Incidental Mutation 'R5579:Ncoa6'
| ID |
438244 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ncoa6
|
| Ensembl Gene |
ENSMUSG00000038369 |
| Gene Name |
nuclear receptor coactivator 6 |
| Synonyms |
PRIP, ASC-2, NRC, AIB3, RAP250, ASC2 |
| MMRRC Submission |
043267-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5579 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
155390656-155473894 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 155406677 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Serine
at position 1569
(L1569S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105295
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043126]
[ENSMUST00000109670]
[ENSMUST00000123293]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000043126
AA Change: L1569S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000045386
Gene: ENSMUSG00000038369
AA Change: L1569S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
47 |
190 |
3.3e-55 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
450 |
597 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
636 |
793 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1564 |
N/A |
INTRINSIC |
|
low complexity region
|
1578 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1607 |
1618 |
N/A |
INTRINSIC |
|
low complexity region
|
1808 |
1825 |
N/A |
INTRINSIC |
|
low complexity region
|
1894 |
1908 |
N/A |
INTRINSIC |
|
low complexity region
|
2043 |
2053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109670
AA Change: L1569S
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000105295
Gene: ENSMUSG00000038369
AA Change: L1569S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
3.6e-60 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
450 |
597 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
636 |
793 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1564 |
N/A |
INTRINSIC |
|
low complexity region
|
1578 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1607 |
1618 |
N/A |
INTRINSIC |
|
low complexity region
|
1808 |
1825 |
N/A |
INTRINSIC |
|
low complexity region
|
1894 |
1908 |
N/A |
INTRINSIC |
|
low complexity region
|
2043 |
2053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123293
|
| SMART Domains |
Protein: ENSMUSP00000118113
Gene: ENSMUSG00000038369
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
2.4e-60 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
low complexity region
|
564 |
573 |
N/A |
INTRINSIC |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146942
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 98.9%
- 20x: 97.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for targeted null mutations exhibit retarded embryonic growth and defects of the placenta, heart, liver, and nervous system. Mutants die around midgestation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 114 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810403A07Rik |
T |
C |
3: 88,700,275 (GRCm38) |
S345P |
probably benign |
Het |
| 6430573F11Rik |
T |
C |
8: 36,512,041 (GRCm38) |
V266A |
probably benign |
Het |
| Abca3 |
G |
T |
17: 24,376,729 (GRCm38) |
C352F |
probably damaging |
Het |
| Abce1 |
A |
T |
8: 79,700,586 (GRCm38) |
I237N |
possibly damaging |
Het |
| Acrbp |
A |
G |
6: 125,061,099 (GRCm38) |
D421G |
probably benign |
Het |
| Adam8 |
T |
A |
7: 139,988,984 (GRCm38) |
Y201F |
probably benign |
Het |
| Adgrf1 |
T |
A |
17: 43,311,064 (GRCm38) |
C731S |
probably damaging |
Het |
| AF067063 |
T |
A |
13: 119,828,415 (GRCm38) |
M82L |
probably benign |
Het |
| Akap8l |
A |
T |
17: 32,321,942 (GRCm38) |
I529N |
probably damaging |
Het |
| Akap9 |
G |
A |
5: 4,064,714 (GRCm38) |
G114D |
possibly damaging |
Het |
| Alox12b |
T |
A |
11: 69,162,932 (GRCm38) |
D158E |
probably benign |
Het |
| Ankrd11 |
A |
G |
8: 122,884,231 (GRCm38) |
S2639P |
probably damaging |
Het |
| Ankrd42 |
T |
C |
7: 92,590,182 (GRCm38) |
Y466C |
possibly damaging |
Het |
| Apobr |
T |
C |
7: 126,587,675 (GRCm38) |
I786T |
probably benign |
Het |
| Arhgef12 |
C |
T |
9: 43,010,193 (GRCm38) |
G329R |
probably benign |
Het |
| Btnl1 |
T |
C |
17: 34,381,552 (GRCm38) |
|
probably null |
Het |
| Ccdc174 |
A |
G |
6: 91,881,350 (GRCm38) |
|
probably null |
Het |
| Ccdc183 |
T |
C |
2: 25,615,422 (GRCm38) |
D177G |
possibly damaging |
Het |
| Cd14 |
A |
G |
18: 36,726,235 (GRCm38) |
Y56H |
probably benign |
Het |
| Cep162 |
G |
A |
9: 87,203,671 (GRCm38) |
A1200V |
probably benign |
Het |
| Clic3 |
T |
C |
2: 25,458,307 (GRCm38) |
L128P |
probably damaging |
Het |
| Cntnap5b |
A |
T |
1: 100,383,395 (GRCm38) |
R538* |
probably null |
Het |
| Cntnap5b |
A |
T |
1: 100,383,399 (GRCm38) |
Q539L |
probably benign |
Het |
| Coq7 |
A |
T |
7: 118,517,335 (GRCm38) |
N214K |
unknown |
Het |
| Cramp1l |
G |
A |
17: 24,973,113 (GRCm38) |
H1018Y |
possibly damaging |
Het |
| Crtac1 |
T |
A |
19: 42,304,806 (GRCm38) |
D288V |
probably damaging |
Het |
| Dab2ip |
C |
T |
2: 35,715,327 (GRCm38) |
R132* |
probably null |
Het |
| Dis3l |
C |
A |
9: 64,330,835 (GRCm38) |
C125F |
probably benign |
Het |
| Dnmt1 |
A |
T |
9: 20,920,205 (GRCm38) |
V543D |
probably damaging |
Het |
| Dock9 |
A |
T |
14: 121,599,695 (GRCm38) |
L67Q |
probably damaging |
Het |
| Ehbp1 |
A |
T |
11: 22,137,846 (GRCm38) |
S413T |
probably damaging |
Het |
| Endov |
A |
G |
11: 119,505,097 (GRCm38) |
I158V |
probably benign |
Het |
| Epb41l4b |
A |
G |
4: 57,064,802 (GRCm38) |
V469A |
possibly damaging |
Het |
| Etf1 |
G |
A |
18: 34,913,601 (GRCm38) |
P119S |
probably damaging |
Het |
| Fam135a |
A |
G |
1: 24,029,727 (GRCm38) |
L491P |
possibly damaging |
Het |
| Fancd2 |
A |
T |
6: 113,560,051 (GRCm38) |
|
probably null |
Het |
| Fank1 |
T |
A |
7: 133,869,329 (GRCm38) |
|
probably null |
Het |
| Fbxo18 |
A |
G |
2: 11,748,993 (GRCm38) |
I846T |
probably damaging |
Het |
| Gas2l3 |
T |
C |
10: 89,414,066 (GRCm38) |
T397A |
probably benign |
Het |
| Gga1 |
T |
C |
15: 78,893,188 (GRCm38) |
V513A |
probably damaging |
Het |
| Ggt1 |
T |
C |
10: 75,585,948 (GRCm38) |
V543A |
probably damaging |
Het |
| Gm11596 |
A |
T |
11: 99,792,891 (GRCm38) |
C134* |
probably null |
Het |
| Gnal |
C |
T |
18: 67,088,771 (GRCm38) |
R82C |
unknown |
Het |
| Hat1 |
T |
C |
2: 71,410,238 (GRCm38) |
V92A |
possibly damaging |
Het |
| Icosl |
C |
T |
10: 78,073,763 (GRCm38) |
R181C |
probably damaging |
Het |
| Ift46 |
A |
G |
9: 44,786,863 (GRCm38) |
M208V |
possibly damaging |
Het |
| Ighv1-26 |
T |
C |
12: 114,788,599 (GRCm38) |
K42E |
possibly damaging |
Het |
| Ipo5 |
A |
G |
14: 120,938,613 (GRCm38) |
K617E |
probably benign |
Het |
| Irx5 |
A |
G |
8: 92,359,913 (GRCm38) |
D208G |
probably benign |
Het |
| Itgal |
T |
G |
7: 127,306,929 (GRCm38) |
V397G |
probably benign |
Het |
| Itpr2 |
G |
A |
6: 146,173,366 (GRCm38) |
R2297* |
probably null |
Het |
| Itpr3 |
A |
G |
17: 27,113,519 (GRCm38) |
D1779G |
probably damaging |
Het |
| Krt4 |
T |
A |
15: 101,921,234 (GRCm38) |
E286D |
probably benign |
Het |
| Loxl4 |
C |
T |
19: 42,604,290 (GRCm38) |
G317E |
probably damaging |
Het |
| Mapk6 |
T |
G |
9: 75,388,062 (GRCm38) |
H718P |
possibly damaging |
Het |
| Mark2 |
A |
C |
19: 7,282,816 (GRCm38) |
V14G |
probably damaging |
Het |
| Mbd5 |
A |
G |
2: 49,272,814 (GRCm38) |
T1103A |
possibly damaging |
Het |
| Mcph1 |
A |
G |
8: 18,632,293 (GRCm38) |
E482G |
probably benign |
Het |
| Mme |
G |
A |
3: 63,348,645 (GRCm38) |
E509K |
probably damaging |
Het |
| Mrgbp |
A |
G |
2: 180,585,483 (GRCm38) |
T204A |
probably damaging |
Het |
| Mycbp2 |
A |
T |
14: 103,291,333 (GRCm38) |
F430I |
probably damaging |
Het |
| Myo6 |
A |
G |
9: 80,217,720 (GRCm38) |
D27G |
probably damaging |
Het |
| Ndc1 |
T |
A |
4: 107,380,704 (GRCm38) |
F235Y |
possibly damaging |
Het |
| Nmur2 |
A |
T |
11: 56,033,009 (GRCm38) |
S240T |
probably benign |
Het |
| Olfr1176 |
A |
T |
2: 88,340,413 (GRCm38) |
I283F |
possibly damaging |
Het |
| Olfr301 |
T |
A |
7: 86,412,726 (GRCm38) |
Y121* |
probably null |
Het |
| Olfr608 |
G |
A |
7: 103,470,914 (GRCm38) |
V292M |
probably damaging |
Het |
| Osbpl1a |
A |
C |
18: 12,892,262 (GRCm38) |
S333A |
probably benign |
Het |
| Osbpl1a |
G |
T |
18: 12,841,192 (GRCm38) |
A62E |
probably damaging |
Het |
| Otud4 |
C |
T |
8: 79,664,108 (GRCm38) |
T417I |
probably benign |
Het |
| Pagr1a |
T |
C |
7: 127,015,442 (GRCm38) |
E197G |
probably damaging |
Het |
| Pcdh18 |
T |
C |
3: 49,744,977 (GRCm38) |
Q1012R |
probably damaging |
Het |
| Pcdhgb5 |
A |
C |
18: 37,731,637 (GRCm38) |
I162L |
probably benign |
Het |
| Pdpr |
T |
A |
8: 111,123,816 (GRCm38) |
Y462N |
probably damaging |
Het |
| Pkhd1 |
A |
T |
1: 20,523,142 (GRCm38) |
H1582Q |
probably damaging |
Het |
| Polr1b |
A |
G |
2: 129,110,108 (GRCm38) |
K352R |
probably damaging |
Het |
| Poteg |
G |
A |
8: 27,448,037 (GRCm38) |
V12M |
probably damaging |
Het |
| Pou2f1 |
A |
C |
1: 165,915,162 (GRCm38) |
V54G |
probably damaging |
Het |
| Ppme1 |
A |
G |
7: 100,344,975 (GRCm38) |
L177P |
probably damaging |
Het |
| Prkce |
A |
G |
17: 86,619,948 (GRCm38) |
D550G |
probably damaging |
Het |
| Prrc2c |
A |
G |
1: 162,680,758 (GRCm38) |
|
probably null |
Het |
| Ptpn22 |
A |
G |
3: 103,882,139 (GRCm38) |
|
probably null |
Het |
| Rabif |
G |
A |
1: 134,506,205 (GRCm38) |
V86M |
probably damaging |
Het |
| Rbm25 |
T |
A |
12: 83,668,507 (GRCm38) |
M484K |
probably benign |
Het |
| Rcn2 |
G |
A |
9: 56,057,429 (GRCm38) |
A224T |
probably benign |
Het |
| Rexo5 |
T |
A |
7: 119,834,403 (GRCm38) |
|
probably null |
Het |
| Rnase1 |
A |
T |
14: 51,145,762 (GRCm38) |
I45N |
probably benign |
Het |
| Rnmt |
T |
A |
18: 68,306,115 (GRCm38) |
D98E |
possibly damaging |
Het |
| Rprd2 |
A |
G |
3: 95,785,059 (GRCm38) |
F188L |
probably damaging |
Het |
| Scube2 |
G |
A |
7: 109,810,737 (GRCm38) |
T643M |
probably damaging |
Het |
| Slc7a15 |
T |
C |
12: 8,539,344 (GRCm38) |
I68V |
probably benign |
Het |
| Slco1a5 |
A |
T |
6: 142,242,125 (GRCm38) |
V496D |
possibly damaging |
Het |
| Slitrk6 |
T |
G |
14: 110,751,217 (GRCm38) |
S353R |
possibly damaging |
Het |
| Smpd5 |
T |
A |
15: 76,295,125 (GRCm38) |
I53K |
possibly damaging |
Het |
| Tas2r108 |
T |
C |
6: 40,494,087 (GRCm38) |
S166P |
probably benign |
Het |
| Tecpr1 |
C |
A |
5: 144,214,344 (GRCm38) |
V245L |
possibly damaging |
Het |
| Tenm3 |
G |
T |
8: 48,236,764 (GRCm38) |
N1929K |
probably damaging |
Het |
| Tigd5 |
T |
G |
15: 75,911,025 (GRCm38) |
F412C |
probably damaging |
Het |
| Timm17a |
A |
T |
1: 135,306,188 (GRCm38) |
S74T |
possibly damaging |
Het |
| Tle1 |
A |
T |
4: 72,139,808 (GRCm38) |
L60Q |
probably damaging |
Het |
| Tmem132d |
T |
C |
5: 127,796,000 (GRCm38) |
E515G |
possibly damaging |
Het |
| Tmem65 |
T |
C |
15: 58,794,397 (GRCm38) |
N115S |
probably benign |
Het |
| Trmt5 |
C |
A |
12: 73,281,652 (GRCm38) |
R259L |
possibly damaging |
Het |
| Ttc37 |
T |
C |
13: 76,185,200 (GRCm38) |
W25R |
probably damaging |
Het |
| Vmn2r50 |
A |
T |
7: 10,050,089 (GRCm38) |
W153R |
probably benign |
Het |
| Vwa3a |
T |
G |
7: 120,768,173 (GRCm38) |
S184A |
probably benign |
Het |
| Zbtb25 |
A |
G |
12: 76,349,164 (GRCm38) |
L428P |
possibly damaging |
Het |
| Zbtb49 |
C |
T |
5: 38,200,816 (GRCm38) |
D698N |
probably damaging |
Het |
| Zbtb8os |
T |
G |
4: 129,340,735 (GRCm38) |
D35E |
probably damaging |
Het |
| Zfp316 |
T |
C |
5: 143,264,491 (GRCm38) |
T56A |
unknown |
Het |
| Zfp334 |
A |
T |
2: 165,380,487 (GRCm38) |
C545* |
probably null |
Het |
| Zmiz1 |
C |
A |
14: 25,644,856 (GRCm38) |
S247R |
probably damaging |
Het |
| Zscan18 |
A |
G |
7: 12,775,381 (GRCm38) |
|
probably benign |
Het |
| Zzef1 |
T |
C |
11: 72,900,637 (GRCm38) |
V2189A |
probably damaging |
Het |
|
| Other mutations in Ncoa6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00484:Ncoa6
|
APN |
2 |
155,406,208 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL00849:Ncoa6
|
APN |
2 |
155,421,688 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
IGL00933:Ncoa6
|
APN |
2 |
155,415,397 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00981:Ncoa6
|
APN |
2 |
155,406,179 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01420:Ncoa6
|
APN |
2 |
155,407,587 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ncoa6
|
APN |
2 |
155,421,083 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
IGL03049:Ncoa6
|
APN |
2 |
155,419,014 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03194:Ncoa6
|
APN |
2 |
155,415,868 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL03269:Ncoa6
|
APN |
2 |
155,406,489 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL03299:Ncoa6
|
APN |
2 |
155,407,287 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL03306:Ncoa6
|
APN |
2 |
155,405,507 (GRCm38) |
missense |
probably benign |
0.30 |
|
alcoa
|
UTSW |
2 |
155,402,664 (GRCm38) |
unclassified |
probably benign |
|
|
Aluminum
|
UTSW |
2 |
155,399,693 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
balboa
|
UTSW |
2 |
155,406,949 (GRCm38) |
missense |
probably benign |
0.05 |
|
mauna_loa
|
UTSW |
2 |
155,415,227 (GRCm38) |
missense |
probably damaging |
0.99 |
|
PIT4466001:Ncoa6
|
UTSW |
2 |
155,405,657 (GRCm38) |
missense |
probably benign |
|
|
R0011:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0014:Ncoa6
|
UTSW |
2 |
155,438,043 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R0079:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0080:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0081:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0164:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0166:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0172:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0173:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0245:Ncoa6
|
UTSW |
2 |
155,391,211 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0284:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0285:Ncoa6
|
UTSW |
2 |
155,415,701 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0285:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0288:Ncoa6
|
UTSW |
2 |
155,408,291 (GRCm38) |
frame shift |
probably null |
|
|
R0539:Ncoa6
|
UTSW |
2 |
155,415,697 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0652:Ncoa6
|
UTSW |
2 |
155,391,211 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0781:Ncoa6
|
UTSW |
2 |
155,411,520 (GRCm38) |
splice site |
probably benign |
|
|
R1053:Ncoa6
|
UTSW |
2 |
155,434,040 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1110:Ncoa6
|
UTSW |
2 |
155,411,520 (GRCm38) |
splice site |
probably benign |
|
|
R1420:Ncoa6
|
UTSW |
2 |
155,421,153 (GRCm38) |
nonsense |
probably null |
|
|
R1521:Ncoa6
|
UTSW |
2 |
155,415,222 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R1541:Ncoa6
|
UTSW |
2 |
155,415,304 (GRCm38) |
missense |
probably benign |
0.35 |
|
R1677:Ncoa6
|
UTSW |
2 |
155,402,664 (GRCm38) |
unclassified |
probably benign |
|
|
R1858:Ncoa6
|
UTSW |
2 |
155,421,639 (GRCm38) |
missense |
probably benign |
0.13 |
|
R1954:Ncoa6
|
UTSW |
2 |
155,406,821 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1955:Ncoa6
|
UTSW |
2 |
155,406,821 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R2040:Ncoa6
|
UTSW |
2 |
155,406,080 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2087:Ncoa6
|
UTSW |
2 |
155,406,159 (GRCm38) |
nonsense |
probably null |
|
|
R2159:Ncoa6
|
UTSW |
2 |
155,407,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2278:Ncoa6
|
UTSW |
2 |
155,407,650 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R2696:Ncoa6
|
UTSW |
2 |
155,438,015 (GRCm38) |
missense |
probably benign |
0.45 |
|
R2891:Ncoa6
|
UTSW |
2 |
155,437,961 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R3618:Ncoa6
|
UTSW |
2 |
155,407,789 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R3747:Ncoa6
|
UTSW |
2 |
155,411,641 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3778:Ncoa6
|
UTSW |
2 |
155,421,195 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3784:Ncoa6
|
UTSW |
2 |
155,407,757 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3802:Ncoa6
|
UTSW |
2 |
155,405,564 (GRCm38) |
missense |
probably benign |
|
|
R3820:Ncoa6
|
UTSW |
2 |
155,406,938 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3821:Ncoa6
|
UTSW |
2 |
155,406,938 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3822:Ncoa6
|
UTSW |
2 |
155,406,938 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3870:Ncoa6
|
UTSW |
2 |
155,415,557 (GRCm38) |
splice site |
probably null |
|
|
R4037:Ncoa6
|
UTSW |
2 |
155,407,370 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4488:Ncoa6
|
UTSW |
2 |
155,407,476 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4719:Ncoa6
|
UTSW |
2 |
155,391,161 (GRCm38) |
unclassified |
probably benign |
|
|
R4732:Ncoa6
|
UTSW |
2 |
155,421,301 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4733:Ncoa6
|
UTSW |
2 |
155,421,301 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4829:Ncoa6
|
UTSW |
2 |
155,415,227 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4835:Ncoa6
|
UTSW |
2 |
155,407,133 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R4883:Ncoa6
|
UTSW |
2 |
155,406,767 (GRCm38) |
missense |
probably benign |
0.29 |
|
R4967:Ncoa6
|
UTSW |
2 |
155,421,332 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R5021:Ncoa6
|
UTSW |
2 |
155,406,949 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5234:Ncoa6
|
UTSW |
2 |
155,438,013 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5356:Ncoa6
|
UTSW |
2 |
155,421,192 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5358:Ncoa6
|
UTSW |
2 |
155,406,987 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5375:Ncoa6
|
UTSW |
2 |
155,433,995 (GRCm38) |
missense |
probably benign |
0.16 |
|
R5412:Ncoa6
|
UTSW |
2 |
155,407,781 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5618:Ncoa6
|
UTSW |
2 |
155,437,897 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R5641:Ncoa6
|
UTSW |
2 |
155,421,836 (GRCm38) |
missense |
probably benign |
0.22 |
|
R5757:Ncoa6
|
UTSW |
2 |
155,411,608 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5761:Ncoa6
|
UTSW |
2 |
155,408,141 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5778:Ncoa6
|
UTSW |
2 |
155,406,768 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5852:Ncoa6
|
UTSW |
2 |
155,405,499 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R5940:Ncoa6
|
UTSW |
2 |
155,415,865 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6155:Ncoa6
|
UTSW |
2 |
155,407,448 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6374:Ncoa6
|
UTSW |
2 |
155,421,156 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6389:Ncoa6
|
UTSW |
2 |
155,395,816 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6669:Ncoa6
|
UTSW |
2 |
155,399,693 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7097:Ncoa6
|
UTSW |
2 |
155,438,063 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7385:Ncoa6
|
UTSW |
2 |
155,407,801 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7963:Ncoa6
|
UTSW |
2 |
155,405,996 (GRCm38) |
missense |
probably benign |
0.30 |
|
R8356:Ncoa6
|
UTSW |
2 |
155,406,252 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R8698:Ncoa6
|
UTSW |
2 |
155,415,121 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8859:Ncoa6
|
UTSW |
2 |
155,406,468 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R8870:Ncoa6
|
UTSW |
2 |
155,421,158 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9041:Ncoa6
|
UTSW |
2 |
155,415,530 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R9062:Ncoa6
|
UTSW |
2 |
155,421,428 (GRCm38) |
missense |
probably benign |
0.42 |
|
R9088:Ncoa6
|
UTSW |
2 |
155,407,806 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9225:Ncoa6
|
UTSW |
2 |
155,407,521 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R9445:Ncoa6
|
UTSW |
2 |
155,408,143 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9497:Ncoa6
|
UTSW |
2 |
155,406,318 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9514:Ncoa6
|
UTSW |
2 |
155,406,213 (GRCm38) |
missense |
probably benign |
0.19 |
|
R9656:Ncoa6
|
UTSW |
2 |
155,432,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9720:Ncoa6
|
UTSW |
2 |
155,408,384 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9732:Ncoa6
|
UTSW |
2 |
155,402,716 (GRCm38) |
missense |
probably damaging |
0.99 |
|
RF033:Ncoa6
|
UTSW |
2 |
155,421,731 (GRCm38) |
small deletion |
probably benign |
|
|
RF040:Ncoa6
|
UTSW |
2 |
155,421,731 (GRCm38) |
small deletion |
probably benign |
|
|
RF048:Ncoa6
|
UTSW |
2 |
155,421,712 (GRCm38) |
small deletion |
probably benign |
|
|
X0017:Ncoa6
|
UTSW |
2 |
155,406,540 (GRCm38) |
missense |
probably benign |
0.05 |
|
Z1176:Ncoa6
|
UTSW |
2 |
155,421,302 (GRCm38) |
missense |
probably damaging |
0.99 |
|
Z1177:Ncoa6
|
UTSW |
2 |
155,421,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Ncoa6
|
UTSW |
2 |
155,406,142 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTGTTGACATCAATGCAGACTG -3'
(R):5'- TTCTTGACAACTCTGGAGCTCC -3'
Sequencing Primer
(F):5'- CAGACTGCAAGTGAGTTGGC -3'
(R):5'- GACAACTCTGGAGCTCCTAATGTG -3'
|
| Posted On |
2016-10-26 |
Incidental Mutation