UTSW	14	103,276,393 (GRCm38)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,243,128 (GRCm38)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,152,191 (GRCm38)	missense	probably damaging	1.00
R7409:Mycbp2	UTSW	14	103,288,744 (GRCm38)	missense	probably damaging	1.00
R7486:Mycbp2	UTSW	14	103,197,254 (GRCm38)	missense	probably damaging	0.97
R7643:Mycbp2	UTSW	14	103,346,265 (GRCm38)	missense	probably benign
R7661:Mycbp2	UTSW	14	103,212,623 (GRCm38)	missense	probably damaging	1.00
R7663:Mycbp2	UTSW	14	103,191,609 (GRCm38)	missense	probably damaging	0.99
R7730:Mycbp2	UTSW	14	103,123,355 (GRCm38)	missense	probably damaging	0.99
R7757:Mycbp2	UTSW	14	103,191,619 (GRCm38)	missense	probably damaging	1.00
R7773:Mycbp2	UTSW	14	103,248,404 (GRCm38)	missense	probably damaging	0.97
R7787:Mycbp2	UTSW	14	103,127,097 (GRCm38)	missense	probably damaging	1.00
R7822:Mycbp2	UTSW	14	103,139,415 (GRCm38)	missense	probably benign	0.00
R7838:Mycbp2	UTSW	14	103,177,293 (GRCm38)	missense	probably benign	0.10
R7841:Mycbp2	UTSW	14	103,146,831 (GRCm38)	critical splice donor site	probably null
R7858:Mycbp2	UTSW	14	103,156,305 (GRCm38)	missense	probably damaging	1.00
R7873:Mycbp2	UTSW	14	103,156,146 (GRCm38)	missense	probably damaging	1.00
R7911:Mycbp2	UTSW	14	103,200,185 (GRCm38)	missense	probably damaging	0.99
R7942:Mycbp2	UTSW	14	103,155,238 (GRCm38)	missense	probably damaging	0.99
R7951:Mycbp2	UTSW	14	103,215,462 (GRCm38)	missense	probably damaging	0.99
R7958:Mycbp2	UTSW	14	103,129,964 (GRCm38)	missense	probably benign	0.00
R8235:Mycbp2	UTSW	14	103,198,674 (GRCm38)	missense	probably damaging	0.99
R8246:Mycbp2	UTSW	14	103,155,204 (GRCm38)	missense	probably damaging	0.99
R8338:Mycbp2	UTSW	14	103,135,265 (GRCm38)	missense	probably damaging	1.00
R8343:Mycbp2	UTSW	14	103,160,675 (GRCm38)	splice site	probably null
R8361:Mycbp2	UTSW	14	103,138,814 (GRCm38)	missense	probably damaging	1.00
R8490:Mycbp2	UTSW	14	103,208,831 (GRCm38)	missense	probably benign	0.00
R8524:Mycbp2	UTSW	14	103,155,459 (GRCm38)	missense	probably benign	0.23
R8525:Mycbp2	UTSW	14	103,212,719 (GRCm38)	missense	probably damaging	1.00
R8711:Mycbp2	UTSW	14	103,169,994 (GRCm38)	missense	probably benign	0.08
R8735:Mycbp2	UTSW	14	103,223,150 (GRCm38)	missense	probably damaging	0.99
R8825:Mycbp2	UTSW	14	103,229,435 (GRCm38)	missense	probably damaging	1.00
R8928:Mycbp2	UTSW	14	103,156,345 (GRCm38)	missense	probably benign
R8974:Mycbp2	UTSW	14	103,124,421 (GRCm38)	missense	probably damaging	1.00
R8987:Mycbp2	UTSW	14	103,208,796 (GRCm38)	missense	probably damaging	1.00
R9021:Mycbp2	UTSW	14	103,314,316 (GRCm38)	missense	probably benign	0.08
R9062:Mycbp2	UTSW	14	103,242,360 (GRCm38)	missense	probably benign	0.00
R9077:Mycbp2	UTSW	14	103,232,538 (GRCm38)	missense	probably damaging	1.00
R9208:Mycbp2	UTSW	14	103,295,228 (GRCm38)	missense	probably benign	0.01
R9285:Mycbp2	UTSW	14	103,197,317 (GRCm38)	missense	probably damaging	0.97
R9290:Mycbp2	UTSW	14	103,188,524 (GRCm38)	missense	probably damaging	0.99
R9362:Mycbp2	UTSW	14	103,260,206 (GRCm38)	missense	probably damaging	0.97
R9520:Mycbp2	UTSW	14	103,260,269 (GRCm38)	missense	probably benign	0.02
R9557:Mycbp2	UTSW	14	103,135,261 (GRCm38)	missense	probably benign	0.03
R9639:Mycbp2	UTSW	14	103,196,381 (GRCm38)	missense	probably damaging	1.00
R9666:Mycbp2	UTSW	14	103,134,038 (GRCm38)	missense	probably damaging	0.98
R9732:Mycbp2	UTSW	14	103,211,313 (GRCm38)	missense	probably damaging	1.00
R9736:Mycbp2	UTSW	14	103,197,416 (GRCm38)	missense	probably damaging	0.96
R9739:Mycbp2	UTSW	14	103,282,793 (GRCm38)	missense	probably benign	0.11
R9755:Mycbp2	UTSW	14	103,314,370 (GRCm38)	missense	probably benign
X0024:Mycbp2	UTSW	14	103,146,942 (GRCm38)	missense	probably damaging	1.00
Z1176:Mycbp2	UTSW	14	103,346,249 (GRCm38)	missense	probably benign
Z1176:Mycbp2	UTSW	14	103,156,637 (GRCm38)	missense	probably benign	0.06
Z1177:Mycbp2	UTSW	14	103,169,873 (GRCm38)	missense	possibly damaging	0.83
Z1177:Mycbp2	UTSW	14	103,135,123 (GRCm38)	missense	probably damaging	1.00
Z1177:Mycbp2	UTSW	14	103,127,063 (GRCm38)	critical splice donor site	probably null

Predicted Primers

PCR Primer
(F):5'- GTCCTCAGCAGACACTAACGAG -3'
(R):5'- TAATATAGTTGGTCTAACCCTGAGG -3'

Sequencing Primer
(F):5'- TCAGCAGACACTAACGAGTACATAGG -3'
(R):5'- AATCACTCTAAGACTGCTGCAATTC -3'

Posted On

2016-10-26