|Institutional Source||Beutler Lab|
|Gene Name||fos-like antigen 1|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R5582 (G1)|
|Chromosomal Location||5447703-5455945 bp(+) (GRCm38)|
|Type of Mutation||unclassified|
|DNA Base Change (assembly)||T to C at 5455267 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000137537 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000025850] [ENSMUST00000179549]|
AA Change: S261P
AA Change: S261P
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.1053|
|Coding Region Coverage||
|Validation Efficiency||98% (61/62)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Homozygous inactivation of this gene leads to in utero lethality. Embryos homozygous for a reporter/null allele are severely growth retarded and display defects in the extra-embryonic compartment, including a highly abnormal yolk sac and a narrow, largely avascular placental labyrinth layer. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fosl1||
(F):5'- AGGTGGTTCTGGCAGCAC -3'
(R):5'- CCAAGCTGGCTCTACATCAAAG -3'
(F):5'- TGCTAGCAGCCCACCAG -3'
(R):5'- GCTGGCTCTACATCAAAGCATAATG -3'