Incidental Mutation 'R5513:Vmn1r11'
ID440172
Institutional Source Beutler Lab
Gene Symbol Vmn1r11
Ensembl Gene ENSMUSG00000115236
Gene Namevomeronasal 1 receptor 11
SynonymsV1rc3
MMRRC Submission 043073-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.128) question?
Stock #R5513 (G1)
Quality Score225
Status Validated
Chromosome6
Chromosomal Location57133455-57139617 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 57137632 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 94 (T94S)
Ref Sequence ENSEMBL: ENSMUSP00000154588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071304] [ENSMUST00000176954] [ENSMUST00000226968] [ENSMUST00000228235]
Predicted Effect probably damaging
Transcript: ENSMUST00000071304
AA Change: T94S

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000071272
Gene: ENSMUSG00000115236
AA Change: T94S

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.5e-56 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000176954
AA Change: T94S

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000135192
Gene: ENSMUSG00000093635
AA Change: T94S

DomainStartEndE-ValueType
Pfam:V1R 28 293 9.7e-59 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226968
AA Change: T94S

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228235
AA Change: T57S

PolyPhen 2 Score 0.836 (Sensitivity: 0.84; Specificity: 0.93)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 97% (59/61)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310035C23Rik G A 1: 105,750,973 V1130I probably damaging Het
Abtb2 A T 2: 103,709,278 probably null Het
Akr1b3 C A 6: 34,316,646 probably benign Het
Alppl2 T A 1: 87,087,338 N434Y probably benign Het
Ampd2 A G 3: 108,075,667 I648T possibly damaging Het
Ankrd11 T C 8: 122,892,520 E1510G probably benign Het
Ano2 A C 6: 126,039,322 K939N possibly damaging Het
Arhgef5 A G 6: 43,272,339 Y8C probably damaging Het
Aspm A T 1: 139,482,398 I2609F probably damaging Het
Camsap2 A T 1: 136,280,863 S964T probably benign Het
Cd22 C T 7: 30,867,025 R823Q probably damaging Het
Cd74 T C 18: 60,811,305 C196R probably damaging Het
Cfap73 A T 5: 120,631,712 I82N probably damaging Het
Cidec A T 6: 113,428,179 Y177N probably damaging Het
Crb1 C T 1: 139,236,821 probably null Het
Cts7 T C 13: 61,355,584 K189E possibly damaging Het
Cyp2c68 A T 19: 39,703,406 Y358N probably damaging Het
Dab2ip A T 2: 35,710,254 H294L probably benign Het
Dnah6 T C 6: 73,190,419 D502G probably null Het
Dnah8 T A 17: 30,752,916 M2768K probably damaging Het
Etl4 C A 2: 20,743,827 S405R probably damaging Het
Fsip2 G T 2: 82,950,908 L19F probably damaging Het
Fsip2 C G 2: 82,950,912 Q217E probably benign Het
Fsip2 T A 2: 82,985,198 N3758K possibly damaging Het
Gm12689 T C 4: 99,296,165 I85T unknown Het
Hivep2 A T 10: 14,132,673 K1672* probably null Het
Igkv2-137 G A 6: 67,556,014 G54S possibly damaging Het
Ints8 A G 4: 11,248,303 V105A possibly damaging Het
Lrba C T 3: 86,542,641 S2089F probably damaging Het
Lrrc8b A G 5: 105,485,984 K774R probably damaging Het
Mcm4 T A 16: 15,630,514 Y393F probably benign Het
Mki67 A G 7: 135,707,750 L324P probably damaging Het
Olfr12 T C 1: 92,620,380 V158A probably benign Het
Olfr1428 A G 19: 12,109,381 L55P probably damaging Het
Olfr1441 G A 19: 12,422,683 V125I probably benign Het
Olfr665 A T 7: 104,881,499 H264L probably damaging Het
Pld4 A G 12: 112,762,554 E19G probably benign Het
Plvap T C 8: 71,511,529 E63G probably damaging Het
Ppig A G 2: 69,750,359 T746A probably benign Het
Prdm2 GCTCCTCCTCCTCCTCCTCCTCCTC GCTCCTCCTCCTCCTCCTCCTC 4: 143,135,893 probably benign Het
Rbm15b A G 9: 106,886,117 L284P probably benign Het
Rhbdl3 T C 11: 80,331,842 V239A probably damaging Het
Sae1 T C 7: 16,366,856 E197G probably benign Het
Sdhaf2 C T 19: 10,517,030 R105H probably damaging Het
Senp3 T C 11: 69,677,139 D425G probably benign Het
Slc35e2 C T 4: 155,610,026 P10L probably benign Het
Slc46a1 T C 11: 78,466,550 F143S probably benign Het
Tom1 T A 8: 75,057,220 N52K probably damaging Het
Zfp236 A G 18: 82,658,022 I390T probably damaging Het
Zfp709 A T 8: 71,890,056 H443L probably damaging Het
Zfp960 C T 17: 17,087,734 P237S possibly damaging Het
Other mutations in Vmn1r11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02134:Vmn1r11 APN 6 57138037 missense possibly damaging 0.66
IGL02141:Vmn1r11 APN 6 57137379 nonsense probably null
IGL03147:Vmn1r11 UTSW 6 57137665 missense probably damaging 0.98
R0908:Vmn1r11 UTSW 6 57138064 missense probably damaging 1.00
R1185:Vmn1r11 UTSW 6 57137507 missense possibly damaging 0.89
R1185:Vmn1r11 UTSW 6 57137507 missense possibly damaging 0.89
R1185:Vmn1r11 UTSW 6 57137507 missense possibly damaging 0.89
R1347:Vmn1r11 UTSW 6 57137978 missense probably benign 0.23
R1347:Vmn1r11 UTSW 6 57137978 missense probably benign 0.23
R1348:Vmn1r11 UTSW 6 57137978 missense probably benign 0.23
R1349:Vmn1r11 UTSW 6 57137978 missense probably benign 0.23
R1373:Vmn1r11 UTSW 6 57137978 missense probably benign 0.23
R1497:Vmn1r11 UTSW 6 57137409 missense probably damaging 1.00
R2147:Vmn1r11 UTSW 6 57137598 missense probably benign 0.29
R2367:Vmn1r11 UTSW 6 57137431 missense probably benign 0.00
R3087:Vmn1r11 UTSW 6 57137706 missense possibly damaging 0.94
R4445:Vmn1r11 UTSW 6 57137530 missense probably benign 0.31
R4667:Vmn1r11 UTSW 6 57137498 missense probably damaging 1.00
R4769:Vmn1r11 UTSW 6 57137612 missense probably damaging 1.00
R5841:Vmn1r11 UTSW 6 57137802 missense probably damaging 1.00
R6089:Vmn1r11 UTSW 6 57137660 missense possibly damaging 0.95
R7155:Vmn1r11 UTSW 6 57138162 missense probably benign 0.07
R7359:Vmn1r11 UTSW 6 57138199 missense probably damaging 1.00
R8846:Vmn1r11 UTSW 6 57137822 missense probably benign 0.19
Predicted Primers PCR Primer
(F):5'- AGCTGGGTTAGGAGTCCTAG -3'
(R):5'- TCTCACTCACATTGGTATAAGCAC -3'

Sequencing Primer
(F):5'- TTTTCATAATCCTAGGGCACAGACC -3'
(R):5'- TGGTATAAGCACCAACATAGAAGATC -3'
Posted On2016-11-08