Incidental Mutation 'R0496:Magi2'
| ID |
43920 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi2
|
| Ensembl Gene |
ENSMUSG00000040003 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 2 |
| Synonyms |
Acvrinp1, Magi-2, S-SCAM |
| MMRRC Submission |
038692-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0496 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
19432034-20909790 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to T
at 20866357 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088516]
[ENSMUST00000101558]
[ENSMUST00000115267]
[ENSMUST00000197354]
[ENSMUST00000197443]
|
| AlphaFold |
Q9WVQ1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088516
|
| SMART Domains |
Protein: ENSMUSP00000085872
Gene: ENSMUSG00000040003
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
5.26e-9 |
SMART |
|
GuKc
|
107 |
290 |
2.76e-45 |
SMART |
|
WW
|
302 |
334 |
7.43e-12 |
SMART |
|
WW
|
348 |
380 |
2.4e-6 |
SMART |
|
PDZ
|
433 |
509 |
3.51e-19 |
SMART |
|
PDZ
|
612 |
682 |
2.3e-14 |
SMART |
|
PDZ
|
785 |
861 |
4.04e-19 |
SMART |
|
low complexity region
|
893 |
907 |
N/A |
INTRINSIC |
|
PDZ
|
928 |
1009 |
5.05e-20 |
SMART |
|
low complexity region
|
1052 |
1063 |
N/A |
INTRINSIC |
|
PDZ
|
1147 |
1221 |
3.88e-21 |
SMART |
|
low complexity region
|
1257 |
1270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000101558
|
| SMART Domains |
Protein: ENSMUSP00000099094
Gene: ENSMUSG00000040003
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
66 |
74 |
N/A |
INTRINSIC |
|
WW
|
139 |
171 |
7.43e-12 |
SMART |
|
WW
|
185 |
217 |
2.4e-6 |
SMART |
|
PDZ
|
270 |
346 |
3.51e-19 |
SMART |
|
PDZ
|
449 |
519 |
2.3e-14 |
SMART |
|
PDZ
|
608 |
684 |
4.04e-19 |
SMART |
|
low complexity region
|
716 |
730 |
N/A |
INTRINSIC |
|
PDZ
|
751 |
832 |
5.05e-20 |
SMART |
|
low complexity region
|
875 |
886 |
N/A |
INTRINSIC |
|
PDZ
|
970 |
1044 |
3.88e-21 |
SMART |
|
low complexity region
|
1080 |
1093 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115267
|
| SMART Domains |
Protein: ENSMUSP00000110922
Gene: ENSMUSG00000040003
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
66 |
74 |
N/A |
INTRINSIC |
|
WW
|
139 |
171 |
7.43e-12 |
SMART |
|
WW
|
185 |
217 |
2.4e-6 |
SMART |
|
PDZ
|
270 |
346 |
3.51e-19 |
SMART |
|
PDZ
|
449 |
519 |
2.3e-14 |
SMART |
|
PDZ
|
622 |
698 |
4.04e-19 |
SMART |
|
low complexity region
|
730 |
744 |
N/A |
INTRINSIC |
|
PDZ
|
765 |
846 |
5.05e-20 |
SMART |
|
low complexity region
|
889 |
900 |
N/A |
INTRINSIC |
|
PDZ
|
984 |
1058 |
3.88e-21 |
SMART |
|
low complexity region
|
1094 |
1107 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197354
|
| SMART Domains |
Protein: ENSMUSP00000142576
Gene: ENSMUSG00000040003
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
2.5e-11 |
SMART |
|
GuKc
|
107 |
290 |
1.4e-47 |
SMART |
|
WW
|
302 |
334 |
4.3e-14 |
SMART |
|
WW
|
348 |
380 |
1.4e-8 |
SMART |
|
PDZ
|
433 |
509 |
1.7e-21 |
SMART |
|
PDZ
|
612 |
682 |
1.1e-16 |
SMART |
|
PDZ
|
785 |
861 |
2e-21 |
SMART |
|
low complexity region
|
893 |
907 |
N/A |
INTRINSIC |
|
PDZ
|
928 |
1009 |
2.4e-22 |
SMART |
|
low complexity region
|
1052 |
1063 |
N/A |
INTRINSIC |
|
PDZ
|
1147 |
1221 |
1.9e-23 |
SMART |
|
low complexity region
|
1255 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1304 |
1319 |
N/A |
INTRINSIC |
|
low complexity region
|
1344 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1384 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197443
|
| SMART Domains |
Protein: ENSMUSP00000142764
Gene: ENSMUSG00000040003
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
2.5e-11 |
SMART |
|
GuKc
|
107 |
290 |
1.4e-47 |
SMART |
|
WW
|
302 |
334 |
4.3e-14 |
SMART |
|
WW
|
348 |
380 |
1.4e-8 |
SMART |
|
PDZ
|
433 |
509 |
1.7e-21 |
SMART |
|
PDZ
|
612 |
682 |
1.1e-16 |
SMART |
|
PDZ
|
771 |
847 |
2e-21 |
SMART |
|
low complexity region
|
879 |
893 |
N/A |
INTRINSIC |
|
PDZ
|
914 |
995 |
2.4e-22 |
SMART |
|
low complexity region
|
1038 |
1049 |
N/A |
INTRINSIC |
|
PDZ
|
1133 |
1207 |
1.9e-23 |
SMART |
|
low complexity region
|
1241 |
1255 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1305 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1349 |
N/A |
INTRINSIC |
|
low complexity region
|
1354 |
1370 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199514
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.6%
|
| Validation Efficiency |
98% (99/101) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a null allele show neonatal death and hippocampal neurons with altered dendritic spine morphology. Homozygotes for a different null allele die neonatally due to anuria and podocyte anomalies. Mice lacking all three isoforms develop proteinuria, podocytopathy and die of renal failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 137,774,005 (GRCm39) |
K1065E |
probably damaging |
Het |
| 4933402N03Rik |
T |
C |
7: 130,747,860 (GRCm39) |
N44S |
probably benign |
Het |
| Abca13 |
A |
G |
11: 9,241,701 (GRCm39) |
D1188G |
probably benign |
Het |
| Abcb11 |
C |
T |
2: 69,108,228 (GRCm39) |
|
probably benign |
Het |
| Abcc8 |
A |
T |
7: 45,758,244 (GRCm39) |
I1274N |
probably damaging |
Het |
| Adamtsl1 |
G |
A |
4: 86,259,435 (GRCm39) |
C827Y |
probably damaging |
Het |
| Agap3 |
T |
A |
5: 24,706,241 (GRCm39) |
V369E |
probably damaging |
Het |
| Ankrd13b |
G |
A |
11: 77,363,867 (GRCm39) |
R195C |
probably damaging |
Het |
| Ap3b1 |
A |
G |
13: 94,609,446 (GRCm39) |
|
probably benign |
Het |
| Arhgef40 |
A |
T |
14: 52,242,364 (GRCm39) |
|
probably benign |
Het |
| Atad5 |
A |
G |
11: 79,991,182 (GRCm39) |
I692V |
probably benign |
Het |
| Atp5f1b |
G |
T |
10: 127,922,043 (GRCm39) |
R310L |
possibly damaging |
Het |
| AY358078 |
A |
T |
14: 52,040,989 (GRCm39) |
M103L |
unknown |
Het |
| Bcl9l |
T |
G |
9: 44,420,815 (GRCm39) |
V1370G |
probably benign |
Het |
| Bglap3 |
T |
A |
3: 88,276,444 (GRCm39) |
Q38L |
probably damaging |
Het |
| Bltp1 |
A |
G |
3: 37,041,784 (GRCm39) |
T2721A |
probably damaging |
Het |
| Ccn2 |
G |
T |
10: 24,473,413 (GRCm39) |
M317I |
possibly damaging |
Het |
| Cd38 |
T |
C |
5: 44,026,233 (GRCm39) |
F6L |
probably damaging |
Het |
| Cela3a |
A |
C |
4: 137,131,779 (GRCm39) |
V138G |
probably damaging |
Het |
| Cemip2 |
A |
T |
19: 21,774,709 (GRCm39) |
N117I |
possibly damaging |
Het |
| Clvs1 |
T |
A |
4: 9,424,241 (GRCm39) |
I229N |
probably damaging |
Het |
| Cpne1 |
G |
A |
2: 155,921,339 (GRCm39) |
H16Y |
probably damaging |
Het |
| Ctc1 |
T |
C |
11: 68,926,333 (GRCm39) |
L1069P |
probably damaging |
Het |
| Dgkd |
G |
A |
1: 87,864,622 (GRCm39) |
S996N |
probably null |
Het |
| Dnah9 |
A |
T |
11: 65,965,961 (GRCm39) |
M1685K |
probably null |
Het |
| Dnajb12 |
C |
T |
10: 59,715,623 (GRCm39) |
R42* |
probably null |
Het |
| Dock5 |
T |
C |
14: 68,054,967 (GRCm39) |
Q633R |
probably damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,155,180 (GRCm39) |
M868T |
probably benign |
Het |
| Enpp1 |
G |
T |
10: 24,547,950 (GRCm39) |
H208Q |
probably benign |
Het |
| Epha7 |
T |
A |
4: 28,821,292 (GRCm39) |
D152E |
probably damaging |
Het |
| Fancd2 |
T |
C |
6: 113,532,091 (GRCm39) |
|
probably benign |
Het |
| Gart |
G |
A |
16: 91,419,925 (GRCm39) |
|
probably benign |
Het |
| Gm10964 |
A |
T |
3: 103,646,745 (GRCm39) |
|
probably null |
Het |
| Gpbar1 |
T |
C |
1: 74,318,140 (GRCm39) |
F128L |
probably benign |
Het |
| Gsx2 |
T |
A |
5: 75,237,726 (GRCm39) |
M226K |
probably benign |
Het |
| Gucd1 |
T |
C |
10: 75,347,100 (GRCm39) |
D50G |
possibly damaging |
Het |
| Has1 |
A |
G |
17: 18,064,008 (GRCm39) |
Y544H |
probably benign |
Het |
| Hc |
A |
T |
2: 34,903,583 (GRCm39) |
Y1024N |
probably damaging |
Het |
| Hoxa13 |
CCG |
CCGCG |
6: 52,237,618 (GRCm39) |
|
probably null |
Het |
| Ift122 |
T |
A |
6: 115,882,863 (GRCm39) |
H659Q |
probably benign |
Het |
| Itga2 |
T |
C |
13: 114,990,435 (GRCm39) |
Q902R |
probably benign |
Het |
| Itgb2l |
T |
C |
16: 96,235,901 (GRCm39) |
K181E |
possibly damaging |
Het |
| Jak3 |
A |
T |
8: 72,135,041 (GRCm39) |
H558L |
probably damaging |
Het |
| Kcnh8 |
A |
G |
17: 53,032,886 (GRCm39) |
T58A |
probably benign |
Het |
| Klhl6 |
GT |
G |
16: 19,775,716 (GRCm39) |
279 |
probably null |
Het |
| Krt33a |
C |
T |
11: 99,903,155 (GRCm39) |
|
probably benign |
Het |
| Map4 |
G |
A |
9: 109,868,918 (GRCm39) |
|
probably benign |
Het |
| Map4k4 |
T |
A |
1: 40,045,982 (GRCm39) |
S754T |
probably damaging |
Het |
| Mapk8ip3 |
A |
G |
17: 25,133,424 (GRCm39) |
|
probably benign |
Het |
| Mib1 |
A |
G |
18: 10,804,773 (GRCm39) |
S918G |
probably benign |
Het |
| Mipol1 |
T |
A |
12: 57,503,963 (GRCm39) |
V377D |
probably damaging |
Het |
| Mlh1 |
T |
C |
9: 111,070,624 (GRCm39) |
T364A |
probably benign |
Het |
| Mta1 |
C |
T |
12: 113,094,941 (GRCm39) |
Q400* |
probably null |
Het |
| Mthfd1l |
C |
G |
10: 4,040,006 (GRCm39) |
R806G |
probably benign |
Het |
| Myh13 |
C |
A |
11: 67,239,641 (GRCm39) |
N730K |
probably damaging |
Het |
| Myom1 |
A |
G |
17: 71,391,301 (GRCm39) |
K937E |
probably damaging |
Het |
| Naxd |
T |
C |
8: 11,560,224 (GRCm39) |
|
probably benign |
Het |
| Negr1 |
G |
T |
3: 156,721,904 (GRCm39) |
K159N |
probably damaging |
Het |
| Nwd2 |
G |
T |
5: 63,963,686 (GRCm39) |
W1090L |
probably damaging |
Het |
| Or1e1f |
T |
C |
11: 73,855,706 (GRCm39) |
S91P |
probably benign |
Het |
| Or2j3 |
A |
G |
17: 38,615,549 (GRCm39) |
S268P |
probably damaging |
Het |
| Or51v14 |
C |
T |
7: 103,261,204 (GRCm39) |
A119T |
probably benign |
Het |
| Or52r1c |
T |
C |
7: 102,734,797 (GRCm39) |
I19T |
probably damaging |
Het |
| Or5d41 |
A |
T |
2: 88,054,499 (GRCm39) |
Y292* |
probably null |
Het |
| Pcsk6 |
G |
A |
7: 65,576,997 (GRCm39) |
S58N |
probably benign |
Het |
| Pdzrn3 |
G |
A |
6: 101,127,531 (GRCm39) |
T1045I |
possibly damaging |
Het |
| Pitrm1 |
T |
C |
13: 6,618,750 (GRCm39) |
L641P |
probably damaging |
Het |
| Pkd1l1 |
G |
T |
11: 8,879,430 (GRCm39) |
H474N |
probably damaging |
Het |
| Pltp |
A |
G |
2: 164,694,381 (GRCm39) |
|
probably benign |
Het |
| Qtrt1 |
C |
T |
9: 21,330,844 (GRCm39) |
T324M |
probably benign |
Het |
| Racgap1 |
A |
T |
15: 99,537,713 (GRCm39) |
|
probably benign |
Het |
| Rhbg |
A |
G |
3: 88,161,805 (GRCm39) |
V50A |
probably benign |
Het |
| Rnf135 |
G |
A |
11: 80,074,776 (GRCm39) |
V12M |
probably damaging |
Het |
| Rnf7l |
G |
T |
10: 63,257,381 (GRCm39) |
C46* |
probably null |
Het |
| Rufy2 |
T |
C |
10: 62,828,949 (GRCm39) |
V117A |
probably damaging |
Het |
| Safb |
A |
G |
17: 56,912,630 (GRCm39) |
M866V |
probably benign |
Het |
| Slc35c2 |
G |
T |
2: 165,122,735 (GRCm39) |
T183K |
probably damaging |
Het |
| Slc39a7 |
A |
G |
17: 34,248,512 (GRCm39) |
L377P |
probably damaging |
Het |
| Slit1 |
G |
A |
19: 41,596,750 (GRCm39) |
|
probably benign |
Het |
| Spaca9 |
G |
A |
2: 28,583,022 (GRCm39) |
H133Y |
probably damaging |
Het |
| Spout1 |
A |
G |
2: 30,064,983 (GRCm39) |
F339S |
probably benign |
Het |
| St6gal2 |
A |
G |
17: 55,789,015 (GRCm39) |
I16M |
probably damaging |
Het |
| Stat2 |
T |
C |
10: 128,112,378 (GRCm39) |
M6T |
probably benign |
Het |
| Swt1 |
T |
A |
1: 151,287,021 (GRCm39) |
H157L |
probably benign |
Het |
| Syne2 |
A |
G |
12: 76,085,714 (GRCm39) |
N147D |
possibly damaging |
Het |
| Tmem222 |
A |
T |
4: 133,004,902 (GRCm39) |
M45K |
possibly damaging |
Het |
| Tmem30a |
T |
A |
9: 79,684,567 (GRCm39) |
H95L |
probably damaging |
Het |
| Tns3 |
A |
C |
11: 8,497,262 (GRCm39) |
|
probably benign |
Het |
| Trpm3 |
A |
G |
19: 22,676,142 (GRCm39) |
I103V |
probably benign |
Het |
| Ube2n |
T |
C |
10: 95,377,206 (GRCm39) |
F57S |
probably benign |
Het |
| Vil1 |
T |
C |
1: 74,460,499 (GRCm39) |
S219P |
possibly damaging |
Het |
| Wdfy4 |
A |
G |
14: 32,862,695 (GRCm39) |
|
probably benign |
Het |
| Wdr7 |
T |
C |
18: 63,924,914 (GRCm39) |
S966P |
probably benign |
Het |
| Wnt8a |
A |
G |
18: 34,677,900 (GRCm39) |
N103D |
probably damaging |
Het |
| Zfp523 |
G |
A |
17: 28,419,419 (GRCm39) |
E186K |
possibly damaging |
Het |
| Zfp791 |
A |
T |
8: 85,836,609 (GRCm39) |
D418E |
probably benign |
Het |
| Zscan20 |
A |
G |
4: 128,485,682 (GRCm39) |
V192A |
probably benign |
Het |
|
| Other mutations in Magi2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00908:Magi2
|
APN |
5 |
20,596,299 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02120:Magi2
|
APN |
5 |
20,433,451 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02341:Magi2
|
APN |
5 |
20,671,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02411:Magi2
|
APN |
5 |
19,883,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02657:Magi2
|
APN |
5 |
19,432,581 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02976:Magi2
|
APN |
5 |
20,739,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03105:Magi2
|
APN |
5 |
20,748,616 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03246:Magi2
|
APN |
5 |
20,563,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03329:Magi2
|
APN |
5 |
20,671,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
LCD18:Magi2
|
UTSW |
5 |
20,159,509 (GRCm39) |
intron |
probably benign |
|
|
PIT4519001:Magi2
|
UTSW |
5 |
20,866,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0009:Magi2
|
UTSW |
5 |
20,816,053 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0009:Magi2
|
UTSW |
5 |
20,816,053 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0352:Magi2
|
UTSW |
5 |
20,270,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0362:Magi2
|
UTSW |
5 |
19,432,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1103:Magi2
|
UTSW |
5 |
20,816,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1435:Magi2
|
UTSW |
5 |
20,563,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1583:Magi2
|
UTSW |
5 |
19,432,330 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1616:Magi2
|
UTSW |
5 |
20,814,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1643:Magi2
|
UTSW |
5 |
20,910,504 (GRCm39) |
unclassified |
probably benign |
|
|
R1707:Magi2
|
UTSW |
5 |
20,420,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1833:Magi2
|
UTSW |
5 |
19,432,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1837:Magi2
|
UTSW |
5 |
20,670,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Magi2
|
UTSW |
5 |
20,670,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1839:Magi2
|
UTSW |
5 |
20,670,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1847:Magi2
|
UTSW |
5 |
20,807,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2223:Magi2
|
UTSW |
5 |
20,670,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2496:Magi2
|
UTSW |
5 |
19,883,750 (GRCm39) |
missense |
probably benign |
0.42 |
|
R2504:Magi2
|
UTSW |
5 |
20,563,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2848:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R2879:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R2935:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R2936:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R3694:Magi2
|
UTSW |
5 |
20,807,459 (GRCm39) |
frame shift |
probably null |
|
|
R3783:Magi2
|
UTSW |
5 |
20,670,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3786:Magi2
|
UTSW |
5 |
20,670,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3787:Magi2
|
UTSW |
5 |
20,670,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3837:Magi2
|
UTSW |
5 |
20,420,466 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4151:Magi2
|
UTSW |
5 |
19,432,290 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4721:Magi2
|
UTSW |
5 |
20,739,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5005:Magi2
|
UTSW |
5 |
20,739,444 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5012:Magi2
|
UTSW |
5 |
20,670,618 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5193:Magi2
|
UTSW |
5 |
20,563,970 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5298:Magi2
|
UTSW |
5 |
20,774,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Magi2
|
UTSW |
5 |
20,907,108 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5580:Magi2
|
UTSW |
5 |
20,420,422 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5806:Magi2
|
UTSW |
5 |
20,856,202 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5924:Magi2
|
UTSW |
5 |
20,816,067 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Magi2
|
UTSW |
5 |
19,432,289 (GRCm39) |
start codon destroyed |
probably null |
0.42 |
|
R6014:Magi2
|
UTSW |
5 |
20,816,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6073:Magi2
|
UTSW |
5 |
20,774,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6500:Magi2
|
UTSW |
5 |
20,807,345 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6664:Magi2
|
UTSW |
5 |
20,907,395 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7229:Magi2
|
UTSW |
5 |
20,670,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7344:Magi2
|
UTSW |
5 |
20,755,238 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7448:Magi2
|
UTSW |
5 |
20,563,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7605:Magi2
|
UTSW |
5 |
20,433,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7712:Magi2
|
UTSW |
5 |
20,755,280 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7808:Magi2
|
UTSW |
5 |
20,670,838 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7955:Magi2
|
UTSW |
5 |
20,594,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8134:Magi2
|
UTSW |
5 |
20,596,392 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8134:Magi2
|
UTSW |
5 |
20,596,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8253:Magi2
|
UTSW |
5 |
20,814,305 (GRCm39) |
missense |
probably benign |
0.44 |
|
R8481:Magi2
|
UTSW |
5 |
20,594,152 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8553:Magi2
|
UTSW |
5 |
20,856,198 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8751:Magi2
|
UTSW |
5 |
20,739,462 (GRCm39) |
missense |
probably benign |
|
|
R8766:Magi2
|
UTSW |
5 |
20,400,123 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8851:Magi2
|
UTSW |
5 |
20,270,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8876:Magi2
|
UTSW |
5 |
20,856,190 (GRCm39) |
nonsense |
probably null |
|
|
R9120:Magi2
|
UTSW |
5 |
20,733,305 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9335:Magi2
|
UTSW |
5 |
20,866,263 (GRCm39) |
missense |
|
|
|
R9367:Magi2
|
UTSW |
5 |
20,766,308 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9454:Magi2
|
UTSW |
5 |
20,671,176 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9474:Magi2
|
UTSW |
5 |
20,400,019 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9577:Magi2
|
UTSW |
5 |
20,814,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Magi2
|
UTSW |
5 |
20,670,582 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9696:Magi2
|
UTSW |
5 |
20,670,864 (GRCm39) |
missense |
probably benign |
0.35 |
|
X0065:Magi2
|
UTSW |
5 |
20,774,176 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1176:Magi2
|
UTSW |
5 |
20,907,107 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1177:Magi2
|
UTSW |
5 |
20,907,410 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTAGAAGCACCTCAGGATGCCCTC -3'
(R):5'- CTCCGTAAAGTGTAAGGCAGCTCAG -3'
Sequencing Primer
(F):5'- CAGGATGCCCTCAATATTTTTTGG -3'
(R):5'- AGTGTAAGGCAGCTCAGATTCTC -3'
|
| Posted On |
2013-05-29 |
Incidental Mutation