Incidental Mutation 'R5615:Lancl2'
ID 438183
Institutional Source Beutler Lab
Gene Symbol Lancl2
Ensembl Gene ENSMUSG00000062190
Gene Name LanC (bacterial lantibiotic synthetase component C)-like 2
Synonyms 1700003F10Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5615 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 57679525-57716424 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 57699496 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 104 (Y104H)
Ref Sequence ENSEMBL: ENSMUSP00000121377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050077] [ENSMUST00000072954] [ENSMUST00000153777]
AlphaFold Q9JJK2
Predicted Effect probably damaging
Transcript: ENSMUST00000050077
AA Change: Y113H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052146
Gene: ENSMUSG00000062190
AA Change: Y113H

DomainStartEndE-ValueType
low complexity region 32 44 N/A INTRINSIC
LANC_like 96 444 2.51e-148 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000072954
AA Change: Y113H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072723
Gene: ENSMUSG00000062190
AA Change: Y113H

DomainStartEndE-ValueType
low complexity region 32 44 N/A INTRINSIC
LANC_like 96 444 2.51e-148 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000153777
AA Change: Y104H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000121377
Gene: ENSMUSG00000062190
AA Change: Y104H

DomainStartEndE-ValueType
low complexity region 23 35 N/A INTRINSIC
LANC_like 87 435 2.51e-148 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A T 1: 71,346,218 (GRCm39) L884H probably damaging Het
Ahr A G 12: 35,553,884 (GRCm39) V745A probably benign Het
Ankrd17 A T 5: 90,431,295 (GRCm39) S830T possibly damaging Het
Aox1 A G 1: 58,136,125 (GRCm39) T1123A probably benign Het
Arhgef11 T C 3: 87,629,792 (GRCm39) probably null Het
Bcas3 T A 11: 85,361,587 (GRCm39) C250S probably damaging Het
Bckdk T C 7: 127,506,489 (GRCm39) I272T probably damaging Het
Cacna1e T C 1: 154,287,916 (GRCm39) K1897E probably damaging Het
Cd180 A T 13: 102,842,711 (GRCm39) I586F probably benign Het
Cep290 A G 10: 100,367,012 (GRCm39) D1121G probably damaging Het
Clasrp A G 7: 19,320,372 (GRCm39) probably benign Het
Col27a1 G T 4: 63,199,351 (GRCm39) K912N probably damaging Het
Dock4 G T 12: 40,699,479 (GRCm39) R231L probably benign Het
Ell G A 8: 71,043,382 (GRCm39) S505N probably benign Het
Ephb6 A G 6: 41,596,225 (GRCm39) T833A probably benign Het
Hemk1 T A 9: 107,208,023 (GRCm39) probably null Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hspa12a T C 19: 58,793,082 (GRCm39) I368V possibly damaging Het
Igkv3-3 A T 6: 70,664,214 (GRCm39) T19S probably benign Het
Itpr1 G A 6: 108,465,561 (GRCm39) A2158T possibly damaging Het
Leng8 G T 7: 4,147,957 (GRCm39) E634* probably null Het
Lrrk1 A T 7: 65,937,363 (GRCm39) C930S probably damaging Het
Lvrn C T 18: 46,983,395 (GRCm39) S46L possibly damaging Het
Mcidas G A 13: 113,133,959 (GRCm39) V148I probably benign Het
Mprip A T 11: 59,649,313 (GRCm39) T1006S probably benign Het
Mrgprb3 T A 7: 48,293,234 (GRCm39) M106L probably benign Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Mtor G A 4: 148,622,733 (GRCm39) V1938I possibly damaging Het
Muc2 A G 7: 141,277,446 (GRCm39) D46G probably damaging Het
Nfkb2 G T 19: 46,296,006 (GRCm39) E170D probably benign Het
Or10ag52 T A 2: 87,044,083 (GRCm39) F282L probably benign Het
Or6c215 A T 10: 129,637,636 (GRCm39) C253S probably damaging Het
Osbp2 C T 11: 3,813,356 (GRCm39) G171D probably benign Het
Otud6b A T 4: 14,818,187 (GRCm39) M238K possibly damaging Het
Pcdhac2 G A 18: 37,279,476 (GRCm39) G819R probably benign Het
Pcdhac2 G T 18: 37,279,477 (GRCm39) G819V probably benign Het
Pcdhga12 T G 18: 37,901,132 (GRCm39) S655A probably damaging Het
Pkd1l3 A G 8: 110,356,842 (GRCm39) I756V probably benign Het
Plekhd1 T A 12: 80,767,364 (GRCm39) S251T probably damaging Het
Ppp2r1a A T 17: 21,179,249 (GRCm39) T96S probably benign Het
Qser1 A C 2: 104,620,039 (GRCm39) S258A possibly damaging Het
Rsph4a G A 10: 33,785,324 (GRCm39) A412T probably benign Het
Sanbr A T 11: 23,556,759 (GRCm39) L407H probably damaging Het
Sass6 T A 3: 116,401,135 (GRCm39) C159S probably benign Het
Scaf4 T C 16: 90,048,848 (GRCm39) Q322R unknown Het
Sema6d C T 2: 124,498,821 (GRCm39) H244Y probably damaging Het
Sigirr T G 7: 140,672,632 (GRCm39) L163F probably damaging Het
Spata31d1c C A 13: 65,183,078 (GRCm39) L207I possibly damaging Het
Tacstd2 A G 6: 67,512,033 (GRCm39) F220L probably damaging Het
Tdpoz4 A T 3: 93,704,806 (GRCm39) T368S probably benign Het
Tnxb C A 17: 34,902,392 (GRCm39) Q1082K probably damaging Het
Trim41 GCCTAGGCGCCCA G 11: 48,698,192 (GRCm39) probably benign Het
Trpm6 C T 19: 18,807,297 (GRCm39) R1014C probably damaging Het
Ugt1a10 TTCATCA TTCA 1: 88,143,880 (GRCm39) probably benign Het
Vmn2r114 ATTT ATT 17: 23,509,906 (GRCm39) probably null Het
Vmn2r61 T A 7: 41,916,677 (GRCm39) M430K probably benign Het
Vmn2r61 A G 7: 41,949,917 (GRCm39) E779G probably damaging Het
Zfp599 T C 9: 22,165,165 (GRCm39) D70G probably benign Het
Zmym1 A T 4: 126,943,191 (GRCm39) I301N probably damaging Het
Other mutations in Lancl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Lancl2 APN 6 57,701,522 (GRCm39) splice site probably benign
IGL00469:Lancl2 APN 6 57,711,011 (GRCm39) missense probably damaging 1.00
IGL00568:Lancl2 APN 6 57,700,470 (GRCm39) splice site probably benign
IGL01527:Lancl2 APN 6 57,709,307 (GRCm39) missense probably damaging 0.99
IGL02086:Lancl2 APN 6 57,711,024 (GRCm39) missense probably damaging 1.00
R0309:Lancl2 UTSW 6 57,680,117 (GRCm39) missense probably damaging 1.00
R4202:Lancl2 UTSW 6 57,689,977 (GRCm39) missense probably benign 0.02
R4468:Lancl2 UTSW 6 57,690,019 (GRCm39) missense probably damaging 1.00
R4469:Lancl2 UTSW 6 57,690,019 (GRCm39) missense probably damaging 1.00
R4729:Lancl2 UTSW 6 57,714,697 (GRCm39) missense probably damaging 1.00
R4823:Lancl2 UTSW 6 57,709,262 (GRCm39) missense probably damaging 1.00
R5296:Lancl2 UTSW 6 57,701,567 (GRCm39) missense probably benign 0.05
R6619:Lancl2 UTSW 6 57,699,566 (GRCm39) missense probably damaging 0.98
R6784:Lancl2 UTSW 6 57,680,240 (GRCm39) missense probably benign
R6873:Lancl2 UTSW 6 57,699,642 (GRCm39) missense possibly damaging 0.86
R7363:Lancl2 UTSW 6 57,699,664 (GRCm39) missense probably benign 0.00
R8018:Lancl2 UTSW 6 57,690,078 (GRCm39) missense probably damaging 1.00
R8204:Lancl2 UTSW 6 57,714,701 (GRCm39) missense probably damaging 1.00
R9212:Lancl2 UTSW 6 57,714,673 (GRCm39) missense probably benign
R9794:Lancl2 UTSW 6 57,714,708 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- AGCCGCAGTATGTCTTGTG -3'
(R):5'- TGGGACTCACATTCACTTTTGAG -3'

Sequencing Primer
(F):5'- CCCATGATAAATTTCAACCTGTTTC -3'
(R):5'- GTTTATGATATATCACAGCTCCCAC -3'
Posted On 2016-10-26