Incidental Mutation 'R4907:Gm14399'
ID 439425
Institutional Source Beutler Lab
Gene Symbol Gm14399
Ensembl Gene ENSMUSG00000090093
Gene Name predicted gene 14399
Synonyms
MMRRC Submission 042509-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # R4907 (G1)
Quality Score 70
Status Validated
Chromosome 2
Chromosomal Location 174971286-174983805 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to A at 174973182 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000104690 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099029] [ENSMUST00000108929] [ENSMUST00000109059] [ENSMUST00000109060] [ENSMUST00000109062]
AlphaFold A2ARW8
Predicted Effect probably benign
Transcript: ENSMUST00000099029
SMART Domains Protein: ENSMUSP00000096627
Gene: ENSMUSG00000090093

DomainStartEndE-ValueType
KRAB 3 63 1.37e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108929
SMART Domains Protein: ENSMUSP00000104557
Gene: ENSMUSG00000090093

DomainStartEndE-ValueType
ZnF_C2H2 46 65 1.61e2 SMART
ZnF_C2H2 71 93 4.17e-3 SMART
ZnF_C2H2 99 121 3.83e-2 SMART
ZnF_C2H2 127 149 8.6e-5 SMART
ZnF_C2H2 155 177 1.69e-3 SMART
ZnF_C2H2 183 205 7.37e-4 SMART
ZnF_C2H2 211 233 4.94e-5 SMART
ZnF_C2H2 239 261 1.12e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000109059
SMART Domains Protein: ENSMUSP00000104687
Gene: ENSMUSG00000090093

DomainStartEndE-ValueType
KRAB 4 64 1.37e-12 SMART
Predicted Effect unknown
Transcript: ENSMUST00000109060
AA Change: Q191L
SMART Domains Protein: ENSMUSP00000104688
Gene: ENSMUSG00000090093
AA Change: Q191L

DomainStartEndE-ValueType
KRAB 4 66 1.84e-13 SMART
ZnF_C2H2 78 97 1.61e2 SMART
ZnF_C2H2 103 125 4.17e-3 SMART
ZnF_C2H2 131 153 3.83e-2 SMART
ZnF_C2H2 159 181 8.6e-5 SMART
ZnF_C2H2 187 209 4.17e-3 SMART
ZnF_C2H2 215 237 6.08e-5 SMART
ZnF_C2H2 243 265 5.99e-4 SMART
ZnF_C2H2 271 293 8.02e-5 SMART
ZnF_C2H2 299 321 3.83e-2 SMART
ZnF_C2H2 327 349 5.14e-3 SMART
ZnF_C2H2 355 377 5.14e-3 SMART
ZnF_C2H2 383 405 9.08e-4 SMART
ZnF_C2H2 411 433 1.69e-3 SMART
ZnF_C2H2 439 461 7.37e-4 SMART
ZnF_C2H2 467 489 9.08e-4 SMART
ZnF_C2H2 495 517 2.57e-3 SMART
ZnF_C2H2 523 545 7.78e-3 SMART
ZnF_C2H2 551 573 4.94e-5 SMART
ZnF_C2H2 579 601 1.12e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000109062
SMART Domains Protein: ENSMUSP00000104690
Gene: ENSMUSG00000090093

DomainStartEndE-ValueType
KRAB 4 66 1.27e-16 SMART
low complexity region 80 91 N/A INTRINSIC
Meta Mutation Damage Score 0.2190 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.1%
Validation Efficiency 98% (89/91)
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700066M21Rik G T 1: 57,422,350 (GRCm39) G242V probably damaging Het
4933412E24Rik T C 15: 59,887,957 (GRCm39) E161G probably benign Het
Abcc5 A G 16: 20,195,296 (GRCm39) S734P possibly damaging Het
Actn1 T G 12: 80,228,188 (GRCm39) H394P probably damaging Het
Adam8 A T 7: 139,569,286 (GRCm39) D144E probably benign Het
Ankrd50 T A 3: 38,509,122 (GRCm39) K1082* probably null Het
Ankrd50 A T 3: 38,510,824 (GRCm39) N514K probably damaging Het
Atp4a A G 7: 30,418,517 (GRCm39) I602V possibly damaging Het
Baz2a A G 10: 127,946,677 (GRCm39) T64A probably damaging Het
Btbd19 A G 4: 116,977,764 (GRCm39) probably benign Het
Casz1 T A 4: 149,028,998 (GRCm39) S1148T probably damaging Het
Ccdc18 T A 5: 108,284,007 (GRCm39) D103E probably benign Het
Cd209d T C 8: 3,927,948 (GRCm39) N52S probably benign Het
Cdh20 T A 1: 110,066,053 (GRCm39) Y776N probably damaging Het
Cdk14 A G 5: 5,299,140 (GRCm39) V101A probably damaging Het
Cldn22 T C 8: 48,277,742 (GRCm39) V60A probably benign Het
Clec10a G A 11: 70,060,797 (GRCm39) G183D probably benign Het
Cnga3 T C 1: 37,281,023 (GRCm39) probably null Het
Cts3 A T 13: 61,714,634 (GRCm39) F224I probably benign Het
Dync2i2 A G 2: 29,922,472 (GRCm39) probably null Het
Fbxo40 A G 16: 36,790,064 (GRCm39) Y349H probably benign Het
Flt1 C A 5: 147,620,749 (GRCm39) A132S probably benign Het
Gm10029 A T 13: 6,712,592 (GRCm39) noncoding transcript Het
Gm9932 T C 5: 100,347,014 (GRCm39) noncoding transcript Het
Immp1l A G 2: 105,767,462 (GRCm39) Y107C probably damaging Het
Ism1 G T 2: 139,520,672 (GRCm39) G28V probably benign Het
Klf1 C A 8: 85,629,814 (GRCm39) S213* probably null Het
Krt12 T C 11: 99,309,188 (GRCm39) E329G probably damaging Het
Lama2 A T 10: 27,040,942 (GRCm39) N1460K probably benign Het
Llgl2 T A 11: 115,744,800 (GRCm39) Y932* probably null Het
Lrrc7 T C 3: 157,866,877 (GRCm39) I955V probably damaging Het
Ltbp1 A G 17: 75,312,899 (GRCm39) R7G probably benign Het
Mcm3ap A G 10: 76,329,275 (GRCm39) E1152G probably damaging Het
Mgam2-ps T C 6: 40,811,677 (GRCm39) noncoding transcript Het
Mical3 T A 6: 120,984,259 (GRCm39) M206L probably benign Het
Mndal T G 1: 173,690,256 (GRCm39) N358T probably damaging Het
Nckap5 A G 1: 125,953,889 (GRCm39) S824P possibly damaging Het
Ndufb2 T C 6: 39,573,554 (GRCm39) probably benign Het
Nfatc3 C A 8: 106,806,359 (GRCm39) H401Q probably damaging Het
Npas2 T C 1: 39,401,066 (GRCm39) V810A unknown Het
Nt5c2 A G 19: 46,884,978 (GRCm39) V245A possibly damaging Het
Or1j4 A T 2: 36,740,270 (GRCm39) I71F probably benign Het
Or4d5 A T 9: 40,011,955 (GRCm39) M277K probably benign Het
Or51ah3 A G 7: 103,210,241 (GRCm39) M186V possibly damaging Het
Or52h9 A G 7: 104,202,518 (GRCm39) R131G probably damaging Het
Or5b109 A G 19: 13,212,157 (GRCm39) D181G probably damaging Het
Otof A T 5: 30,536,005 (GRCm39) probably null Het
Pck1 C T 2: 172,998,816 (GRCm39) T358I probably damaging Het
Pclo T C 5: 14,730,065 (GRCm39) probably benign Het
Pgm2 T A 5: 64,261,221 (GRCm39) F238L probably benign Het
Pgr G A 9: 8,947,044 (GRCm39) probably benign Het
Pkd1l3 T A 8: 110,367,475 (GRCm39) V1224E probably damaging Het
Pkd2l1 A G 19: 44,142,581 (GRCm39) V487A possibly damaging Het
Pkhd1 T C 1: 20,279,450 (GRCm39) D2956G probably damaging Het
Rexo2 A T 9: 48,390,703 (GRCm39) probably null Het
Rgs22 T A 15: 36,087,570 (GRCm39) L573F possibly damaging Het
Rufy3 T G 5: 88,732,051 (GRCm39) I18S possibly damaging Het
Slc30a9 T C 5: 67,503,505 (GRCm39) L393P probably damaging Het
Snw1 T C 12: 87,506,259 (GRCm39) I214V probably benign Het
Sorbs1 G A 19: 40,328,491 (GRCm39) Q595* probably null Het
Spata21 T A 4: 140,824,432 (GRCm39) probably null Het
Ss18l1 G T 2: 179,705,192 (GRCm39) probably null Het
Tmem163 A T 1: 127,447,107 (GRCm39) L176H probably damaging Het
Tpd52 T C 3: 9,009,668 (GRCm39) probably null Het
Tpsab1 T A 17: 25,562,436 (GRCm39) Y297F possibly damaging Het
Trim55 A G 3: 19,728,538 (GRCm39) T450A probably benign Het
Ttf1 C T 2: 28,954,668 (GRCm39) H11Y possibly damaging Het
Txndc11 A T 16: 10,906,398 (GRCm39) H377Q probably benign Het
Usp17la A G 7: 104,510,355 (GRCm39) Y320C probably damaging Het
Vmn2r109 T C 17: 20,770,348 (GRCm39) N547D probably damaging Het
Vmn2r54 A T 7: 12,350,150 (GRCm39) probably null Het
Wdr33 T C 18: 32,040,046 (GRCm39) *1331Q probably null Het
Wdr90 T A 17: 26,079,624 (GRCm39) probably benign Het
Xpo7 T C 14: 70,908,069 (GRCm39) M903V probably benign Het
Zfhx3 T A 8: 109,519,986 (GRCm39) S369R probably damaging Het
Zfp808 T C 13: 62,319,287 (GRCm39) F172S possibly damaging Het
Zfp821 A G 8: 110,450,625 (GRCm39) E55G probably benign Het
Zfp964 T C 8: 70,115,972 (GRCm39) Y191H possibly damaging Het
Zfyve1 T C 12: 83,621,646 (GRCm39) T250A probably damaging Het
Other mutations in Gm14399
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Gm14399 APN 2 174,973,315 (GRCm39) nonsense probably null
R2185:Gm14399 UTSW 2 174,973,188 (GRCm39) missense probably damaging 1.00
R3711:Gm14399 UTSW 2 174,973,303 (GRCm39) nonsense probably null
R5361:Gm14399 UTSW 2 174,973,371 (GRCm39) missense probably damaging 1.00
R7252:Gm14399 UTSW 2 174,974,991 (GRCm39) missense probably damaging 0.98
R7278:Gm14399 UTSW 2 174,972,252 (GRCm39) intron probably benign
R7289:Gm14399 UTSW 2 174,972,204 (GRCm39) missense unknown
R7946:Gm14399 UTSW 2 174,973,273 (GRCm39) missense probably damaging 1.00
R8390:Gm14399 UTSW 2 174,972,605 (GRCm39) nonsense probably null
RF051:Gm14399 UTSW 2 174,972,994 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGACTGCTTTGTGAAAAGGC -3'
(R):5'- AGCCTTTGCATATGAGAGTGG -3'

Sequencing Primer
(F):5'- GACTGCTTTGTGAAAAGGCTTTACC -3'
(R):5'- GGACTTTAGAACATGGAATGTCCTGC -3'
Posted On 2016-10-28