Incidental Mutation 'R5014:Ints6'
ID 439470
Institutional Source Beutler Lab
Gene Symbol Ints6
Ensembl Gene ENSMUSG00000035161
Gene Name integrator complex subunit 6
Synonyms Notch2l, DICE1, Ddx26, 2900075H24Rik
MMRRC Submission 042605-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5014 (G1)
Quality Score 71
Status Validated
Chromosome 14
Chromosomal Location 62913779-62998618 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 62997640 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 55 (F55Y)
Ref Sequence ENSEMBL: ENSMUSP00000152954 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053959] [ENSMUST00000223585]
AlphaFold Q6PCM2
Predicted Effect probably benign
Transcript: ENSMUST00000053959
AA Change: F55Y

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000086788
Gene: ENSMUSG00000035161
AA Change: F55Y

DomainStartEndE-ValueType
VWA 1 158 4.11e-1 SMART
Blast:VWA 307 331 1e-7 BLAST
Blast:RRM_2 701 727 3e-8 BLAST
Pfam:INT_SG_DDX_CT_C 803 865 4e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181344
Predicted Effect probably benign
Transcript: ENSMUST00000223585
AA Change: F55Y

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225193
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225250
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225406
Meta Mutation Damage Score 0.0650 question?
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.4%
  • 20x: 91.7%
Validation Efficiency 97% (83/86)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,520,896 (GRCm39) T1353A probably benign Het
Abca8b A T 11: 109,840,957 (GRCm39) I1072N probably damaging Het
Atp1a2 T C 1: 172,112,438 (GRCm39) T517A probably benign Het
Blk T G 14: 63,617,236 (GRCm39) N257T probably benign Het
Brd4 A T 17: 32,417,372 (GRCm39) probably benign Het
Calr4 C T 4: 109,092,994 (GRCm39) Q25* probably null Het
Cbl T C 9: 44,065,696 (GRCm39) probably null Het
Ccdc30 T G 4: 119,250,824 (GRCm39) H6P possibly damaging Het
Cd101 A C 3: 100,911,139 (GRCm39) Y840D probably damaging Het
Cd68 T A 11: 69,556,165 (GRCm39) N178Y probably damaging Het
Cep350 T C 1: 155,803,952 (GRCm39) T1044A probably benign Het
Cfap46 A G 7: 139,207,291 (GRCm39) V1876A probably benign Het
Clec2g T A 6: 128,925,765 (GRCm39) M58K probably benign Het
Clip1 T C 5: 123,755,793 (GRCm39) E860G probably damaging Het
Col18a1 C T 10: 76,906,794 (GRCm39) probably null Het
Cul7 A G 17: 46,966,868 (GRCm39) *650W probably null Het
Dkk4 C T 8: 23,115,315 (GRCm39) A55V probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Dnai7 T C 6: 145,128,992 (GRCm39) E407G probably damaging Het
Dnase1 C A 16: 3,856,880 (GRCm39) Y170* probably null Het
Dnmt1 A C 9: 20,823,550 (GRCm39) I1019S probably benign Het
Epha6 T A 16: 59,486,942 (GRCm39) H1035L probably benign Het
Fam124b T C 1: 80,177,776 (GRCm39) T408A probably benign Het
Fam227b G A 2: 125,958,043 (GRCm39) P241S probably damaging Het
Galnt7 T C 8: 57,998,414 (GRCm39) E305G probably damaging Het
Garin1b C T 6: 29,326,723 (GRCm39) probably benign Het
Git1 T A 11: 77,389,821 (GRCm39) V28E probably damaging Het
Gm10010 C T 6: 128,177,556 (GRCm39) noncoding transcript Het
Gm4956 T C 1: 21,363,821 (GRCm39) noncoding transcript Het
Gpr152 T G 19: 4,193,506 (GRCm39) V349G probably benign Het
Gtsf1l C T 2: 162,929,112 (GRCm39) V124I probably damaging Het
Gucy1b1 C G 3: 81,953,974 (GRCm39) G114A probably benign Het
Hk2 T C 6: 82,720,936 (GRCm39) Q166R possibly damaging Het
Hook2 A G 8: 85,718,006 (GRCm39) I44M probably damaging Het
Ildr1 T A 16: 36,541,921 (GRCm39) M222K probably damaging Het
Kcnh1 A G 1: 191,959,388 (GRCm39) N314S probably damaging Het
Lpin3 T C 2: 160,746,748 (GRCm39) F748L probably damaging Het
Lrsam1 T C 2: 32,826,407 (GRCm39) probably benign Het
Msh2 A T 17: 88,025,004 (GRCm39) K627N possibly damaging Het
Myrip A G 9: 120,251,534 (GRCm39) Q219R probably damaging Het
Ndufb3 T A 1: 58,630,401 (GRCm39) W51R probably damaging Het
Nfasc A T 1: 132,512,185 (GRCm39) probably benign Het
Or2c1 T A 16: 3,656,912 (GRCm39) I25N probably benign Het
Or2h2 T A 17: 37,396,446 (GRCm39) I204F probably benign Het
Or8s8 T C 15: 98,354,857 (GRCm39) V222A possibly damaging Het
P3h3 T A 6: 124,832,199 (GRCm39) E229V probably damaging Het
Ppfia2 T A 10: 106,701,224 (GRCm39) L837* probably null Het
Ppp2r1a G A 17: 21,179,101 (GRCm39) probably null Het
Rabgap1 T A 2: 37,377,152 (GRCm39) V328E probably damaging Het
Ralgapb G A 2: 158,337,455 (GRCm39) R1138Q probably damaging Het
Ranbp2 A T 10: 58,299,942 (GRCm39) Q498L probably benign Het
Rbx1 T A 15: 81,355,161 (GRCm39) C56S probably damaging Het
Rcan2 T C 17: 44,328,704 (GRCm39) F45S probably damaging Het
Rgs20 T C 1: 4,980,770 (GRCm39) Y185C probably damaging Het
Rorc T G 3: 94,298,460 (GRCm39) L315R probably damaging Het
Skic2 A G 17: 35,066,401 (GRCm39) V194A probably benign Het
Slc13a2 T C 11: 78,290,987 (GRCm39) K406E possibly damaging Het
Slc35g3 T A 11: 69,651,866 (GRCm39) K62* probably null Het
Sox30 T C 11: 45,882,736 (GRCm39) S589P probably benign Het
Sp110 A C 1: 85,505,050 (GRCm39) F434C probably benign Het
Ssh2 T A 11: 77,346,102 (GRCm39) C1362* probably null Het
Tecta C T 9: 42,284,538 (GRCm39) C849Y probably damaging Het
Thbs1 T A 2: 117,950,518 (GRCm39) probably null Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Tut4 T C 4: 108,384,043 (GRCm39) probably benign Het
Tyk2 C T 9: 21,027,126 (GRCm39) probably null Het
Tyw5 C A 1: 57,446,004 (GRCm39) probably benign Het
Vcp T C 4: 42,980,828 (GRCm39) T761A probably benign Het
Wdfy4 A T 14: 32,822,897 (GRCm39) C1401S probably benign Het
Wiz T C 17: 32,578,340 (GRCm39) N391D probably damaging Het
Ylpm1 G A 12: 85,061,523 (GRCm39) E475K unknown Het
Zfp108 G T 7: 23,960,163 (GRCm39) K251N probably benign Het
Zfp184 A G 13: 22,142,594 (GRCm39) D100G probably benign Het
Zfp990 T A 4: 145,264,669 (GRCm39) C556S possibly damaging Het
Zkscan16 C T 4: 58,951,892 (GRCm39) P189L probably damaging Het
Other mutations in Ints6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00535:Ints6 APN 14 62,940,628 (GRCm39) missense probably damaging 1.00
IGL00763:Ints6 APN 14 62,938,314 (GRCm39) splice site probably benign
IGL01624:Ints6 APN 14 62,934,320 (GRCm39) missense probably benign 0.07
IGL01721:Ints6 APN 14 62,951,188 (GRCm39) missense probably damaging 0.96
IGL02146:Ints6 APN 14 62,996,709 (GRCm39) missense possibly damaging 0.91
G1Funyon:Ints6 UTSW 14 62,939,902 (GRCm39) missense probably benign
R0302:Ints6 UTSW 14 62,946,961 (GRCm39) missense probably damaging 1.00
R0320:Ints6 UTSW 14 62,945,084 (GRCm39) nonsense probably null
R0543:Ints6 UTSW 14 62,934,060 (GRCm39) missense probably damaging 1.00
R0554:Ints6 UTSW 14 62,942,200 (GRCm39) missense possibly damaging 0.87
R0620:Ints6 UTSW 14 62,934,208 (GRCm39) missense probably benign
R0960:Ints6 UTSW 14 62,947,015 (GRCm39) missense probably benign 0.39
R1216:Ints6 UTSW 14 62,945,147 (GRCm39) missense probably damaging 1.00
R1254:Ints6 UTSW 14 62,953,823 (GRCm39) missense probably benign 0.27
R1296:Ints6 UTSW 14 62,942,352 (GRCm39) splice site probably benign
R1548:Ints6 UTSW 14 62,951,141 (GRCm39) missense probably damaging 1.00
R1944:Ints6 UTSW 14 62,931,089 (GRCm39) missense probably benign 0.03
R2040:Ints6 UTSW 14 62,951,138 (GRCm39) missense probably damaging 0.99
R2279:Ints6 UTSW 14 62,942,131 (GRCm39) critical splice donor site probably null
R2844:Ints6 UTSW 14 62,942,275 (GRCm39) missense probably damaging 0.97
R3107:Ints6 UTSW 14 62,998,041 (GRCm39) missense possibly damaging 0.92
R3407:Ints6 UTSW 14 62,934,386 (GRCm39) missense probably benign 0.00
R3895:Ints6 UTSW 14 62,934,060 (GRCm39) missense probably damaging 1.00
R4608:Ints6 UTSW 14 62,940,678 (GRCm39) missense probably damaging 1.00
R4903:Ints6 UTSW 14 62,939,911 (GRCm39) missense probably damaging 1.00
R4964:Ints6 UTSW 14 62,939,911 (GRCm39) missense probably damaging 1.00
R4966:Ints6 UTSW 14 62,939,911 (GRCm39) missense probably damaging 1.00
R5369:Ints6 UTSW 14 62,981,384 (GRCm39) missense probably damaging 1.00
R6478:Ints6 UTSW 14 62,938,235 (GRCm39) missense probably benign 0.37
R7022:Ints6 UTSW 14 62,951,786 (GRCm39) missense probably damaging 1.00
R7403:Ints6 UTSW 14 62,945,104 (GRCm39) missense possibly damaging 0.50
R7422:Ints6 UTSW 14 62,942,224 (GRCm39) missense probably benign
R7909:Ints6 UTSW 14 62,996,779 (GRCm39) missense probably damaging 0.99
R8147:Ints6 UTSW 14 62,951,186 (GRCm39) missense probably damaging 1.00
R8301:Ints6 UTSW 14 62,939,902 (GRCm39) missense probably benign
R8496:Ints6 UTSW 14 62,943,325 (GRCm39) missense probably benign 0.06
R8502:Ints6 UTSW 14 62,998,028 (GRCm39) missense possibly damaging 0.92
R8514:Ints6 UTSW 14 62,933,166 (GRCm39) missense possibly damaging 0.89
R8540:Ints6 UTSW 14 62,934,353 (GRCm39) missense probably benign 0.39
R8733:Ints6 UTSW 14 62,934,297 (GRCm39) missense probably benign 0.01
R8810:Ints6 UTSW 14 62,939,902 (GRCm39) missense probably benign 0.02
R8839:Ints6 UTSW 14 62,931,122 (GRCm39) missense probably benign 0.06
R9057:Ints6 UTSW 14 62,951,740 (GRCm39) critical splice donor site probably null
R9178:Ints6 UTSW 14 62,947,036 (GRCm39) missense probably damaging 1.00
R9318:Ints6 UTSW 14 62,934,147 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ATGTTGATCGTAGCGCCTC -3'
(R):5'- TGAAGGTACCGACTAACCCAGC -3'

Sequencing Primer
(F):5'- TGGGCCAGAAACTGCCAC -3'
(R):5'- GGTTTACTGCGGGCTCC -3'
Posted On 2016-10-31