Incidental Mutation 'R5582:Vmn1r69'
ID 438500
Institutional Source Beutler Lab
Gene Symbol Vmn1r69
Ensembl Gene ENSMUSG00000091662
Gene Name vomeronasal 1 receptor 69
Synonyms V1re9
MMRRC Submission 043136-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R5582 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 10313683-10315414 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 10314435 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 20 (Y20H)
Ref Sequence ENSEMBL: ENSMUSP00000154473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163658] [ENSMUST00000176284] [ENSMUST00000176707] [ENSMUST00000226160] [ENSMUST00000226190] [ENSMUST00000226228] [ENSMUST00000228478] [ENSMUST00000227853] [ENSMUST00000228638] [ENSMUST00000228296]
AlphaFold Q8VIC1
Predicted Effect probably damaging
Transcript: ENSMUST00000163658
AA Change: Y99H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000129646
Gene: ENSMUSG00000091662
AA Change: Y99H

DomainStartEndE-ValueType
Pfam:V1R 50 307 3.3e-32 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000176284
AA Change: Y99H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000176707
AA Change: Y99H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226160
AA Change: Y99H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226190
AA Change: Y99H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226228
AA Change: Y99H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226990
Predicted Effect probably damaging
Transcript: ENSMUST00000228478
AA Change: Y20H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227853
AA Change: Y20H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228638
AA Change: Y20H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228296
AA Change: Y20H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6401 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.6%
Validation Efficiency 98% (61/62)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A C 11: 9,586,639 (GRCm39) probably null Het
Agxt2 A G 15: 10,399,245 (GRCm39) D444G probably damaging Het
Aldh1b1 G T 4: 45,802,750 (GRCm39) R96L probably damaging Het
Ank2 T C 3: 126,739,954 (GRCm39) probably benign Het
Apob A G 12: 8,060,788 (GRCm39) Y3090C probably damaging Het
Bbx A G 16: 50,043,719 (GRCm39) S647P probably damaging Het
Brinp2 T C 1: 158,076,979 (GRCm39) Y372C probably damaging Het
Btaf1 T C 19: 36,965,573 (GRCm39) probably null Het
Cdk5rap1 T A 2: 154,187,894 (GRCm39) E477D probably benign Het
Cfap65 G A 1: 74,946,677 (GRCm39) probably benign Het
Chdh A G 14: 29,758,816 (GRCm39) Y587C probably damaging Het
Chek2 T C 5: 111,015,901 (GRCm39) V472A probably damaging Het
Clasrp A C 7: 19,320,781 (GRCm39) I326S probably damaging Het
Clic6 A T 16: 92,296,342 (GRCm39) Q334L possibly damaging Het
Cyp2d11 A T 15: 82,276,319 (GRCm39) probably null Het
Entpd7 T C 19: 43,693,433 (GRCm39) I171T probably damaging Het
Fosl1 T C 19: 5,505,295 (GRCm39) probably benign Het
Gm6124 A G 7: 38,869,622 (GRCm39) noncoding transcript Het
H3f3a A T 1: 180,637,650 (GRCm39) probably benign Het
Hs1bp3 AGAGGAGGAGGAGGAGGAGGAGGAGGAGG AGAGGAGGAGGAGGAGGAGGAGGAGG 12: 8,374,048 (GRCm39) probably benign Het
Idh2 CCAGGGC CC 7: 79,748,087 (GRCm39) probably null Het
Igkv3-7 A G 6: 70,584,990 (GRCm39) Y110C probably damaging Het
Ints9 C T 14: 65,266,345 (GRCm39) T399M possibly damaging Het
Kctd19 G A 8: 106,135,075 (GRCm39) T62M probably damaging Het
Lsmem1 A G 12: 40,230,643 (GRCm39) probably null Het
Obscn T C 11: 58,990,802 (GRCm39) probably null Het
Or11h23 T C 14: 50,948,425 (GRCm39) Y213H probably damaging Het
Or1j12 T C 2: 36,343,233 (GRCm39) I212T probably benign Het
Otop3 T A 11: 115,230,165 (GRCm39) M14K unknown Het
Pibf1 C T 14: 99,374,566 (GRCm39) A335V possibly damaging Het
Pkd1l2 A T 8: 117,767,522 (GRCm39) L1256* probably null Het
Plbd2 T C 5: 120,631,171 (GRCm39) E202G probably benign Het
Ppp1r37 A G 7: 19,266,219 (GRCm39) S516P probably damaging Het
Ppt2 G A 17: 34,836,373 (GRCm39) T229M probably damaging Het
Prr14 A T 7: 127,075,569 (GRCm39) I526F probably damaging Het
Scel T C 14: 103,820,575 (GRCm39) probably benign Het
Scn9a A T 2: 66,395,373 (GRCm39) probably benign Het
Senp6 T A 9: 79,997,158 (GRCm39) D57E possibly damaging Het
Setd5 T C 6: 113,091,886 (GRCm39) Y217H probably damaging Het
Sgcg T C 14: 61,462,754 (GRCm39) T198A probably damaging Het
Sipa1 C T 19: 5,704,729 (GRCm39) G622D probably benign Het
Slc27a2 C T 2: 126,406,610 (GRCm39) A98V probably damaging Het
Slitrk3 G T 3: 72,957,737 (GRCm39) P345Q probably benign Het
Slx4 T C 16: 3,803,652 (GRCm39) D1054G possibly damaging Het
Sned1 A T 1: 93,210,083 (GRCm39) T898S probably damaging Het
Tg C T 15: 66,565,284 (GRCm39) P1209S probably damaging Het
Tmem63b C A 17: 45,978,689 (GRCm39) V294L probably benign Het
Tnks G A 8: 35,408,015 (GRCm39) R238C probably benign Het
Tsn G A 1: 118,232,944 (GRCm39) T120I probably damaging Het
Txnrd1 T A 10: 82,731,814 (GRCm39) F479I possibly damaging Het
Ubr1 T C 2: 120,745,888 (GRCm39) M849V probably benign Het
Usp13 T C 3: 32,965,738 (GRCm39) S574P probably damaging Het
Zfp1001 T C 2: 150,204,972 (GRCm39) probably benign Het
Zfp780b T A 7: 27,664,252 (GRCm39) N101I probably damaging Het
Other mutations in Vmn1r69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Vmn1r69 APN 7 10,313,879 (GRCm39) missense probably benign 0.00
IGL01972:Vmn1r69 APN 7 10,314,586 (GRCm39) nonsense probably null
IGL02339:Vmn1r69 APN 7 10,314,645 (GRCm39) nonsense probably null
IGL02424:Vmn1r69 APN 7 10,314,585 (GRCm39) missense probably benign 0.00
IGL02602:Vmn1r69 APN 7 10,313,901 (GRCm39) missense probably benign 0.14
IGL03271:Vmn1r69 APN 7 10,314,596 (GRCm39) missense probably benign 0.11
R0034:Vmn1r69 UTSW 7 10,314,738 (GRCm39) intron probably benign
R0052:Vmn1r69 UTSW 7 10,314,327 (GRCm39) missense probably benign 0.00
R0096:Vmn1r69 UTSW 7 10,313,985 (GRCm39) missense probably damaging 1.00
R0539:Vmn1r69 UTSW 7 10,314,874 (GRCm39) splice site probably benign
R0604:Vmn1r69 UTSW 7 10,314,581 (GRCm39) missense probably benign 0.00
R1681:Vmn1r69 UTSW 7 10,314,179 (GRCm39) missense probably benign 0.06
R1884:Vmn1r69 UTSW 7 10,314,678 (GRCm39) missense probably benign 0.00
R3741:Vmn1r69 UTSW 7 10,314,069 (GRCm39) missense possibly damaging 0.47
R4655:Vmn1r69 UTSW 7 10,314,026 (GRCm39) missense probably benign 0.03
R4735:Vmn1r69 UTSW 7 10,314,926 (GRCm39) utr 5 prime probably benign
R4758:Vmn1r69 UTSW 7 10,314,473 (GRCm39) missense probably benign 0.00
R5966:Vmn1r69 UTSW 7 10,314,717 (GRCm39) missense probably benign 0.00
R5977:Vmn1r69 UTSW 7 10,314,417 (GRCm39) missense probably damaging 1.00
R6458:Vmn1r69 UTSW 7 10,314,365 (GRCm39) missense probably benign
R6987:Vmn1r69 UTSW 7 10,314,491 (GRCm39) start codon destroyed probably null 0.99
R7133:Vmn1r69 UTSW 7 10,314,995 (GRCm39) intron probably benign
R7532:Vmn1r69 UTSW 7 10,314,281 (GRCm39) missense probably damaging 0.98
R7878:Vmn1r69 UTSW 7 10,314,717 (GRCm39) missense probably benign 0.00
R9100:Vmn1r69 UTSW 7 10,314,064 (GRCm39) missense probably damaging 0.98
R9558:Vmn1r69 UTSW 7 10,314,185 (GRCm39) missense probably benign
Z1176:Vmn1r69 UTSW 7 10,314,023 (GRCm39) missense possibly damaging 0.64
Predicted Primers PCR Primer
(F):5'- TCATTTTGCCCTACAATGTAGCAG -3'
(R):5'- TGGATTTCCGGAATCTGGC -3'

Sequencing Primer
(F):5'- GCAGTATTTAAAATCACGGTCTCTTG -3'
(R):5'- CACAAACTACAATTGGAATTCTGGG -3'
Posted On 2016-10-26