Incidental Mutation 'R5592:Olfr1157'
ID437559
Institutional Source Beutler Lab
Gene Symbol Olfr1157
Ensembl Gene ENSMUSG00000075143
Gene Nameolfactory receptor 1157
SynonymsMOR174-1, GA_x6K02T2Q125-49446395-49445457
MMRRC Submission 043144-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.098) question?
Stock #R5592 (G1)
Quality Score225
Status Validated
Chromosome2
Chromosomal Location87958485-87968299 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 87962340 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 184 (L184P)
Ref Sequence ENSEMBL: ENSMUSP00000097429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099841]
Predicted Effect probably damaging
Transcript: ENSMUST00000099841
AA Change: L184P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097429
Gene: ENSMUSG00000075143
AA Change: L184P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.7e-48 PFAM
Pfam:7tm_1 41 290 2.6e-20 PFAM
Meta Mutation Damage Score 0.5110 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.8%
  • 20x: 96.7%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630001G21Rik A T 1: 85,726,611 F2I probably damaging Het
Adam17 C T 12: 21,334,137 S454N probably damaging Het
Adcy1 A T 11: 7,139,088 K501* probably null Het
Arhgap28 A T 17: 67,858,272 M543K probably damaging Het
Art3 T A 5: 92,392,820 Y141N probably damaging Het
Ccdc38 C T 10: 93,550,202 T60I possibly damaging Het
Crmp1 A C 5: 37,265,265 I139L probably benign Het
Cul9 G A 17: 46,520,591 L1566F probably benign Het
Cysltr2 T C 14: 73,029,491 K260E probably benign Het
Dpcr1 T C 17: 35,643,643 Y9C probably damaging Het
Drd1 A T 13: 54,054,171 M1K probably null Het
Flii T G 11: 60,720,399 M449L probably benign Het
Galnt16 T C 12: 80,588,519 V343A probably damaging Het
Gimap4 A T 6: 48,691,158 E154D probably damaging Het
Glmp T G 3: 88,326,026 probably benign Het
Glt1d1 A T 5: 127,657,119 D119V probably benign Het
Gm5930 C T 14: 44,331,429 M245I probably benign Het
Gm7102 C T 19: 61,175,926 G24R unknown Het
Golgb1 T A 16: 36,925,763 H2901Q probably benign Het
Krt12 C T 11: 99,420,824 V184I probably benign Het
Lyst T G 13: 13,743,333 I3326S probably damaging Het
Mier3 T A 13: 111,706,661 Y182* probably null Het
Mlip G A 9: 77,230,482 S381L probably damaging Het
Mmp25 A G 17: 23,640,202 V157A possibly damaging Het
Ms4a6c A G 19: 11,480,277 probably benign Het
Ms4a6c A G 19: 11,481,132 probably benign Het
Muc19 T C 15: 91,930,314 noncoding transcript Het
Mycbp2 C A 14: 103,194,677 M2308I probably benign Het
Myo1a G T 10: 127,714,039 V463F probably damaging Het
Ogdh A T 11: 6,316,763 probably null Het
Olfr651 A T 7: 104,553,731 N271Y probably benign Het
Otx1 C A 11: 21,997,037 A91S probably damaging Het
Paip1 C A 13: 119,450,798 D124E probably damaging Het
Pdcd11 T A 19: 47,102,725 N379K probably benign Het
Pitpnm2 T C 5: 124,142,149 E112G probably damaging Het
Prrg4 T C 2: 104,832,778 Y161C probably benign Het
Rb1 A G 14: 73,211,747 Y648H probably damaging Het
Rpa3 A T 6: 8,257,694 M56K probably benign Het
Scarf1 A T 11: 75,525,687 T652S probably benign Het
Slc16a5 A G 11: 115,472,782 K423R probably benign Het
Sptan1 C T 2: 29,986,719 probably benign Het
Ssrp1 T C 2: 85,045,519 I574T probably benign Het
Synm A G 7: 67,759,516 L38P probably damaging Het
Ubqln4 T G 3: 88,556,864 M224R probably damaging Het
Uroc1 A G 6: 90,355,344 N561S probably damaging Het
Vav1 A G 17: 57,304,835 Y483C probably benign Het
Vps13a G A 19: 16,725,571 L673F probably damaging Het
Zfp418 G T 7: 7,181,315 K92N possibly damaging Het
Other mutations in Olfr1157
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4453001:Olfr1157 UTSW 2 87962458 missense possibly damaging 0.90
R1502:Olfr1157 UTSW 2 87962035 missense probably damaging 1.00
R2127:Olfr1157 UTSW 2 87962832 missense probably benign 0.01
R2284:Olfr1157 UTSW 2 87962793 missense probably damaging 0.99
R2443:Olfr1157 UTSW 2 87962865 missense possibly damaging 0.47
R4021:Olfr1157 UTSW 2 87962722 missense possibly damaging 0.77
R4693:Olfr1157 UTSW 2 87962709 missense probably benign 0.39
R4752:Olfr1157 UTSW 2 87962349 missense probably damaging 1.00
R4879:Olfr1157 UTSW 2 87962696 missense possibly damaging 0.91
R4983:Olfr1157 UTSW 2 87962698 missense probably benign 0.26
R5945:Olfr1157 UTSW 2 87962602 missense probably damaging 1.00
R6412:Olfr1157 UTSW 2 87962349 missense probably damaging 1.00
R7470:Olfr1157 UTSW 2 87962449 missense possibly damaging 0.74
Predicted Primers PCR Primer
(F):5'- AAGGATCGTCCCATGGAAGAC -3'
(R):5'- TGTAGCCATCTGTAACCCACTAC -3'

Sequencing Primer
(F):5'- TCGTCCCATGGAAGACAATGATGAC -3'
(R):5'- TCTGTAACCCACTACTATATACGGC -3'
Posted On2016-10-26