Incidental Mutation 'R5633:Or6c204'
ID 439985
Institutional Source Beutler Lab
Gene Symbol Or6c204
Ensembl Gene ENSMUSG00000096000
Gene Name olfactory receptor family 6 subfamily C member 204
Synonyms Olfr773-ps1, GA_x6K02T2PULF-10872859-10871923, MOR114-15, Olfr773
MMRRC Submission 043284-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R5633 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129022353-129023288 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129022718 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 191 (F191I)
Ref Sequence ENSEMBL: ENSMUSP00000072743 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072976]
AlphaFold F6VS78
Predicted Effect probably benign
Transcript: ENSMUST00000072976
AA Change: F191I

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000072743
Gene: ENSMUSG00000096000
AA Change: F191I

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.6e-48 PFAM
Pfam:7tm_1 38 287 4.4e-22 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 T A 4: 144,344,598 (GRCm39) C125S probably benign Het
Abcb8 T C 5: 24,608,107 (GRCm39) L382P probably damaging Het
Acot3 A G 12: 84,105,724 (GRCm39) probably null Het
Acsl6 A T 11: 54,228,015 (GRCm39) Q345L probably benign Het
Adcy8 A G 15: 64,571,134 (GRCm39) S1170P probably damaging Het
Ankrd28 T G 14: 31,457,022 (GRCm39) D182A probably damaging Het
B3galt5 A T 16: 96,116,709 (GRCm39) H114L probably benign Het
Bcas2 T A 3: 103,085,740 (GRCm39) Y207* probably null Het
Best1 A G 19: 9,969,467 (GRCm39) L197P probably benign Het
Chil6 C A 3: 106,296,068 (GRCm39) C389F probably damaging Het
Chrna4 T C 2: 180,671,253 (GRCm39) T168A probably damaging Het
Ckmt1 C G 2: 121,194,110 (GRCm39) probably benign Het
Dhcr7 T C 7: 143,401,160 (GRCm39) L441P probably damaging Het
Dmtn T C 14: 70,842,419 (GRCm39) M365V probably benign Het
Dmxl1 T A 18: 50,010,764 (GRCm39) S974T probably damaging Het
Dnajb13 T C 7: 100,156,626 (GRCm39) D150G probably benign Het
Eef2k C A 7: 120,472,513 (GRCm39) probably benign Het
Elp2 T A 18: 24,748,267 (GRCm39) V213E probably damaging Het
Fbxo43 A T 15: 36,162,241 (GRCm39) probably null Het
Gm11559 C A 11: 99,755,412 (GRCm39) C20* probably null Het
Gnb2 T C 5: 137,527,454 (GRCm39) I213V probably benign Het
Gnb5 C T 9: 75,251,796 (GRCm39) T306I probably damaging Het
Ica1 A T 6: 8,667,257 (GRCm39) I303N possibly damaging Het
Idh1 A G 1: 65,204,295 (GRCm39) Y272H probably damaging Het
Ikzf2 G A 1: 69,578,256 (GRCm39) Q273* probably null Het
Itpkb A T 1: 180,154,790 (GRCm39) ⇒1 probably benign Het
Kntc1 C T 5: 123,957,120 (GRCm39) T2143I probably damaging Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Lmbrd1 C A 1: 24,787,943 (GRCm39) D464E possibly damaging Het
Med13 A G 11: 86,169,757 (GRCm39) probably benign Het
Mn1 T C 5: 111,568,192 (GRCm39) F721L possibly damaging Het
Myo9a T A 9: 59,775,467 (GRCm39) L1026Q possibly damaging Het
P4htm A C 9: 108,456,922 (GRCm39) D428E probably damaging Het
Parp8 C T 13: 117,013,116 (GRCm39) R602H probably damaging Het
Pkd2 T A 5: 104,646,372 (GRCm39) S726R probably damaging Het
Pla2g6 A T 15: 79,183,342 (GRCm39) I495N possibly damaging Het
Psmd5 A G 2: 34,746,500 (GRCm39) I359T probably benign Het
Rassf6 T C 5: 90,751,977 (GRCm39) H292R possibly damaging Het
Rnf145 T C 11: 44,450,915 (GRCm39) I413T probably damaging Het
Rpn2 T A 2: 157,125,516 (GRCm39) V9D possibly damaging Het
Rpp30 T C 19: 36,064,390 (GRCm39) L57P probably damaging Het
Slc41a1 A G 1: 131,774,325 (GRCm39) H464R possibly damaging Het
Slc47a1 G T 11: 61,260,087 (GRCm39) P163Q probably damaging Het
Smc4 T A 3: 68,915,443 (GRCm39) I165K probably damaging Het
Stra6l T A 4: 45,881,455 (GRCm39) I439K probably benign Het
Syt9 C T 7: 107,024,503 (GRCm39) T132I probably damaging Het
Timd6 C T 11: 46,465,433 (GRCm39) S9L unknown Het
Trpm2 T C 10: 77,774,187 (GRCm39) I471V possibly damaging Het
Uap1l1 A G 2: 25,253,361 (GRCm39) M358T probably benign Het
Vmn1r91 A T 7: 19,835,870 (GRCm39) H263L possibly damaging Het
Zfp407 T C 18: 84,579,169 (GRCm39) D648G probably benign Het
Zpbp2 T C 11: 98,445,584 (GRCm39) I150T probably damaging Het
Other mutations in Or6c204
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01539:Or6c204 APN 10 129,022,804 (GRCm39) missense probably benign 0.04
R1924:Or6c204 UTSW 10 129,023,044 (GRCm39) missense possibly damaging 0.78
R4171:Or6c204 UTSW 10 129,022,453 (GRCm39) missense probably benign 0.39
R4688:Or6c204 UTSW 10 129,022,514 (GRCm39) missense probably damaging 0.99
R4952:Or6c204 UTSW 10 129,022,466 (GRCm39) missense probably benign 0.12
R5066:Or6c204 UTSW 10 129,022,433 (GRCm39) missense possibly damaging 0.88
R5610:Or6c204 UTSW 10 129,022,426 (GRCm39) missense probably damaging 0.96
R6953:Or6c204 UTSW 10 129,022,474 (GRCm39) missense probably benign 0.01
R9644:Or6c204 UTSW 10 129,022,738 (GRCm39) missense possibly damaging 0.94
RF007:Or6c204 UTSW 10 129,022,562 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGTTGATGGCCACCTCATC -3'
(R):5'- TGAGTACCACAGTCTGCAGAAG -3'

Sequencing Primer
(F):5'- TGCAGCTGCCATAGGTAATG -3'
(R):5'- CTGCAGAAGACTTGTGTTTTGTTC -3'
Posted On 2016-11-08