Incidental Mutation 'R5580:Vmn1r83'
ID 438388
Institutional Source Beutler Lab
Gene Symbol Vmn1r83
Ensembl Gene ENSMUSG00000066804
Gene Name vomeronasal 1 receptor 83
Synonyms V1rg8
MMRRC Submission 043134-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R5580 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 12054177-12056055 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 12055800 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 86 (I86L)
Ref Sequence ENSEMBL: ENSMUSP00000154521 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086229] [ENSMUST00000226701]
AlphaFold Q8R287
Predicted Effect probably benign
Transcript: ENSMUST00000086229
AA Change: I86L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000083406
Gene: ENSMUSG00000066804
AA Change: I86L

DomainStartEndE-ValueType
Pfam:TAS2R 1 303 1.3e-8 PFAM
Pfam:V1R 26 299 1.7e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226701
AA Change: I86L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 102 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410002F23Rik A G 7: 43,900,664 (GRCm39) T73A possibly damaging Het
A1bg A T 15: 60,790,881 (GRCm39) V365E probably benign Het
Abcg5 A C 17: 84,967,582 (GRCm39) V406G probably damaging Het
Adamts12 A G 15: 11,152,086 (GRCm39) Y192C probably benign Het
Add3 C T 19: 53,233,642 (GRCm39) S649L probably damaging Het
Adgrg6 A T 10: 14,286,228 (GRCm39) C1129* probably null Het
Arsb T A 13: 93,944,053 (GRCm39) V248D probably damaging Het
AW554918 A T 18: 25,472,922 (GRCm39) N39I probably damaging Het
Cacna1b A T 2: 24,540,566 (GRCm39) I1383N probably damaging Het
Caprin2 A T 6: 148,760,232 (GRCm39) V625D possibly damaging Het
Cd9 A G 6: 125,441,420 (GRCm39) L67P probably damaging Het
Cdh5 T A 8: 104,852,126 (GRCm39) Y80* probably null Het
Csf2ra A G 19: 61,214,655 (GRCm39) L223P probably damaging Het
Cyp2c67 T C 19: 39,604,094 (GRCm39) K421E probably damaging Het
Dzank1 T C 2: 144,348,098 (GRCm39) R223G probably damaging Het
Emilin2 A G 17: 71,582,225 (GRCm39) V167A probably benign Het
Eps8l3 A G 3: 107,788,919 (GRCm39) T81A probably damaging Het
Esrra T C 19: 6,897,755 (GRCm39) M1V probably null Het
Evpl C A 11: 116,125,058 (GRCm39) A135S probably benign Het
Fam193a A G 5: 34,578,132 (GRCm39) I209V probably benign Het
Fbxl19 C A 7: 127,350,168 (GRCm39) C253* probably null Het
Fer1l5 T A 1: 36,424,539 (GRCm39) Y305* probably null Het
Fzd2 A C 11: 102,496,665 (GRCm39) I370L probably damaging Het
Gnl3 T C 14: 30,737,242 (GRCm39) K212R probably benign Het
Golm1 A G 13: 59,790,179 (GRCm39) L207P probably benign Het
Gphn T A 12: 78,538,818 (GRCm39) F155I probably damaging Het
Grhl1 G A 12: 24,659,739 (GRCm39) G500S probably benign Het
Gucd1 C A 10: 75,346,968 (GRCm39) G55V possibly damaging Het
Haus6 A T 4: 86,517,503 (GRCm39) I287K possibly damaging Het
Hmcn1 G A 1: 150,453,290 (GRCm39) P5342S probably benign Het
Hspa12a A G 19: 58,788,092 (GRCm39) S577P probably benign Het
Ido2 T A 8: 25,040,882 (GRCm39) I113F possibly damaging Het
Ifrd2 C T 9: 107,469,511 (GRCm39) P396S probably damaging Het
Igkv4-86 T A 6: 68,887,990 (GRCm39) probably benign Het
Ipo11 A G 13: 107,037,255 (GRCm39) V196A probably benign Het
Itih2 T C 2: 10,128,287 (GRCm39) E138G probably damaging Het
Kidins220 T G 12: 25,097,896 (GRCm39) C1179G probably benign Het
Kif20b T A 19: 34,927,128 (GRCm39) probably null Het
Klk1 T A 7: 43,878,238 (GRCm39) Y63N probably benign Het
L3mbtl3 T G 10: 26,179,604 (GRCm39) D517A unknown Het
Lars1 G T 18: 42,347,916 (GRCm39) P969H probably damaging Het
Lrp1 C T 10: 127,424,389 (GRCm39) V766I probably benign Het
Lrrc8c A G 5: 105,755,553 (GRCm39) I443V probably benign Het
Lsg1 T C 16: 30,387,985 (GRCm39) M439V probably null Het
Magi2 T A 5: 20,420,422 (GRCm39) M286K probably benign Het
Med11 T C 11: 70,342,891 (GRCm39) probably null Het
Med13l A G 5: 118,889,695 (GRCm39) K1819E possibly damaging Het
Ms4a14 T A 19: 11,280,590 (GRCm39) Q656L probably benign Het
Muc5b A G 7: 141,415,084 (GRCm39) T2677A possibly damaging Het
Myo7a A T 7: 97,722,367 (GRCm39) L1186H probably damaging Het
Naca C A 10: 127,876,462 (GRCm39) probably benign Het
Nbeal1 T C 1: 60,281,761 (GRCm39) I828T probably benign Het
Ncor1 A T 11: 62,280,604 (GRCm39) C75* probably null Het
Nepn A C 10: 52,280,398 (GRCm39) S497R probably damaging Het
Nf2 A G 11: 4,753,689 (GRCm39) F222L probably damaging Het
Nlrp9b A C 7: 19,757,089 (GRCm39) T109P probably damaging Het
Nr1h4 A T 10: 89,352,302 (GRCm39) F22I probably benign Het
Ogg1 A G 6: 113,306,337 (GRCm39) Y178C probably damaging Het
Or1e22 G T 11: 73,377,036 (GRCm39) P205T probably benign Het
Or4b12 C A 2: 90,096,694 (GRCm39) V27L probably benign Het
Or5b119 T A 19: 13,456,791 (GRCm39) Y257F probably damaging Het
Or5b21 G A 19: 12,839,168 (GRCm39) V10M possibly damaging Het
Or5d14 A T 2: 87,880,668 (GRCm39) M100K possibly damaging Het
Osr1 G A 12: 9,629,325 (GRCm39) R66Q probably damaging Het
Pi4ka A G 16: 17,098,951 (GRCm39) S1978P probably damaging Het
Pik3c2g A T 6: 139,603,531 (GRCm39) Q239L probably damaging Het
Pin1rt1 A G 2: 104,544,670 (GRCm39) I154T probably damaging Het
Pkdcc A G 17: 83,527,511 (GRCm39) T230A probably damaging Het
Por A T 5: 135,762,675 (GRCm39) I430F probably damaging Het
Prb1c T C 6: 132,338,432 (GRCm39) N262S unknown Het
Prkcsh T A 9: 21,922,551 (GRCm39) probably null Het
Pros1 A G 16: 62,746,689 (GRCm39) probably null Het
Pus10 T A 11: 23,622,556 (GRCm39) L59I probably benign Het
Pxmp2 A G 5: 110,431,542 (GRCm39) V67A possibly damaging Het
Rab3gap1 C A 1: 127,858,727 (GRCm39) A612E probably benign Het
Rpap2 A G 5: 107,768,011 (GRCm39) E206G probably benign Het
Rpl31 C T 1: 39,409,108 (GRCm39) R41C probably benign Het
Ryr3 C T 2: 112,672,293 (GRCm39) G1393R probably damaging Het
Scara5 T C 14: 65,968,528 (GRCm39) M267T probably benign Het
Sema5a A T 15: 32,575,031 (GRCm39) I380F probably benign Het
Slc36a3 A G 11: 55,026,279 (GRCm39) S180P probably benign Het
Slc44a5 A G 3: 153,966,922 (GRCm39) K536R probably benign Het
Smg1 T C 7: 117,748,125 (GRCm39) probably benign Het
Spata31d1e A T 13: 59,890,070 (GRCm39) D583E probably benign Het
Strc T C 2: 121,205,493 (GRCm39) K879R probably damaging Het
Swt1 T C 1: 151,260,206 (GRCm39) E731G probably benign Het
Syngap1 G A 17: 27,181,305 (GRCm39) A9T probably damaging Het
Tex15 C T 8: 34,062,457 (GRCm39) T903I probably damaging Het
Tg A G 15: 66,557,149 (GRCm39) I937V possibly damaging Het
Tm9sf4 T C 2: 153,024,350 (GRCm39) Y58H probably damaging Het
Tsen2 A T 6: 115,554,941 (GRCm39) D458V probably damaging Het
Ttn T A 2: 76,748,146 (GRCm39) D4301V probably benign Het
Txk C A 5: 72,864,932 (GRCm39) L314F probably damaging Het
Ube3b A G 5: 114,553,384 (GRCm39) T919A probably benign Het
Ubn2 A G 6: 38,460,187 (GRCm39) M641V probably damaging Het
Usp4 C T 9: 108,243,058 (GRCm39) T242I probably benign Het
Usp53 A G 3: 122,727,883 (GRCm39) S900P probably benign Het
Vmn1r225 T C 17: 20,723,101 (GRCm39) Y181H probably damaging Het
Vmn2r65 T C 7: 84,596,802 (GRCm39) I84M probably damaging Het
Vstm2b A G 7: 40,552,050 (GRCm39) H126R probably damaging Het
Zfp524 A T 7: 5,021,416 (GRCm39) I315F probably benign Het
Zfp975 A T 7: 42,314,513 (GRCm39) L20* probably null Het
Other mutations in Vmn1r83
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01371:Vmn1r83 APN 7 12,055,160 (GRCm39) missense probably benign 0.10
IGL01447:Vmn1r83 APN 7 12,055,424 (GRCm39) missense probably benign
IGL01793:Vmn1r83 APN 7 12,055,504 (GRCm39) missense probably benign 0.02
IGL02137:Vmn1r83 APN 7 12,055,761 (GRCm39) missense probably damaging 1.00
IGL03155:Vmn1r83 APN 7 12,055,617 (GRCm39) missense probably benign
IGL03182:Vmn1r83 APN 7 12,055,617 (GRCm39) missense probably benign
R0627:Vmn1r83 UTSW 7 12,055,919 (GRCm39) missense probably damaging 0.99
R1511:Vmn1r83 UTSW 7 12,055,197 (GRCm39) missense possibly damaging 0.87
R3882:Vmn1r83 UTSW 7 12,055,329 (GRCm39) missense probably damaging 1.00
R4613:Vmn1r83 UTSW 7 12,055,695 (GRCm39) missense probably benign 0.00
R4678:Vmn1r83 UTSW 7 12,055,697 (GRCm39) missense possibly damaging 0.67
R6982:Vmn1r83 UTSW 7 12,055,763 (GRCm39) missense probably damaging 1.00
R7440:Vmn1r83 UTSW 7 12,055,556 (GRCm39) missense probably damaging 1.00
R7476:Vmn1r83 UTSW 7 12,055,542 (GRCm39) missense possibly damaging 0.93
R7522:Vmn1r83 UTSW 7 12,055,505 (GRCm39) missense possibly damaging 0.61
R7759:Vmn1r83 UTSW 7 12,055,360 (GRCm39) missense probably benign 0.06
R8886:Vmn1r83 UTSW 7 12,055,843 (GRCm39) missense probably benign 0.10
R9077:Vmn1r83 UTSW 7 12,055,571 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGGCGTCATAATGTTTAGAAGC -3'
(R):5'- CCCAGATTGTCATGGGAATGC -3'

Sequencing Primer
(F):5'- CGTCATAATGTTTAGAAGCAGGTGC -3'
(R):5'- CATGGGAATGCTTGGCAATTCCTC -3'
Posted On 2016-10-26