Incidental Mutation 'R5614:Dtx4'
ID 438164
Institutional Source Beutler Lab
Gene Symbol Dtx4
Ensembl Gene ENSMUSG00000039982
Gene Name deltex 4, E3 ubiquitin ligase
Synonyms RNF155
MMRRC Submission 043275-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.418) question?
Stock # R5614 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 12443702-12478818 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 12459547 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 419 (Y419C)
Ref Sequence ENSEMBL: ENSMUSP00000040229 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045521]
AlphaFold Q6PDK8
Predicted Effect probably damaging
Transcript: ENSMUST00000045521
AA Change: Y419C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000040229
Gene: ENSMUSG00000039982
AA Change: Y419C

DomainStartEndE-ValueType
WWE 5 86 1.38e-38 SMART
WWE 88 163 6.72e-28 SMART
low complexity region 175 192 N/A INTRINSIC
low complexity region 372 386 N/A INTRINSIC
RING 406 464 2.2e-6 SMART
Blast:RING 510 532 3e-7 BLAST
Meta Mutation Damage Score 0.6750 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency 100% (62/62)
Allele List at MGI

All alleles(1) : Gene trapped(1)

Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 A G 4: 53,046,132 (GRCm39) V1712A probably damaging Het
Ankmy2 T C 12: 36,243,783 (GRCm39) S333P probably damaging Het
Arfrp1 A G 2: 181,001,236 (GRCm39) probably benign Het
Atp13a2 A G 4: 140,719,493 (GRCm39) T21A probably benign Het
Bud23 C A 5: 135,087,966 (GRCm39) A152S probably benign Het
Cant1 T C 11: 118,299,569 (GRCm39) D260G probably benign Het
Ces1b T C 8: 93,794,836 (GRCm39) I254M probably benign Het
Ces1d T C 8: 93,902,832 (GRCm39) T375A probably benign Het
Cfap54 A G 10: 92,880,911 (GRCm39) L384P probably damaging Het
Chrne C T 11: 70,505,879 (GRCm39) V469I possibly damaging Het
Clspn A G 4: 126,474,755 (GRCm39) E968G probably damaging Het
Col5a3 A G 9: 20,694,772 (GRCm39) probably benign Het
Fam171b T A 2: 83,643,217 (GRCm39) I42N probably damaging Het
Fam43a T C 16: 30,420,490 (GRCm39) I358T possibly damaging Het
Fasn T C 11: 120,704,154 (GRCm39) S1422G probably benign Het
Fig4 A T 10: 41,148,981 (GRCm39) V157E probably damaging Het
Fus T C 7: 127,573,543 (GRCm39) probably benign Het
Hmcn2 G T 2: 31,318,315 (GRCm39) V3887F probably damaging Het
Hmgcll1 A G 9: 75,988,675 (GRCm39) Y182C probably damaging Het
Hook2 T A 8: 85,729,137 (GRCm39) I585N probably damaging Het
Iars2 T C 1: 185,021,705 (GRCm39) T866A probably benign Het
Iqca1l G A 5: 24,755,140 (GRCm39) A330V probably benign Het
Lrit1 T A 14: 36,783,911 (GRCm39) M413K probably benign Het
Myl9 G A 2: 156,623,083 (GRCm39) probably benign Het
Nelfa A T 5: 34,077,844 (GRCm39) L179Q probably damaging Het
Nod2 A T 8: 89,390,824 (GRCm39) D355V probably damaging Het
Npbwr1 A T 1: 5,987,030 (GRCm39) S161R probably damaging Het
Nxpe2 A T 9: 48,234,401 (GRCm39) F289I probably benign Het
Odf2 A G 2: 29,810,879 (GRCm39) I538M probably damaging Het
Osbpl6 T A 2: 76,398,453 (GRCm39) V379E probably damaging Het
Pkhd1 A G 1: 20,143,750 (GRCm39) C3859R possibly damaging Het
Rgs1 G T 1: 144,121,995 (GRCm39) T99N probably benign Het
Rnf6 T C 5: 146,154,910 (GRCm39) probably null Het
Rtp1 C A 16: 23,249,940 (GRCm39) Q102K possibly damaging Het
Sec24c T A 14: 20,732,806 (GRCm39) V123E possibly damaging Het
Serpini2 T C 3: 75,165,014 (GRCm39) probably benign Het
Stxbp5 A T 10: 9,636,638 (GRCm39) probably benign Het
Tecta A G 9: 42,250,351 (GRCm39) S1809P probably damaging Het
Tgfb2 T A 1: 186,357,710 (GRCm39) I394F probably benign Het
Thg1l T C 11: 45,841,054 (GRCm39) Y175C possibly damaging Het
Tmem67 C A 4: 12,061,755 (GRCm39) K572N possibly damaging Het
Tollip T C 7: 141,445,825 (GRCm39) T19A probably damaging Het
Ttn A G 2: 76,542,451 (GRCm39) Y25185H probably damaging Het
Vgll2 A T 10: 51,901,318 (GRCm39) R83* probably null Het
Wfdc8 G T 2: 164,445,123 (GRCm39) A164E probably damaging Het
Ylpm1 T C 12: 85,111,718 (GRCm39) probably benign Het
Zfp326 T A 5: 106,036,361 (GRCm39) S91T probably damaging Het
Zfp638 T C 6: 83,906,623 (GRCm39) F263L probably damaging Het
Zfp800 G A 6: 28,243,135 (GRCm39) T610I probably damaging Het
Zmym4 A G 4: 126,804,729 (GRCm39) F475L possibly damaging Het
Other mutations in Dtx4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01533:Dtx4 APN 19 12,455,579 (GRCm39) missense possibly damaging 0.88
IGL02173:Dtx4 APN 19 12,450,621 (GRCm39) nonsense probably null
IGL03127:Dtx4 APN 19 12,463,864 (GRCm39) splice site probably benign
G5030:Dtx4 UTSW 19 12,446,943 (GRCm39) missense probably benign 0.07
R0143:Dtx4 UTSW 19 12,463,846 (GRCm39) missense probably damaging 0.98
R0932:Dtx4 UTSW 19 12,469,515 (GRCm39) missense probably benign
R1066:Dtx4 UTSW 19 12,478,373 (GRCm39) missense probably damaging 0.98
R2155:Dtx4 UTSW 19 12,462,646 (GRCm39) nonsense probably null
R2182:Dtx4 UTSW 19 12,460,471 (GRCm39) missense probably null 0.75
R2362:Dtx4 UTSW 19 12,469,899 (GRCm39) missense probably damaging 1.00
R3880:Dtx4 UTSW 19 12,463,820 (GRCm39) missense probably benign 0.01
R4108:Dtx4 UTSW 19 12,478,487 (GRCm39) missense probably damaging 0.96
R4361:Dtx4 UTSW 19 12,462,660 (GRCm39) missense probably benign 0.04
R4943:Dtx4 UTSW 19 12,478,424 (GRCm39) missense probably damaging 1.00
R5361:Dtx4 UTSW 19 12,462,626 (GRCm39) critical splice donor site probably null
R5440:Dtx4 UTSW 19 12,469,681 (GRCm39) missense probably damaging 1.00
R5613:Dtx4 UTSW 19 12,462,767 (GRCm39) missense probably damaging 0.97
R5703:Dtx4 UTSW 19 12,459,574 (GRCm39) missense possibly damaging 0.84
R5994:Dtx4 UTSW 19 12,478,517 (GRCm39) missense probably damaging 1.00
R6695:Dtx4 UTSW 19 12,450,599 (GRCm39) nonsense probably null
R7107:Dtx4 UTSW 19 12,450,624 (GRCm39) nonsense probably null
R7208:Dtx4 UTSW 19 12,459,437 (GRCm39) critical splice donor site probably null
R7231:Dtx4 UTSW 19 12,447,022 (GRCm39) nonsense probably null
R7521:Dtx4 UTSW 19 12,469,861 (GRCm39) missense probably benign 0.30
R7609:Dtx4 UTSW 19 12,469,645 (GRCm39) missense probably damaging 1.00
R7721:Dtx4 UTSW 19 12,459,500 (GRCm39) missense probably benign 0.09
R7775:Dtx4 UTSW 19 12,469,374 (GRCm39) missense probably benign 0.02
R8685:Dtx4 UTSW 19 12,446,995 (GRCm39) missense probably benign 0.36
Z1176:Dtx4 UTSW 19 12,469,273 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTACGAGTTCCAACAACGTGTG -3'
(R):5'- AGCCTGTATGCATGTATGGG -3'

Sequencing Primer
(F):5'- TGTGGGAGAACAAGGACACTC -3'
(R):5'- CTCTGCTGGTAAATTAAGACAACAC -3'
Posted On 2016-10-26