Incidental Mutation 'R5634:Ccrl2'
ID 440037
Institutional Source Beutler Lab
Gene Symbol Ccrl2
Ensembl Gene ENSMUSG00000043953
Gene Name C-C motif chemokine receptor-like 2
Synonyms L-CCR, 1810047I05Rik, Ackr5, CCR11, Cmkbr1l2
MMRRC Submission 043285-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5634 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 110883902-110886586 bp(-) (GRCm39)
Type of Mutation splice site (43 bp from exon)
DNA Base Change (assembly) T to A at 110885055 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143105 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111888] [ENSMUST00000195968] [ENSMUST00000199839]
AlphaFold O35457
Predicted Effect possibly damaging
Transcript: ENSMUST00000111888
AA Change: T148S

PolyPhen 2 Score 0.653 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000107519
Gene: ENSMUSG00000043953
AA Change: T148S

DomainStartEndE-ValueType
Pfam:7tm_1 54 304 6e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000195968
SMART Domains Protein: ENSMUSP00000143105
Gene: ENSMUSG00000043953

DomainStartEndE-ValueType
Pfam:7tm_1 54 130 1.1e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197851
Predicted Effect possibly damaging
Transcript: ENSMUST00000199839
AA Change: T148S

PolyPhen 2 Score 0.653 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000143116
Gene: ENSMUSG00000043953
AA Change: T148S

DomainStartEndE-ValueType
Pfam:7tm_1 54 304 4.2e-31 PFAM
Meta Mutation Damage Score 0.6124 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 98% (60/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat1 T C 9: 53,494,921 (GRCm39) probably benign Het
Aen A T 7: 78,552,255 (GRCm39) T34S probably benign Het
Apoh T A 11: 108,302,875 (GRCm39) V280E probably damaging Het
Ccdc87 A G 19: 4,890,693 (GRCm39) H395R probably benign Het
Cdh20 T C 1: 104,902,800 (GRCm39) F497S probably damaging Het
Cfap54 C A 10: 92,740,125 (GRCm39) probably benign Het
Cimap1b T A 15: 89,262,410 (GRCm39) T70S probably benign Het
Cipc T A 12: 86,999,749 (GRCm39) probably null Het
Col14a1 T A 15: 55,381,694 (GRCm39) Y1756N probably damaging Het
Cyp2c54 G A 19: 40,060,858 (GRCm39) A95V possibly damaging Het
Dcdc5 A G 2: 106,234,325 (GRCm39) noncoding transcript Het
Dnah17 T C 11: 117,943,752 (GRCm39) probably null Het
Eepd1 A T 9: 25,514,849 (GRCm39) N552I probably benign Het
Eif2ak4 A T 2: 118,292,792 (GRCm39) R1218W probably damaging Het
Fbxw18 T A 9: 109,505,871 (GRCm39) I467F possibly damaging Het
Ffar4 GCTTCTT GCTT 19: 38,102,373 (GRCm39) probably benign Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
Gpha2 A G 19: 6,276,890 (GRCm39) T25A probably benign Het
Grin3a T A 4: 49,792,843 (GRCm39) I297F probably damaging Het
Herc2 G A 7: 55,856,531 (GRCm39) G3924R probably damaging Het
Hmcn2 G T 2: 31,223,893 (GRCm39) D97Y probably damaging Het
Igdcc4 G A 9: 65,041,828 (GRCm39) G1131D probably benign Het
Il18rap T C 1: 40,578,536 (GRCm39) probably benign Het
Ino80d C A 1: 63,101,442 (GRCm39) probably benign Het
Klhl1 T C 14: 96,477,707 (GRCm39) T454A probably damaging Het
Krt84 C A 15: 101,437,084 (GRCm39) V360L probably benign Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Lrrc37 T C 11: 103,432,840 (GRCm39) N1267S possibly damaging Het
Mapkbp1 A G 2: 119,803,576 (GRCm39) N15S probably damaging Het
Med13l T C 5: 118,698,915 (GRCm39) F22S possibly damaging Het
Mrc2 T A 11: 105,227,040 (GRCm39) C548* probably null Het
Nacad T C 11: 6,552,387 (GRCm39) E268G possibly damaging Het
Nfxl1 A G 5: 72,686,833 (GRCm39) C527R probably damaging Het
Nphp1 A T 2: 127,601,570 (GRCm39) C412S possibly damaging Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or4g16 A G 2: 111,137,437 (GRCm39) I296V probably benign Het
Per2 C T 1: 91,372,429 (GRCm39) C215Y probably benign Het
Pias1 T C 9: 62,803,255 (GRCm39) T343A probably benign Het
Pja2 C T 17: 64,599,862 (GRCm39) V541M probably damaging Het
Plxna4 G A 6: 32,214,658 (GRCm39) Q608* probably null Het
Ppil4 T A 10: 7,690,542 (GRCm39) D398E probably benign Het
Ppp4r3a T A 12: 101,009,780 (GRCm39) D8V probably damaging Het
Pstk A C 7: 130,973,072 (GRCm39) D57A probably damaging Het
Ptprd T C 4: 75,990,255 (GRCm39) I53V probably benign Het
Pyroxd2 A G 19: 42,728,924 (GRCm39) F159L probably benign Het
Rnf103 A G 6: 71,486,601 (GRCm39) M411V probably benign Het
Scn4a T C 11: 106,220,830 (GRCm39) D943G probably benign Het
Sdk2 T C 11: 113,742,540 (GRCm39) T790A probably damaging Het
Sfr1 T C 19: 47,722,310 (GRCm39) L242P probably damaging Het
Snx25 T C 8: 46,494,428 (GRCm39) D819G possibly damaging Het
Sult2b1 A G 7: 45,383,506 (GRCm39) V183A probably damaging Het
Tcf4 C A 18: 69,769,918 (GRCm39) S8R possibly damaging Het
Ttc7 A G 17: 87,649,515 (GRCm39) D531G probably benign Het
Uap1l1 A C 2: 25,254,145 (GRCm39) C271G probably damaging Het
Ubtf T C 11: 102,201,150 (GRCm39) Y268C probably damaging Het
Vinac1 A T 2: 128,881,406 (GRCm39) D173E probably benign Het
Zfp951 A T 5: 104,963,155 (GRCm39) M137K probably benign Het
Other mutations in Ccrl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02382:Ccrl2 APN 9 110,884,947 (GRCm39) missense probably benign 0.22
IGL02492:Ccrl2 APN 9 110,884,871 (GRCm39) missense probably benign 0.01
octomom UTSW 9 110,885,055 (GRCm39) splice site probably null
IGL03134:Ccrl2 UTSW 9 110,884,725 (GRCm39) missense probably damaging 1.00
R0321:Ccrl2 UTSW 9 110,885,279 (GRCm39) missense probably damaging 0.97
R0924:Ccrl2 UTSW 9 110,885,036 (GRCm39) missense probably benign 0.39
R0967:Ccrl2 UTSW 9 110,884,754 (GRCm39) missense probably benign 0.02
R2033:Ccrl2 UTSW 9 110,884,938 (GRCm39) missense possibly damaging 0.95
R3720:Ccrl2 UTSW 9 110,885,432 (GRCm39) missense probably benign 0.01
R3721:Ccrl2 UTSW 9 110,885,432 (GRCm39) missense probably benign 0.01
R4244:Ccrl2 UTSW 9 110,884,422 (GRCm39) missense probably benign 0.33
R7027:Ccrl2 UTSW 9 110,884,953 (GRCm39) missense probably benign 0.11
R7060:Ccrl2 UTSW 9 110,884,682 (GRCm39) missense probably damaging 1.00
R8957:Ccrl2 UTSW 9 110,884,557 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGAACGTACTTCCAGAGCGG -3'
(R):5'- CTGGGGAACATCTACTTCCTAAACC -3'

Sequencing Primer
(F):5'- GCGCTTCGATTGGCAAG -3'
(R):5'- TAAACCTGGCACTTTCAAACCTGTG -3'
Posted On 2016-11-08