Incidental Mutation 'R0071:Or5k3'
ID 43891
Institutional Source Beutler Lab
Gene Symbol Or5k3
Ensembl Gene ENSMUSG00000062608
Gene Name olfactory receptor family 5 subfamily K member 3
Synonyms MOR184-5, GA_x54KRFPKG5P-55369823-55370749, Olfr195
MMRRC Submission 038362-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R0071 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 58969215-58970141 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 58969578 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 122 (R122S)
Ref Sequence ENSEMBL: ENSMUSP00000150249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075381] [ENSMUST00000216957]
AlphaFold Q8VGQ6
Predicted Effect probably benign
Transcript: ENSMUST00000075381
AA Change: R122S

PolyPhen 2 Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000073737
Gene: ENSMUSG00000062608
AA Change: R122S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 161 2.7e-8 PFAM
Pfam:7tm_1 41 307 9.4e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208239
AA Change: R122S
Predicted Effect probably benign
Transcript: ENSMUST00000216957
AA Change: R122S

PolyPhen 2 Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 92.2%
Validation Efficiency 99% (78/79)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930474N05Rik A G 14: 35,812,746 (GRCm39) probably benign Het
Acot12 T C 13: 91,929,293 (GRCm39) probably benign Het
Acrbp T C 6: 125,027,915 (GRCm39) probably benign Het
Amotl1 G A 9: 14,460,069 (GRCm39) A890V probably benign Het
Aox3 T A 1: 58,211,050 (GRCm39) C931* probably null Het
Apob T A 12: 8,052,111 (GRCm39) V1184E probably damaging Het
Arhgap44 A T 11: 64,902,721 (GRCm39) L582Q possibly damaging Het
Bbx C T 16: 50,100,755 (GRCm39) E47K probably benign Het
Bccip A G 7: 133,315,960 (GRCm39) D72G probably damaging Het
Bckdha A T 7: 25,329,868 (GRCm39) probably null Het
Bmerb1 A G 16: 13,906,818 (GRCm39) D11G probably damaging Het
Cald1 C T 6: 34,735,069 (GRCm39) probably benign Het
Cby2 A G 14: 75,821,621 (GRCm39) S44P probably benign Het
Cdk11b T C 4: 155,733,880 (GRCm39) probably benign Het
Cebpe G T 14: 54,948,061 (GRCm39) R261S probably damaging Het
Cep95 C T 11: 106,681,554 (GRCm39) probably benign Het
Chi3l1 T C 1: 134,113,017 (GRCm39) Y150H probably benign Het
Chrnd T C 1: 87,120,559 (GRCm39) probably benign Het
Clec4g T A 8: 3,767,489 (GRCm39) probably benign Het
Cog2 T C 8: 125,275,407 (GRCm39) probably benign Het
Coro7 A T 16: 4,488,391 (GRCm39) L93Q probably damaging Het
Csmd3 T C 15: 47,460,217 (GRCm39) T3525A probably benign Het
Ctsc G A 7: 87,957,357 (GRCm39) probably benign Het
Dnajc16 T C 4: 141,495,318 (GRCm39) T467A probably benign Het
Dnmt1 G A 9: 20,819,916 (GRCm39) T1409I probably damaging Het
Fam227b T A 2: 125,965,994 (GRCm39) N144Y probably benign Het
Fam83h A G 15: 75,874,377 (GRCm39) S987P probably benign Het
Fhod1 A T 8: 106,063,857 (GRCm39) probably null Het
Folr1 A G 7: 101,513,130 (GRCm39) probably null Het
Glis3 C T 19: 28,241,255 (GRCm39) probably benign Het
Gm10069 T C 6: 128,449,688 (GRCm39) noncoding transcript Het
Golgb1 G A 16: 36,735,865 (GRCm39) R1704Q probably benign Het
Gpr158 C A 2: 21,815,479 (GRCm39) T624K probably benign Het
Helz2 T C 2: 180,878,200 (GRCm39) Y866C probably damaging Het
Itpkb T A 1: 180,160,330 (GRCm39) V152E probably damaging Het
Kcnma1 C T 14: 23,576,835 (GRCm39) R236H probably damaging Het
Klhl32 A G 4: 24,743,907 (GRCm39) V88A probably damaging Het
Lct C T 1: 128,219,755 (GRCm39) W1631* probably null Het
Lipa T A 19: 34,472,482 (GRCm39) K313M probably damaging Het
Ly75 T C 2: 60,152,163 (GRCm39) K1130R probably benign Het
Mamdc2 C A 19: 23,280,994 (GRCm39) E685* probably null Het
Mdm1 A G 10: 117,982,701 (GRCm39) E112G probably damaging Het
Metrnl A T 11: 121,606,826 (GRCm39) M212L probably benign Het
Mettl2 A G 11: 105,022,468 (GRCm39) probably benign Het
Mxd3 A T 13: 55,477,449 (GRCm39) L11Q probably damaging Het
Myo7a A T 7: 97,706,037 (GRCm39) Y1836N probably damaging Het
Nsun7 A G 5: 66,421,388 (GRCm39) Y118C probably benign Het
Obscn G A 11: 58,955,027 (GRCm39) T3962M possibly damaging Het
Or13a20 A T 7: 140,232,170 (GRCm39) I93F probably benign Het
Or2d36 A G 7: 106,746,919 (GRCm39) Y132C probably damaging Het
Osbpl11 T C 16: 33,034,708 (GRCm39) probably benign Het
Pcdhb22 A T 18: 37,653,131 (GRCm39) D276V probably damaging Het
Pik3cb A T 9: 98,926,918 (GRCm39) D886E probably benign Het
Pkhd1 T A 1: 20,271,568 (GRCm39) Y2995F probably benign Het
Raver2 C T 4: 100,977,642 (GRCm39) probably benign Het
Rhbdf1 A G 11: 32,160,498 (GRCm39) L684P probably damaging Het
Rufy2 C A 10: 62,824,946 (GRCm39) L75M possibly damaging Het
Sec22c A G 9: 121,521,979 (GRCm39) F44L probably damaging Het
Sephs1 A G 2: 4,904,371 (GRCm39) T250A probably benign Het
Serpina1a T C 12: 103,822,002 (GRCm39) K310R probably benign Het
Shoc1 A G 4: 59,059,643 (GRCm39) Y1006H possibly damaging Het
Sobp A G 10: 43,033,993 (GRCm39) L111P probably damaging Het
Sparcl1 G T 5: 104,233,707 (GRCm39) Y547* probably null Het
Spata31d1b G A 13: 59,863,163 (GRCm39) A104T probably benign Het
Spsb3 A G 17: 25,106,878 (GRCm39) D184G probably damaging Het
Sptan1 A T 2: 29,893,354 (GRCm39) K1148* probably null Het
Tdrd12 A G 7: 35,228,671 (GRCm39) V17A possibly damaging Het
Tlr9 A G 9: 106,100,777 (GRCm39) T23A probably benign Het
Tra2b A T 16: 22,073,151 (GRCm39) probably benign Het
Tspan15 A G 10: 62,038,849 (GRCm39) probably benign Het
Ttc41 A G 10: 86,572,710 (GRCm39) N694S probably benign Het
Ttn T G 2: 76,597,813 (GRCm39) D19700A probably damaging Het
Ube3b G A 5: 114,557,558 (GRCm39) G1014D probably damaging Het
Unc5d A G 8: 29,209,854 (GRCm39) V422A possibly damaging Het
Vmn2r80 C T 10: 79,007,566 (GRCm39) T514I possibly damaging Het
Zfp595 T C 13: 67,464,917 (GRCm39) K452E possibly damaging Het
Zfp607a A G 7: 27,577,694 (GRCm39) K255E probably damaging Het
Zxdc T G 6: 90,347,398 (GRCm39) V253G probably damaging Het
Other mutations in Or5k3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01937:Or5k3 APN 16 58,969,827 (GRCm39) missense probably benign 0.01
IGL01945:Or5k3 APN 16 58,969,827 (GRCm39) missense probably benign 0.01
R0390:Or5k3 UTSW 16 58,969,662 (GRCm39) missense probably benign 0.01
R0601:Or5k3 UTSW 16 58,970,117 (GRCm39) missense probably benign 0.00
R1499:Or5k3 UTSW 16 58,969,287 (GRCm39) missense probably benign
R1612:Or5k3 UTSW 16 58,969,987 (GRCm39) missense probably benign 0.00
R1785:Or5k3 UTSW 16 58,969,660 (GRCm39) missense probably damaging 1.00
R2082:Or5k3 UTSW 16 58,969,248 (GRCm39) missense probably damaging 0.99
R3605:Or5k3 UTSW 16 58,969,846 (GRCm39) missense probably damaging 1.00
R4168:Or5k3 UTSW 16 58,969,363 (GRCm39) missense probably benign 0.00
R4839:Or5k3 UTSW 16 58,969,393 (GRCm39) missense probably damaging 1.00
R4989:Or5k3 UTSW 16 58,969,981 (GRCm39) missense probably damaging 1.00
R5285:Or5k3 UTSW 16 58,969,633 (GRCm39) missense probably damaging 1.00
R7107:Or5k3 UTSW 16 58,969,279 (GRCm39) missense probably benign 0.10
R7136:Or5k3 UTSW 16 58,969,327 (GRCm39) missense probably damaging 1.00
R7317:Or5k3 UTSW 16 58,969,684 (GRCm39) missense possibly damaging 0.80
R7601:Or5k3 UTSW 16 58,969,597 (GRCm39) missense probably benign 0.01
R7729:Or5k3 UTSW 16 58,969,570 (GRCm39) missense probably damaging 1.00
R8004:Or5k3 UTSW 16 58,969,351 (GRCm39) missense probably damaging 1.00
R8208:Or5k3 UTSW 16 58,969,382 (GRCm39) missense probably benign 0.41
R8282:Or5k3 UTSW 16 58,969,529 (GRCm39) nonsense probably null
R8954:Or5k3 UTSW 16 58,969,319 (GRCm39) nonsense probably null
R9137:Or5k3 UTSW 16 58,969,635 (GRCm39) missense probably benign 0.30
R9197:Or5k3 UTSW 16 58,969,489 (GRCm39) missense probably damaging 0.99
R9396:Or5k3 UTSW 16 58,969,302 (GRCm39) missense probably damaging 0.97
R9547:Or5k3 UTSW 16 58,970,107 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- ACATCTTTCTGGGCAACCTGGC -3'
(R):5'- GCTGAATGTGGTTGAGCATACATGAAG -3'

Sequencing Primer
(F):5'- AACCTGGCTCTGATGGACTC -3'
(R):5'- TTGAATTGAACCTGCCAAGAC -3'
Posted On 2013-05-29