Incidental Mutation 'IGL00472:Tex21'
ID4397
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tex21
Ensembl Gene ENSMUSG00000021056
Gene Nametestis expressed gene 21
Synonyms4931412D23Rik, tsec-2, 4931406F04Rik, 4931421K24Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.097) question?
Stock #IGL00472
Quality Score
Status
Chromosome12
Chromosomal Location76198686-76246746 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 76206797 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Lysine at position 447 (N447K)
Ref Sequence ENSEMBL: ENSMUSP00000021453 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021453] [ENSMUST00000218426]
Predicted Effect probably damaging
Transcript: ENSMUST00000021453
AA Change: N447K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000021453
Gene: ENSMUSG00000021056
AA Change: N447K

DomainStartEndE-ValueType
coiled coil region 83 190 N/A INTRINSIC
coiled coil region 308 356 N/A INTRINSIC
coiled coil region 409 447 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000218426
AA Change: N447K

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 16 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk3 C T 7: 81,095,653 probably benign Het
Atp8b1 T A 18: 64,564,430 I448F probably benign Het
C2cd2l A G 9: 44,317,103 L156P probably damaging Het
Cbll1 G A 12: 31,487,833 P308S probably damaging Het
Ccl3 C T 11: 83,648,641 S39N possibly damaging Het
Cnih4 G T 1: 181,162,094 G30C probably damaging Het
Endod1 A T 9: 14,356,753 F479I possibly damaging Het
Gm572 T G 4: 148,667,392 V238G possibly damaging Het
Grhl1 G T 12: 24,612,170 R536L probably damaging Het
Itgae A G 11: 73,113,694 K269R probably benign Het
Nin C A 12: 70,030,088 M1064I probably damaging Het
Pnkd A G 1: 74,285,922 K50E probably damaging Het
Rpl39l A G 16: 10,174,394 M29V probably benign Het
Spata5 A G 3: 37,436,644 H446R probably benign Het
Strip2 C T 6: 29,931,214 A388V probably benign Het
Zfp760 A G 17: 21,723,476 Y544C possibly damaging Het
Other mutations in Tex21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Tex21 APN 12 76245111 missense probably damaging 1.00
IGL01062:Tex21 APN 12 76198944 missense probably benign 0.03
IGL01063:Tex21 APN 12 76198818 missense probably benign 0.34
IGL02624:Tex21 APN 12 76214624 missense probably damaging 1.00
IGL03349:Tex21 APN 12 76221591 missense probably benign 0.14
IGL03387:Tex21 APN 12 76198920 missense probably damaging 1.00
IGL03412:Tex21 APN 12 76245006 critical splice donor site probably null
R0189:Tex21 UTSW 12 76239533 missense probably benign 0.13
R0730:Tex21 UTSW 12 76204166 missense probably benign 0.25
R1521:Tex21 UTSW 12 76204270 missense probably benign 0.38
R1572:Tex21 UTSW 12 76206891 missense probably benign 0.03
R1700:Tex21 UTSW 12 76221672 missense probably damaging 0.99
R1941:Tex21 UTSW 12 76221684 missense possibly damaging 0.68
R4654:Tex21 UTSW 12 76217086 missense probably benign 0.32
R4943:Tex21 UTSW 12 76221700 missense probably damaging 1.00
R6175:Tex21 UTSW 12 76198933 missense probably benign 0.00
R6262:Tex21 UTSW 12 76212532 missense probably damaging 0.99
R6738:Tex21 UTSW 12 76239509 missense probably benign 0.12
R6759:Tex21 UTSW 12 76204312 critical splice acceptor site probably null
R6890:Tex21 UTSW 12 76239455 critical splice donor site probably null
Z1176:Tex21 UTSW 12 76204120 missense probably damaging 1.00
Posted On2012-04-20