Incidental Mutation 'R5585:Calm5'
ID 438672
Institutional Source Beutler Lab
Gene Symbol Calm5
Ensembl Gene ENSMUSG00000099269
Gene Name calmodulin 5
Synonyms Scarf2
MMRRC Submission 043139-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R5585 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 3904173-3904761 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 3904372 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 22 (D22G)
Ref Sequence ENSEMBL: ENSMUSP00000139342 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000183198] [ENSMUST00000184271]
AlphaFold Q6W3E0
Predicted Effect probably benign
Transcript: ENSMUST00000183198
SMART Domains Protein: ENSMUSP00000139172
Gene: ENSMUSG00000099269

DomainStartEndE-ValueType
EFh 12 40 1.9e-7 SMART
EFh 45 73 6.7e-10 SMART
EFh 81 109 1.5e-2 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000184271
AA Change: D22G

PolyPhen 2 Score 0.712 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000139342
Gene: ENSMUSG00000099269
AA Change: D22G

DomainStartEndE-ValueType
EFh 35 63 3.7e-5 SMART
EFh 68 96 1.35e-7 SMART
EFh 104 132 3.12e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192737
AA Change: M67V
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202762
AA Change: M67V
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600014C23Rik A T 17: 46,044,670 (GRCm39) I17N unknown Het
4932414N04Rik A G 2: 68,571,770 (GRCm39) T549A probably benign Het
9330159F19Rik C A 10: 29,101,271 (GRCm39) S548Y possibly damaging Het
Aanat A G 11: 116,487,799 (GRCm39) Y166C probably damaging Het
Adra2a G T 19: 54,034,670 (GRCm39) A9S probably benign Het
Ap4m1 A G 5: 138,170,502 (GRCm39) Y17C probably damaging Het
Arhgap33 T G 7: 30,223,260 (GRCm39) M891L probably benign Het
Ccdc15 C T 9: 37,188,699 (GRCm39) R795H probably benign Het
Cngb1 T A 8: 95,989,767 (GRCm39) I323F probably damaging Het
Cyp26b1 A G 6: 84,554,171 (GRCm39) F74L probably damaging Het
Dpagt1 G A 9: 44,240,439 (GRCm39) probably null Het
Ercc8 C T 13: 108,312,123 (GRCm39) P196S probably damaging Het
Gm10985 A C 3: 53,752,674 (GRCm39) Y19S probably damaging Het
Hfm1 G A 5: 107,059,305 (GRCm39) S239L probably benign Het
Hgf A G 5: 16,769,799 (GRCm39) D91G possibly damaging Het
Lefty2 T A 1: 180,720,828 (GRCm39) V27D possibly damaging Het
Lrp2 G A 2: 69,294,968 (GRCm39) T3450I possibly damaging Het
Lrrc38 A G 4: 143,076,961 (GRCm39) I75V probably damaging Het
Ncor2 C A 5: 125,144,975 (GRCm39) E556* probably null Het
Nedd9 A G 13: 41,469,950 (GRCm39) L401P probably damaging Het
Nfatc4 T C 14: 56,064,212 (GRCm39) L163P probably damaging Het
Nln T C 13: 104,161,569 (GRCm39) N667S possibly damaging Het
Or5w20 A G 2: 87,727,019 (GRCm39) T159A possibly damaging Het
Pnpla8 T C 12: 44,329,847 (GRCm39) I133T probably benign Het
Psma1 C T 7: 113,873,302 (GRCm39) G12S probably damaging Het
Psmd3 G A 11: 98,573,707 (GRCm39) G51D possibly damaging Het
Ptprb A G 10: 116,216,759 (GRCm39) Q1959R probably damaging Het
Rhbdf1 A G 11: 32,160,222 (GRCm39) probably null Het
Rnf167 T C 11: 70,540,308 (GRCm39) V110A probably damaging Het
Rrp9 C T 9: 106,362,525 (GRCm39) S470F probably benign Het
Rtn3 G A 19: 7,435,560 (GRCm39) P125L probably benign Het
Scube1 C T 15: 83,561,124 (GRCm39) C156Y probably damaging Het
Tgm2 A T 2: 157,973,375 (GRCm39) Y245* probably null Het
Timeless T C 10: 128,076,112 (GRCm39) I68T probably damaging Het
Ttn A G 2: 76,645,054 (GRCm39) S12934P probably damaging Het
Vwa5b2 T A 16: 20,413,428 (GRCm39) Y214* probably null Het
Yars2 T A 16: 16,122,484 (GRCm39) N7K probably damaging Het
Zfp142 G A 1: 74,617,404 (GRCm39) Q150* probably null Het
Zfp995 C T 17: 22,106,339 (GRCm39) probably benign Het
Other mutations in Calm5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3732:Calm5 UTSW 13 3,904,337 (GRCm39) missense probably damaging 1.00
R3940:Calm5 UTSW 13 3,904,485 (GRCm39) missense possibly damaging 0.87
R4563:Calm5 UTSW 13 3,904,402 (GRCm39) nonsense probably null
R4793:Calm5 UTSW 13 3,904,401 (GRCm39) missense probably benign 0.06
R5775:Calm5 UTSW 13 3,904,435 (GRCm39) missense probably damaging 0.99
R5869:Calm5 UTSW 13 3,904,321 (GRCm39) splice site probably benign
R6125:Calm5 UTSW 13 3,904,491 (GRCm39) nonsense probably null
R7621:Calm5 UTSW 13 3,904,629 (GRCm39) missense possibly damaging 0.75
R8062:Calm5 UTSW 13 3,904,405 (GRCm39) missense probably benign 0.01
R8690:Calm5 UTSW 13 3,904,277 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCAGCTCTTCAACAGGCAC -3'
(R):5'- ATTCTGGTCAAGGACACTGAAC -3'

Sequencing Primer
(F):5'- TTCAGAGCCCAGCAGTAGC -3'
(R):5'- TCTGGTCAAGGACACTGAACATAGC -3'
Posted On 2016-10-26