Incidental Mutation 'R0071:Coro7'
ID 43885
Institutional Source Beutler Lab
Gene Symbol Coro7
Ensembl Gene ENSMUSG00000039637
Gene Name coronin 7
Synonyms 0610011B16Rik
MMRRC Submission 038362-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R0071 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 4444748-4497584 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 4488391 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 93 (L93Q)
Ref Sequence ENSEMBL: ENSMUSP00000118310 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038552] [ENSMUST00000090480] [ENSMUST00000135823]
AlphaFold Q9D2V7
Predicted Effect probably damaging
Transcript: ENSMUST00000038552
AA Change: L93Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000048489
Gene: ENSMUSG00000039637
AA Change: L93Q

DomainStartEndE-ValueType
DUF1899 3 64 6.41e-15 SMART
WD40 66 106 1.83e-7 SMART
WD40 115 154 4.13e0 SMART
WD40 157 196 1.78e-5 SMART
DUF1900 251 385 4.49e-60 SMART
low complexity region 427 456 N/A INTRINSIC
DUF1899 463 528 1.2e-19 SMART
WD40 531 570 3.64e-2 SMART
WD40 580 620 8.55e-8 SMART
WD40 623 662 1.16e-9 SMART
low complexity region 667 679 N/A INTRINSIC
DUF1900 718 854 6.69e-68 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000090480
AA Change: L93Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000087966
Gene: ENSMUSG00000039637
AA Change: L93Q

DomainStartEndE-ValueType
DUF1899 3 64 6.41e-15 SMART
WD40 66 106 1.83e-7 SMART
WD40 115 154 4.13e0 SMART
WD40 157 196 1.78e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123031
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127850
Predicted Effect probably damaging
Transcript: ENSMUST00000135823
AA Change: L93Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000118310
Gene: ENSMUSG00000039637
AA Change: L93Q

DomainStartEndE-ValueType
DUF1899 3 64 6.41e-15 SMART
WD40 66 106 1.83e-7 SMART
WD40 115 154 4.13e0 SMART
WD40 157 196 1.78e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144815
Meta Mutation Damage Score 0.8957 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 92.2%
Validation Efficiency 99% (78/79)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele are viable and overtly normal but exhibit disruption of the Golgi apparatus. Mutant fibroblasts show increased cell spreading and cellular F-actin content, increased cell polarization and migration, and enhanced wound healing in a scratch-wound assay. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930474N05Rik A G 14: 35,812,746 (GRCm39) probably benign Het
Acot12 T C 13: 91,929,293 (GRCm39) probably benign Het
Acrbp T C 6: 125,027,915 (GRCm39) probably benign Het
Amotl1 G A 9: 14,460,069 (GRCm39) A890V probably benign Het
Aox3 T A 1: 58,211,050 (GRCm39) C931* probably null Het
Apob T A 12: 8,052,111 (GRCm39) V1184E probably damaging Het
Arhgap44 A T 11: 64,902,721 (GRCm39) L582Q possibly damaging Het
Bbx C T 16: 50,100,755 (GRCm39) E47K probably benign Het
Bccip A G 7: 133,315,960 (GRCm39) D72G probably damaging Het
Bckdha A T 7: 25,329,868 (GRCm39) probably null Het
Bmerb1 A G 16: 13,906,818 (GRCm39) D11G probably damaging Het
Cald1 C T 6: 34,735,069 (GRCm39) probably benign Het
Cby2 A G 14: 75,821,621 (GRCm39) S44P probably benign Het
Cdk11b T C 4: 155,733,880 (GRCm39) probably benign Het
Cebpe G T 14: 54,948,061 (GRCm39) R261S probably damaging Het
Cep95 C T 11: 106,681,554 (GRCm39) probably benign Het
Chi3l1 T C 1: 134,113,017 (GRCm39) Y150H probably benign Het
Chrnd T C 1: 87,120,559 (GRCm39) probably benign Het
Clec4g T A 8: 3,767,489 (GRCm39) probably benign Het
Cog2 T C 8: 125,275,407 (GRCm39) probably benign Het
Csmd3 T C 15: 47,460,217 (GRCm39) T3525A probably benign Het
Ctsc G A 7: 87,957,357 (GRCm39) probably benign Het
Dnajc16 T C 4: 141,495,318 (GRCm39) T467A probably benign Het
Dnmt1 G A 9: 20,819,916 (GRCm39) T1409I probably damaging Het
Fam227b T A 2: 125,965,994 (GRCm39) N144Y probably benign Het
Fam83h A G 15: 75,874,377 (GRCm39) S987P probably benign Het
Fhod1 A T 8: 106,063,857 (GRCm39) probably null Het
Folr1 A G 7: 101,513,130 (GRCm39) probably null Het
Glis3 C T 19: 28,241,255 (GRCm39) probably benign Het
Gm10069 T C 6: 128,449,688 (GRCm39) noncoding transcript Het
Golgb1 G A 16: 36,735,865 (GRCm39) R1704Q probably benign Het
Gpr158 C A 2: 21,815,479 (GRCm39) T624K probably benign Het
Helz2 T C 2: 180,878,200 (GRCm39) Y866C probably damaging Het
Itpkb T A 1: 180,160,330 (GRCm39) V152E probably damaging Het
Kcnma1 C T 14: 23,576,835 (GRCm39) R236H probably damaging Het
Klhl32 A G 4: 24,743,907 (GRCm39) V88A probably damaging Het
Lct C T 1: 128,219,755 (GRCm39) W1631* probably null Het
Lipa T A 19: 34,472,482 (GRCm39) K313M probably damaging Het
Ly75 T C 2: 60,152,163 (GRCm39) K1130R probably benign Het
Mamdc2 C A 19: 23,280,994 (GRCm39) E685* probably null Het
Mdm1 A G 10: 117,982,701 (GRCm39) E112G probably damaging Het
Metrnl A T 11: 121,606,826 (GRCm39) M212L probably benign Het
Mettl2 A G 11: 105,022,468 (GRCm39) probably benign Het
Mxd3 A T 13: 55,477,449 (GRCm39) L11Q probably damaging Het
Myo7a A T 7: 97,706,037 (GRCm39) Y1836N probably damaging Het
Nsun7 A G 5: 66,421,388 (GRCm39) Y118C probably benign Het
Obscn G A 11: 58,955,027 (GRCm39) T3962M possibly damaging Het
Or13a20 A T 7: 140,232,170 (GRCm39) I93F probably benign Het
Or2d36 A G 7: 106,746,919 (GRCm39) Y132C probably damaging Het
Or5k3 C A 16: 58,969,578 (GRCm39) R122S probably benign Het
Osbpl11 T C 16: 33,034,708 (GRCm39) probably benign Het
Pcdhb22 A T 18: 37,653,131 (GRCm39) D276V probably damaging Het
Pik3cb A T 9: 98,926,918 (GRCm39) D886E probably benign Het
Pkhd1 T A 1: 20,271,568 (GRCm39) Y2995F probably benign Het
Raver2 C T 4: 100,977,642 (GRCm39) probably benign Het
Rhbdf1 A G 11: 32,160,498 (GRCm39) L684P probably damaging Het
Rufy2 C A 10: 62,824,946 (GRCm39) L75M possibly damaging Het
Sec22c A G 9: 121,521,979 (GRCm39) F44L probably damaging Het
Sephs1 A G 2: 4,904,371 (GRCm39) T250A probably benign Het
Serpina1a T C 12: 103,822,002 (GRCm39) K310R probably benign Het
Shoc1 A G 4: 59,059,643 (GRCm39) Y1006H possibly damaging Het
Sobp A G 10: 43,033,993 (GRCm39) L111P probably damaging Het
Sparcl1 G T 5: 104,233,707 (GRCm39) Y547* probably null Het
Spata31d1b G A 13: 59,863,163 (GRCm39) A104T probably benign Het
Spsb3 A G 17: 25,106,878 (GRCm39) D184G probably damaging Het
Sptan1 A T 2: 29,893,354 (GRCm39) K1148* probably null Het
Tdrd12 A G 7: 35,228,671 (GRCm39) V17A possibly damaging Het
Tlr9 A G 9: 106,100,777 (GRCm39) T23A probably benign Het
Tra2b A T 16: 22,073,151 (GRCm39) probably benign Het
Tspan15 A G 10: 62,038,849 (GRCm39) probably benign Het
Ttc41 A G 10: 86,572,710 (GRCm39) N694S probably benign Het
Ttn T G 2: 76,597,813 (GRCm39) D19700A probably damaging Het
Ube3b G A 5: 114,557,558 (GRCm39) G1014D probably damaging Het
Unc5d A G 8: 29,209,854 (GRCm39) V422A possibly damaging Het
Vmn2r80 C T 10: 79,007,566 (GRCm39) T514I possibly damaging Het
Zfp595 T C 13: 67,464,917 (GRCm39) K452E possibly damaging Het
Zfp607a A G 7: 27,577,694 (GRCm39) K255E probably damaging Het
Zxdc T G 6: 90,347,398 (GRCm39) V253G probably damaging Het
Other mutations in Coro7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Coro7 APN 16 4,452,500 (GRCm39) missense possibly damaging 0.83
IGL00885:Coro7 APN 16 4,452,890 (GRCm39) missense probably benign 0.00
IGL02944:Coro7 APN 16 4,453,276 (GRCm39) missense probably benign 0.14
IGL03104:Coro7 APN 16 4,446,990 (GRCm39) missense probably damaging 1.00
IGL03153:Coro7 APN 16 4,453,246 (GRCm39) critical splice donor site probably null
R0022:Coro7 UTSW 16 4,451,168 (GRCm39) missense probably benign 0.01
R0022:Coro7 UTSW 16 4,451,168 (GRCm39) missense probably benign 0.01
R0071:Coro7 UTSW 16 4,488,391 (GRCm39) missense probably damaging 1.00
R0080:Coro7 UTSW 16 4,448,328 (GRCm39) missense probably damaging 1.00
R0193:Coro7 UTSW 16 4,445,368 (GRCm39) unclassified probably benign
R0242:Coro7 UTSW 16 4,448,042 (GRCm39) splice site probably benign
R0318:Coro7 UTSW 16 4,493,671 (GRCm39) missense probably benign 0.09
R0554:Coro7 UTSW 16 4,450,121 (GRCm39) missense possibly damaging 0.63
R0666:Coro7 UTSW 16 4,449,775 (GRCm39) missense possibly damaging 0.70
R0835:Coro7 UTSW 16 4,450,118 (GRCm39) missense probably benign 0.12
R0968:Coro7 UTSW 16 4,487,919 (GRCm39) splice site probably benign
R1670:Coro7 UTSW 16 4,446,097 (GRCm39) missense possibly damaging 0.76
R1709:Coro7 UTSW 16 4,452,305 (GRCm39) splice site probably null
R1848:Coro7 UTSW 16 4,448,298 (GRCm39) missense probably damaging 0.99
R1884:Coro7 UTSW 16 4,446,683 (GRCm39) unclassified probably benign
R1935:Coro7 UTSW 16 4,446,596 (GRCm39) missense probably benign
R1937:Coro7 UTSW 16 4,446,596 (GRCm39) missense probably benign
R1939:Coro7 UTSW 16 4,446,596 (GRCm39) missense probably benign
R1967:Coro7 UTSW 16 4,452,753 (GRCm39) missense probably damaging 1.00
R1969:Coro7 UTSW 16 4,451,620 (GRCm39) missense probably benign 0.19
R1970:Coro7 UTSW 16 4,451,620 (GRCm39) missense probably benign 0.19
R3034:Coro7 UTSW 16 4,450,155 (GRCm39) missense probably damaging 0.99
R4638:Coro7 UTSW 16 4,450,151 (GRCm39) missense probably damaging 0.96
R4710:Coro7 UTSW 16 4,452,797 (GRCm39) intron probably benign
R4723:Coro7 UTSW 16 4,449,858 (GRCm39) missense probably benign 0.00
R4789:Coro7 UTSW 16 4,446,085 (GRCm39) missense probably damaging 1.00
R5493:Coro7 UTSW 16 4,450,351 (GRCm39) missense probably damaging 0.99
R5619:Coro7 UTSW 16 4,494,799 (GRCm39) critical splice donor site probably null
R5756:Coro7 UTSW 16 4,450,148 (GRCm39) missense probably damaging 0.97
R5974:Coro7 UTSW 16 4,449,753 (GRCm39) missense possibly damaging 0.83
R6010:Coro7 UTSW 16 4,487,820 (GRCm39) missense possibly damaging 0.68
R6038:Coro7 UTSW 16 4,497,414 (GRCm39) critical splice donor site probably null
R6038:Coro7 UTSW 16 4,497,414 (GRCm39) critical splice donor site probably null
R6906:Coro7 UTSW 16 4,451,168 (GRCm39) missense probably benign 0.00
R6925:Coro7 UTSW 16 4,446,538 (GRCm39) critical splice donor site probably null
R7069:Coro7 UTSW 16 4,497,475 (GRCm39) start codon destroyed probably damaging 0.99
R7326:Coro7 UTSW 16 4,449,912 (GRCm39) missense probably damaging 0.96
R7421:Coro7 UTSW 16 4,486,615 (GRCm39) missense probably benign 0.19
R7521:Coro7 UTSW 16 4,449,346 (GRCm39) missense probably benign 0.00
R7773:Coro7 UTSW 16 4,449,870 (GRCm39) missense probably damaging 1.00
R7846:Coro7 UTSW 16 4,488,400 (GRCm39) missense probably damaging 1.00
R8240:Coro7 UTSW 16 4,486,660 (GRCm39) missense probably damaging 0.96
R8726:Coro7 UTSW 16 4,486,619 (GRCm39) missense possibly damaging 0.95
R8762:Coro7 UTSW 16 4,452,203 (GRCm39) missense probably benign
R9383:Coro7 UTSW 16 4,452,888 (GRCm39) missense probably damaging 1.00
R9451:Coro7 UTSW 16 4,488,402 (GRCm39) missense probably damaging 1.00
R9553:Coro7 UTSW 16 4,486,624 (GRCm39) missense possibly damaging 0.55
Predicted Primers PCR Primer
(F):5'- AACAGCAGCTCTGAGAAGGCAC -3'
(R):5'- CAGCCAAAGGACTCACCAGGATATG -3'

Sequencing Primer
(F):5'- TCTGAGAAGGCACTTGGGG -3'
(R):5'- tgggaggcagagacagg -3'
Posted On 2013-05-29