Incidental Mutation 'R5587:Acad11'
ID 438827
Institutional Source Beutler Lab
Gene Symbol Acad11
Ensembl Gene ENSMUSG00000090150
Gene Name acyl-Coenzyme A dehydrogenase family, member 11
Synonyms 5730439E10Rik
MMRRC Submission 043141-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R5587 (G1)
Quality Score 146
Status Not validated
Chromosome 9
Chromosomal Location 103940923-104004855 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 103940966 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 3 (T3A)
Ref Sequence ENSEMBL: ENSMUSP00000141064 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035166] [ENSMUST00000047799] [ENSMUST00000120854] [ENSMUST00000140768] [ENSMUST00000144195] [ENSMUST00000189998]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000035166
SMART Domains Protein: ENSMUSP00000035166
Gene: ENSMUSG00000032557

DomainStartEndE-ValueType
coiled coil region 1 30 N/A INTRINSIC
Pfam:ThiF 51 309 2.8e-48 PFAM
low complexity region 317 332 N/A INTRINSIC
low complexity region 343 353 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000047799
AA Change: T3A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000043424
Gene: ENSMUSG00000090150
AA Change: T3A

DomainStartEndE-ValueType
Pfam:APH 43 307 3.5e-45 PFAM
Pfam:Acyl-CoA_dh_N 376 498 1.5e-13 PFAM
Pfam:Acyl-CoA_dh_M 502 605 1.7e-21 PFAM
Pfam:Acyl-CoA_dh_1 617 768 2.7e-36 PFAM
Pfam:Acyl-CoA_dh_2 632 743 2e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120854
SMART Domains Protein: ENSMUSP00000112994
Gene: ENSMUSG00000090150

DomainStartEndE-ValueType
Pfam:APH 1 188 1.1e-28 PFAM
Pfam:EcKinase 49 143 4.8e-9 PFAM
Pfam:Acyl-CoA_dh_N 257 380 8.7e-15 PFAM
Pfam:Acyl-CoA_dh_M 385 439 2.4e-19 PFAM
Pfam:Acyl-CoA_dh_1 499 650 1.3e-37 PFAM
Pfam:Acyl-CoA_dh_2 514 632 2.7e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000140768
SMART Domains Protein: ENSMUSP00000118734
Gene: ENSMUSG00000032557

DomainStartEndE-ValueType
coiled coil region 1 30 N/A INTRINSIC
Pfam:ThiF 70 101 1.5e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144195
SMART Domains Protein: ENSMUSP00000118535
Gene: ENSMUSG00000032557

DomainStartEndE-ValueType
Pfam:ThiF 1 119 1.9e-22 PFAM
low complexity region 220 235 N/A INTRINSIC
low complexity region 246 256 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000147249
SMART Domains Protein: ENSMUSP00000115381
Gene: ENSMUSG00000101152

DomainStartEndE-ValueType
Pfam:TPR_12 1 48 3e-14 PFAM
Pfam:TPR_12 12 75 2.1e-14 PFAM
Pfam:TPR_10 15 56 7.8e-13 PFAM
Pfam:TPR_1 16 49 4.4e-9 PFAM
Pfam:TPR_7 18 58 7e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185819
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191568
Predicted Effect probably benign
Transcript: ENSMUST00000189998
AA Change: T3A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000214222
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.9%
Validation Efficiency 96% (78/81)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,771,170 (GRCm39) R120G probably benign Het
Adamts18 G A 8: 114,501,992 (GRCm39) Q290* probably null Het
Ahnak A G 19: 8,986,840 (GRCm39) D2708G possibly damaging Het
Asxl3 T A 18: 22,658,304 (GRCm39) C2105S probably benign Het
Atp8b1 A T 18: 64,672,281 (GRCm39) F1028I probably damaging Het
Axdnd1 C G 1: 156,178,982 (GRCm39) W615C probably damaging Het
Bcl3 A T 7: 19,543,559 (GRCm39) Y10* probably null Het
Bmp2 T A 2: 133,396,566 (GRCm39) V74E possibly damaging Het
Ccdc121 G T 5: 31,643,428 (GRCm39) G53W probably benign Het
Ccdc78 C A 17: 26,005,651 (GRCm39) P21Q probably benign Het
Cluap1 T A 16: 3,733,348 (GRCm39) V199E probably damaging Het
Cntnap3 T C 13: 64,894,552 (GRCm39) E1120G probably damaging Het
Col1a2 T A 6: 4,540,531 (GRCm39) W1330R unknown Het
Coq4 A G 2: 29,685,526 (GRCm39) probably null Het
Cwf19l1 G A 19: 44,109,316 (GRCm39) T346I possibly damaging Het
Cyct T C 2: 76,184,547 (GRCm39) Y68C probably damaging Het
Dnah10 T C 5: 124,870,977 (GRCm39) L2368P probably benign Het
Dnah2 A T 11: 69,328,068 (GRCm39) F3346I probably damaging Het
Dpp3 A T 19: 4,968,295 (GRCm39) V259E probably damaging Het
Dpyd A C 3: 118,858,600 (GRCm39) S605R probably damaging Het
Emc1 A G 4: 139,089,459 (GRCm39) E209G probably damaging Het
Esrra A G 19: 6,897,575 (GRCm39) S61P probably benign Het
Garin2 C A 12: 78,761,849 (GRCm39) P171H probably damaging Het
Gbx2 T A 1: 89,860,844 (GRCm39) probably benign Het
Hepacam A G 9: 37,295,980 (GRCm39) H377R probably damaging Het
Igkv12-46 T C 6: 69,741,534 (GRCm39) Y107C probably damaging Het
Intu A G 3: 40,629,738 (GRCm39) D356G probably damaging Het
Izumo4 A T 10: 80,539,054 (GRCm39) N113Y probably damaging Het
Krt86 G A 15: 101,371,474 (GRCm39) A15T probably benign Het
Lhx8 A T 3: 154,017,316 (GRCm39) S275R probably damaging Het
Lingo3 A T 10: 80,671,364 (GRCm39) S189T probably damaging Het
Llgl1 T A 11: 60,601,168 (GRCm39) M702K probably benign Het
Lpin1 T C 12: 16,623,715 (GRCm39) Y223C Het
Lrit3 G T 3: 129,582,547 (GRCm39) A359E probably benign Het
Lrp2 T C 2: 69,329,607 (GRCm39) E1720G probably benign Het
Mcub A C 3: 129,710,619 (GRCm39) V271G probably benign Het
Nktr C T 9: 121,577,555 (GRCm39) probably benign Het
Or10g9 A T 9: 39,911,917 (GRCm39) I202N possibly damaging Het
Or13p4 T A 4: 118,547,067 (GRCm39) D194V probably damaging Het
Or1j18 A T 2: 36,624,633 (GRCm39) Q100L probably damaging Het
Or4d5 A T 9: 40,012,540 (GRCm39) L82Q probably damaging Het
Or52z12 T A 7: 103,233,738 (GRCm39) Y170N probably benign Het
Or9i1 G A 19: 13,839,940 (GRCm39) R261H probably damaging Het
Pcdha4 T C 18: 37,087,875 (GRCm39) V686A probably benign Het
Pelo A G 13: 115,226,409 (GRCm39) V16A possibly damaging Het
Plcd1 A G 9: 118,902,900 (GRCm39) S539P probably benign Het
Prss1 A G 6: 41,440,199 (GRCm39) I179V possibly damaging Het
Ptgs2 T C 1: 149,981,306 (GRCm39) Y530H probably damaging Het
Rai1 T C 11: 60,080,685 (GRCm39) V1583A probably damaging Het
Raph1 T G 1: 60,537,632 (GRCm39) D508A probably damaging Het
Rmnd5a A G 6: 71,371,603 (GRCm39) probably benign Het
Rsf1 T C 7: 97,311,328 (GRCm39) L686P probably benign Het
Samd9l T C 6: 3,373,291 (GRCm39) I1323M possibly damaging Het
Scn1a T C 2: 66,103,425 (GRCm39) N1934S probably benign Het
Sec23ip C T 7: 128,352,151 (GRCm39) H176Y probably benign Het
Sh3glb2 A G 2: 30,244,863 (GRCm39) probably null Het
Sis A G 3: 72,821,909 (GRCm39) I1384T possibly damaging Het
Spata31d1a A C 13: 59,850,432 (GRCm39) C565W probably damaging Het
Srbd1 T A 17: 86,435,229 (GRCm39) Q278L probably damaging Het
Sry T C Y: 2,662,625 (GRCm39) H345R unknown Het
Suox A T 10: 128,507,694 (GRCm39) D111E probably damaging Het
Taar7a A T 10: 23,868,726 (GRCm39) F218L probably benign Het
Tfcp2l1 C A 1: 118,592,492 (GRCm39) N288K possibly damaging Het
Tmem128 G T 5: 38,417,765 (GRCm39) R7L possibly damaging Het
Tmem266 A G 9: 55,344,850 (GRCm39) N494S probably damaging Het
Tmprss3 T A 17: 31,412,966 (GRCm39) H80L probably benign Het
Tnrc6c C T 11: 117,640,097 (GRCm39) Q1211* probably null Het
Tns1 T A 1: 73,959,755 (GRCm39) D1671V possibly damaging Het
Trmt1l T A 1: 151,311,455 (GRCm39) probably benign Het
Tshz2 A T 2: 169,726,262 (GRCm39) D286V probably damaging Het
Ttyh2 A G 11: 114,566,485 (GRCm39) E39G probably benign Het
Vmn2r125 G A 4: 156,702,433 (GRCm39) C73Y probably damaging Het
Vmn2r5 T C 3: 64,411,497 (GRCm39) D357G probably damaging Het
Vmn2r61 T C 7: 41,949,911 (GRCm39) F777S probably damaging Het
Vmn2r9 T C 5: 108,995,427 (GRCm39) E407G probably damaging Het
Vwa3a A G 7: 120,379,458 (GRCm39) N521S probably damaging Het
Zan C G 5: 137,390,024 (GRCm39) S4816T unknown Het
Zc3h7b T C 15: 81,656,059 (GRCm39) Y136H possibly damaging Het
Zfp101 T C 17: 33,600,295 (GRCm39) K487R possibly damaging Het
Other mutations in Acad11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00966:Acad11 APN 9 104,003,855 (GRCm39) missense probably damaging 1.00
IGL01100:Acad11 APN 9 103,953,607 (GRCm39) missense probably damaging 0.98
IGL01920:Acad11 APN 9 103,941,104 (GRCm39) critical splice donor site probably null
IGL02019:Acad11 APN 9 103,992,544 (GRCm39) missense probably damaging 1.00
IGL02506:Acad11 APN 9 103,968,931 (GRCm39) critical splice donor site probably null
IGL02742:Acad11 APN 9 103,972,824 (GRCm39) missense probably damaging 1.00
IGL02830:Acad11 APN 9 103,953,118 (GRCm39) missense probably damaging 1.00
IGL02936:Acad11 APN 9 103,990,711 (GRCm39) missense probably benign 0.31
R0092:Acad11 UTSW 9 103,967,540 (GRCm39) splice site probably benign
R0277:Acad11 UTSW 9 104,001,224 (GRCm39) missense probably damaging 1.00
R0377:Acad11 UTSW 9 103,958,891 (GRCm39) splice site probably benign
R0411:Acad11 UTSW 9 103,993,495 (GRCm39) missense probably damaging 1.00
R0556:Acad11 UTSW 9 103,992,501 (GRCm39) missense probably damaging 1.00
R0594:Acad11 UTSW 9 103,972,762 (GRCm39) missense probably benign 0.09
R0688:Acad11 UTSW 9 104,001,299 (GRCm39) missense probably damaging 1.00
R1416:Acad11 UTSW 9 103,950,822 (GRCm39) missense probably damaging 0.96
R1551:Acad11 UTSW 9 104,003,785 (GRCm39) missense probably damaging 0.99
R1730:Acad11 UTSW 9 103,941,081 (GRCm39) missense probably benign 0.02
R1819:Acad11 UTSW 9 103,991,738 (GRCm39) critical splice donor site probably null
R1884:Acad11 UTSW 9 103,991,684 (GRCm39) missense probably benign 0.13
R2411:Acad11 UTSW 9 103,963,222 (GRCm39) intron probably benign
R3055:Acad11 UTSW 9 103,953,535 (GRCm39) missense probably damaging 0.98
R3683:Acad11 UTSW 9 103,992,543 (GRCm39) missense probably damaging 1.00
R3954:Acad11 UTSW 9 103,963,351 (GRCm39) intron probably benign
R3956:Acad11 UTSW 9 103,963,351 (GRCm39) intron probably benign
R4425:Acad11 UTSW 9 103,950,844 (GRCm39) missense probably damaging 1.00
R4557:Acad11 UTSW 9 103,960,038 (GRCm39) missense probably benign 0.00
R4701:Acad11 UTSW 9 103,972,764 (GRCm39) nonsense probably null
R4764:Acad11 UTSW 9 103,953,076 (GRCm39) missense probably damaging 0.99
R4872:Acad11 UTSW 9 103,963,465 (GRCm39) intron probably benign
R5132:Acad11 UTSW 9 104,003,791 (GRCm39) missense probably benign 0.03
R5161:Acad11 UTSW 9 104,001,227 (GRCm39) missense probably benign 0.19
R5222:Acad11 UTSW 9 103,974,576 (GRCm39) missense probably damaging 1.00
R5683:Acad11 UTSW 9 103,961,482 (GRCm39) missense probably damaging 1.00
R6512:Acad11 UTSW 9 103,972,758 (GRCm39) nonsense probably null
R6815:Acad11 UTSW 9 103,958,526 (GRCm39) missense probably benign 0.01
R7035:Acad11 UTSW 9 103,990,694 (GRCm39) missense probably damaging 1.00
R7318:Acad11 UTSW 9 103,958,466 (GRCm39) missense probably damaging 1.00
R7564:Acad11 UTSW 9 104,000,288 (GRCm39) missense possibly damaging 0.94
R7673:Acad11 UTSW 9 103,941,105 (GRCm39) splice site probably null
R7812:Acad11 UTSW 9 103,972,747 (GRCm39) missense probably benign 0.41
R7850:Acad11 UTSW 9 103,991,728 (GRCm39) missense probably damaging 1.00
R8037:Acad11 UTSW 9 103,953,035 (GRCm39) missense possibly damaging 0.93
R8251:Acad11 UTSW 9 103,968,906 (GRCm39) missense possibly damaging 0.88
R9021:Acad11 UTSW 9 104,003,864 (GRCm39) missense possibly damaging 0.88
R9657:Acad11 UTSW 9 103,953,035 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- AAGTCTGGTCCCACAACAGG -3'
(R):5'- ACATGTTCCCAGGAGGCAAAG -3'

Sequencing Primer
(F):5'- ATTTCTCCACCAGACTCCGAG -3'
(R):5'- GCAAAGGCTATGGTTGATACCTG -3'
Posted On 2016-10-26