Incidental Mutation 'R5631:Or5w1b'
ID 439836
Institutional Source Beutler Lab
Gene Symbol Or5w1b
Ensembl Gene ENSMUSG00000075155
Gene Name olfactory receptor family 5 subfamily W member 1B
Synonyms GA_x6K02T2Q125-49151278-49150337, Olfr1133, MOR176-2
MMRRC Submission 043282-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R5631 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87475524-87476465 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87475952 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 172 (S172T)
Ref Sequence ENSEMBL: ENSMUSP00000149460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099855] [ENSMUST00000217368]
AlphaFold Q7TR44
Predicted Effect probably benign
Transcript: ENSMUST00000099855
AA Change: S172T

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000097441
Gene: ENSMUSG00000075155
AA Change: S172T

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
Pfam:7tm_4 32 308 7e-51 PFAM
Pfam:7tm_1 42 291 1.8e-15 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118805
Predicted Effect probably benign
Transcript: ENSMUST00000217368
AA Change: S172T

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427D14Rik C A 11: 72,067,590 (GRCm39) V567L possibly damaging Het
Abraxas1 T G 5: 100,965,840 (GRCm39) Y68S probably damaging Het
Adamtsl1 C T 4: 86,195,160 (GRCm39) Q543* probably null Het
Anapc1 T C 2: 128,499,137 (GRCm39) Y845C possibly damaging Het
Ap4m1 A G 5: 138,173,051 (GRCm39) *98W probably null Het
Clock G A 5: 76,378,185 (GRCm39) P572S probably benign Het
Cramp1 T A 17: 25,204,577 (GRCm39) T275S possibly damaging Het
Dock3 T C 9: 106,832,898 (GRCm39) S1038G probably benign Het
Fancm T C 12: 65,160,617 (GRCm39) V1397A probably damaging Het
Fn1 T C 1: 71,629,355 (GRCm39) T2203A probably damaging Het
Gm57858 G C 3: 36,101,026 (GRCm39) Q49E probably damaging Het
Heatr5a T A 12: 52,002,310 (GRCm39) I209F probably benign Het
Hfm1 A G 5: 107,052,629 (GRCm39) S285P probably damaging Het
Hpx A T 7: 105,244,808 (GRCm39) C126S probably damaging Het
Ipo4 A G 14: 55,869,526 (GRCm39) V378A probably damaging Het
Ipo4 C T 14: 55,870,838 (GRCm39) V265I probably benign Het
Kcnv1 T A 15: 44,972,753 (GRCm39) T377S probably damaging Het
Kmt2a A T 9: 44,731,985 (GRCm39) probably benign Het
Ldlrad3 T C 2: 101,900,301 (GRCm39) D67G probably damaging Het
Lrrc71 T A 3: 87,646,456 (GRCm39) M535L probably benign Het
Mfhas1 G A 8: 36,055,573 (GRCm39) R16Q probably damaging Het
Mrc1 A T 2: 14,333,383 (GRCm39) K1355* probably null Het
Mrgprf A G 7: 144,862,283 (GRCm39) I282V probably benign Het
Mvb12b G T 2: 33,717,715 (GRCm39) P142Q probably damaging Het
Naip6 T C 13: 100,436,646 (GRCm39) I626V probably benign Het
Ncoa5 T C 2: 164,855,041 (GRCm39) D27G possibly damaging Het
Nrap T G 19: 56,342,553 (GRCm39) E780A probably benign Het
Oplah T C 15: 76,189,441 (GRCm39) I228V probably benign Het
Pkdrej T C 15: 85,704,638 (GRCm39) M433V probably benign Het
Polr3h T A 15: 81,810,113 (GRCm39) probably benign Het
Ppfibp1 T C 6: 146,898,358 (GRCm39) Y105H probably damaging Het
Rplp2 A C 7: 141,031,172 (GRCm39) probably benign Het
Rps6ka4 T C 19: 6,808,345 (GRCm39) probably benign Het
Rspry1 A T 8: 95,355,706 (GRCm39) M1L possibly damaging Het
Runx1 C A 16: 92,492,451 (GRCm39) R64L possibly damaging Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Slc9a5 C T 8: 106,076,141 (GRCm39) H45Y possibly damaging Het
Smc4 T C 3: 68,937,645 (GRCm39) I890T probably benign Het
Smtnl1 T C 2: 84,649,098 (GRCm39) E52G probably benign Het
Stag3 T A 5: 138,294,139 (GRCm39) I319N probably damaging Het
Stt3b G A 9: 115,083,913 (GRCm39) T421I probably benign Het
Thumpd1 A G 7: 119,319,825 (GRCm39) L47P probably damaging Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Top2b T C 14: 16,409,882 (GRCm38) Y850H probably damaging Het
Trim34a A T 7: 103,897,946 (GRCm39) E158V probably damaging Het
Trp53i13 C A 11: 77,400,419 (GRCm39) probably null Het
Ugt3a1 T C 15: 9,361,971 (GRCm39) V249A probably damaging Het
Vmn1r128 G A 7: 21,083,300 (GRCm39) M1I probably null Het
Yars1 T G 4: 129,103,542 (GRCm39) L297R probably damaging Het
Yju2b G T 8: 84,990,510 (GRCm39) Q41K probably damaging Het
Zkscan3 A G 13: 21,578,703 (GRCm39) L176P probably damaging Het
Other mutations in Or5w1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02377:Or5w1b APN 2 87,475,630 (GRCm39) missense probably damaging 1.00
IGL03354:Or5w1b APN 2 87,475,939 (GRCm39) missense probably damaging 0.99
PIT4366001:Or5w1b UTSW 2 87,475,534 (GRCm39) nonsense probably null
R1375:Or5w1b UTSW 2 87,476,081 (GRCm39) missense probably damaging 1.00
R1413:Or5w1b UTSW 2 87,476,182 (GRCm39) missense probably benign 0.02
R2011:Or5w1b UTSW 2 87,476,233 (GRCm39) missense probably damaging 0.97
R2016:Or5w1b UTSW 2 87,476,396 (GRCm39) missense probably benign 0.18
R2026:Or5w1b UTSW 2 87,475,753 (GRCm39) missense probably damaging 1.00
R2106:Or5w1b UTSW 2 87,475,895 (GRCm39) missense probably damaging 1.00
R4393:Or5w1b UTSW 2 87,476,256 (GRCm39) nonsense probably null
R5292:Or5w1b UTSW 2 87,476,339 (GRCm39) missense probably damaging 1.00
R5562:Or5w1b UTSW 2 87,476,063 (GRCm39) missense probably benign 0.00
R5632:Or5w1b UTSW 2 87,475,573 (GRCm39) missense probably damaging 1.00
R6801:Or5w1b UTSW 2 87,475,667 (GRCm39) missense probably benign 0.23
R7014:Or5w1b UTSW 2 87,476,320 (GRCm39) missense probably damaging 1.00
R7963:Or5w1b UTSW 2 87,475,769 (GRCm39) missense probably benign 0.16
R8769:Or5w1b UTSW 2 87,475,960 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GGTGGAAAATGCTTTGTGCC -3'
(R):5'- TGCAGATGTAGAATGTCTCATGC -3'

Sequencing Primer
(F):5'- TCAGCAGAGTTCATCCTGCAG -3'
(R):5'- AGAATGTCTCATGCTAGCTGTC -3'
Posted On 2016-11-08