Incidental Mutation 'R5606:Aldh1a7'
ID 439313
Institutional Source Beutler Lab
Gene Symbol Aldh1a7
Ensembl Gene ENSMUSG00000024747
Gene Name aldehyde dehydrogenase family 1, subfamily A7
Synonyms Aldh-pb, Ahd2-like
MMRRC Submission 043157-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.231) question?
Stock # R5606 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 20670318-20704920 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20699731 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 75 (S75P)
Ref Sequence ENSEMBL: ENSMUSP00000025656 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025656]
AlphaFold O35945
Predicted Effect probably damaging
Transcript: ENSMUST00000025656
AA Change: S75P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000025656
Gene: ENSMUSG00000024747
AA Change: S75P

DomainStartEndE-ValueType
Pfam:Aldedh 29 492 2.5e-185 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 96.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankib1 A T 5: 3,751,907 (GRCm39) I711N probably damaging Het
Ankmy2 A G 12: 36,215,920 (GRCm39) N40S probably benign Het
Armc8 T C 9: 99,418,315 (GRCm39) K80E probably benign Het
Blm C A 7: 80,110,580 (GRCm39) probably null Het
Cand1 C A 10: 119,047,359 (GRCm39) Q710H possibly damaging Het
Ckap2l A T 2: 129,127,959 (GRCm39) I73N probably damaging Het
Ddx27 T A 2: 166,861,886 (GRCm39) D129E probably benign Het
Dnm3 T C 1: 162,113,587 (GRCm39) E491G probably damaging Het
Fgd6 C A 10: 93,974,190 (GRCm39) Y1310* probably null Het
Hnrnph3 C T 10: 62,855,222 (GRCm39) R21H possibly damaging Het
Hs3st4 C A 7: 123,996,365 (GRCm39) Q344K probably damaging Het
Hyal3 T C 9: 107,462,265 (GRCm39) S100P probably benign Het
Map3k19 G A 1: 127,750,694 (GRCm39) R886C probably benign Het
Mmrn2 G A 14: 34,119,581 (GRCm39) D187N probably damaging Het
Myo5c G A 9: 75,182,790 (GRCm39) A810T probably damaging Het
Noxa1 T A 2: 24,976,292 (GRCm39) E332V possibly damaging Het
Or10al7 T C 17: 38,365,693 (GRCm39) T264A probably damaging Het
Or12j5 T A 7: 140,083,713 (GRCm39) I220F probably damaging Het
Or51r1 T C 7: 102,228,481 (GRCm39) S260P probably damaging Het
Or7c70 A G 10: 78,683,395 (GRCm39) M118T probably benign Het
Parg T A 14: 31,984,693 (GRCm39) V241E probably damaging Het
Pitrm1 T A 13: 6,610,101 (GRCm39) V391D probably damaging Het
Plch1 A T 3: 63,648,108 (GRCm39) V421E probably benign Het
Slc27a2 C T 2: 126,406,610 (GRCm39) A98V probably damaging Het
Spta1 A T 1: 174,047,468 (GRCm39) H1704L probably damaging Het
Tbpl2 G A 2: 23,977,245 (GRCm39) P258S possibly damaging Het
Thoc2l T C 5: 104,669,744 (GRCm39) I1422T probably benign Het
Tlr11 T C 14: 50,599,717 (GRCm39) C568R probably benign Het
Tmem260 T A 14: 48,722,437 (GRCm39) M324K probably damaging Het
Tmprss11g T A 5: 86,635,269 (GRCm39) T402S probably damaging Het
Trim21 C G 7: 102,208,813 (GRCm39) R302P probably damaging Het
Uox T A 3: 146,316,057 (GRCm39) Y21* probably null Het
Vmn1r74 A G 7: 11,580,822 (GRCm39) M41V probably benign Het
Vmn2r59 A C 7: 41,695,318 (GRCm39) S365A probably benign Het
Zfp345 A T 2: 150,316,788 (GRCm39) Y6* probably null Het
Zpld2 A C 4: 133,927,523 (GRCm39) V410G probably benign Het
Other mutations in Aldh1a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00693:Aldh1a7 APN 19 20,677,410 (GRCm39) missense probably damaging 1.00
IGL01132:Aldh1a7 APN 19 20,704,404 (GRCm39) missense possibly damaging 0.76
IGL01630:Aldh1a7 APN 19 20,673,693 (GRCm39) splice site probably benign
IGL01901:Aldh1a7 APN 19 20,695,103 (GRCm39) missense probably damaging 0.99
IGL02324:Aldh1a7 APN 19 20,704,368 (GRCm39) missense probably damaging 1.00
IGL02822:Aldh1a7 APN 19 20,679,630 (GRCm39) missense possibly damaging 0.85
IGL03162:Aldh1a7 APN 19 20,685,645 (GRCm39) missense probably benign 0.21
PIT4514001:Aldh1a7 UTSW 19 20,679,604 (GRCm39) missense probably benign 0.07
R0125:Aldh1a7 UTSW 19 20,704,430 (GRCm39) splice site probably benign
R0268:Aldh1a7 UTSW 19 20,686,866 (GRCm39) critical splice acceptor site probably null
R0833:Aldh1a7 UTSW 19 20,679,607 (GRCm39) missense probably damaging 1.00
R1665:Aldh1a7 UTSW 19 20,704,825 (GRCm39) missense probably benign
R1709:Aldh1a7 UTSW 19 20,693,316 (GRCm39) missense probably damaging 1.00
R1772:Aldh1a7 UTSW 19 20,693,383 (GRCm39) missense probably damaging 1.00
R1917:Aldh1a7 UTSW 19 20,704,819 (GRCm39) missense probably benign
R2570:Aldh1a7 UTSW 19 20,677,320 (GRCm39) missense probably benign 0.35
R3778:Aldh1a7 UTSW 19 20,696,675 (GRCm39) missense possibly damaging 0.70
R3832:Aldh1a7 UTSW 19 20,685,602 (GRCm39) missense probably damaging 1.00
R3894:Aldh1a7 UTSW 19 20,673,762 (GRCm39) nonsense probably null
R4601:Aldh1a7 UTSW 19 20,693,343 (GRCm39) missense probably damaging 0.98
R4948:Aldh1a7 UTSW 19 20,704,374 (GRCm39) missense possibly damaging 0.77
R5562:Aldh1a7 UTSW 19 20,679,628 (GRCm39) nonsense probably null
R5641:Aldh1a7 UTSW 19 20,693,293 (GRCm39) missense probably benign 0.00
R5808:Aldh1a7 UTSW 19 20,685,561 (GRCm39) missense possibly damaging 0.79
R6646:Aldh1a7 UTSW 19 20,677,275 (GRCm39) missense possibly damaging 0.94
R6759:Aldh1a7 UTSW 19 20,677,320 (GRCm39) missense possibly damaging 0.89
R7034:Aldh1a7 UTSW 19 20,685,542 (GRCm39) missense possibly damaging 0.95
R7036:Aldh1a7 UTSW 19 20,685,542 (GRCm39) missense possibly damaging 0.95
R7150:Aldh1a7 UTSW 19 20,693,382 (GRCm39) missense probably damaging 1.00
R7255:Aldh1a7 UTSW 19 20,692,092 (GRCm39) missense probably damaging 1.00
R7875:Aldh1a7 UTSW 19 20,693,343 (GRCm39) missense possibly damaging 0.90
R7964:Aldh1a7 UTSW 19 20,693,406 (GRCm39) missense probably benign 0.05
R7964:Aldh1a7 UTSW 19 20,677,371 (GRCm39) missense probably damaging 0.99
R7984:Aldh1a7 UTSW 19 20,686,764 (GRCm39) missense probably damaging 0.98
R8547:Aldh1a7 UTSW 19 20,692,067 (GRCm39) missense possibly damaging 0.93
X0022:Aldh1a7 UTSW 19 20,696,679 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTGGACTCTGAGAAGTTCTAGAG -3'
(R):5'- ACATACTACAGTGAGGTATGGCG -3'

Sequencing Primer
(F):5'- CAGGAGGAAGTTTGTCATTGTACTC -3'
(R):5'- ATGGCGGCTTGGCTTCTC -3'
Posted On 2016-10-26