Incidental Mutation 'R0496:Tns3'
ID |
43951 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tns3
|
Ensembl Gene |
ENSMUSG00000020422 |
Gene Name |
tensin 3 |
Synonyms |
TEM6, F830010I22Rik, Tens1 |
MMRRC Submission |
038692-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.371)
|
Stock # |
R0496 (G1)
|
Quality Score |
88 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
8431652-8664535 bp(-) (GRCm38) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
A to C
at 8547262 bp (GRCm38)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000020695
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020695]
|
AlphaFold |
Q5SSZ5 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000020695
|
SMART Domains |
Protein: ENSMUSP00000020695 Gene: ENSMUSG00000020422
Domain | Start | End | E-Value | Type |
SCOP:d1d5ra2
|
1 |
171 |
5e-28 |
SMART |
PTEN_C2
|
173 |
300 |
1.15e-48 |
SMART |
low complexity region
|
854 |
864 |
N/A |
INTRINSIC |
low complexity region
|
1102 |
1126 |
N/A |
INTRINSIC |
SH2
|
1165 |
1268 |
1.32e-18 |
SMART |
PTB
|
1301 |
1438 |
3.14e-24 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131941
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134823
|
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.6%
|
Validation Efficiency |
98% (99/101) |
MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit one third postnatal lethality, reduced body weight, growth retardation, smaller digestive tracts with defects in villi and enterocyte differentiation, abnormal lung morphology, and thinner bones with decreased chondrocyte proliferation. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 97 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1110002E22Rik |
A |
G |
3: 138,068,244 (GRCm38) |
K1065E |
probably damaging |
Het |
4933402N03Rik |
T |
C |
7: 131,146,131 (GRCm38) |
N44S |
probably benign |
Het |
Abca13 |
A |
G |
11: 9,291,701 (GRCm38) |
D1188G |
probably benign |
Het |
Abcb11 |
C |
T |
2: 69,277,884 (GRCm38) |
|
probably benign |
Het |
Abcc8 |
A |
T |
7: 46,108,820 (GRCm38) |
I1274N |
probably damaging |
Het |
Adamtsl1 |
G |
A |
4: 86,341,198 (GRCm38) |
C827Y |
probably damaging |
Het |
Agap3 |
T |
A |
5: 24,501,243 (GRCm38) |
V369E |
probably damaging |
Het |
Ankrd13b |
G |
A |
11: 77,473,041 (GRCm38) |
R195C |
probably damaging |
Het |
Ap3b1 |
A |
G |
13: 94,472,938 (GRCm38) |
|
probably benign |
Het |
Arhgef40 |
A |
T |
14: 52,004,907 (GRCm38) |
|
probably benign |
Het |
Atad5 |
A |
G |
11: 80,100,356 (GRCm38) |
I692V |
probably benign |
Het |
Atp5f1b |
G |
T |
10: 128,086,174 (GRCm38) |
R310L |
possibly damaging |
Het |
AY358078 |
A |
T |
14: 51,803,532 (GRCm38) |
M103L |
unknown |
Het |
Bcl9l |
T |
G |
9: 44,509,518 (GRCm38) |
V1370G |
probably benign |
Het |
Bglap3 |
T |
A |
3: 88,369,137 (GRCm38) |
Q38L |
probably damaging |
Het |
Bltp1 |
A |
G |
3: 36,987,635 (GRCm38) |
T2721A |
probably damaging |
Het |
Ccn2 |
G |
T |
10: 24,597,515 (GRCm38) |
M317I |
possibly damaging |
Het |
Cd38 |
T |
C |
5: 43,868,891 (GRCm38) |
F6L |
probably damaging |
Het |
Cela3a |
A |
C |
4: 137,404,468 (GRCm38) |
V138G |
probably damaging |
Het |
Cemip2 |
A |
T |
19: 21,797,345 (GRCm38) |
N117I |
possibly damaging |
Het |
Clvs1 |
T |
A |
4: 9,424,241 (GRCm38) |
I229N |
probably damaging |
Het |
Cpne1 |
G |
A |
2: 156,079,419 (GRCm38) |
H16Y |
probably damaging |
Het |
Ctc1 |
T |
C |
11: 69,035,507 (GRCm38) |
L1069P |
probably damaging |
Het |
Dgkd |
G |
A |
1: 87,936,900 (GRCm38) |
S996N |
probably null |
Het |
Dnah9 |
A |
T |
11: 66,075,135 (GRCm38) |
M1685K |
probably null |
Het |
Dnajb12 |
C |
T |
10: 59,879,801 (GRCm38) |
R42* |
probably null |
Het |
Dock5 |
T |
C |
14: 67,817,518 (GRCm38) |
Q633R |
probably damaging |
Het |
Dync2h1 |
A |
G |
9: 7,155,180 (GRCm38) |
M868T |
probably benign |
Het |
Enpp1 |
G |
T |
10: 24,672,052 (GRCm38) |
H208Q |
probably benign |
Het |
Epha7 |
T |
A |
4: 28,821,292 (GRCm38) |
D152E |
probably damaging |
Het |
Fancd2 |
T |
C |
6: 113,555,130 (GRCm38) |
|
probably benign |
Het |
Gart |
G |
A |
16: 91,623,037 (GRCm38) |
|
probably benign |
Het |
Gm10964 |
A |
T |
3: 103,739,429 (GRCm38) |
|
probably null |
Het |
Gpbar1 |
T |
C |
1: 74,278,981 (GRCm38) |
F128L |
probably benign |
Het |
Gsx2 |
T |
A |
5: 75,077,065 (GRCm38) |
M226K |
probably benign |
Het |
Gucd1 |
T |
C |
10: 75,511,266 (GRCm38) |
D50G |
possibly damaging |
Het |
Has1 |
A |
G |
17: 17,843,746 (GRCm38) |
Y544H |
probably benign |
Het |
Hc |
A |
T |
2: 35,013,571 (GRCm38) |
Y1024N |
probably damaging |
Het |
Hoxa13 |
CCG |
CCGCG |
6: 52,260,635 (GRCm38) |
|
probably null |
Het |
Ift122 |
T |
A |
6: 115,905,902 (GRCm38) |
H659Q |
probably benign |
Het |
Itga2 |
T |
C |
13: 114,853,899 (GRCm38) |
Q902R |
probably benign |
Het |
Itgb2l |
T |
C |
16: 96,434,701 (GRCm38) |
K181E |
possibly damaging |
Het |
Jak3 |
A |
T |
8: 71,682,397 (GRCm38) |
H558L |
probably damaging |
Het |
Kcnh8 |
A |
G |
17: 52,725,858 (GRCm38) |
T58A |
probably benign |
Het |
Klhl6 |
GT |
G |
16: 19,956,966 (GRCm38) |
279 |
probably null |
Het |
Krt33a |
C |
T |
11: 100,012,329 (GRCm38) |
|
probably benign |
Het |
Magi2 |
A |
T |
5: 20,661,359 (GRCm38) |
|
probably benign |
Het |
Map4 |
G |
A |
9: 110,039,850 (GRCm38) |
|
probably benign |
Het |
Map4k4 |
T |
A |
1: 40,006,822 (GRCm38) |
S754T |
probably damaging |
Het |
Mapk8ip3 |
A |
G |
17: 24,914,450 (GRCm38) |
|
probably benign |
Het |
Mib1 |
A |
G |
18: 10,804,773 (GRCm38) |
S918G |
probably benign |
Het |
Mipol1 |
T |
A |
12: 57,457,177 (GRCm38) |
V377D |
probably damaging |
Het |
Mlh1 |
T |
C |
9: 111,241,556 (GRCm38) |
T364A |
probably benign |
Het |
Mta1 |
C |
T |
12: 113,131,321 (GRCm38) |
Q400* |
probably null |
Het |
Mthfd1l |
C |
G |
10: 4,090,006 (GRCm38) |
R806G |
probably benign |
Het |
Myh13 |
C |
A |
11: 67,348,815 (GRCm38) |
N730K |
probably damaging |
Het |
Myom1 |
A |
G |
17: 71,084,306 (GRCm38) |
K937E |
probably damaging |
Het |
Naxd |
T |
C |
8: 11,510,224 (GRCm38) |
|
probably benign |
Het |
Negr1 |
G |
T |
3: 157,016,267 (GRCm38) |
K159N |
probably damaging |
Het |
Nwd2 |
G |
T |
5: 63,806,343 (GRCm38) |
W1090L |
probably damaging |
Het |
Or1e1f |
T |
C |
11: 73,964,880 (GRCm38) |
S91P |
probably benign |
Het |
Or2j3 |
A |
G |
17: 38,304,658 (GRCm38) |
S268P |
probably damaging |
Het |
Or51v14 |
C |
T |
7: 103,611,997 (GRCm38) |
A119T |
probably benign |
Het |
Or52r1c |
T |
C |
7: 103,085,590 (GRCm38) |
I19T |
probably damaging |
Het |
Or5d41 |
A |
T |
2: 88,224,155 (GRCm38) |
Y292* |
probably null |
Het |
Pcsk6 |
G |
A |
7: 65,927,249 (GRCm38) |
S58N |
probably benign |
Het |
Pdzrn3 |
G |
A |
6: 101,150,570 (GRCm38) |
T1045I |
possibly damaging |
Het |
Pitrm1 |
T |
C |
13: 6,568,714 (GRCm38) |
L641P |
probably damaging |
Het |
Pkd1l1 |
G |
T |
11: 8,929,430 (GRCm38) |
H474N |
probably damaging |
Het |
Pltp |
A |
G |
2: 164,852,461 (GRCm38) |
|
probably benign |
Het |
Qtrt1 |
C |
T |
9: 21,419,548 (GRCm38) |
T324M |
probably benign |
Het |
Racgap1 |
A |
T |
15: 99,639,832 (GRCm38) |
|
probably benign |
Het |
Rhbg |
A |
G |
3: 88,254,498 (GRCm38) |
V50A |
probably benign |
Het |
Rnf135 |
G |
A |
11: 80,183,950 (GRCm38) |
V12M |
probably damaging |
Het |
Rnf7l |
G |
T |
10: 63,421,602 (GRCm38) |
C46* |
probably null |
Het |
Rufy2 |
T |
C |
10: 62,993,170 (GRCm38) |
V117A |
probably damaging |
Het |
Safb |
A |
G |
17: 56,605,630 (GRCm38) |
M866V |
probably benign |
Het |
Slc35c2 |
G |
T |
2: 165,280,815 (GRCm38) |
T183K |
probably damaging |
Het |
Slc39a7 |
A |
G |
17: 34,029,538 (GRCm38) |
L377P |
probably damaging |
Het |
Slit1 |
G |
A |
19: 41,608,311 (GRCm38) |
|
probably benign |
Het |
Spaca9 |
G |
A |
2: 28,693,010 (GRCm38) |
H133Y |
probably damaging |
Het |
Spout1 |
A |
G |
2: 30,174,971 (GRCm38) |
F339S |
probably benign |
Het |
St6gal2 |
A |
G |
17: 55,482,014 (GRCm38) |
I16M |
probably damaging |
Het |
Stat2 |
T |
C |
10: 128,276,509 (GRCm38) |
M6T |
probably benign |
Het |
Swt1 |
T |
A |
1: 151,411,270 (GRCm38) |
H157L |
probably benign |
Het |
Syne2 |
A |
G |
12: 76,038,940 (GRCm38) |
N147D |
possibly damaging |
Het |
Tmem222 |
A |
T |
4: 133,277,591 (GRCm38) |
M45K |
possibly damaging |
Het |
Tmem30a |
T |
A |
9: 79,777,285 (GRCm38) |
H95L |
probably damaging |
Het |
Trpm3 |
A |
G |
19: 22,698,778 (GRCm38) |
I103V |
probably benign |
Het |
Ube2n |
T |
C |
10: 95,541,344 (GRCm38) |
F57S |
probably benign |
Het |
Vil1 |
T |
C |
1: 74,421,340 (GRCm38) |
S219P |
possibly damaging |
Het |
Wdfy4 |
A |
G |
14: 33,140,738 (GRCm38) |
|
probably benign |
Het |
Wdr7 |
T |
C |
18: 63,791,843 (GRCm38) |
S966P |
probably benign |
Het |
Wnt8a |
A |
G |
18: 34,544,847 (GRCm38) |
N103D |
probably damaging |
Het |
Zfp523 |
G |
A |
17: 28,200,445 (GRCm38) |
E186K |
possibly damaging |
Het |
Zfp791 |
A |
T |
8: 85,109,980 (GRCm38) |
D418E |
probably benign |
Het |
Zscan20 |
A |
G |
4: 128,591,889 (GRCm38) |
V192A |
probably benign |
Het |
|
Other mutations in Tns3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00163:Tns3
|
APN |
11 |
8,451,066 (GRCm38) |
missense |
probably benign |
0.42 |
IGL00822:Tns3
|
APN |
11 |
8,443,976 (GRCm38) |
missense |
probably damaging |
0.99 |
IGL01075:Tns3
|
APN |
11 |
8,478,399 (GRCm38) |
missense |
probably benign |
0.45 |
IGL01286:Tns3
|
APN |
11 |
8,492,617 (GRCm38) |
missense |
probably benign |
0.01 |
IGL01680:Tns3
|
APN |
11 |
8,548,937 (GRCm38) |
missense |
probably damaging |
1.00 |
IGL01687:Tns3
|
APN |
11 |
8,492,798 (GRCm38) |
missense |
probably damaging |
1.00 |
IGL01734:Tns3
|
APN |
11 |
8,519,192 (GRCm38) |
splice site |
probably benign |
|
IGL01844:Tns3
|
APN |
11 |
8,437,177 (GRCm38) |
missense |
possibly damaging |
0.58 |
IGL01984:Tns3
|
APN |
11 |
8,548,992 (GRCm38) |
nonsense |
probably null |
|
IGL02137:Tns3
|
APN |
11 |
8,492,578 (GRCm38) |
missense |
possibly damaging |
0.93 |
IGL02273:Tns3
|
APN |
11 |
8,434,531 (GRCm38) |
missense |
probably damaging |
1.00 |
IGL02623:Tns3
|
APN |
11 |
8,437,141 (GRCm38) |
missense |
probably damaging |
1.00 |
IGL02697:Tns3
|
APN |
11 |
8,492,346 (GRCm38) |
missense |
probably benign |
0.00 |
IGL02829:Tns3
|
APN |
11 |
8,519,564 (GRCm38) |
missense |
probably damaging |
1.00 |
ANU74:Tns3
|
UTSW |
11 |
8,492,149 (GRCm38) |
missense |
probably benign |
0.38 |
R0020:Tns3
|
UTSW |
11 |
8,545,227 (GRCm38) |
critical splice donor site |
probably null |
|
R0064:Tns3
|
UTSW |
11 |
8,435,856 (GRCm38) |
nonsense |
probably null |
|
R0064:Tns3
|
UTSW |
11 |
8,435,856 (GRCm38) |
nonsense |
probably null |
|
R0370:Tns3
|
UTSW |
11 |
8,445,730 (GRCm38) |
missense |
possibly damaging |
0.80 |
R0388:Tns3
|
UTSW |
11 |
8,445,703 (GRCm38) |
missense |
probably benign |
0.07 |
R0410:Tns3
|
UTSW |
11 |
8,435,852 (GRCm38) |
missense |
probably benign |
0.02 |
R0562:Tns3
|
UTSW |
11 |
8,493,262 (GRCm38) |
missense |
possibly damaging |
0.93 |
R0626:Tns3
|
UTSW |
11 |
8,493,121 (GRCm38) |
missense |
probably benign |
0.04 |
R0736:Tns3
|
UTSW |
11 |
8,519,474 (GRCm38) |
missense |
possibly damaging |
0.94 |
R0893:Tns3
|
UTSW |
11 |
8,493,302 (GRCm38) |
missense |
probably damaging |
1.00 |
R1367:Tns3
|
UTSW |
11 |
8,448,704 (GRCm38) |
missense |
probably benign |
0.01 |
R1386:Tns3
|
UTSW |
11 |
8,518,261 (GRCm38) |
missense |
probably benign |
0.02 |
R1975:Tns3
|
UTSW |
11 |
8,435,738 (GRCm38) |
missense |
probably benign |
0.04 |
R2205:Tns3
|
UTSW |
11 |
8,531,719 (GRCm38) |
missense |
probably damaging |
1.00 |
R2319:Tns3
|
UTSW |
11 |
8,541,200 (GRCm38) |
missense |
probably damaging |
1.00 |
R2830:Tns3
|
UTSW |
11 |
8,435,870 (GRCm38) |
missense |
probably damaging |
1.00 |
R3720:Tns3
|
UTSW |
11 |
8,492,999 (GRCm38) |
missense |
probably damaging |
1.00 |
R3765:Tns3
|
UTSW |
11 |
8,451,133 (GRCm38) |
missense |
probably benign |
0.00 |
R3817:Tns3
|
UTSW |
11 |
8,434,619 (GRCm38) |
missense |
probably damaging |
1.00 |
R4058:Tns3
|
UTSW |
11 |
8,492,275 (GRCm38) |
missense |
probably damaging |
1.00 |
R4599:Tns3
|
UTSW |
11 |
8,531,747 (GRCm38) |
missense |
probably damaging |
1.00 |
R4631:Tns3
|
UTSW |
11 |
8,451,119 (GRCm38) |
missense |
probably benign |
0.30 |
R4731:Tns3
|
UTSW |
11 |
8,450,986 (GRCm38) |
missense |
probably benign |
0.28 |
R4732:Tns3
|
UTSW |
11 |
8,450,986 (GRCm38) |
missense |
probably benign |
0.28 |
R4733:Tns3
|
UTSW |
11 |
8,450,986 (GRCm38) |
missense |
probably benign |
0.28 |
R5472:Tns3
|
UTSW |
11 |
8,451,092 (GRCm38) |
missense |
probably benign |
|
R5749:Tns3
|
UTSW |
11 |
8,451,177 (GRCm38) |
missense |
probably benign |
0.01 |
R5807:Tns3
|
UTSW |
11 |
8,493,211 (GRCm38) |
missense |
probably damaging |
1.00 |
R5844:Tns3
|
UTSW |
11 |
8,434,580 (GRCm38) |
missense |
probably damaging |
1.00 |
R5942:Tns3
|
UTSW |
11 |
8,435,860 (GRCm38) |
missense |
probably damaging |
1.00 |
R5982:Tns3
|
UTSW |
11 |
8,492,245 (GRCm38) |
missense |
probably damaging |
0.99 |
R6025:Tns3
|
UTSW |
11 |
8,492,578 (GRCm38) |
missense |
possibly damaging |
0.93 |
R6266:Tns3
|
UTSW |
11 |
8,492,987 (GRCm38) |
missense |
probably damaging |
1.00 |
R6322:Tns3
|
UTSW |
11 |
8,492,147 (GRCm38) |
missense |
probably benign |
0.01 |
R6536:Tns3
|
UTSW |
11 |
8,434,531 (GRCm38) |
missense |
probably damaging |
1.00 |
R6577:Tns3
|
UTSW |
11 |
8,549,058 (GRCm38) |
missense |
probably damaging |
1.00 |
R6577:Tns3
|
UTSW |
11 |
8,549,057 (GRCm38) |
missense |
probably damaging |
1.00 |
R6864:Tns3
|
UTSW |
11 |
8,493,196 (GRCm38) |
missense |
probably damaging |
1.00 |
R6897:Tns3
|
UTSW |
11 |
8,531,743 (GRCm38) |
missense |
probably damaging |
1.00 |
R7108:Tns3
|
UTSW |
11 |
8,437,251 (GRCm38) |
missense |
probably benign |
0.00 |
R7443:Tns3
|
UTSW |
11 |
8,451,442 (GRCm38) |
missense |
probably benign |
0.01 |
R7459:Tns3
|
UTSW |
11 |
8,492,793 (GRCm38) |
missense |
probably benign |
0.16 |
R7474:Tns3
|
UTSW |
11 |
8,530,894 (GRCm38) |
missense |
probably damaging |
1.00 |
R7576:Tns3
|
UTSW |
11 |
8,541,192 (GRCm38) |
missense |
possibly damaging |
0.78 |
R7979:Tns3
|
UTSW |
11 |
8,492,701 (GRCm38) |
missense |
probably benign |
0.01 |
R8055:Tns3
|
UTSW |
11 |
8,545,343 (GRCm38) |
missense |
probably damaging |
1.00 |
R8057:Tns3
|
UTSW |
11 |
8,492,773 (GRCm38) |
missense |
probably benign |
|
R8077:Tns3
|
UTSW |
11 |
8,445,667 (GRCm38) |
missense |
probably damaging |
1.00 |
R8518:Tns3
|
UTSW |
11 |
8,492,971 (GRCm38) |
missense |
probably damaging |
0.96 |
R8523:Tns3
|
UTSW |
11 |
8,448,779 (GRCm38) |
missense |
probably damaging |
1.00 |
R8790:Tns3
|
UTSW |
11 |
8,518,273 (GRCm38) |
missense |
probably damaging |
0.99 |
R9228:Tns3
|
UTSW |
11 |
8,450,094 (GRCm38) |
missense |
probably damaging |
1.00 |
R9374:Tns3
|
UTSW |
11 |
8,492,606 (GRCm38) |
missense |
probably damaging |
1.00 |
R9476:Tns3
|
UTSW |
11 |
8,445,702 (GRCm38) |
missense |
probably damaging |
0.99 |
R9510:Tns3
|
UTSW |
11 |
8,445,702 (GRCm38) |
missense |
probably damaging |
0.99 |
R9594:Tns3
|
UTSW |
11 |
8,451,142 (GRCm38) |
missense |
possibly damaging |
0.79 |
R9595:Tns3
|
UTSW |
11 |
8,451,142 (GRCm38) |
missense |
possibly damaging |
0.79 |
R9596:Tns3
|
UTSW |
11 |
8,451,142 (GRCm38) |
missense |
possibly damaging |
0.79 |
R9624:Tns3
|
UTSW |
11 |
8,451,142 (GRCm38) |
missense |
possibly damaging |
0.79 |
R9629:Tns3
|
UTSW |
11 |
8,451,142 (GRCm38) |
missense |
possibly damaging |
0.79 |
T0975:Tns3
|
UTSW |
11 |
8,451,146 (GRCm38) |
missense |
probably benign |
0.00 |
T0975:Tns3
|
UTSW |
11 |
8,549,100 (GRCm38) |
start gained |
probably benign |
|
T0975:Tns3
|
UTSW |
11 |
8,479,518 (GRCm38) |
missense |
probably benign |
|
X0005:Tns3
|
UTSW |
11 |
8,479,518 (GRCm38) |
missense |
probably benign |
|
X0005:Tns3
|
UTSW |
11 |
8,451,224 (GRCm38) |
missense |
probably benign |
0.00 |
Z1177:Tns3
|
UTSW |
11 |
8,451,014 (GRCm38) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- GGATGCTGGACCTGTATGCGTTTAA -3'
(R):5'- TCCTCATGCTGAGCAGGACTAAGAA -3'
Sequencing Primer
(F):5'- TGAAGTAAGACGTGTACTCACC -3'
(R):5'- ccatccatccatccatccatc -3'
|
Posted On |
2013-05-29 |