Incidental Mutation 'R5586:Ccdc88a'
| ID |
438736 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ccdc88a
|
| Ensembl Gene |
ENSMUSG00000032740 |
| Gene Name |
coiled coil domain containing 88A |
| Synonyms |
GIV, Girdin, D130005J21Rik, HkRP1, C330012F17Rik, C130096N06Rik, A430106J12Rik |
| MMRRC Submission |
043140-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5586 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
29323658-29460808 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 29453484 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 344
(I344V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114942
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040182]
[ENSMUST00000140194]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040182
AA Change: I1616V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000048978
Gene: ENSMUSG00000032740
AA Change: I1616V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:HOOK
|
14 |
590 |
8.1e-36 |
PFAM |
|
low complexity region
|
614 |
625 |
N/A |
INTRINSIC |
|
Blast:BRLZ
|
665 |
719 |
6e-22 |
BLAST |
|
low complexity region
|
826 |
839 |
N/A |
INTRINSIC |
|
low complexity region
|
883 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
955 |
985 |
N/A |
INTRINSIC |
|
low complexity region
|
1093 |
1104 |
N/A |
INTRINSIC |
|
coiled coil region
|
1268 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1437 |
1444 |
N/A |
INTRINSIC |
|
low complexity region
|
1566 |
1576 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1609 |
1702 |
2.38e-6 |
PROSPERO |
|
internal_repeat_1
|
1708 |
1808 |
2.38e-6 |
PROSPERO |
|
low complexity region
|
1811 |
1824 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000123561
AA Change: I596V
|
| SMART Domains |
Protein: ENSMUSP00000119173
Gene: ENSMUSG00000032740
AA Change: I596V
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
212 |
N/A |
INTRINSIC |
|
coiled coil region
|
248 |
365 |
N/A |
INTRINSIC |
|
low complexity region
|
418 |
425 |
N/A |
INTRINSIC |
|
low complexity region
|
547 |
557 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140194
AA Change: I344V
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000114942
Gene: ENSMUSG00000032740
AA Change: I344V
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
3 |
85 |
N/A |
INTRINSIC |
|
low complexity region
|
137 |
144 |
N/A |
INTRINSIC |
|
low complexity region
|
294 |
304 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0578 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.6%
- 20x: 96.0%
|
| Validation Efficiency |
98% (101/103) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal weight loss, reduced angiogenesis, and premature death by P25. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432E11Rik |
A |
G |
7: 29,277,153 (GRCm39) |
|
noncoding transcript |
Het |
| Aaas |
A |
T |
15: 102,255,111 (GRCm39) |
|
probably null |
Het |
| Abcc3 |
G |
A |
11: 94,255,247 (GRCm39) |
R600W |
probably damaging |
Het |
| Abhd13 |
A |
T |
8: 10,038,318 (GRCm39) |
Q305L |
probably benign |
Het |
| Adcy5 |
A |
T |
16: 34,977,486 (GRCm39) |
I340F |
probably damaging |
Het |
| Adgrl3 |
T |
A |
5: 81,871,994 (GRCm39) |
I964N |
probably damaging |
Het |
| Anks1b |
T |
A |
10: 89,912,926 (GRCm39) |
H316Q |
probably damaging |
Het |
| Ap3d1 |
A |
T |
10: 80,554,964 (GRCm39) |
F454I |
possibly damaging |
Het |
| Apol7c |
T |
C |
15: 77,410,599 (GRCm39) |
R116G |
possibly damaging |
Het |
| Arhgap5 |
A |
G |
12: 52,566,695 (GRCm39) |
E1222G |
possibly damaging |
Het |
| AW551984 |
A |
G |
9: 39,502,559 (GRCm39) |
V673A |
probably benign |
Het |
| Baiap2l1 |
A |
G |
5: 144,218,949 (GRCm39) |
S220P |
probably damaging |
Het |
| Bcl6 |
A |
G |
16: 23,791,926 (GRCm39) |
F143L |
probably benign |
Het |
| Calb1 |
A |
T |
4: 15,900,811 (GRCm39) |
T165S |
probably benign |
Het |
| Ccdc66 |
C |
A |
14: 27,228,668 (GRCm39) |
G6C |
probably damaging |
Het |
| Cdh19 |
T |
A |
1: 110,857,587 (GRCm39) |
D249V |
probably damaging |
Het |
| Ces1c |
T |
A |
8: 93,854,227 (GRCm39) |
T103S |
probably benign |
Het |
| Cfap54 |
T |
A |
10: 92,808,473 (GRCm39) |
K1401* |
probably null |
Het |
| Copa |
T |
A |
1: 171,932,789 (GRCm39) |
N371K |
probably damaging |
Het |
| Cyp2b10 |
A |
T |
7: 25,616,437 (GRCm39) |
Y348F |
probably damaging |
Het |
| Dennd5a |
T |
C |
7: 109,504,928 (GRCm39) |
R861G |
possibly damaging |
Het |
| Dhx8 |
T |
C |
11: 101,623,862 (GRCm39) |
|
probably benign |
Het |
| Dido1 |
C |
T |
2: 180,301,445 (GRCm39) |
W2153* |
probably null |
Het |
| Dlgap1 |
T |
A |
17: 71,125,156 (GRCm39) |
V969D |
probably damaging |
Het |
| Dvl3 |
A |
G |
16: 20,336,039 (GRCm39) |
D32G |
probably damaging |
Het |
| Epdr1 |
T |
C |
13: 19,778,718 (GRCm39) |
D24G |
probably benign |
Het |
| Etnk2 |
T |
A |
1: 133,307,043 (GRCm39) |
|
probably null |
Het |
| Fhad1 |
C |
T |
4: 141,632,442 (GRCm39) |
M1232I |
probably benign |
Het |
| Gcnt2 |
A |
C |
13: 41,014,429 (GRCm39) |
E200A |
probably damaging |
Het |
| Gm5174 |
A |
G |
10: 86,492,409 (GRCm39) |
|
noncoding transcript |
Het |
| Gm6408 |
T |
A |
5: 146,421,267 (GRCm39) |
F299I |
possibly damaging |
Het |
| Gpr85 |
G |
T |
6: 13,836,000 (GRCm39) |
Y301* |
probably null |
Het |
| Gucy2e |
G |
T |
11: 69,117,082 (GRCm39) |
P780T |
probably damaging |
Het |
| Icam5 |
A |
T |
9: 20,946,116 (GRCm39) |
N316I |
probably damaging |
Het |
| Ifit1bl1 |
C |
T |
19: 34,571,677 (GRCm39) |
R260Q |
probably damaging |
Het |
| Il1r1 |
A |
C |
1: 40,264,411 (GRCm39) |
|
probably benign |
Het |
| Kif3c |
A |
T |
12: 3,439,656 (GRCm39) |
I86F |
probably benign |
Het |
| Klhdc2 |
A |
G |
12: 69,354,467 (GRCm39) |
|
probably null |
Het |
| Mast2 |
A |
G |
4: 116,292,760 (GRCm39) |
L9P |
probably damaging |
Het |
| Mcoln1 |
G |
T |
8: 3,560,389 (GRCm39) |
C316F |
probably damaging |
Het |
| Mon1a |
A |
T |
9: 107,775,894 (GRCm39) |
D4V |
probably damaging |
Het |
| Ms4a18 |
T |
A |
19: 10,991,038 (GRCm39) |
M19L |
probably benign |
Het |
| Nbea |
T |
C |
3: 55,539,392 (GRCm39) |
K2790E |
probably benign |
Het |
| Niban1 |
C |
T |
1: 151,593,307 (GRCm39) |
T664I |
probably benign |
Het |
| Noc3l |
C |
T |
19: 38,803,139 (GRCm39) |
E167K |
possibly damaging |
Het |
| Nol10 |
G |
A |
12: 17,466,829 (GRCm39) |
E570K |
possibly damaging |
Het |
| Nr2e3 |
T |
C |
9: 59,856,484 (GRCm39) |
R69G |
probably damaging |
Het |
| Obscn |
G |
A |
11: 58,892,294 (GRCm39) |
R1358* |
probably null |
Het |
| Or14j4 |
A |
T |
17: 37,921,145 (GRCm39) |
F166I |
probably damaging |
Het |
| Or2b7 |
C |
A |
13: 21,739,266 (GRCm39) |
V309F |
probably damaging |
Het |
| Or52e8b |
A |
G |
7: 104,673,428 (GRCm39) |
I253T |
probably damaging |
Het |
| Or5b117 |
A |
T |
19: 13,431,746 (GRCm39) |
M45K |
probably benign |
Het |
| Pak2 |
A |
T |
16: 31,860,337 (GRCm39) |
D175E |
probably benign |
Het |
| Pccb |
C |
T |
9: 100,867,856 (GRCm39) |
V357I |
possibly damaging |
Het |
| Pcdhb4 |
C |
T |
18: 37,442,034 (GRCm39) |
P448L |
probably damaging |
Het |
| Pcdhb9 |
A |
G |
18: 37,534,167 (GRCm39) |
M54V |
probably benign |
Het |
| Ppp3cb |
A |
G |
14: 20,570,758 (GRCm39) |
|
probably benign |
Het |
| Ppp4r1 |
A |
G |
17: 66,131,563 (GRCm39) |
D452G |
probably benign |
Het |
| Pramel18 |
T |
A |
4: 101,767,317 (GRCm39) |
F189I |
probably benign |
Het |
| Prmt3 |
T |
A |
7: 49,476,499 (GRCm39) |
D369E |
probably damaging |
Het |
| Psmd12 |
T |
A |
11: 107,377,301 (GRCm39) |
V120D |
probably benign |
Het |
| Ptprb |
T |
C |
10: 116,189,732 (GRCm39) |
L1797P |
probably damaging |
Het |
| Ptprm |
A |
G |
17: 67,227,191 (GRCm39) |
S653P |
probably damaging |
Het |
| Pxdn |
T |
A |
12: 30,053,141 (GRCm39) |
V926D |
probably damaging |
Het |
| Retreg3 |
T |
G |
11: 100,997,165 (GRCm39) |
Q105P |
probably damaging |
Het |
| Sacs |
A |
T |
14: 61,443,890 (GRCm39) |
R1979* |
probably null |
Het |
| Scn2a |
T |
A |
2: 65,537,639 (GRCm39) |
L696* |
probably null |
Het |
| Sema3c |
A |
T |
5: 17,916,422 (GRCm39) |
N465Y |
probably damaging |
Het |
| Slc25a32 |
A |
T |
15: 38,963,308 (GRCm39) |
V171E |
possibly damaging |
Het |
| Slc30a7 |
C |
T |
3: 115,783,700 (GRCm39) |
V158I |
probably benign |
Het |
| Slc44a5 |
G |
A |
3: 153,975,802 (GRCm39) |
|
probably benign |
Het |
| Slc4a8 |
A |
G |
15: 100,685,045 (GRCm39) |
D140G |
probably damaging |
Het |
| Slc7a11 |
G |
A |
3: 50,397,532 (GRCm39) |
S60L |
possibly damaging |
Het |
| Spryd3 |
A |
T |
15: 102,040,372 (GRCm39) |
H59Q |
probably benign |
Het |
| Sqstm1 |
T |
C |
11: 50,093,849 (GRCm39) |
D256G |
probably damaging |
Het |
| Sst |
A |
T |
16: 23,708,487 (GRCm39) |
S115T |
probably damaging |
Het |
| Stimate |
A |
G |
14: 30,592,776 (GRCm39) |
K166E |
probably damaging |
Het |
| Surf1 |
T |
C |
2: 26,805,963 (GRCm39) |
|
probably benign |
Het |
| Synj1 |
A |
T |
16: 90,806,865 (GRCm39) |
|
probably benign |
Het |
| Tet1 |
C |
A |
10: 62,714,073 (GRCm39) |
C574F |
probably damaging |
Het |
| Thnsl1 |
T |
A |
2: 21,217,201 (GRCm39) |
Y318* |
probably null |
Het |
| Tomm70a |
A |
G |
16: 56,942,493 (GRCm39) |
E90G |
probably damaging |
Het |
| Treml4 |
A |
G |
17: 48,571,927 (GRCm39) |
D110G |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Txnl1 |
C |
T |
18: 63,797,396 (GRCm39) |
G283D |
probably damaging |
Het |
| Uba6 |
T |
C |
5: 86,282,906 (GRCm39) |
D559G |
probably damaging |
Het |
| Usp4 |
T |
C |
9: 108,233,661 (GRCm39) |
V94A |
possibly damaging |
Het |
| Vmn2r25 |
A |
C |
6: 123,802,255 (GRCm39) |
C549W |
probably damaging |
Het |
| Vmn2r59 |
G |
T |
7: 41,695,105 (GRCm39) |
Q436K |
probably benign |
Het |
| Wdr70 |
A |
T |
15: 7,913,769 (GRCm39) |
Y627N |
possibly damaging |
Het |
| Xpr1 |
T |
C |
1: 155,188,609 (GRCm39) |
I344V |
probably benign |
Het |
| Zfp423 |
T |
A |
8: 88,585,968 (GRCm39) |
Q61L |
possibly damaging |
Het |
|
| Other mutations in Ccdc88a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00499:Ccdc88a
|
APN |
11 |
29,449,341 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL00577:Ccdc88a
|
APN |
11 |
29,374,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00766:Ccdc88a
|
APN |
11 |
29,451,046 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01384:Ccdc88a
|
APN |
11 |
29,453,915 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01541:Ccdc88a
|
APN |
11 |
29,350,283 (GRCm39) |
missense |
probably benign |
|
|
IGL01647:Ccdc88a
|
APN |
11 |
29,454,321 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02648:Ccdc88a
|
APN |
11 |
29,451,051 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02885:Ccdc88a
|
APN |
11 |
29,398,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03117:Ccdc88a
|
APN |
11 |
29,324,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03196:Ccdc88a
|
APN |
11 |
29,432,340 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
trailor
|
UTSW |
11 |
29,444,099 (GRCm39) |
splice site |
probably null |
|
|
R0011:Ccdc88a
|
UTSW |
11 |
29,324,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Ccdc88a
|
UTSW |
11 |
29,324,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0083:Ccdc88a
|
UTSW |
11 |
29,453,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0108:Ccdc88a
|
UTSW |
11 |
29,453,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0326:Ccdc88a
|
UTSW |
11 |
29,411,021 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0565:Ccdc88a
|
UTSW |
11 |
29,411,042 (GRCm39) |
unclassified |
probably benign |
|
|
R0631:Ccdc88a
|
UTSW |
11 |
29,443,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0632:Ccdc88a
|
UTSW |
11 |
29,432,749 (GRCm39) |
unclassified |
probably benign |
|
|
R0762:Ccdc88a
|
UTSW |
11 |
29,413,112 (GRCm39) |
unclassified |
probably benign |
|
|
R0838:Ccdc88a
|
UTSW |
11 |
29,350,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0946:Ccdc88a
|
UTSW |
11 |
29,406,509 (GRCm39) |
missense |
probably benign |
|
|
R1192:Ccdc88a
|
UTSW |
11 |
29,454,049 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R1500:Ccdc88a
|
UTSW |
11 |
29,432,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1701:Ccdc88a
|
UTSW |
11 |
29,427,427 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1826:Ccdc88a
|
UTSW |
11 |
29,439,637 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1902:Ccdc88a
|
UTSW |
11 |
29,411,788 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1903:Ccdc88a
|
UTSW |
11 |
29,411,788 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2021:Ccdc88a
|
UTSW |
11 |
29,453,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2023:Ccdc88a
|
UTSW |
11 |
29,413,546 (GRCm39) |
nonsense |
probably null |
|
|
R2284:Ccdc88a
|
UTSW |
11 |
29,444,099 (GRCm39) |
splice site |
probably null |
|
|
R3236:Ccdc88a
|
UTSW |
11 |
29,397,995 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R3409:Ccdc88a
|
UTSW |
11 |
29,436,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3410:Ccdc88a
|
UTSW |
11 |
29,436,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3411:Ccdc88a
|
UTSW |
11 |
29,436,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3430:Ccdc88a
|
UTSW |
11 |
29,398,033 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3620:Ccdc88a
|
UTSW |
11 |
29,380,227 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4204:Ccdc88a
|
UTSW |
11 |
29,413,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4515:Ccdc88a
|
UTSW |
11 |
29,432,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4518:Ccdc88a
|
UTSW |
11 |
29,432,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4519:Ccdc88a
|
UTSW |
11 |
29,432,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4693:Ccdc88a
|
UTSW |
11 |
29,432,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4705:Ccdc88a
|
UTSW |
11 |
29,372,586 (GRCm39) |
missense |
probably benign |
|
|
R4707:Ccdc88a
|
UTSW |
11 |
29,397,956 (GRCm39) |
missense |
probably benign |
|
|
R4732:Ccdc88a
|
UTSW |
11 |
29,435,906 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4733:Ccdc88a
|
UTSW |
11 |
29,435,906 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4734:Ccdc88a
|
UTSW |
11 |
29,432,720 (GRCm39) |
missense |
probably benign |
|
|
R4749:Ccdc88a
|
UTSW |
11 |
29,432,720 (GRCm39) |
missense |
probably benign |
|
|
R4817:Ccdc88a
|
UTSW |
11 |
29,410,907 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4828:Ccdc88a
|
UTSW |
11 |
29,413,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4979:Ccdc88a
|
UTSW |
11 |
29,432,133 (GRCm39) |
nonsense |
probably null |
|
|
R5288:Ccdc88a
|
UTSW |
11 |
29,448,416 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5373:Ccdc88a
|
UTSW |
11 |
29,413,409 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5374:Ccdc88a
|
UTSW |
11 |
29,413,409 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5401:Ccdc88a
|
UTSW |
11 |
29,413,279 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6660:Ccdc88a
|
UTSW |
11 |
29,432,663 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7116:Ccdc88a
|
UTSW |
11 |
29,454,051 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7353:Ccdc88a
|
UTSW |
11 |
29,413,368 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7538:Ccdc88a
|
UTSW |
11 |
29,413,370 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7663:Ccdc88a
|
UTSW |
11 |
29,448,614 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7769:Ccdc88a
|
UTSW |
11 |
29,432,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7798:Ccdc88a
|
UTSW |
11 |
29,427,348 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7810:Ccdc88a
|
UTSW |
11 |
29,435,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7826:Ccdc88a
|
UTSW |
11 |
29,453,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7956:Ccdc88a
|
UTSW |
11 |
29,413,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8260:Ccdc88a
|
UTSW |
11 |
29,443,934 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8402:Ccdc88a
|
UTSW |
11 |
29,413,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8409:Ccdc88a
|
UTSW |
11 |
29,453,544 (GRCm39) |
missense |
probably benign |
|
|
R8555:Ccdc88a
|
UTSW |
11 |
29,380,169 (GRCm39) |
missense |
probably benign |
|
|
R8676:Ccdc88a
|
UTSW |
11 |
29,410,860 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8846:Ccdc88a
|
UTSW |
11 |
29,414,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8963:Ccdc88a
|
UTSW |
11 |
29,448,416 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8972:Ccdc88a
|
UTSW |
11 |
29,435,888 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9353:Ccdc88a
|
UTSW |
11 |
29,427,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9362:Ccdc88a
|
UTSW |
11 |
29,453,922 (GRCm39) |
missense |
probably null |
0.55 |
|
R9385:Ccdc88a
|
UTSW |
11 |
29,405,422 (GRCm39) |
missense |
probably benign |
0.24 |
|
R9509:Ccdc88a
|
UTSW |
11 |
29,414,143 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9610:Ccdc88a
|
UTSW |
11 |
29,427,316 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9611:Ccdc88a
|
UTSW |
11 |
29,427,316 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9664:Ccdc88a
|
UTSW |
11 |
29,405,484 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9720:Ccdc88a
|
UTSW |
11 |
29,413,813 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTGAGGAACAAGTAACATAGCTTAC -3'
(R):5'- CTAACCTGTATTGAGGTAAGCTTG -3'
Sequencing Primer
(F):5'- GGAACAAGTAACATAGCTTACCTAAG -3'
(R):5'- GTTGCTTTCTTCCAAAAACTGTTG -3'
|
| Posted On |
2016-10-26 |
Incidental Mutation