Incidental Mutation 'R5587:Olfr617'
ID 438819
Institutional Source Beutler Lab
Gene Symbol Olfr617
Ensembl Gene ENSMUSG00000073946
Gene Name olfactory receptor 617
Synonyms GA_x6K02T2PBJ9-6306819-6307775, MOR31-10
MMRRC Submission 043141-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R5587 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 103573061-103586795 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 103584531 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 170 (Y170N)
Ref Sequence ENSEMBL: ENSMUSP00000149045 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048265] [ENSMUST00000215755] [ENSMUST00000216516]
AlphaFold Q8VGA1
Predicted Effect probably benign
Transcript: ENSMUST00000048265
AA Change: Y170N

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000040319
Gene: ENSMUSG00000073946
AA Change: Y170N

Pfam:7tm_4 37 316 8.5e-109 PFAM
Pfam:7TM_GPCR_Srsx 41 225 2.3e-10 PFAM
Pfam:7tm_1 47 299 4.6e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000179692
Predicted Effect probably benign
Transcript: ENSMUST00000215755
AA Change: Y170N

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000216516
AA Change: Y170N

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.9%
Validation Efficiency 96% (78/81)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 138,065,409 (GRCm38) R120G probably benign Het
4930548H24Rik G T 5: 31,486,084 (GRCm38) G53W probably benign Het
Acad11 A G 9: 104,063,767 (GRCm38) T3A probably benign Het
Adamts18 G A 8: 113,775,360 (GRCm38) Q290* probably null Het
Ahnak A G 19: 9,009,476 (GRCm38) D2708G possibly damaging Het
Asxl3 T A 18: 22,525,247 (GRCm38) C2105S probably benign Het
Atp8b1 A T 18: 64,539,210 (GRCm38) F1028I probably damaging Het
Axdnd1 C G 1: 156,351,412 (GRCm38) W615C probably damaging Het
Bcl3 A T 7: 19,809,634 (GRCm38) Y10* probably null Het
Bmp2 T A 2: 133,554,646 (GRCm38) V74E possibly damaging Het
Ccdc78 C A 17: 25,786,677 (GRCm38) P21Q probably benign Het
Cluap1 T A 16: 3,915,484 (GRCm38) V199E probably damaging Het
Cntnap3 T C 13: 64,746,738 (GRCm38) E1120G probably damaging Het
Col1a2 T A 6: 4,540,531 (GRCm38) W1330R unknown Het
Coq4 A G 2: 29,795,514 (GRCm38) probably null Het
Cwf19l1 G A 19: 44,120,877 (GRCm38) T346I possibly damaging Het
Cyct T C 2: 76,354,203 (GRCm38) Y68C probably damaging Het
Dnah10 T C 5: 124,793,913 (GRCm38) L2368P probably benign Het
Dnah2 A T 11: 69,437,242 (GRCm38) F3346I probably damaging Het
Dpp3 A T 19: 4,918,267 (GRCm38) V259E probably damaging Het
Dpyd A C 3: 119,064,951 (GRCm38) S605R probably damaging Het
Emc1 A G 4: 139,362,148 (GRCm38) E209G probably damaging Het
Esrra A G 19: 6,920,207 (GRCm38) S61P probably benign Het
Fam71d C A 12: 78,715,075 (GRCm38) P171H probably damaging Het
Gbx2 T A 1: 89,933,122 (GRCm38) probably benign Het
Hepacam A G 9: 37,384,684 (GRCm38) H377R probably damaging Het
Igkv12-46 T C 6: 69,764,550 (GRCm38) Y107C probably damaging Het
Intu A G 3: 40,675,308 (GRCm38) D356G probably damaging Het
Izumo4 A T 10: 80,703,220 (GRCm38) N113Y probably damaging Het
Krt86 G A 15: 101,473,593 (GRCm38) A15T probably benign Het
Lhx8 A T 3: 154,311,679 (GRCm38) S275R probably damaging Het
Lingo3 A T 10: 80,835,530 (GRCm38) S189T probably damaging Het
Llgl1 T A 11: 60,710,342 (GRCm38) M702K probably benign Het
Lpin1 T C 12: 16,573,714 (GRCm38) Y223C Het
Lrit3 G T 3: 129,788,898 (GRCm38) A359E probably benign Het
Lrp2 T C 2: 69,499,263 (GRCm38) E1720G probably benign Het
Mcub A C 3: 129,916,970 (GRCm38) V271G probably benign Het
Nktr C T 9: 121,748,489 (GRCm38) probably benign Het
Olfr1342 T A 4: 118,689,870 (GRCm38) D194V probably damaging Het
Olfr1502 G A 19: 13,862,576 (GRCm38) R261H probably damaging Het
Olfr347 A T 2: 36,734,621 (GRCm38) Q100L probably damaging Het
Olfr979 A T 9: 40,000,621 (GRCm38) I202N possibly damaging Het
Olfr984 A T 9: 40,101,244 (GRCm38) L82Q probably damaging Het
Pcdha4 T C 18: 36,954,822 (GRCm38) V686A probably benign Het
Pelo A G 13: 115,089,873 (GRCm38) V16A possibly damaging Het
Plcd1 A G 9: 119,073,832 (GRCm38) S539P probably benign Het
Prss1 A G 6: 41,463,265 (GRCm38) I179V possibly damaging Het
Ptgs2 T C 1: 150,105,555 (GRCm38) Y530H probably damaging Het
Rai1 T C 11: 60,189,859 (GRCm38) V1583A probably damaging Het
Raph1 T G 1: 60,498,473 (GRCm38) D508A probably damaging Het
Rmnd5a A G 6: 71,394,619 (GRCm38) probably benign Het
Rsf1 T C 7: 97,662,121 (GRCm38) L686P probably benign Het
Samd9l T C 6: 3,373,291 (GRCm38) I1323M possibly damaging Het
Scn1a T C 2: 66,273,081 (GRCm38) N1934S probably benign Het
Sec23ip C T 7: 128,750,427 (GRCm38) H176Y probably benign Het
Sh3glb2 A G 2: 30,354,851 (GRCm38) probably null Het
Sis A G 3: 72,914,576 (GRCm38) I1384T possibly damaging Het
Spata31d1a A C 13: 59,702,618 (GRCm38) C565W probably damaging Het
Srbd1 T A 17: 86,127,801 (GRCm38) Q278L probably damaging Het
Sry T C Y: 2,662,625 (GRCm38) H345R unknown Het
Suox A T 10: 128,671,825 (GRCm38) D111E probably damaging Het
Taar7a A T 10: 23,992,828 (GRCm38) F218L probably benign Het
Tfcp2l1 C A 1: 118,664,762 (GRCm38) N288K possibly damaging Het
Tmem128 G T 5: 38,260,421 (GRCm38) R7L possibly damaging Het
Tmem266 A G 9: 55,437,566 (GRCm38) N494S probably damaging Het
Tmprss3 T A 17: 31,193,992 (GRCm38) H80L probably benign Het
Tnrc6c C T 11: 117,749,271 (GRCm38) Q1211* probably null Het
Tns1 T A 1: 73,920,596 (GRCm38) D1671V possibly damaging Het
Trmt1l T A 1: 151,435,704 (GRCm38) probably benign Het
Tshz2 A T 2: 169,884,342 (GRCm38) D286V probably damaging Het
Ttyh2 A G 11: 114,675,659 (GRCm38) E39G probably benign Het
Vmn2r125 G A 4: 156,350,138 (GRCm38) C73Y probably damaging Het
Vmn2r5 T C 3: 64,504,076 (GRCm38) D357G probably damaging Het
Vmn2r61 T C 7: 42,300,487 (GRCm38) F777S probably damaging Het
Vmn2r9 T C 5: 108,847,561 (GRCm38) E407G probably damaging Het
Vwa3a A G 7: 120,780,235 (GRCm38) N521S probably damaging Het
Zan C G 5: 137,391,762 (GRCm38) S4816T unknown Het
Zc3h7b T C 15: 81,771,858 (GRCm38) Y136H possibly damaging Het
Zfp101 T C 17: 33,381,321 (GRCm38) K487R possibly damaging Het
Other mutations in Olfr617
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01306:Olfr617 APN 7 103,584,693 (GRCm38) missense probably damaging 1.00
IGL01355:Olfr617 APN 7 103,584,373 (GRCm38) missense probably damaging 1.00
IGL01411:Olfr617 APN 7 103,584,117 (GRCm38) missense probably damaging 1.00
IGL01412:Olfr617 APN 7 103,584,907 (GRCm38) missense probably damaging 1.00
IGL02379:Olfr617 APN 7 103,584,892 (GRCm38) missense possibly damaging 0.84
ANU23:Olfr617 UTSW 7 103,584,693 (GRCm38) missense probably damaging 1.00
IGL03054:Olfr617 UTSW 7 103,584,840 (GRCm38) missense probably benign 0.23
R0536:Olfr617 UTSW 7 103,584,261 (GRCm38) missense probably damaging 1.00
R4222:Olfr617 UTSW 7 103,584,759 (GRCm38) missense probably damaging 1.00
R4224:Olfr617 UTSW 7 103,584,759 (GRCm38) missense probably damaging 1.00
R5342:Olfr617 UTSW 7 103,584,828 (GRCm38) missense probably benign 0.05
R5607:Olfr617 UTSW 7 103,584,299 (GRCm38) nonsense probably null
R5608:Olfr617 UTSW 7 103,584,299 (GRCm38) nonsense probably null
R6904:Olfr617 UTSW 7 103,584,520 (GRCm38) missense possibly damaging 0.83
R6929:Olfr617 UTSW 7 103,584,444 (GRCm38) missense probably damaging 0.98
R7399:Olfr617 UTSW 7 103,584,381 (GRCm38) missense possibly damaging 0.78
R7607:Olfr617 UTSW 7 103,584,930 (GRCm38) missense probably damaging 0.97
R7771:Olfr617 UTSW 7 103,584,090 (GRCm38) missense probably benign 0.33
Z1177:Olfr617 UTSW 7 103,584,947 (GRCm38) missense probably benign
Z1177:Olfr617 UTSW 7 103,584,699 (GRCm38) missense probably benign 0.41
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-10-26