Incidental Mutation 'R5601:Or4n4b'
ID 439040
Institutional Source Beutler Lab
Gene Symbol Or4n4b
Ensembl Gene ENSMUSG00000090874
Gene Name olfactory receptor family 4 subfamily N member 4B
Synonyms Olfr733, GA_x6K02T2PMLR-5992342-5991416, MOR241-2
MMRRC Submission 043153-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R5601 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 50535794-50536787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 50536318 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Cysteine at position 149 (W149C)
Ref Sequence ENSEMBL: ENSMUSP00000149807 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163469] [ENSMUST00000214372] [ENSMUST00000214756] [ENSMUST00000216195]
AlphaFold Q14AK5
Predicted Effect probably damaging
Transcript: ENSMUST00000163469
AA Change: W149C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128332
Gene: ENSMUSG00000090874
AA Change: W149C

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 6.4e-41 PFAM
Pfam:7tm_1 41 288 1e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214372
AA Change: W149C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214756
AA Change: W149C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216195
AA Change: W149C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot12 G A 13: 91,931,029 (GRCm39) V426I probably benign Het
Asmt T C X: 169,110,127 (GRCm39) V212A probably damaging Het
Atn1 A G 6: 124,720,191 (GRCm39) probably null Het
Auts2 G T 5: 131,505,662 (GRCm39) probably benign Het
AW551984 C T 9: 39,502,563 (GRCm39) V672M possibly damaging Het
Bltp3a C A 17: 28,103,468 (GRCm39) A392D probably damaging Het
Ccdc13 G A 9: 121,629,638 (GRCm39) Q114* probably null Het
Ces2e A T 8: 105,656,126 (GRCm39) I146F probably benign Het
Cfap44 A G 16: 44,280,549 (GRCm39) K1443E probably damaging Het
Cma2 T A 14: 56,211,246 (GRCm39) H179Q possibly damaging Het
Cpsf2 G T 12: 101,951,614 (GRCm39) probably null Het
Cwh43 A G 5: 73,575,283 (GRCm39) probably null Het
Dnajb12 GC G 10: 59,728,574 (GRCm39) probably null Het
Dram1 A G 10: 88,160,629 (GRCm39) S231P probably damaging Het
Fbxw7 A G 3: 84,883,515 (GRCm39) D482G probably damaging Het
Fstl1 T C 16: 37,647,161 (GRCm39) I177T probably benign Het
Fut9 T C 4: 25,620,299 (GRCm39) T172A probably benign Het
Gm5134 G A 10: 75,821,786 (GRCm39) V207M probably damaging Het
Hccs G A X: 168,096,597 (GRCm39) R203C probably damaging Het
Hmgxb3 A T 18: 61,270,694 (GRCm39) F877I probably damaging Het
Ide A G 19: 37,292,379 (GRCm39) V272A unknown Het
Impact C T 18: 13,109,064 (GRCm39) T65I probably benign Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Muc17 A G 5: 137,166,863 (GRCm39) S309P probably damaging Het
Myf6 A C 10: 107,330,475 (GRCm39) S31A probably damaging Het
Or8b35 C G 9: 37,904,010 (GRCm39) T74R possibly damaging Het
P4hb T A 11: 120,462,441 (GRCm39) E88D possibly damaging Het
Pcdhb9 T C 18: 37,535,259 (GRCm39) C418R probably damaging Het
Pramel51 T C 12: 88,142,817 (GRCm39) D267G probably damaging Het
Prdm4 TCTCCTCCT TCTCCT 10: 85,728,987 (GRCm39) probably null Het
Prss58 A T 6: 40,874,783 (GRCm39) N19K possibly damaging Het
Ptprq C T 10: 107,444,291 (GRCm39) A1438T probably benign Het
Rfx4 A T 10: 84,634,442 (GRCm39) T61S probably damaging Het
Sclt1 T A 3: 41,685,354 (GRCm39) N35Y probably benign Het
Sec24b CTG CTGGTG 3: 129,834,483 (GRCm39) probably benign Het
Serpinb12 T C 1: 106,881,427 (GRCm39) I188T probably damaging Het
Slc27a4 A T 2: 29,695,672 (GRCm39) Y69F probably benign Het
Slc3a1 T C 17: 85,340,319 (GRCm39) V247A probably benign Het
Slc4a2 C T 5: 24,643,772 (GRCm39) T854I probably benign Het
Stat5b G A 11: 100,674,001 (GRCm39) T761M probably damaging Het
Stkld1 T C 2: 26,842,717 (GRCm39) L563P probably damaging Het
Tbc1d23 C A 16: 57,018,672 (GRCm39) C283F probably benign Het
Tcaf3 T C 6: 42,564,462 (GRCm39) N900S possibly damaging Het
Tkfc T C 19: 10,571,927 (GRCm39) T370A probably benign Het
Tpr T C 1: 150,311,604 (GRCm39) V1868A possibly damaging Het
Triobp T A 15: 78,857,833 (GRCm39) W1145R probably damaging Het
Vmn2r82 T G 10: 79,232,025 (GRCm39) L675V probably damaging Het
Zfp423 T C 8: 88,508,637 (GRCm39) E444G probably damaging Het
Other mutations in Or4n4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01879:Or4n4b APN 14 50,535,969 (GRCm39) missense probably benign 0.00
IGL02247:Or4n4b APN 14 50,536,571 (GRCm39) missense probably damaging 1.00
IGL02307:Or4n4b APN 14 50,536,295 (GRCm39) missense probably damaging 1.00
IGL02492:Or4n4b APN 14 50,536,060 (GRCm39) missense probably damaging 1.00
PIT4378001:Or4n4b UTSW 14 50,536,355 (GRCm39) missense probably benign
R0544:Or4n4b UTSW 14 50,536,139 (GRCm39) missense probably benign 0.20
R1603:Or4n4b UTSW 14 50,536,491 (GRCm39) missense possibly damaging 0.95
R1881:Or4n4b UTSW 14 50,536,472 (GRCm39) missense probably damaging 1.00
R3731:Or4n4b UTSW 14 50,535,962 (GRCm39) missense probably damaging 1.00
R4271:Or4n4b UTSW 14 50,535,908 (GRCm39) missense probably damaging 1.00
R4512:Or4n4b UTSW 14 50,536,453 (GRCm39) missense probably damaging 1.00
R6468:Or4n4b UTSW 14 50,535,924 (GRCm39) missense probably benign 0.02
R6614:Or4n4b UTSW 14 50,536,494 (GRCm39) missense probably benign 0.00
R7013:Or4n4b UTSW 14 50,536,656 (GRCm39) missense probably damaging 0.99
R7083:Or4n4b UTSW 14 50,536,736 (GRCm39) missense possibly damaging 0.81
R7274:Or4n4b UTSW 14 50,535,879 (GRCm39) missense probably benign 0.01
R7493:Or4n4b UTSW 14 50,536,281 (GRCm39) missense probably benign 0.02
R7653:Or4n4b UTSW 14 50,536,604 (GRCm39) missense possibly damaging 0.82
R7659:Or4n4b UTSW 14 50,536,698 (GRCm39) missense probably benign 0.00
R7885:Or4n4b UTSW 14 50,536,041 (GRCm39) missense probably damaging 1.00
R9138:Or4n4b UTSW 14 50,536,494 (GRCm39) missense probably benign
R9497:Or4n4b UTSW 14 50,536,362 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GGTAAGCAGGCCACTATTGAAG -3'
(R):5'- CCTTCATTGTGGCTCCTAGG -3'

Sequencing Primer
(F):5'- CAGGCCACTATTGAAGATCATAAG -3'
(R):5'- GGCTCCTAGGATGTTGATAGAC -3'
Posted On 2016-10-26