Mutagenetix > Incidental Mutation

Incidental Mutation 'R5579:Itpr3'

438330

Institutional Source

Beutler Lab

Gene Symbol

Itpr3

Ensembl Gene

ENSMUSG00000042644

Gene Name

inositol 1,4,5-triphosphate receptor 3

Synonyms

Itpr-3, Ip3r3, tf

MMRRC Submission

043267-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5579 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

27276278-27341197 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 27332493 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 1779 (D1779G)

Ref Sequence

ENSEMBL: ENSMUSP00000038150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049308]

AlphaFold

P70227

PDB Structure

Crystal structure of the ligand binding suppressor domain of type 3 inositol 1,4,5-trisphosphate receptor [X-RAY DIFFRACTION]

Predicted Effect

probably damaging
Transcript: ENSMUST00000049308
AA Change: D1779G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000038150
Gene: ENSMUSG00000042644
AA Change: D1779G

Domain	Start	End	E-Value	Type
MIR	113	167	7.75e-6	SMART
MIR	174	224	1.16e-4	SMART
MIR	232	288	1.21e-7	SMART
MIR	295	402	9.38e-14	SMART
Pfam:RYDR_ITPR	473	670	7.8e-64	PFAM
low complexity region	881	889	N/A	INTRINSIC
Pfam:RYDR_ITPR	1175	1333	5.8e-16	PFAM
low complexity region	1549	1567	N/A	INTRINSIC
low complexity region	1831	1851	N/A	INTRINSIC
Pfam:RIH_assoc	1863	1973	2.6e-34	PFAM
transmembrane domain	2203	2225	N/A	INTRINSIC
Pfam:Ion_trans	2235	2527	8.1e-20	PFAM
coiled coil region	2631	2660	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 98.9%
20x: 97.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 114 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca3	G	T	17: 24,595,703 (GRCm39)	C352F	probably damaging	Het
Abce1	A	T	8: 80,427,215 (GRCm39)	I237N	possibly damaging	Het
Acrbp	A	G	6: 125,038,062 (GRCm39)	D421G	probably benign	Het
Adam8	T	A	7: 139,568,897 (GRCm39)	Y201F	probably benign	Het
Adgrf1	T	A	17: 43,621,955 (GRCm39)	C731S	probably damaging	Het
Akap8l	A	T	17: 32,540,916 (GRCm39)	I529N	probably damaging	Het
Akap9	G	A	5: 4,114,714 (GRCm39)	G114D	possibly damaging	Het
Alox12b	T	A	11: 69,053,758 (GRCm39)	D158E	probably benign	Het
Ankrd11	A	G	8: 123,610,970 (GRCm39)	S2639P	probably damaging	Het
Ankrd42	T	C	7: 92,239,390 (GRCm39)	Y466C	possibly damaging	Het
Apobr	T	C	7: 126,186,847 (GRCm39)	I786T	probably benign	Het
Arhgef12	C	T	9: 42,921,489 (GRCm39)	G329R	probably benign	Het
Btnl1	T	C	17: 34,600,526 (GRCm39)		probably null	Het
Ccdc174	A	G	6: 91,858,331 (GRCm39)		probably null	Het
Ccdc183	T	C	2: 25,505,434 (GRCm39)	D177G	possibly damaging	Het
Cd14	A	G	18: 36,859,288 (GRCm39)	Y56H	probably benign	Het
Cep162	G	A	9: 87,085,724 (GRCm39)	A1200V	probably benign	Het
Clic3	T	C	2: 25,348,319 (GRCm39)	L128P	probably damaging	Het
Cntnap5b	A	T	1: 100,311,120 (GRCm39)	R538*	probably null	Het
Cntnap5b	A	T	1: 100,311,124 (GRCm39)	Q539L	probably benign	Het
Coq7	A	T	7: 118,116,558 (GRCm39)	N214K	unknown	Het
Cramp1	G	A	17: 25,192,087 (GRCm39)	H1018Y	possibly damaging	Het
Crtac1	T	A	19: 42,293,245 (GRCm39)	D288V	probably damaging	Het
Dab2ip	C	T	2: 35,605,339 (GRCm39)	R132*	probably null	Het
Dis3l	C	A	9: 64,238,117 (GRCm39)	C125F	probably benign	Het
Dnmt1	A	T	9: 20,831,501 (GRCm39)	V543D	probably damaging	Het
Dock9	A	T	14: 121,837,107 (GRCm39)	L67Q	probably damaging	Het
Ehbp1	A	T	11: 22,087,846 (GRCm39)	S413T	probably damaging	Het
Endov	A	G	11: 119,395,923 (GRCm39)	I158V	probably benign	Het
Epb41l4b	A	G	4: 57,064,802 (GRCm39)	V469A	possibly damaging	Het
Etf1	G	A	18: 35,046,654 (GRCm39)	P119S	probably damaging	Het
Fam135a	A	G	1: 24,068,808 (GRCm39)	L491P	possibly damaging	Het
Fancd2	A	T	6: 113,537,012 (GRCm39)		probably null	Het
Fank1	T	A	7: 133,471,058 (GRCm39)		probably null	Het
Fbh1	A	G	2: 11,753,804 (GRCm39)	I846T	probably damaging	Het
Gas2l3	T	C	10: 89,249,928 (GRCm39)	T397A	probably benign	Het
Gga1	T	C	15: 78,777,388 (GRCm39)	V513A	probably damaging	Het
Ggt1	T	C	10: 75,421,782 (GRCm39)	V543A	probably damaging	Het
Gm11596	A	T	11: 99,683,717 (GRCm39)	C134*	probably null	Het
Gnal	C	T	18: 67,221,842 (GRCm39)	R82C	unknown	Het
Hat1	T	C	2: 71,240,582 (GRCm39)	V92A	possibly damaging	Het
Icosl	C	T	10: 77,909,597 (GRCm39)	R181C	probably damaging	Het
Ift46	A	G	9: 44,698,160 (GRCm39)	M208V	possibly damaging	Het
Ighv1-26	T	C	12: 114,752,219 (GRCm39)	K42E	possibly damaging	Het
Ipo5	A	G	14: 121,176,025 (GRCm39)	K617E	probably benign	Het
Irx5	A	G	8: 93,086,541 (GRCm39)	D208G	probably benign	Het
Itgal	T	G	7: 126,906,101 (GRCm39)	V397G	probably benign	Het
Itpr2	G	A	6: 146,074,864 (GRCm39)	R2297*	probably null	Het
Khdc4	T	C	3: 88,607,582 (GRCm39)	S345P	probably benign	Het
Krt4	T	A	15: 101,829,669 (GRCm39)	E286D	probably benign	Het
Loxl4	C	T	19: 42,592,729 (GRCm39)	G317E	probably damaging	Het
Mapk6	T	G	9: 75,295,344 (GRCm39)	H718P	possibly damaging	Het
Mark2	A	C	19: 7,260,181 (GRCm39)	V14G	probably damaging	Het
Mbd5	A	G	2: 49,162,826 (GRCm39)	T1103A	possibly damaging	Het
Mcph1	A	G	8: 18,682,309 (GRCm39)	E482G	probably benign	Het
Mme	G	A	3: 63,256,066 (GRCm39)	E509K	probably damaging	Het
Mrgbp	A	G	2: 180,227,276 (GRCm39)	T204A	probably damaging	Het
Mycbp2	A	T	14: 103,528,769 (GRCm39)	F430I	probably damaging	Het
Myo6	A	G	9: 80,125,002 (GRCm39)	D27G	probably damaging	Het
Ncoa6	A	G	2: 155,248,597 (GRCm39)	L1569S	probably damaging	Het
Ndc1	T	A	4: 107,237,901 (GRCm39)	F235Y	possibly damaging	Het
Nmur2	A	T	11: 55,923,835 (GRCm39)	S240T	probably benign	Het
Or14c44	T	A	7: 86,061,934 (GRCm39)	Y121*	probably null	Het
Or52ae7	G	A	7: 103,120,121 (GRCm39)	V292M	probably damaging	Het
Or5d46	A	T	2: 88,170,757 (GRCm39)	I283F	possibly damaging	Het
Osbpl1a	G	T	18: 12,974,249 (GRCm39)	A62E	probably damaging	Het
Osbpl1a	A	C	18: 13,025,319 (GRCm39)	S333A	probably benign	Het
Otud4	C	T	8: 80,390,737 (GRCm39)	T417I	probably benign	Het
Pagr1a	T	C	7: 126,614,614 (GRCm39)	E197G	probably damaging	Het
Pcdh18	T	C	3: 49,699,426 (GRCm39)	Q1012R	probably damaging	Het
Pcdhgb5	A	C	18: 37,864,690 (GRCm39)	I162L	probably benign	Het
Pdpr	T	A	8: 111,850,448 (GRCm39)	Y462N	probably damaging	Het
Pkhd1	A	T	1: 20,593,366 (GRCm39)	H1582Q	probably damaging	Het
Polr1b	A	G	2: 128,952,028 (GRCm39)	K352R	probably damaging	Het
Poteg	G	A	8: 27,938,065 (GRCm39)	V12M	probably damaging	Het
Pou2f1	A	C	1: 165,742,731 (GRCm39)	V54G	probably damaging	Het
Ppme1	A	G	7: 99,994,182 (GRCm39)	L177P	probably damaging	Het
Prkce	A	G	17: 86,927,376 (GRCm39)	D550G	probably damaging	Het
Prrc2c	A	G	1: 162,508,327 (GRCm39)		probably null	Het
Ptpn22	A	G	3: 103,789,455 (GRCm39)		probably null	Het
Rabif	G	A	1: 134,433,943 (GRCm39)	V86M	probably damaging	Het
Rbm25	T	A	12: 83,715,281 (GRCm39)	M484K	probably benign	Het
Rcn2	G	A	9: 55,964,713 (GRCm39)	A224T	probably benign	Het
Rexo5	T	A	7: 119,433,626 (GRCm39)		probably null	Het
Rnase1	A	T	14: 51,383,219 (GRCm39)	I45N	probably benign	Het
Rnmt	T	A	18: 68,439,186 (GRCm39)	D98E	possibly damaging	Het
Rprd2	A	G	3: 95,692,371 (GRCm39)	F188L	probably damaging	Het
Scube2	G	A	7: 109,409,944 (GRCm39)	T643M	probably damaging	Het
Skic3	T	C	13: 76,333,319 (GRCm39)	W25R	probably damaging	Het
Slc7a15	T	C	12: 8,589,344 (GRCm39)	I68V	probably benign	Het
Slco1a5	A	T	6: 142,187,851 (GRCm39)	V496D	possibly damaging	Het
Slitrk6	T	G	14: 110,988,649 (GRCm39)	S353R	possibly damaging	Het
Smpd5	T	A	15: 76,179,325 (GRCm39)	I53K	possibly damaging	Het
Tas2r108	T	C	6: 40,471,021 (GRCm39)	S166P	probably benign	Het
Tcstv7a	T	A	13: 120,289,951 (GRCm39)	M82L	probably benign	Het
Tecpr1	C	A	5: 144,151,162 (GRCm39)	V245L	possibly damaging	Het
Tenm3	G	T	8: 48,689,799 (GRCm39)	N1929K	probably damaging	Het
Tigd5	T	G	15: 75,782,874 (GRCm39)	F412C	probably damaging	Het
Timm17a	A	T	1: 135,233,926 (GRCm39)	S74T	possibly damaging	Het
Tle1	A	T	4: 72,058,045 (GRCm39)	L60Q	probably damaging	Het
Tmem132d	T	C	5: 127,873,064 (GRCm39)	E515G	possibly damaging	Het
Tmem65	T	C	15: 58,666,246 (GRCm39)	N115S	probably benign	Het
Trmt5	C	A	12: 73,328,426 (GRCm39)	R259L	possibly damaging	Het
Trmt9b	T	C	8: 36,979,195 (GRCm39)	V266A	probably benign	Het
Vmn2r50	A	T	7: 9,784,016 (GRCm39)	W153R	probably benign	Het
Vwa3a	T	G	7: 120,367,396 (GRCm39)	S184A	probably benign	Het
Zbtb25	A	G	12: 76,395,938 (GRCm39)	L428P	possibly damaging	Het
Zbtb49	C	T	5: 38,358,160 (GRCm39)	D698N	probably damaging	Het
Zbtb8os	T	G	4: 129,234,528 (GRCm39)	D35E	probably damaging	Het
Zfp316	T	C	5: 143,250,246 (GRCm39)	T56A	unknown	Het
Zfp334	A	T	2: 165,222,407 (GRCm39)	C545*	probably null	Het
Zmiz1	C	A	14: 25,645,280 (GRCm39)	S247R	probably damaging	Het
Zscan18	A	G	7: 12,509,308 (GRCm39)		probably benign	Het
Zzef1	T	C	11: 72,791,463 (GRCm39)	V2189A	probably damaging	Het

Other mutations in Itpr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00715:Itpr3	APN	17	27,302,603 (GRCm39)	missense	probably benign	0.05
IGL00980:Itpr3	APN	17	27,329,930 (GRCm39)	missense	probably benign
IGL01151:Itpr3	APN	17	27,310,503 (GRCm39)	missense	probably damaging	1.00
IGL01289:Itpr3	APN	17	27,318,739 (GRCm39)	missense	probably damaging	0.99
IGL01403:Itpr3	APN	17	27,337,569 (GRCm39)	missense	probably damaging	0.97
IGL01666:Itpr3	APN	17	27,336,152 (GRCm39)	missense	probably benign	0.02
IGL01897:Itpr3	APN	17	27,330,236 (GRCm39)	missense	probably damaging	1.00
IGL02003:Itpr3	APN	17	27,340,449 (GRCm39)	missense	probably damaging	1.00
IGL02012:Itpr3	APN	17	27,323,069 (GRCm39)	missense	probably benign
IGL02063:Itpr3	APN	17	27,338,997 (GRCm39)	missense	probably benign	0.01
IGL02146:Itpr3	APN	17	27,336,249 (GRCm39)	missense	probably damaging	1.00
IGL02158:Itpr3	APN	17	27,317,416 (GRCm39)	missense	probably damaging	1.00
IGL02177:Itpr3	APN	17	27,318,588 (GRCm39)	missense	possibly damaging	0.74
IGL02247:Itpr3	APN	17	27,317,153 (GRCm39)	missense	probably damaging	1.00
IGL02606:Itpr3	APN	17	27,333,486 (GRCm39)	splice site	probably benign
IGL02651:Itpr3	APN	17	27,325,372 (GRCm39)	missense	probably damaging	0.99
IGL02902:Itpr3	APN	17	27,323,530 (GRCm39)	missense	probably benign	0.21
IGL03001:Itpr3	APN	17	27,308,586 (GRCm39)	splice site	probably benign
IGL03004:Itpr3	APN	17	27,316,952 (GRCm39)	missense	possibly damaging	0.90
IGL03065:Itpr3	APN	17	27,310,907 (GRCm39)	missense	probably damaging	1.00
IGL03117:Itpr3	APN	17	27,338,240 (GRCm39)	missense	probably damaging	1.00
IGL03181:Itpr3	APN	17	27,330,242 (GRCm39)	missense	probably benign
IGL03404:Itpr3	APN	17	27,310,492 (GRCm39)	missense	probably damaging	1.00
Allure	UTSW	17	27,326,277 (GRCm39)	missense	probably damaging	1.00
alopecia	UTSW	17	27,314,452 (GRCm39)	missense	probably damaging	0.98
Beauty	UTSW	17	27,325,316 (GRCm39)	missense	probably damaging	1.00
Opuesto	UTSW	17	27,306,566 (GRCm39)	missense	probably damaging	1.00
Paradox	UTSW	17	27,317,145 (GRCm39)	missense	probably damaging	1.00
Pulchritude	UTSW	17	27,305,934 (GRCm39)	missense	probably damaging	0.97
R0010:Itpr3	UTSW	17	27,339,951 (GRCm39)	missense	probably damaging	1.00
R0055:Itpr3	UTSW	17	27,317,296 (GRCm39)	missense	probably damaging	1.00
R0068:Itpr3	UTSW	17	27,323,034 (GRCm39)	splice site	probably benign
R0068:Itpr3	UTSW	17	27,323,034 (GRCm39)	splice site	probably benign
R0104:Itpr3	UTSW	17	27,314,966 (GRCm39)	missense	probably benign	0.01
R0195:Itpr3	UTSW	17	27,333,088 (GRCm39)	missense	probably damaging	1.00
R0212:Itpr3	UTSW	17	27,308,293 (GRCm39)	missense	probably damaging	1.00
R0454:Itpr3	UTSW	17	27,332,793 (GRCm39)	missense	probably benign
R0485:Itpr3	UTSW	17	27,330,903 (GRCm39)	missense	probably damaging	0.98
R0501:Itpr3	UTSW	17	27,326,263 (GRCm39)	missense	probably benign	0.09
R0781:Itpr3	UTSW	17	27,329,529 (GRCm39)	missense	probably benign	0.00
R0890:Itpr3	UTSW	17	27,307,985 (GRCm39)	nonsense	probably null
R1028:Itpr3	UTSW	17	27,310,343 (GRCm39)	missense	probably benign	0.04
R1144:Itpr3	UTSW	17	27,333,897 (GRCm39)	missense	probably benign	0.01
R1347:Itpr3	UTSW	17	27,330,535 (GRCm39)	missense	probably benign	0.02
R1347:Itpr3	UTSW	17	27,330,535 (GRCm39)	missense	probably benign	0.02
R1458:Itpr3	UTSW	17	27,337,346 (GRCm39)	missense	probably benign	0.01
R1463:Itpr3	UTSW	17	27,336,128 (GRCm39)	splice site	probably benign
R1472:Itpr3	UTSW	17	27,333,199 (GRCm39)	missense	probably benign	0.09
R1529:Itpr3	UTSW	17	27,324,459 (GRCm39)	splice site	probably null
R1533:Itpr3	UTSW	17	27,314,534 (GRCm39)	missense	possibly damaging	0.71
R1537:Itpr3	UTSW	17	27,333,121 (GRCm39)	missense	possibly damaging	0.96
R1618:Itpr3	UTSW	17	27,335,581 (GRCm39)	critical splice acceptor site	probably null
R1672:Itpr3	UTSW	17	27,307,987 (GRCm39)	missense	probably benign
R1726:Itpr3	UTSW	17	27,330,664 (GRCm39)	missense	probably damaging	0.96
R1865:Itpr3	UTSW	17	27,338,997 (GRCm39)	missense	probably benign	0.01
R1940:Itpr3	UTSW	17	27,330,191 (GRCm39)	missense	probably damaging	1.00
R2023:Itpr3	UTSW	17	27,321,785 (GRCm39)	missense	possibly damaging	0.76
R2063:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2064:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2065:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2067:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2068:Itpr3	UTSW	17	27,317,050 (GRCm39)	missense	probably benign	0.19
R2219:Itpr3	UTSW	17	27,334,027 (GRCm39)	missense	probably benign
R2248:Itpr3	UTSW	17	27,334,033 (GRCm39)	missense	probably damaging	1.00
R2291:Itpr3	UTSW	17	27,332,553 (GRCm39)	missense	possibly damaging	0.92
R2320:Itpr3	UTSW	17	27,314,889 (GRCm39)	missense	probably benign
R2864:Itpr3	UTSW	17	27,310,525 (GRCm39)	missense	probably benign	0.01
R2865:Itpr3	UTSW	17	27,310,525 (GRCm39)	missense	probably benign	0.01
R3778:Itpr3	UTSW	17	27,314,446 (GRCm39)	missense	possibly damaging	0.57
R3881:Itpr3	UTSW	17	27,332,814 (GRCm39)	missense	probably benign	0.01
R3979:Itpr3	UTSW	17	27,310,546 (GRCm39)	missense	probably damaging	1.00
R3979:Itpr3	UTSW	17	27,304,105 (GRCm39)	missense	probably benign	0.23
R4224:Itpr3	UTSW	17	27,326,232 (GRCm39)	missense	probably damaging	1.00
R4259:Itpr3	UTSW	17	27,325,298 (GRCm39)	missense	probably damaging	1.00
R4321:Itpr3	UTSW	17	27,330,948 (GRCm39)	missense	probably benign	0.00
R4466:Itpr3	UTSW	17	27,325,316 (GRCm39)	missense	probably damaging	1.00
R4493:Itpr3	UTSW	17	27,323,586 (GRCm39)	missense	probably damaging	1.00
R4597:Itpr3	UTSW	17	27,312,257 (GRCm39)	missense	probably damaging	1.00
R4823:Itpr3	UTSW	17	27,304,121 (GRCm39)	missense	probably benign	0.30
R4921:Itpr3	UTSW	17	27,316,979 (GRCm39)	missense	probably damaging	1.00
R4974:Itpr3	UTSW	17	27,302,582 (GRCm39)	missense	probably damaging	0.96
R5063:Itpr3	UTSW	17	27,308,885 (GRCm39)	missense	possibly damaging	0.94
R5079:Itpr3	UTSW	17	27,317,397 (GRCm39)	missense	probably damaging	1.00
R5303:Itpr3	UTSW	17	27,335,663 (GRCm39)	missense	probably benign	0.38
R5518:Itpr3	UTSW	17	27,306,566 (GRCm39)	missense	probably damaging	1.00
R5521:Itpr3	UTSW	17	27,326,308 (GRCm39)	missense	probably benign	0.09
R5566:Itpr3	UTSW	17	27,334,926 (GRCm39)	missense	possibly damaging	0.71
R5567:Itpr3	UTSW	17	27,322,880 (GRCm39)	missense	possibly damaging	0.66
R5610:Itpr3	UTSW	17	27,337,540 (GRCm39)	missense	probably benign	0.42
R5658:Itpr3	UTSW	17	27,326,852 (GRCm39)	missense	possibly damaging	0.74
R5856:Itpr3	UTSW	17	27,325,379 (GRCm39)	missense	probably damaging	1.00
R5872:Itpr3	UTSW	17	27,305,950 (GRCm39)	missense	probably benign	0.02
R5878:Itpr3	UTSW	17	27,329,836 (GRCm39)	missense	probably benign	0.01
R5889:Itpr3	UTSW	17	27,334,039 (GRCm39)	missense	probably damaging	0.99
R5907:Itpr3	UTSW	17	27,336,867 (GRCm39)	missense	probably damaging	1.00
R5930:Itpr3	UTSW	17	27,329,895 (GRCm39)	missense	possibly damaging	0.49
R5987:Itpr3	UTSW	17	27,323,575 (GRCm39)	missense	probably damaging	1.00
R6029:Itpr3	UTSW	17	27,317,145 (GRCm39)	missense	probably damaging	1.00
R6195:Itpr3	UTSW	17	27,305,934 (GRCm39)	missense	probably damaging	0.97
R6213:Itpr3	UTSW	17	27,330,174 (GRCm39)	missense	probably benign	0.03
R6233:Itpr3	UTSW	17	27,305,934 (GRCm39)	missense	probably damaging	0.97
R6376:Itpr3	UTSW	17	27,314,449 (GRCm39)	missense	possibly damaging	0.94
R6514:Itpr3	UTSW	17	27,310,344 (GRCm39)	missense	probably benign
R6515:Itpr3	UTSW	17	27,310,344 (GRCm39)	missense	probably benign
R6516:Itpr3	UTSW	17	27,310,344 (GRCm39)	missense	probably benign
R6955:Itpr3	UTSW	17	27,340,441 (GRCm39)	missense	probably damaging	1.00
R7002:Itpr3	UTSW	17	27,329,554 (GRCm39)	missense	probably benign	0.00
R7064:Itpr3	UTSW	17	27,308,269 (GRCm39)	missense	probably damaging	1.00
R7257:Itpr3	UTSW	17	27,337,535 (GRCm39)	missense	probably benign	0.00
R7349:Itpr3	UTSW	17	27,326,786 (GRCm39)	splice site	probably null
R7469:Itpr3	UTSW	17	27,340,028 (GRCm39)	missense	possibly damaging	0.74
R7493:Itpr3	UTSW	17	27,313,774 (GRCm39)	missense	probably benign	0.09
R7510:Itpr3	UTSW	17	27,308,013 (GRCm39)	missense	probably damaging	0.97
R7565:Itpr3	UTSW	17	27,329,862 (GRCm39)	missense	probably benign	0.01
R7616:Itpr3	UTSW	17	27,307,951 (GRCm39)	missense	probably damaging	1.00
R7728:Itpr3	UTSW	17	27,317,088 (GRCm39)	missense	probably damaging	1.00
R7779:Itpr3	UTSW	17	27,315,037 (GRCm39)	missense	probably damaging	1.00
R7788:Itpr3	UTSW	17	27,337,571 (GRCm39)	nonsense	probably null
R7871:Itpr3	UTSW	17	27,336,153 (GRCm39)	missense	probably damaging	1.00
R7889:Itpr3	UTSW	17	27,335,751 (GRCm39)	missense	probably damaging	1.00
R7966:Itpr3	UTSW	17	27,331,002 (GRCm39)	critical splice donor site	probably null
R8065:Itpr3	UTSW	17	27,329,836 (GRCm39)	missense	probably benign	0.01
R8067:Itpr3	UTSW	17	27,329,836 (GRCm39)	missense	probably benign	0.01
R8230:Itpr3	UTSW	17	27,326,711 (GRCm39)	critical splice donor site	probably null
R8263:Itpr3	UTSW	17	27,334,887 (GRCm39)	nonsense	probably null
R8264:Itpr3	UTSW	17	27,323,086 (GRCm39)	synonymous	silent
R8269:Itpr3	UTSW	17	27,312,258 (GRCm39)	missense	possibly damaging	0.60
R8271:Itpr3	UTSW	17	27,306,622 (GRCm39)	missense	probably damaging	1.00
R8316:Itpr3	UTSW	17	27,325,199 (GRCm39)	missense	possibly damaging	0.50
R8354:Itpr3	UTSW	17	27,334,893 (GRCm39)	missense	possibly damaging	0.74
R8413:Itpr3	UTSW	17	27,330,900 (GRCm39)	missense	probably damaging	1.00
R8437:Itpr3	UTSW	17	27,326,277 (GRCm39)	missense	probably damaging	1.00
R8676:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8679:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8846:Itpr3	UTSW	17	27,330,996 (GRCm39)	missense	probably damaging	1.00
R8884:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8885:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8886:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8887:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8888:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8891:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8896:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R8975:Itpr3	UTSW	17	27,335,628 (GRCm39)	missense	possibly damaging	0.56
R9025:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9026:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9063:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9087:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9088:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9089:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9090:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9091:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9200:Itpr3	UTSW	17	27,326,636 (GRCm39)	missense	probably damaging	0.99
R9270:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9271:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9294:Itpr3	UTSW	17	27,330,191 (GRCm39)	missense	probably damaging	1.00
R9389:Itpr3	UTSW	17	27,314,899 (GRCm39)	missense	possibly damaging	0.84
R9433:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9434:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9443:Itpr3	UTSW	17	27,324,523 (GRCm39)	missense	probably damaging	1.00
R9472:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9474:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9475:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9476:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9477:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9507:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9508:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9511:Itpr3	UTSW	17	27,337,651 (GRCm39)	unclassified	probably benign
R9694:Itpr3	UTSW	17	27,334,927 (GRCm39)	missense	probably damaging	0.99
R9789:Itpr3	UTSW	17	27,308,915 (GRCm39)	missense	probably benign	0.15
V7732:Itpr3	UTSW	17	27,330,000 (GRCm39)	splice site	probably null
V7732:Itpr3	UTSW	17	27,329,998 (GRCm39)	splice site	probably benign
Z1088:Itpr3	UTSW	17	27,332,502 (GRCm39)	missense	possibly damaging	0.50
Z1177:Itpr3	UTSW	17	27,338,961 (GRCm39)	missense	probably damaging	1.00
Z1177:Itpr3	UTSW	17	27,333,903 (GRCm39)	missense	probably damaging	1.00
Z31818:Itpr3	UTSW	17	27,314,452 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- CCTCTGGGAGTGCATATGTC -3'
(R):5'- GTACCCCATACCCTGTATATATCTG -3'

Sequencing Primer
(F):5'- GCACTGAGTGTTGTTCTCAAAC -3'
(R):5'- ATACCCTGTATATATCTGCCCGGAG -3'

Posted On

2016-10-26